Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease

Norbenzomorphan Framework as a Novel Scaffold for Generating Sigma 2 Receptor/PGRMC1 Subtype-Selective Ligands

(2016) James J. Sahn et al.   ChemMedChem

Crystal structure of the human σ1 receptor

(2016) Hayden R. Schmidt et al.   NATURE

The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems

(2016) Tsung-Ping Su et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance

(2016) Yasuaki Kabe et al.   Nature Communications

Sigma-2 Receptor Ligands: Neurobiological Effects

(2015) Lin Guo et al.   CURRENT MEDICINAL CHEMISTRY

Elements in support of the ‘non-identity’ of the PGRMC1 protein with the σ2 receptor

(2015) Carmen Abate et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Progesterone attenuates Aβ 25–35 -induced neuronal toxicity via JNK inactivation and progesterone receptor membrane component 1-dependent inhibition of mitochondrial apoptotic pathway

(2015) Yabin Qin et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

The PGRMC1 Protein Level Correlates with the Binding Activity of a Sigma-2 Fluorescent Probe (SW120) in Rat Brain Cells

(2015) Chenbo Zeng et al.   MOLECULAR IMAGING AND BIOLOGY

The Sigma-2 Receptor and Progesterone Receptor Membrane Component 1 are Different Binding Sites Derived From Independent Genes

(2015) Uyen B. Chu et al.   EBioMedicine

Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers

(2014) Christiane Reitz et al.   BIOCHEMICAL PHARMACOLOGY

Sigma receptors as potential therapeutic targets for neuroprotection

(2014) Linda Nguyen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Contribution of Alzheimer disease to mortality in the United States

(2014) B. D. James et al.   NEUROLOGY

Evolution of a strategy for preparing bioactive small molecules by sequential multicomponent assembly processes, cyclizations, and diversification

(2014) James J. Sahn et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers II: Sigma-2/PGRMC1 Receptors Mediate Abeta 42 Oligomer Binding and Synaptotoxicity

(2014) Nicholas J. Izzo et al.   PLoS One

Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers I: Abeta 42 Oligomer Binding to Specific Neuronal Receptors Is Displaced by Drug Candidates That Improve Cognitive Deficits

(2014) Nicholas J. Izzo et al.   PLoS One

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

β1-adrenergic receptor activation enhances memory in Alzheimer's disease model

(2014) Laurence Coutellier et al.   Annals of Clinical and Translational Neurology

The ire-1 ER stress-response pathway is required for normal secretory-protein metabolism in C. elegans

(2013) M. Safra et al.   JOURNAL OF CELL SCIENCE

The σ2 Receptor: A Novel Protein for the Imaging and Treatment of Cancer

(2013) Robert H. Mach et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sigma-2 Receptor Ligands and Their Perspectives in Cancer Diagnosis and Therapy

(2013) Yun-Sheng Huang et al.   MEDICINAL RESEARCH REVIEWS

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Pan-Neuronal Expression of APL-1, an APP-Related Protein, Disrupts Olfactory, Gustatory, and Touch Plasticity in Caenorhabditis elegans

(2012) C. Y. Ewald et al.   JOURNAL OF NEUROSCIENCE

Early Presynaptic and Postsynaptic Calcium Signaling Abnormalities Mask Underlying Synaptic Depression in Presymptomatic Alzheimer's Disease Mice

(2012) S. Chakroborty et al.   JOURNAL OF NEUROSCIENCE

Automated design of ligands to polypharmacological profiles

(2012) Jérémy Besnard et al.   NATURE

Sigma-1 receptor chaperone and brain-derived neurotrophic factor: Emerging links between cardiovascular disease and depression

(2012) Kenji Hashimoto   PROGRESS IN NEUROBIOLOGY

Expedient Synthesis of Norbenzomorphan Library via Multicomponent Assembly Process Coupled with Ring-Closing Reactions

(2012) James J. Sahn et al.   ACS Combinatorial Science

Strength in numbers

(2012) Karina T. Simonsen et al.   Virulence

Thy1-hAPPLond/Swe+mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function

(2012) Mehrdad Faizi et al.   Brain and Behavior

Chemistry and the Worm: Caenorhabditis elegans as a Platform for Integrating Chemical and Biological Research

(2011) S. Elizabeth Hulme et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chronic Apocynin Treatment Attenuates Beta Amyloid Plaque Size and Microglial Number in hAPP(751)SL Mice

(2011) Melinda E. Lull et al.   PLoS One

Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site

(2011) Jinbin Xu et al.   Nature Communications

Relationships between Gene Expression and Brain Wiring in the Adult Rodent Brain

(2011) Leon French et al.   PLoS Computational Biology

Calcium Signaling and Amyloid Toxicity in Alzheimer Disease

(2010) Angelo Demuro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mitochondrial UPR - protecting organelle protein homeostasis

(2010) C. M. Haynes et al.   JOURNAL OF CELL SCIENCE

Alzheimer's disease: strategies for disease modification

(2010) Martin Citron   NATURE REVIEWS DRUG DISCOVERY

The sigma-1 receptor chaperone as an inter-organelle signaling modulator

(2010) Tsung-Ping Su et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells

(2009) Giuseppe Cassano et al.   CELL CALCIUM

Progesterone Increases Rat Neural Progenitor Cell Cycle Gene Expression and Proliferation Via Extracellularly Regulated Kinase and Progesterone Receptor Membrane Components 1 and 2

(2009) Lifei Liu et al.   ENDOCRINOLOGY

Calcium hypothesis of Alzheimer’s disease

(2009) Michael J. Berridge   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Oligomeric amyloid   associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

(2009) R. M. Koffie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium signaling and neurodegenerative diseases

(2009) Ilya Bezprozvanny   TRENDS IN MOLECULAR MEDICINE

Complement C3 Deficiency Leads to Accelerated Amyloid   Plaque Deposition and Neurodegeneration and Modulation of the Microglia/Macrophage Phenotype in Amyloid Precursor Protein Transgenic Mice

(2008) M. Maier et al.   JOURNAL OF NEUROSCIENCE

Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease

(2008) Melanie Meyer-Luehmann et al.   NATURE

Single-copy insertion of transgenes in Caenorhabditis elegans

(2008) Christian Frøkjær-Jensen et al.   NATURE GENETICS

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

PGRMC1 (progesterone receptor membrane component 1): A targetable protein with multiple functions in steroid signaling, P450 activation and drug binding

(2008) Hannah J. Rohe et al.   PHARMACOLOGY & THERAPEUTICS

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

(2008) Ilya Bezprozvanny et al.   TRENDS IN NEUROSCIENCES