Activation of the sigma-1 receptor chaperone alleviates symptoms of Wolfram syndrome in preclinical models

The role of sigma 1 receptor in organization of endoplasmic reticulum signaling microdomains

(2021) Vladimir Zhemkov et al.   eLife

Antipsychotic drugs counteract autophagy and mitophagy in multiple sclerosis

(2021) Simone Patergnani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bi-phasic dose response in the preclinical and clinical developments of sigma-1 receptor ligands for the treatment of neurodegenerative disorders

(2020) Tangui Maurice   Expert Opinion on Drug Discovery

PRE-084 as a tool to uncover potential therapeutic applications for selective sigma-1 receptor activation

(2020) Zeinab Y. Motawe et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Asbestos induces mesothelial cell transformation via HMGB1-driven autophagy

(2020) Jiaming Xue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER-mitochondria contact sites in neurodegeneration: genetic screening approaches to investigate novel disease mechanisms

(2020) Emma Louise Wilson et al.   CELL DEATH AND DIFFERENTIATION

The Molecular Mechanisms Underlying Mitochondria-Associated Endoplasmic Reticulum Membrane-Induced Insulin Resistance

(2020) Han Cheng et al.   Frontiers in Endocrinology

Sigma-1 Receptor Activation Induces Autophagy and Increases Proteostasis Capacity In Vitro and In Vivo

(2019) Maximilian Christ et al.   Cells

Sigma-1 receptor ablation impairs autophagosome clearance

(2019) Huan Yang et al.   Autophagy

Current Landscape of Treatments for Wolfram Syndrome

(2019) Damien Abreu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Molecular Function of σ Receptors: Past, Present, and Future

(2019) Hayden R. Schmidt et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mutational Analysis of Sigma-1 Receptor’s Role in Synaptic Stability

(2019) Daniel A. Ryskamp et al.   Frontiers in Neuroscience

Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overload

(2019) Nicoletta Plotegher et al.   CELL DEATH AND DIFFERENTIATION

Calcium signaling and molecular mechanisms underlying neurodegenerative diseases

(2018) Ekaterina Pchitskaya et al.   CELL CALCIUM

Disruption of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Contributes to Muscle Insulin Resistance in Mice and Humans

(2018) Emily Tubbs et al.   DIABETES

Lower Urinary Tract Dysfunction and Associated Pons Volume in Wolfram Syndrome

(2018) Kyle O. Rove et al.   JOURNAL OF UROLOGY

Genetic and clinical aspects of Wolfram syndrome 1, a severe neurodegenerative disease

(2018) Luciana Rigoli et al.   PEDIATRIC RESEARCH

The sigma-1 receptor as a regulator of dopamine neurotransmission: A potential therapeutic target for methamphetamine addiction

(2018) Danielle O. Sambo et al.   PHARMACOLOGY & THERAPEUTICS

Calcium Dynamics as a Machine for Decoding Signals

(2018) Carlotta Giorgi et al.   TRENDS IN CELL BIOLOGY

Wolfram syndrome: MAMs’ connection?

(2018) Benjamin Delprat et al.   Cell Death & Disease

The machineries, regulation and cellular functions of mitochondrial calcium

(2018) Carlotta Giorgi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Altered ER–mitochondria contact impacts mitochondria calcium homeostasis and contributes to neurodegeneration in vivo in disease models

(2018) Kyu-Sun Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER-mitochondria cross-talk is regulated by the Ca2+ sensor NCS1 and is impaired in Wolfram syndrome

(2018) Claire Angebault et al.   Science Signaling

Mania in Wolfram’s Disease: From Bedside to Bench

(2017) Seshadri Sekhar Chatterjee et al.   Clinical Psychopharmacology and Neuroscience

Schizophrenia in Wolfram Syndrome (DIDMOAD Syndrome): A case report in support of the mitochondrial dysfunction hypothesis

(2017) Guru S. Gowda et al.   SCHIZOPHRENIA RESEARCH

Wfs1- deficient rats develop primary symptoms of Wolfram syndrome: insulin-dependent diabetes, optic nerve atrophy and medullary degeneration

(2017) Mario Plaas et al.   Scientific Reports

Wolfram Syndrome: Diagnosis, Management, and Treatment

(2016) Fumihiko Urano   Current Diabetes Reports

Pridopidine activates neuroprotective pathways impaired in Huntington Disease

(2016) Michal Geva et al.   HUMAN MOLECULAR GENETICS

Bipolar Disorder Type 1 in a 17-Year-Old Girl with Wolfram Syndrome

(2016) Jean Xavier et al.   JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

Anxiety-related behavioral responses of pentylenetetrazole-treated zebrafish larvae to light-dark transitions

(2016) Xiaolan Peng et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

There's Something Wrong with my MAM; the ER–Mitochondria Axis and Neurodegenerative Diseases

(2016) Sebastien Paillusson et al.   TRENDS IN NEUROSCIENCES

Role of Mitochondrial Dynamics in Neuronal Development: Mechanism for Wolfram Syndrome

(2016) Michal Cagalinec et al.   PLOS BIOLOGY

ER-to-mitochondria miscommunication and metabolic diseases

(2015) Camila López-Crisosto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Targeted siRNA Screens Identify ER-to-Mitochondrial Calcium Exchange in Autophagy and Mitophagy Responses in RPE1 Cells

