Sigma-1 Receptor Activation Induces Autophagy and Increases Proteostasis Capacity In Vitro and In Vivo

Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease

(2018) Daniel J. Colacurcio et al.   FREE RADICAL BIOLOGY AND MEDICINE

A molecular perspective of mammalian autophagosome biogenesis

(2018) Thomas J. Mercer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Modulators of Proteostasis: RNAi Screen of Chromosome I in a Heat Stress Paradigm in C. elegans

(2018) Andreas Kern et al.   Cells

The mammalian ULK1 complex and autophagy initiation

(2017) Maria Zachari et al.   Essays in Biochemistry

Pathways of cellular proteostasis in aging and disease

(2017) Courtney L. Klaips et al.   JOURNAL OF CELL BIOLOGY

Small-Molecule Sigma1 Modulator Induces Autophagic Degradation of PD-L1

(2017) Christina M. Maher et al.   MOLECULAR CANCER RESEARCH

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

(2017) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

Sigma-1 Receptor Agonists Induce Oxidative Stress in Mitochondria and Enhance Complex I Activity in Physiological Condition but Protect Against Pathological Oxidative Stress

(2017) Nino Goguadze et al.   NEUROTOXICITY RESEARCH

Sigma 1 receptor regulates ERK activation and promotes survival of optic nerve head astrocytes

(2017) Jing Zhao et al.   PLoS One

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Loss-of-function mutations in theSIGMAR1gene cause distal hereditary motor neuropathy by impairing ER-mitochondria tethering and Ca2+signalling

(2016) Elisa Gregianin et al.   HUMAN MOLECULAR GENETICS

Sigma1 receptors inhibit store-operated Ca 2+ entry by attenuating coupling of STIM1 to Orai1

(2016) Shyam Srivats et al.   JOURNAL OF CELL BIOLOGY

Crystal structure of the human σ1 receptor

(2016) Hayden R. Schmidt et al.   NATURE

The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems

(2016) Tsung-Ping Su et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Sigma-1 Receptor Agonism Promotes Mechanical Allodynia After Priming the Nociceptive System with Capsaicin

(2016) J. M. Entrena et al.   Scientific Reports

Role of sigma-1 receptors in neurodegenerative diseases

(2015) Linda Nguyen et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

High-throughput screening approaches to identify regulators of mammalian autophagy

(2015) Justin Joachim et al.   METHODS

Cocaine-Mediated Autophagy in Astrocytes Involves Sigma 1 Receptor, PI3K, mTOR, Atg5/7, Beclin-1 and Induces Type II Programed Cell Death

(2015) Lu Cao et al.   MOLECULAR NEUROBIOLOGY

Mitochondrial protection by the mixed muscarinic/σ1 ligand ANAVEX2-73, a tetrahydrofuran derivative, in Aβ25–35 peptide-injected mice, a nontransgenic Alzheimer’s disease model

(2015) Valentine Lahmy et al.   Frontiers in Cellular Neuroscience

RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy

(2014) Natalie Spang et al.   Autophagy

The Sigma Enigma: In Vitro/in Silico Site-Directed Mutagenesis Studies Unveil σ1 Receptor Ligand Binding

(2014) S. Brune et al.   BIOCHEMISTRY

Proteostasis impairment in protein-misfolding and -aggregation diseases

(2014) Mark S. Hipp et al.   TRENDS IN CELL BIOLOGY

Loss of function of the ALS protein SigR1 leads to ER pathology associated with defective autophagy and lipid raft disturbances

(2014) J T Vollrath et al.   Cell Death & Disease

Acetylcholine Mediates AMPK-Dependent Autophagic Cytoprotection in H9c2 Cells During Hypoxia/Reoxygenation Injury

(2013) Mei Zhao et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Lack of sigma-1 receptor exacerbates ALS progression in mice

(2013) T.A. Mavlyutov et al.   NEUROSCIENCE

Protein Homeostasis, Aging and Alzheimer’s Disease

(2012) Tobias Morawe et al.   MOLECULAR NEUROBIOLOGY

Sigma-1R Agonist Improves Motor Function and Motoneuron Survival in ALS Mice

(2012) Renzo Mancuso et al.   Neurotherapeutics

A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis

(2011) Amr Al-Saif et al.   ANNALS OF NEUROLOGY

AMPK Activates Autophagy by Phosphorylating ULK1

(2011) Kai Mao et al.   CIRCULATION RESEARCH

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

GABARAPL1 (GEC1) associates with autophagic vesicles

(2010) Fatima Zahra Chakrama et al.   Autophagy

Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor/sigma1 (σ1) ligand ANAVEX2-73, a novel aminotetrahydrofuran derivative

(2010) Vanessa Villard et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

(2009) Martin Gamerdinger et al.   EMBO JOURNAL

The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy

(2008) Naonobu Fujita et al.   MOLECULAR BIOLOGY OF THE CELL

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE