Sphingoid Bases Regulate the Sigma-1 Receptor—Sphingosine and N,N’-Dimethylsphingosine Are Endogenous Agonists

Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore

(2022) Yuta Tanaka et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine

(2022) Shao-Ming Wang et al.   Autophagy

An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway

(2022) Fuhui Meng et al.   Nature Communications

Differential Responses to Sigma-1 or Sigma-2 Receptor Ablation in Adiposity, Fat Oxidation, and Sexual Dimorphism

(2022) Jing Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The regulatory role of endoplasmic reticulum chaperone proteins in neurodevelopment

(2022) Hongji Sun et al.   Frontiers in Neuroscience

Genomic Action of Sigma-1 Receptor Chaperone Relates to Neuropathic Pain

(2021) Shao-Ming Wang et al.   MOLECULAR NEUROBIOLOGY

Spinal mechanisms contributing to the development of pain hypersensitivity induced by sphingolipids in the rat

(2021) Hong Wei et al.   Pharmacological Reports

Sigma-1 Receptor (S1R) Interaction with Cholesterol: Mechanisms of S1R Activation and Its Role in Neurodegenerative Diseases

(2021) Vladimir Zhemkov et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of sigma 1 receptor in organization of endoplasmic reticulum signaling microdomains

(2021) Vladimir Zhemkov et al.   eLife

Development of New Benzylpiperazine Derivatives as σ1 Receptor Ligands with in Vivo Antinociceptive and Anti-Allodynic Effects

(2021) Giuseppe Romeo et al.   ACS Chemical Neuroscience

Multi-Target Directed Ligands (MTDLs) Binding the σ1 Receptor as Promising Therapeutics: State of the Art and Perspectives

(2021) Francesca Serena Abatematteo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sigmar1’s Molecular, Cellular, and Biological Functions in Regulating Cellular Pathophysiology

(2021) Richa Aishwarya et al.   Frontiers in Physiology

Mapping Sphingolipid Metabolism Pathways during Phagosomal Maturation

(2021) Neelay Mehendale et al.   ACS Chemical Biology

Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes

(2021) Suresh Kumar et al.   CELL

The Sigma-1 receptor is an ER-localized type II membrane protein

(2021) Neeraj Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct regulation of sigma-1 receptor multimerization by its agonists and antagonists in transfected cells and rat liver membranes

(2020) Weimin Conrad Hong   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Virtual Screening for Ligand Discovery at the σ1 Receptor

(2020) Daniel A. Greenfield et al.   ACS Medicinal Chemistry Letters

Simple ammonium salts acting on sigma-1 receptors yield potential treatments for cancer and depression

(2020) James M. Brimson et al.   Scientific Reports

TRP Channels Role in Pain Associated With Neurodegenerative Diseases

(2020) Milena Duitama et al.   Frontiers in Neuroscience

Bi-phasic dose response in the preclinical and clinical developments of sigma-1 receptor ligands for the treatment of neurodegenerative disorders

(2020) Tangui Maurice   Expert Opinion on Drug Discovery

Choline Is an Intracellular Messenger Linking Extracellular Stimuli to IP3-Evoked Ca2+ Signals through Sigma-1 Receptors

(2019) Eugen Brailoiu et al.   Cell Reports

Mechanisms of Small Heat Shock Proteins

(2019) Maria K. Janowska et al.   Cold Spring Harbor Perspectives in Biology

Sigma-1 receptor ablation impairs autophagosome clearance

(2019) Huan Yang et al.   Autophagy

The role of ceramide in regulating endoplasmic reticulum function

(2019) Iris D. Zelnik et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lipid binding controls dimerization of the coat protein p24 transmembrane helix

(2019) Stefanie Pannwitt et al.   BIOPHYSICAL JOURNAL

The Molecular Function of σ Receptors: Past, Present, and Future

(2019) Hayden R. Schmidt et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Neuronal Sigma-1 Receptors: Signaling Functions and Protective Roles in Neurodegenerative Diseases

(2019) Daniel A. Ryskamp et al.   Frontiers in Neuroscience

The Sigma-1 Receptor in Cellular Stress Signaling

(2019) Teruo Hayashi   Frontiers in Neuroscience

New Insights into the Opening of the Occluded Ligand-Binding Pocket of Sigma1 Receptor: Binding of a Novel Bivalent RC-33 Derivative

(2019) Giacomo Rossino et al.   Journal of Chemical Information and Modeling

The Effects of Terminal Tagging on Homomeric Interactions of the Sigma 1 Receptor

(2019) Hideaki Yano et al.   Frontiers in Neuroscience

Pharmacological profiling of sigma 1 receptor ligands by novel receptor homomer assays

(2018) Hideaki Yano et al.   NEUROPHARMACOLOGY

Dipentylammonium Binds to the Sigma-1 Receptor and Protects Against Glutamate Toxicity, Attenuates Dopamine Toxicity and Potentiates Neurite Outgrowth in Various Cultured Cell Lines

(2018) James M. Brimson et al.   NEUROTOXICITY RESEARCH

Structural basis for σ1 receptor ligand recognition

(2018) Hayden R. Schmidt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sigma 1 receptor: A novel therapeutic target in retinal disease

(2018) Sylvia B. Smith et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Small heat shock proteins: Simplicity meets complexity

(2018) Martin Haslbeck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis, Receptor Affinity, and Antiallodynic Activity of Spirocyclic σ Receptor Ligands with Exocyclic Amino Moiety

(2018) Melanie Bergkemper et al.   JOURNAL OF MEDICINAL CHEMISTRY

The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats

(2017) Weimin Conrad Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sigma-1 receptor ligands inhibit catecholamine secretion from adrenal chromaffin cells due to block of nicotinic acetylcholine receptors

(2017) Rebecca L. Brindley et al.   JOURNAL OF NEUROCHEMISTRY

APEX2-enhanced electron microscopy distinguishes sigma-1 receptor localization in the nucleoplasmic reticulum

(2017) Timur A. Mavlyutov et al.   Oncotarget

APEX2- tagging of Sigma 1-receptor indicates subcellular protein topology with cytosolic N-terminus and ER luminal C-terminus

(2017) Timur Mavylutov et al.   Protein & Cell

Lysosphingolipids and sphingolipidoses: Psychosine in Krabbe's disease

(2016) Stefka Spassieva et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Crystal structure of the human σ1 receptor

(2016) Hayden R. Schmidt et al.   NATURE

Sphingosine Kinases: Emerging Structure–Function Insights

(2016) David R. Adams et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems

(2016) Tsung-Ping Su et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The sigma-1 receptors are present in monomeric and oligomeric forms in living cells in the presence and absence of ligands

(2015) Ashish K. Mishra et al.   BIOCHEMICAL JOURNAL

Revisiting the sphingolipid rheostat: Evolving concepts in cancer therapy

(2015) Jason Newton et al.   EXPERIMENTAL CELL RESEARCH

Alterations in Spinal Cord Metabolism during Treatment of Neuropathic Pain

(2015) Caroline H. Johnson et al.   Journal of Neuroimmune Pharmacology

Sigma-1 receptor regulates Tau phosphorylation and axon extension by shaping p35 turnover via myristic acid

(2015) Shang-Yi A. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sigma-1 receptor mediates cocaine-induced transcriptional regulation by recruiting chromatin-remodeling factors at the nuclear envelope

(2015) Shang-Yi A. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of novel sphingolipid-binding motifs in mammalian membrane proteins

(2014) Patrik Björkholm et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Small Molecule Inhibitors of Ceramidases

(2014) Essa M. Saied et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The Oligomeric States of the Purified Sigma-1 Receptor Are Stabilized by Ligands

(2014) Katarzyna A. Gromek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammation triggers production of dimethylsphingosine from oligodendrocytes

(2014) Y.-J. Chen et al.   NEUROSCIENCE

Sphingolipids as modulators of membrane proteins

(2013) Andreas Max Ernst et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Characterization of the Human Sigma-1 Receptor Chaperone Domain Structure and Binding Immunoglobulin Protein (BiP) Interactions

(2013) Jose Luis Ortega-Roldan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic targeting of the ceramide-to-sphingosine 1-phosphate pathway in pain

(2013) Daniela Salvemini et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

How cholesterol interacts with membrane proteins: an exploration of cholesterol-binding sites including CRAC, CARC, and tilted domains

(2013) Jacques Fantini et al.   Frontiers in Physiology

Sphingosine-1-phosphate receptors as emerging targets for treatment of pain

(2012) Sandra P. Welch et al.   BIOCHEMICAL PHARMACOLOGY

The Ligand Binding Region of the Sigma-1 Receptor: Studies Utilizing Photoaffinity Probes, Sphingosine and N-Alkylamines

(2012) Arnold E. Ruoho et al.   CURRENT PHARMACEUTICAL DESIGN

The Lifetime of UDP-galactose:Ceramide Galactosyltransferase Is Controlled by a Distinct Endoplasmic Reticulum-associated Degradation (ERAD) Regulated by Sigma-1 Receptor Chaperones

(2012) Teruo Hayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Automation of the CHARMM General Force Field (CGenFF) I: Bond Perception and Atom Typing

(2012) K. Vanommeslaeghe et al.   Journal of Chemical Information and Modeling

Molecular recognition of a single sphingolipid species by a protein’s transmembrane domain

(2012) F.-Xabier Contreras et al.   NATURE

The sigma-1 receptor: roles in neuronal plasticity and disease

(2012) Saïd Kourrich et al.   TRENDS IN NEUROSCIENCES

Characterization of Interactions of 4-Nitrophenylpropyl-N-alkylamine with Sigma Receptors

(2011) Uyen B. Chu et al.   BIOCHEMISTRY

Antagonists show GTP-sensitive high-affinity binding to the sigma-1 receptor

(2011) JM Brimson et al.   BRITISH JOURNAL OF PHARMACOLOGY

Chloroquine inhibits glutamate-induced death of a neuronal cell line by reducing reactive oxygen species through sigma-1 receptor

(2011) Yoko Hirata et al.   JOURNAL OF NEUROCHEMISTRY

Role of alkaline ceramidases in the generation of sphingosine and its phosphate in erythrocytes

(2010) Ruijuan Xu et al.   FASEB JOURNAL

The sigma1 receptor interacts with N-alkyl amines and endogenous sphingolipids

(2009) Subramaniam Ramachandran et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

The pharmacology of sigma-1 receptors

(2009) Tangui Maurice et al.   PHARMACOLOGY & THERAPEUTICS

The Hallucinogen N,N-Dimethyltryptamine (DMT) Is an Endogenous Sigma-1 Receptor Regulator

(2009) D. Fontanilla et al.   SCIENCE

Probing the Steroid Binding Domain-like I (SBDLI) of the Sigma-1 Receptor Binding Site Using N-Substituted Photoaffinity Labels†

(2008) Dominique Fontanilla et al.   BIOCHEMISTRY

Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate

(2008) C MAO   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

N,N-Dimethyl-D-erythro-Sphingosine Inhibits Store-Operated Ca2+ Entry in U937 Monocytes

(2008) Ji-Yeong Jo et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY