DOPAL derived alpha-synuclein oligomers impair synaptic vesicles physiological function

Lysines, Achilles’ heel in alpha-synuclein conversion to a deadly neuronal endotoxin

(2016) Nicoletta Plotegher et al.   AGEING RESEARCH REVIEWS

LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate

(2016) Elisa Belluzzi et al.   Molecular Neurodegeneration

Structural disorder of monomeric α-synuclein persists in mammalian cells

(2016) Francois-Xavier Theillet et al.   NATURE

Cholesterol facilitates interactions between α-synuclein oligomers and charge-neutral membranes

(2015) Andreas van Maarschalkerweerd et al.   FEBS LETTERS

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation

(2015) Serene W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation

(2014) Guoxiang Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Aldehyde dehydrogenase variation enhances effect of pesticides associated with Parkinson disease

(2014) A. G. Fitzmaurice et al.   NEUROLOGY

Divalent metal ions enhance DOPAL-induced oligomerization of alpha-synuclein

(2014) Yunden Jinsmaa et al.   NEUROSCIENCE LETTERS

Biophysical groundwork as a hinge to unravel the biology of α-synuclein aggregation and toxicity

(2014) Nicoletta Plotegher et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

(2014) B. G. Wilhelm et al.   SCIENCE

Dysfunction of dopamine homeostasis: clues in the hunt for novel Parkinson's disease therapies

(2013) Marco Bisaglia et al.   FASEB JOURNAL

Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease

(2013) David S. Goldstein et al.   JOURNAL OF NEUROCHEMISTRY

The many faces of alpha-synuclein mutations

(2013) Meike Kasten et al.   MOVEMENT DISORDERS

α-Synuclein and Mitochondria: Partners in Crime?

(2013) Ken Nakamura   Neurotherapeutics

Aldehyde dehydrogenase inhibition generates a reactive dopamine metabolite autotoxic to dopamine neurons

(2013) Jonathan A. Doorn et al.   PARKINSONISM & RELATED DISORDERS

Protein degradation pathways in Parkinson’s disease: curse or blessing

(2012) Darius Ebrahimi-Fakhari et al.   ACTA NEUROPATHOLOGICA

Alpha-synuclein pore forming activity upon membrane association

(2012) Laura Tosatto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Vesicular uptake blockade generates the toxic dopamine metabolite 3,4-dihydroxyphenylacetaldehyde in PC12 cells: relevance to the pathogenesis of Parkinson's disease

(2012) David S. Goldstein et al.   JOURNAL OF NEUROCHEMISTRY

 -Synuclein Inhibits Intersynaptic Vesicle Mobility and Maintains Recycling-Pool Homeostasis

(2012) D. Scott et al.   JOURNAL OF NEUROSCIENCE

Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease

(2012) A. G. Fitzmaurice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and Morphological Characterization of Aggregated Species of α-Synuclein Induced by Docosahexaenoic Acid

(2011) Giorgia De Franceschi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LRRK2 Controls Synaptic Vesicle Storage and Mobilization within the Recycling Pool

(2011) G. Piccoli et al.   JOURNAL OF NEUROSCIENCE

α-Synuclein: Membrane Interactions and Toxicity in Parkinson's Disease

(2010) Pavan K. Auluck et al.   Annual Review of Cell and Developmental Biology

Catechols in post-mortem brain of patients with Parkinson disease

(2010) D. S. Goldstein et al.   EUROPEAN JOURNAL OF NEUROLOGY

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Protein Reactivity of 3,4-Dihydroxyphenylacetaldehyde, a Toxic Dopamine Metabolite, Is Dependent on Both the Aldehyde and the Catechol

(2009) Jennifer N. Rees et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Structural Properties of Pore-Forming Oligomers of α-Synuclein

(2009) Hai-Young Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dopamine-Induced Conformational Changes in Alpha-Synuclein

(2009) Tiago F. Outeiro et al.   PLoS One

The Reaction of α-Synuclein with Tyrosinase

(2008) Isabella Tessari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of membrane-bound  -synuclein from site-directed spin labeling and computational refinement

(2008) C. C. Jao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA