Sigma-1 and dopamine D2/D3 receptor occupancy of pridopidine in healthy volunteers and patients with Huntington disease: a [18F] fluspidine and [18F] fallypride PET study

Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1G93A Model

(2019) Ariel Ionescu et al.   Cell Death & Disease

Pridopidine Induces Functional Neurorestoration Via the Sigma-1 Receptor in a Mouse Model of Parkinson’s Disease

(2019) Veronica Francardo et al.   Neurotherapeutics

Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor

(2019) Chelsy R. Eddings et al.   NEUROBIOLOGY OF DISEASE

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(2018)   NUKLEARMEDIZIN-NUCLEAR MEDICINE

Therapeutic approaches to Huntington disease: from the bench to the clinic

(2018) Nicholas S. Caron et al.   NATURE REVIEWS DRUG DISCOVERY

Pridopidine, a clinic-ready compound, reduces 3,4-dihydroxyphenylalanine-induced dyskinesia in Parkinsonian macaques

(2018) Tom H. Johnston et al.   MOVEMENT DISORDERS

Safety and efficacy of pridopidine in patients with Huntington's disease (PRIDE-HD): a phase 2, randomised, placebo-controlled, multicentre, dose-ranging study

(2018) Ralf Reilmann et al.   LANCET NEUROLOGY

PET Imaging Evaluation of Four σ 1 Radiotracers in Nonhuman Primates

(2017) Evan Baum et al.   JOURNAL OF NUCLEAR MEDICINE

The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease

(2017) Daniel Ryskamp et al.   NEUROBIOLOGY OF DISEASE

Pridopidine for the treatment of Huntington’s disease

(2016) Kathleen M. Shannon   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Pridopidine activates neuroprotective pathways impaired in Huntington Disease

(2016) Michal Geva et al.   HUMAN MOLECULAR GENETICS

Loss-of-function mutations in theSIGMAR1gene cause distal hereditary motor neuropathy by impairing ER-mitochondria tethering and Ca2+signalling

(2016) Elisa Gregianin et al.   HUMAN MOLECULAR GENETICS

Evaluation of the Enantiomer Specific Biokinetics and Radiation Doses of [18F]Fluspidine—A New Tracer in Clinical Translation for Imaging of σ1 Receptors

(2016) Mathias Kranz et al.   MOLECULES

Crystal structure of the human σ1 receptor

(2016) Hayden R. Schmidt et al.   NATURE

Pridopidine, a dopamine stabilizer, improves motor performance and shows neuroprotective effects in Huntington disease R6/2 mouse model

(2015) Ferdinando Squitieri et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The involvement of the sigma-1 receptor in neurodegeneration and neurorestoration

(2015) Karsten Ruscher et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Amyotrophic lateral sclerosis: Current perspectives from basic research to the clinic

(2015) Renzo Mancuso et al.   PROGRESS IN NEUROBIOLOGY

Pridopidine selectively occupies sigma-1 rather than dopamine D2 receptors at behaviorally active doses

(2015) Kristoffer Sahlholm et al.   PSYCHOPHARMACOLOGY

Distinctive In Vivo Kinetics of the New  1 Receptor Ligands (R)-(+)- and (S)-(-)-18F-Fluspidine in Porcine Brain

(2014) P. Brust et al.   JOURNAL OF NUCLEAR MEDICINE

Evaluation of metabolism, plasma protein binding and other biological parameters after administration of (−)-[18F]Flubatine in humans

(2014) Marianne Patt et al.   NUCLEAR MEDICINE AND BIOLOGY

Automation of the radiosynthesis and purification procedures for [18F]Fluspidine preparation, a new radiotracer for clinical investigations in PET imaging of σ1 receptors in brain

(2013) Aurélie Maisonial-Besset et al.   APPLIED RADIATION AND ISOTOPES

Evaluation of P-glycoprotein (abcb1a/b) modulation of [18F]fallypride in MicroPET imaging studies

(2013) Markus Piel et al.   NEUROPHARMACOLOGY

The dopaminergic stabilizer pridopidine is to a major extent N-depropylated by CYP2D6 in humans

(2012) A. Helldén et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

The dopamine stabilizers ACR16 and (−)-OSU6162 display nanomolar affinities at the σ-1 receptor

(2012) K Sahlholm et al.   MOLECULAR PSYCHIATRY

A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis

(2011) Amr Al-Saif et al.   ANNALS OF NEUROLOGY

Molecular imaging of σ receptors: synthesis and evaluation of the potent σ1 selective radioligand [18F]fluspidine

(2010) Steffen Fischer et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Fitting Emax models to clinical trial dose-response data

(2010) Simon Kirby et al.   PHARMACEUTICAL STATISTICS

The sigma-1 receptor chaperone as an inter-organelle signaling modulator

(2010) Tsung-Ping Su et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The dopaminergic stabilizers pridopidine (ACR16) and (−)-OSU6162 display dopamine D2 receptor antagonism and fast receptor dissociation properties

(2009) Tino Dyhring et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Measuring Drug Occupancy in the Absence of a Reference Region: The Lassen Plot Re-Visited

(2009) Vincent J Cunningham et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Brain and Plasma Pharmacokinetics of Aripiprazole in Patients With Schizophrenia: An [18F]Fallypride PET Study

(2008) Gerhard Gründer et al.   AMERICAN JOURNAL OF PSYCHIATRY

Effects of (−)-OSU6162 and ACR16 on motor activity in rats, indicating a unique mechanism of dopaminergic stabilization

(2008) Johan P. Rung et al.   JOURNAL OF NEURAL TRANSMISSION