(R)-ketamine ameliorates demyelination and facilitates remyelination in cuprizone-treated mice: A role of gut–microbiota–brain axis

Repeated intermittent administration of (R)-ketamine during juvenile and adolescent stages prevents schizophrenia-relevant phenotypes in adult offspring after maternal immune activation: a role of TrkB signaling

(2022) Yunfei Tan et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

A role of the subdiaphragmatic vagus nerve in depression-like phenotypes in mice after fecal microbiota transplantation from Chrna7 knock-out mice with depression-like phenotypes

(2021) Yaoyu Pu et al.   BRAIN BEHAVIOR AND IMMUNITY

Dextran sulfate sodium-induced inflammation and colitis in mice are ameliorated by (R)-ketamine, but not (S)-ketamine: A role of TrkB signaling

(2021) Yuko Fujita et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Molecular mechanisms underlying the antidepressant actions of arketamine: beyond the NMDA receptor

(2021) Yan Wei et al.   MOLECULAR PSYCHIATRY

Pharmacological and behavioral divergence of ketamine enantiomers: implications for abuse liability

(2021) Jordi Bonaventura et al.   MOLECULAR PSYCHIATRY

Economic Burden of Multiple Sclerosis in Low- and Middle‐Income Countries: A Systematic Review

(2021) Jalal Dahham et al.   PHARMACOECONOMICS

Ingestion of Faecalibaculum rodentium causes depression-like phenotypes in resilient Ephx2 knock-out mice: A role of brain–gut–microbiota axis via the subdiaphragmatic vagus nerve

(2021) Siming Wang et al.   JOURNAL OF AFFECTIVE DISORDERS

(R)-Ketamine attenuates LPS-induced endotoxin-derived delirium through inhibition of neuroinflammation

(2021) Jiancheng Zhang et al.   PSYCHOPHARMACOLOGY

Abnormal composition of microbiota in the gut and skin of imiquimod-treated mice

(2021) Hiroyo Shinno-Hashimoto et al.   Scientific Reports

Depression in multiple sclerosis: Is one approach for its management enough?

(2021) C. Danielle Jones et al.   Multiple Sclerosis and Related Disorders

The Gut-Brain Axis in Multiple Sclerosis. Is Its Dysfunction a Pathological Trigger or a Consequence of the Disease?

(2021) Benedetta Parodi et al.   Frontiers in Immunology

Oligodendrocytes and Microglia: Key Players in Myelin Development, Damage and Repair

(2021) Ilias Kalafatakis et al.   Biomolecules

Antibiotic-induced gut dysbiosis leads to activation of microglia and impairment of cholinergic gamma oscillations in the hippocampus

(2021) Gürsel Çalışkan et al.   BRAIN BEHAVIOR AND IMMUNITY

(R)-ketamine ameliorates the progression of experimental autoimmune encephalomyelitis in mice

(2021) Xingming Wang et al.   BRAIN RESEARCH BULLETIN

Powering up microbiome-microglia interactions

(2021) Caoimhe M.K. Lynch et al.   Cell Metabolism

Gut microbiota–driven brain Aβ amyloidosis in mice requires microglia

(2021) Hemraj B. Dodiya et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The second brain: The connection between gut microbiota composition and multiple sclerosis

(2021) Melina Farshbafnadi et al.   JOURNAL OF NEUROIMMUNOLOGY

(R)-Ketamine ameliorates lethal inflammatory responses and multi-organ injury in mice induced by cecum ligation and puncture

(2021) Jiancheng Zhang et al.   LIFE SCIENCES

Reduction in CD11c+ microglia correlates with clinical progression in chronic experimental autoimmune demyelination

(2021) Florian Mayrhofer et al.   NEUROBIOLOGY OF DISEASE

Intravenous arketamine for treatment-resistant depression: open-label pilot study

(2020) Gustavo C. Leal et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

A historical review of antidepressant effects of ketamine and its enantiomers

(2020) Yan Wei et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Essential role of microglial transforming growth factor-β1 in antidepressant actions of (R)-ketamine and the novel antidepressant TGF-β1

(2020) Kai Zhang et al.   Translational Psychiatry

Risk of psychosis after repeated intermittent administration of (S)-ketamine, but not (R)-ketamine, in mice

(2020) Yunfei Tan et al.   JOURNAL OF AFFECTIVE DISORDERS

Microglia in Multiple Sclerosis: Friend or Foe?

(2020) Brooke L. Guerrero et al.   Frontiers in Immunology

The Cuprizone Model: Dos and Do Nots

(2020) Jiangshan Zhan et al.   Cells

Molecular mechanisms of the rapid-acting and long-lasting antidepressant actions of (R)-ketamine

(2020) Kenji Hashimoto   BIOCHEMICAL PHARMACOLOGY

Development of a Novel Metagenomic Biomarker for Prediction of Upper Gastrointestinal Tract Involvement in Patients With Crohn’s Disease

(2020) Min Seob Kwak et al.   Frontiers in Microbiology

A One-Two Punch in the Gut May Trigger Multiple Sclerosis

(2020) Amir-Hadi Maghzi et al.   IMMUNITY

Ingestion of Lactobacillus intestinalis and Lactobacillus reuteri causes depression- and anhedonia-like phenotypes in antibiotic-treated mice via the vagus nerve

(2020) Siming Wang et al.   Journal of Neuroinflammation

Annual Cost Burden by Level of Relapse Severity in Patients with Multiple Sclerosis

(2020) Jacqueline Nicholas et al.   ADVANCES IN THERAPY

Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade

(2020) Gladys Ferrere et al.   JCI Insight

Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis

(2019) Qianquan Ma et al.   Journal of Neuroinflammation

Comparison of antidepressant and side effects in mice after intranasal administration of (R,S)-ketamine, (R)-ketamine, and (S)-ketamine

