Blockade of Tau Hyperphosphorylation and Aβ1–42 Generation by the Aminotetrahydrofuran Derivative ANAVEX2-73, a Mixed Muscarinic and σ1 Receptor Agonist, in a Nontransgenic Mouse Model of Alzheimer’s Disease

Roles of Glycogen Synthase Kinase 3 in Alzheimer’s Disease

(2012) Zhiyou Cai et al.   Current Alzheimer Research

The γ-secretase inhibitor 2-[(1R)-1-[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl) amino]ethyl-5-fluorobenzenebutanoic acid (BMS-299897) alleviates Aβ1–42 seeding and short-term memory deficits in the Aβ25–35 mouse model of Alzheimer's disease

(2012) Johann Meunier et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Anti-amnesic effect of neurosteroid PREGS in Aβ25–35-injected mice through σ1 receptor- and α7nAChR-mediated neuroprotection

(2012) Rong Yang et al.   NEUROPHARMACOLOGY

Time-Course and Regional Analyses of the Physiopathological Changes Induced after Cerebral Injection of an Amyloid β Fragment in Rats

(2011) Charleine Zussy et al.   AMERICAN JOURNAL OF PATHOLOGY

The phosphodiesterase-4 inhibitor rolipram reverses Aβ-induced cognitive impairment and neuroinflammatory and apoptotic responses in rats

(2011) Chuang Wang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

A novel glycogen synthase kinase-3 inhibitor 2-methyl-5-(3-{4-[(S )-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer’s disease

(2011) Tomohiro Onishi et al.   JOURNAL OF NEUROCHEMISTRY

Cholinergic modulation of amyloid precursor protein processing with emphasis on M1 muscarinic receptor: perspectives and challenges in treatment of Alzheimer’s disease

(2011) Abraham Fisher   JOURNAL OF NEUROCHEMISTRY

Synaptic Stimulation of mTOR Is Mediated by Wnt Signaling and Regulation of Glycogen Synthetase Kinase-3

(2011) T. Ma et al.   JOURNAL OF NEUROSCIENCE

ERK1-independent α-secretase cut of β-amyloid precursor protein via M1 muscarinic receptors and PKCα/ε

(2011) Moustapha Cisse et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease

(2011) B. DaRocha-Souto et al.   NEUROBIOLOGY OF DISEASE

Cognitive dysfunctions induced by a cholinergic blockade and Aβ25–35 peptide are attenuated by salvianolic acid B

(2011) Dong Hyun Kim et al.   NEUROPHARMACOLOGY

Xanthoceraside attenuates amyloid β peptide25–35-induced learning and memory impairments in mice

(2011) Ping Lu et al.   PSYCHOPHARMACOLOGY

GSK3 and Alzheimer’s disease: facts and fiction…

(2011) Anna Kremer   Frontiers in Molecular Neuroscience

Nicotine exacerbates tau phosphorylation and cognitive impairment induced by amyloid-beta 25–35 in rats

(2010) Juan Deng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Anesthetic-Induced Neurodegeneration Mediated via Inositol 1,4,5-Trisphosphate Receptors

(2010) Y. Zhao et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor/sigma1 (σ1) ligand ANAVEX2-73, a novel aminotetrahydrofuran derivative

(2010) Vanessa Villard et al.   JOURNAL OF PSYCHOPHARMACOLOGY

DHEA prevents Aβ25–35-impaired survival of newborn neurons in the dentate gyrus through a modulation of PI3K-Akt-mTOR signaling

(2010) Liang Li et al.   NEUROPHARMACOLOGY

Effects of trans-2,4-dimethoxystibene against the neurotoxicity induced by Aβ25–35 both in vitro and in vivo

(2010) Can-Jun Ruan et al.   NEUROSCIENCE RESEARCH

Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

(2010) Tao Ma et al.   PLoS One

Calcineurin dephosphorylates glycogen synthase kinase-3 beta at serine-9 in neuroblast-derived cells

(2009) Yeni Kim et al.   JOURNAL OF NEUROCHEMISTRY

Imipramine, in Part through Tumor Necrosis Factor   Inhibition, Prevents Cognitive Decline and  -Amyloid Accumulation in a Mouse Model of Alzheimer's Disease

(2009) F. Chavant et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Sigma-1 Receptors Regulate Bcl-2 Expression by Reactive Oxygen Species-Dependent Transcriptional Regulation of Nuclear Factor  B

(2009) J. Meunier et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Fluvoxamine and sigma-1 receptor agonists dehydroepiandrosterone (DHEA)-sulfate induces the Ser473-phosphorylation of Akt-1 in PC12 cells

(2009) Miho Nakano et al.   LIFE SCIENCES

GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals

(2008) Shuxin Hu et al.   NEUROBIOLOGY OF DISEASE

Antiamnesic and Neuroprotective Effects of the Aminotetrahydrofuran Derivative ANAVEX1-41 Against Amyloid β25–35-Induced Toxicity in Mice

(2008) Vanessa Villard et al.   NEUROPSYCHOPHARMACOLOGY

Cholinergic treatments with emphasis on M1 muscarinic agonists as potential disease-modifying agents for Alzheimer’s disease

(2008) Abraham Fisher   Neurotherapeutics

The anti-amnesic and neuroprotective effects of donepezil against amyloid β25-35 peptide-induced toxicity in mice involve an interaction with the σ1 receptor

(2006) J Meunier et al.   BRITISH JOURNAL OF PHARMACOLOGY