Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse
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Title
Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse
Authors
Keywords
Huntington disease, Movement disorders, Neurodegeneration
Journal
Molecular Neurodegeneration
Volume 13, Issue 1, Pages -
Publisher
Springer Nature
Online
2018-05-21
DOI
10.1186/s13024-018-0259-3
References
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Note: Only part of the references are listed.- The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease
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- (2016) Khanh Q. Nguyen et al. Frontiers in Cellular Neuroscience
- limma powers differential expression analyses for RNA-sequencing and microarray studies
- (2015) Matthew E. Ritchie et al. NUCLEIC ACIDS RESEARCH
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- (2015) Kristoffer Sahlholm et al. PSYCHOPHARMACOLOGY
- The Role of H3K4me3 in Transcriptional Regulation Is Altered in Huntington’s Disease
- (2015) Xianjun Dong et al. PLoS One
- Npas4 Regulates Excitatory-Inhibitory Balance within Neural Circuits through Cell-Type-Specific Gene Programs
- (2014) Ivo Spiegel et al. CELL
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- (2014) M. Maheshwari et al. HUMAN MOLECULAR GENETICS
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- (2014) Joshua L. Plotkin et al. NEURON
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- (2013) Peikai Chen et al. BMC BIOINFORMATICS
- Bidirectional Control of Postsynaptic Density-95 (PSD-95) Clustering by Huntingtin
- (2013) Matthew P. Parsons et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A randomized, double-blind, placebo-controlled trial of pridopidine in Huntington's disease
- (2013) MOVEMENT DISORDERS
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- Dopamine D1 Receptors, Regulation of Gene Expression in the Brain, and Neurodegeneration
- (2012) Jean Lud Cadet et al. CNS & Neurological Disorders-Drug Targets
- The dopaminergic stabilizer pridopidine decreases expression of l-DOPA-induced locomotor sensitisation in the rat unilateral 6-OHDA model
- (2012) Henrik Ponten et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- PSD-95 expression controls l-DOPA dyskinesia through dopamine D1 receptor trafficking
- (2012) Gregory Porras et al. JOURNAL OF CLINICAL INVESTIGATION
- Regulation of Feedback between Protein Kinase A and the Proteasome System Worsens Huntington's Disease
- (2012) J.-T. Lin et al. MOLECULAR AND CELLULAR BIOLOGY
- Pridopidine for the treatment of motor function in patients with Huntington's disease (MermaiHD): a phase 3, randomised, double-blind, placebo-controlled trial
- (2011) Justo Garcia de Yebenes et al. LANCET NEUROLOGY
- In vivo pharmacology of the dopaminergic stabilizer pridopidine
- (2010) Henrik Ponten et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- BDNF Overexpression in the Forebrain Rescues Huntington's Disease Phenotypes in YAC128 Mice
- (2010) Y. Xie et al. JOURNAL OF NEUROSCIENCE
- edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
- (2009) M. D. Robinson et al. BIOINFORMATICS
- The dopaminergic stabilizers pridopidine (ACR16) and (−)-OSU6162 display dopamine D2 receptor antagonism and fast receptor dissociation properties
- (2009) Tino Dyhring et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Increased Hypothalamic-Pituitary-Adrenal Axis Activity in Huntington’s Disease
- (2009) N. Ahmad Aziz et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- CREB is a key regulator of striatal vulnerability in chemical and genetic models of Huntington's disease
- (2009) Yun-Sik Choi et al. NEUROBIOLOGY OF DISEASE
- GPR3 Receptor, a Novel Actor in the Emotional-Like Responses
- (2009) Olga Valverde et al. PLoS One
- Short-Term Striatal Gene Expression Responses to Brain-Derived Neurotrophic Factor Are Dependent on MEK and ERK Activation
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- Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons
- (2008) Emilie Colin et al. EMBO JOURNAL
- Large-scale analysis of glucocorticoid target genes in rat hypothalamus
- (2008) Hirohito Sato et al. JOURNAL OF NEUROCHEMISTRY
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