(2019) Lijia Chang et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Rapid‐acting antidepressant ketamine, its metabolites and other candidates: A historical overview and future perspective

(2019) Kenji Hashimoto   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Beneficial effects of (R)-ketamine, but not its metabolite (2R,6R)-hydroxynorketamine, in the depression-like phenotype, inflammatory bone markers, and bone mineral density in a chronic social defeat stress model

(2019) Zhongwei Xiong et al.   BEHAVIOURAL BRAIN RESEARCH

The Microbiota-Gut-Brain Axis

(2019) John F. Cryan et al.   PHYSIOLOGICAL REVIEWS

MPTP-induced dopaminergic neurotoxicity in mouse brain is attenuated after subsequent intranasal administration of (R)-ketamine: a role of TrkB signaling

(2019) Atsuhiro Fujita et al.   PSYCHOPHARMACOLOGY

Abnormal composition of gut microbiota is associated with resilience versus susceptibility to inescapable electric stress

(2019) Kai Zhang et al.   Translational Psychiatry

Molecular and cellular mechanisms underlying the antidepressant effects of ketamine enantiomers and its metabolites

(2019) Chun Yang et al.   Translational Psychiatry

Splenic NKG2D confers resilience versus susceptibility in mice after chronic social defeat stress: beneficial effects of (R)-ketamine

(2019) Kai Zhang et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Phencyclidine-induced cognitive deficits in mice are ameliorated by subsequent repeated intermittent administration of (R)-ketamine, but not (S)-ketamine: Role of BDNF-TrkB signaling

(2019) Yunfei Tan et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Mechanistic Target of Rapamycin–Independent Antidepressant Effects of ( R )-Ketamine in a Social Defeat Stress Model

(2018) Chun Yang et al.   BIOLOGICAL PSYCHIATRY

The roles of macrophages and microglia in multiple sclerosis and experimental autoimmune encephalomyelitis

(2018) Fengna Chu et al.   JOURNAL OF NEUROIMMUNOLOGY

Expression of heat shock protein HSP-70 in the retrosplenial cortex of rat brain after administration of ( R,S )-ketamine and ( S )-ketamine, but not ( R )-ketamine

(2018) Zheng Tian et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Predominant gut Lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice

(2018) Fengwei Pan et al.   Microbiome

An update on ketamine and its two enantiomers as rapid-acting antidepressants

(2018) Kai Zhang et al.   Expert Review of Neurotherapeutics

Microglial modulation through colony-stimulating factor-1 receptor inhibition attenuates demyelination

(2018) Victoria Sofía Berenice Wies Mancini et al.   GLIA

Microbiome–microglia connections via the gut–brain axis

(2018) Reem Abdel-Haq et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology

(2018) Sofie Voet et al.   TRENDS IN MOLECULAR MEDICINE

The Gut-Microglia Connection: Implications for Central Nervous System Diseases

(2018) Yiliang Wang et al.   Frontiers in Immunology

Regenerating CNS myelin — from mechanisms to experimental medicines

(2017) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models

(2017) Egle Cekanaviciute et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of (R)-ketamine and lanicemine on depression-like phenotype and abnormal composition of gut microbiota in a social defeat stress model

(2017) Youge Qu et al.   Scientific Reports

Possible role of the gut microbiota–brain axis in the antidepressant effects of (R)-ketamine in a social defeat stress model

(2017) Chun Yang et al.   Translational Psychiatry

Reduction of dopamine D2/3 receptor binding in the striatum after a single administration of esketamine, but not R-ketamine: a PET study in conscious monkeys

(2016) Kenji Hashimoto et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Loss of parvalbumin-immunoreactivity in mouse brain regions after repeated intermittent administration of esketamine, but not R-ketamine

(2016) Chun Yang et al.   PSYCHIATRY RESEARCH

Comparison of R-ketamine and rapastinel antidepressant effects in the social defeat stress model of depression

(2016) Bangkun Yang et al.   PSYCHOPHARMACOLOGY

Animal models of Multiple Sclerosis

(2015) Claudio Procaccini et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Gut Microbiota in Multiple Sclerosis

(2015) Brandi L. Cantarel et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Comparison of ketamine, 7,8-dihydroxyflavone, and ANA-12 antidepressant effects in the social defeat stress model of depression

(2015) Ji-chun Zhang et al.   PSYCHOPHARMACOLOGY

BDNF–TrkB signaling in the nucleus accumbens shell of mice has key role in methamphetamine withdrawal symptoms

(2015) Q Ren et al.   Translational Psychiatry

R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects

(2015) C Yang et al.   Translational Psychiatry

The Benefits and Detriments of Macrophages/Microglia in Models of Multiple Sclerosis

(2013) Khalil S. Rawji et al.   Clinical & Developmental Immunology

Robustness of Gut Microbiota of Healthy Adults in Response to Probiotic Intervention Revealed by High-Throughput Pyrosequencing

(2013) S.-W. Kim et al.   DNA RESEARCH

R (−)-ketamine shows greater potency and longer lasting antidepressant effects than S (+)-ketamine

(2013) Ji-chun Zhang et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Myelin debris regulates inflammatory responses in an experimental demyelination animal model and multiple sclerosis lesions

(2012) Tim Clarner et al.   GLIA

Metagenomic biomarker discovery and explanation

(2011) Nicola Segata et al.   GENOME BIOLOGY

The cuprizone model for demyelination

(2008) Ø. Torkildsen et al.   ACTA NEUROLOGICA SCANDINAVICA