The Biological Function of Sigma-2 Receptor/TMEM97 and Its Utility in PET Imaging Studies in Cancer

Cell-proliferation imaging for monitoring response to CDK4/6 inhibition combined with endocrine-therapy in breast cancer: Comparison of [18F]FLT and [18F]ISO-1 PET/CT

(2019) Azadeh Elmi et al.   CLINICAL CANCER RESEARCH

The Molecular Function of σ Receptors: Past, Present, and Future

(2019) Hayden R. Schmidt et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Small-Molecule Modulators of Sigma1 and Sigma2/TMEM97 in the Context of Cancer: Foundational Concepts and Emerging Themes

(2019) Halley M. Oyer et al.   Frontiers in Pharmacology

Breast Cancer 18F-ISO-1 Uptake as a Marker of Proliferation Status

(2019) Elizabeth S. McDonald et al.   JOURNAL OF NUCLEAR MEDICINE

Sigma-2 receptor: past, present and perspectives on multiple therapeutic exploitations

(2018) Carmen Abate et al.   Future Medicinal Chemistry

A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97

(2018) João Ramalho-Carvalho et al.   Clinical Epigenetics

Sigma-2 Receptor/TMEM97 and PGRMC-1 Increase the Rate of Internalization of LDL by LDL Receptor through the Formation of a Ternary Complex

(2018) Aladdin Riad et al.   Scientific Reports

The prognostic role of MAC30 in advanced gastric cancer patients receiving platinum-based chemotherapy

(2017) Xiaohong Wu et al.   Future Oncology

Palbociclib Combined with Fulvestrant in Premenopausal Women with Advanced Breast Cancer and Prior Progression on Endocrine Therapy: PALOMA‐3 Results

(2017) Sibylle Loibl et al.   ONCOLOGIST

Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1

(2017) Maria Laura Pati et al.   PHARMACOLOGICAL RESEARCH

Identification of the gene that codes for the σ2receptor

(2017) Assaf Alon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduction of TMEM97 increases NPC1 protein levels and restores cholesterol trafficking in Niemann-pick type C1 disease cells

(2016) Darius Ebrahimi-Fakhari et al.   HUMAN MOLECULAR GENETICS

The Prognostic Effect of MAC30 Expression on Patients With Non–Small Cell Lung Cancer Receiving Adjuvant Chemotherapy

(2016) Hui Ding et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

RNA interference against TMEM97 inhibits cell proliferation, migration, and invasion in glioma cells

(2015) Guanzhong Qiu et al.   TUMOR BIOLOGY

The Sigma-2 Receptor and Progesterone Receptor Membrane Component 1 are Different Binding Sites Derived From Independent Genes

(2015) Uyen B. Chu et al.   EBioMedicine

Down-Regulated MAC30 Expression Inhibits Proliferation and Mobility of Human Gastric Cancer Cells

(2014) Xiao-Yan Xu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Cholesterol and Cancer, in the Balance

(2014) S. Silvente-Poirot et al.   SCIENCE

TM6SF2 and MAC30, new enzyme homologs in sterol metabolism and common metabolic disease

(2014) Luis Sanchez-Pulido et al.   Frontiers in Genetics

Molecular Pathways: Sterols and Receptor Signaling in Cancer

(2013) L. Gabitova et al.   CLINICAL CANCER RESEARCH

The σ2 Receptor: A Novel Protein for the Imaging and Treatment of Cancer

(2013) Robert H. Mach et al.   JOURNAL OF MEDICINAL CHEMISTRY

Assessment of Cellular Proliferation in Tumors by PET Using 18F-ISO-1

(2013) F. Dehdashti et al.   JOURNAL OF NUCLEAR MEDICINE

Quantitative Receptor-Based Imaging of Tumor Proliferation with the Sigma-2 Ligand [18F]ISO-1

(2013) Kooresh I. Shoghi et al.   PLoS One

Expression of MAC30 protein is related to survival and clinicopathological variables in breast cancer

(2012) Min Xiao et al.   JOURNAL OF SURGICAL ONCOLOGY

Elevated expression of MAC30 predicts lymph node metastasis and unfavorable prognosis in patients with epithelial ovarian cancer

(2012) Shanshan Yang et al.   MEDICAL ONCOLOGY

Significance of mRNA and Protein Expression of MAC30 in Progression of Colorectal Cancer

(2011) Zeng-Ren Zhao et al.   CHEMOTHERAPY

Expression of NF-κB p65 phosphorylated at serine-536 in rectal cancer with or without preoperative radiotherapy

(2011) Andreas Lewander et al.   Radiology and Oncology

Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site

(2011) Jinbin Xu et al.   Nature Communications

Identification of Cholesterol-Regulating Genes by Targeted RNAi Screening

(2009) Fabian Bartz et al.   Cell Metabolism