(2015) Thomas MacVicar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cocaine-Mediated Autophagy in Astrocytes Involves Sigma 1 Receptor, PI3K, mTOR, Atg5/7, Beclin-1 and Induces Type II Programed Cell Death

(2015) Lu Cao et al.   MOLECULAR NEUROBIOLOGY

Selective cognitive and psychiatric manifestations in Wolfram Syndrome

(2015) Allison Bischoff et al.   Orphanet Journal of Rare Diseases

Mitochondrial protection by the mixed muscarinic/σ1 ligand ANAVEX2-73, a tetrahydrofuran derivative, in Aβ25–35 peptide-injected mice, a nontransgenic Alzheimer’s disease model

(2015) Valentine Lahmy et al.   Frontiers in Cellular Neuroscience

Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism

(2014) Veronica Francardo et al.   BRAIN

PRKCB/protein kinase C, beta and the mitochondrial axis as key regulators of autophagy

(2013) Simone Patergnani et al.   Autophagy

Evidence for impaired function of dopaminergic system in Wfs1-deficient mice

(2013) Tanel Visnapuu et al.   BEHAVIOURAL BRAIN RESEARCH

Subcellular calcium measurements in mammalian cells using jellyfish photoprotein aequorin-based probes

(2013) Massimo Bonora et al.   Nature Protocols

Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation

(2013) Marco Peviani et al.   NEUROBIOLOGY OF DISEASE

Blockade of Tau Hyperphosphorylation and Aβ1–42 Generation by the Aminotetrahydrofuran Derivative ANAVEX2-73, a Mixed Muscarinic and σ1 Receptor Agonist, in a Nontransgenic Mouse Model of Alzheimer’s Disease

(2013) Valentine Lahmy et al.   NEUROPSYCHOPHARMACOLOGY

Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-κB pathway

(2013) A Hyrskyluoto et al.   Cell Death & Disease

The Lifetime of UDP-galactose:Ceramide Galactosyltransferase Is Controlled by a Distinct Endoplasmic Reticulum-associated Degradation (ERAD) Regulated by Sigma-1 Receptor Chaperones

(2012) Teruo Hayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acute administration of dopaminergic drugs has differential effects on locomotion in larval zebrafish

(2012) T.D. Irons et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

ATP synthesis and storage

(2012) Massimo Bonora et al.   Purinergic Signalling

Measuring thigmotaxis in larval zebrafish

(2011) S.J. Schnörr et al.   BEHAVIOURAL BRAIN RESEARCH

Diabetes and Neurodegeneration in Wolfram Syndrome: A multicenter study of phenotype and genotype

(2011) J. Rohayem et al.   DIABETES CARE

Cognitive impairments in adult mice with constitutive inactivation ofRIP140gene expression

(2011) F. Duclot et al.   GENES BRAIN AND BEHAVIOR

Neurologic features and genotype-phenotype correlation in Wolfram syndrome

(2010) Annabelle Chaussenot et al.   ANNALS OF NEUROLOGY

Sigma Receptor Agonists: Receptor Binding and Effects on Mesolimbic Dopamine Neurotransmission Assessed by Microdialysis

(2010) Linda Garcés-Ramírez et al.   BIOLOGICAL PSYCHIATRY

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

(2010) César Cárdenas et al.   CELL

Impaired striatal dopamine output of homozygous Wfs1 mutant mice in response to [K+] challenge

(2010) Vallo Matto et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor/sigma1 (σ1) ligand ANAVEX2-73, a novel aminotetrahydrofuran derivative

(2010) Vanessa Villard et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Primary diagnosis of Wolfram syndrome in an adult patient — Case report and description of a novel pathogenic mutation

(2010) Anne Waschbisch et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The sigma-1 receptor chaperone as an inter-organelle signaling modulator

(2010) Tsung-Ping Su et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Wfs1 gene deletion causes growth retardation in mice and interferes with the growth hormone pathway

(2009) S. Kõks et al.   PHYSIOLOGICAL GENOMICS

Distribution of Wfs1 protein in the central nervous system of the mouse and its relation to clinical symptoms of the Wolfram syndrome

(2008) Hendrik Luuk et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Wolfram syndrome 1 (Wfs1) gene expression in the normal mouse visual system

(2008) June Kawano et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Psychiatric symptoms in a patient with Wolfram syndrome caused by a combination of thalamic deficit and endocrinological pathologies

(2008) T. Nickl-Jockschat et al.   NEUROCASE

Antiamnesic and Neuroprotective Effects of the Aminotetrahydrofuran Derivative ANAVEX1-41 Against Amyloid β25–35-Induced Toxicity in Mice

(2008) Vanessa Villard et al.   NEUROPSYCHOPHARMACOLOGY

Behavioral and gene expression analyses of Wfs1 knockout mice as a possible animal model of mood disorder

(2008) Tadafumi Kato et al.   NEUROSCIENCE RESEARCH

The anti-amnesic and neuroprotective effects of donepezil against amyloid β25-35 peptide-induced toxicity in mice involve an interaction with the σ1 receptor

(2006) J Meunier et al.   BRITISH JOURNAL OF PHARMACOLOGY