The Role of Lipids Interacting with α-Synuclein in the Pathogenesis of Parkinson’s Disease

α-Synuclein structural features inhibit harmful polyunsaturated fatty acid oxidation, suggesting roles in neuroprotection

(2017) Giorgia De Franceschi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

(2017) Michele Perni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification

(2017) Ricardo Gaspar et al.   QUARTERLY REVIEWS OF BIOPHYSICS

A Human Neural Crest Stem Cell-Derived Dopaminergic Neuronal Model Recapitulates Biochemical Abnormalities in GBA1 Mutation Carriers

(2017) Shi-Yu Yang et al.   Stem Cell Reports

Elevated GM3 plasma concentration in idiopathic Parkinson’s disease: A lipidomic analysis

(2017) Robin B. Chan et al.   PLoS One

Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice

(2016) Anna Migdalska-Richards et al.   ANNALS OF NEUROLOGY

Alpha-synuclein and familial variants affect the chain order and the thermotropic phase behavior of anionic lipid vesicles

(2016) Manuela Pantusa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Autophagic lysosome reformation dysfunction in glucocerebrosidase deficient cells: relevance to Parkinson disease

(2016) Joana Magalhaes et al.   HUMAN MOLECULAR GENETICS

Preparation and Characterization of Stable α-Synuclein Lipoprotein Particles

(2016) Cédric Eichmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A New Glucocerebrosidase Chaperone Reduces  -Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism

(2016) E. Aflaki et al.   JOURNAL OF NEUROSCIENCE

Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein

(2016) Céline Galvagnion et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxysterols: From cholesterol metabolites to key mediators

(2016) Valentin Mutemberezi et al.   PROGRESS IN LIPID RESEARCH

Structural Ensembles of Membrane-bound α-Synuclein Reveal the Molecular Determinants of Synaptic Vesicle Affinity

(2016) Giuliana Fusco et al.   Scientific Reports

Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein

(2016) Marija Iljina et al.   Scientific Reports

β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces

(2016) James W. P. Brown et al.   Scientific Reports

α-Synuclein interactions with phospholipid model membranes: Key roles for electrostatic interactions and lipid-bilayer structure

(2015) Katja Pirc et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease–Parkinson's disease overlap?

(2015) Gurdeep Marwarha et al.   EXPERIMENTAL GERONTOLOGY

Glucocerebrosidase deficiency accelerates the accumulation of proteinase K-resistant α-synuclein and aggravates neurodegeneration in aDrosophilamodel of Parkinson's disease

(2015) Mari Suzuki et al.   HUMAN MOLECULAR GENETICS

Definition of a Molecular Pathway Mediating  -Synuclein Neurotoxicity

(2015) J. Burre et al.   JOURNAL OF NEUROSCIENCE

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

(2015) Céline Galvagnion et al.   Nature Chemical Biology

Biophysics of α-synuclein induced membrane remodelling

(2015) Zheng Shi et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Methyl-branched lipids promote the membrane adsorption of α-synuclein by enhancing shallow lipid-packing defects

(2015) Matthias Garten et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

The Synaptic Function of α-Synuclein

(2015) Jacqueline Burré   Journal of Parkinsons Disease

Acceleration of α-Synuclein Aggregation by Exosomes

(2014) Marie Grey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Surface Effects on Aggregation Kinetics of Amyloidogenic Peptides

(2014) Robert Vácha et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

α-Synuclein-Induced Membrane Remodeling Is Driven by Binding Affinity, Partition Depth, and Interleaflet Order Asymmetry

(2014) Anthony R. Braun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Presence of an Air–Water Interface Affects Formation and Elongation of α-Synuclein Fibrils

(2014) Silvia Campioni et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-Alpha-Acetylation of α-Synuclein Increases Its Helical Folding Propensity, GM1 Binding Specificity and Resistance to Aggregation

(2014) Tim Bartels et al.   PLoS One

Solution conditions determine the relative importance of nucleation and growth processes in  -synuclein aggregation

(2014) A. K. Buell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

(2014) B. G. Wilhelm et al.   SCIENCE

Chemical kinetics for drug discovery to combat protein aggregation diseases

(2014) Paolo Arosio et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

iPSC-derived neurons from GBA1-associated Parkinson’s disease patients show autophagic defects and impaired calcium homeostasis

(2014) David C. Schöndorf et al.   Nature Communications

Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour

(2014) Giuliana Fusco et al.   Nature Communications

Adsorption of α-Synuclein to Supported Lipid Bilayers: Positioning and Role of Electrostatics

(2013) Erik Hellstrand et al.   ACS Chemical Neuroscience

Glucocerebrosidase mutations and the pathogenesis of Parkinson disease

(2013) Michelle S. Beavan et al.   ANNALS OF MEDICINE

Mitochondria and Quality Control Defects in a Mouse Model of Gaucher Disease—Links to Parkinson’s Disease

(2013) Laura D. Osellame et al.   Cell Metabolism

α-Synuclein Oligomers with Broken Helical Conformation Form Lipoprotein Nanoparticles

(2013) Jobin Varkey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein Senses Lipid Packing Defects and Induces Lateral Expansion of Lipids Leading to Membrane Remodeling

(2013) Myriam M. Ouberai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Remodeling by α-Synuclein and Effects on Amyloid Formation

(2013) Zhiping Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Membrane Lipid Co-Aggregation with α-Synuclein Fibrils

(2013) Erik Hellstrand et al.   PLoS One

α-Synuclein Oligomers Induced by Docosahexaenoic Acid Affect Membrane Integrity

(2013) Chiara Fecchio et al.   PLoS One

Lipid Sorting and Multivesicular Endosome Biogenesis

(2013) C. Bissig et al.   Cold Spring Harbor Perspectives in Biology

Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains

(2012) Matthew E. Gegg et al.   ANNALS OF NEUROLOGY

Depth of α-Synuclein in a Bilayer Determined by Fluorescence, Neutron Reflectometry, and Computation

(2012) Candace M. Pfefferkorn et al.   BIOPHYSICAL JOURNAL

Monomeric Synucleins Generate Membrane Curvature

(2012) Christopher H. Westphal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucocerebrosidase inhibition causes mitochondrial dysfunction and free radical damage

(2012) Michael W.J. Cleeter et al.   NEUROCHEMISTRY INTERNATIONAL

Acid β-glucosidase mutants linked to gaucher disease, parkinson disease, and lewy body dementia alter α-synuclein processing

(2011) Valerie Cullen et al.   ANNALS OF NEUROLOGY

The late endosome/lysosome-anchored p18-mTORC1 pathway controls terminal maturation of lysosomes

(2011) Yusuke Takahashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

(2011) Joseph R. Mazzulli et al.   CELL

Structural and Morphological Characterization of Aggregated Species of α-Synuclein Induced by Docosahexaenoic Acid

(2011) Giorgia De Franceschi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The oxysterol 27-hydroxycholesterol regulates α-synuclein and tyrosine hydroxylase expression levels in human neuroblastoma cells through modulation of liver X receptors and estrogen receptors-relevance to Parkinson’s disease

(2011) Gurdeep Marwarha et al.   JOURNAL OF NEUROCHEMISTRY

α-Synuclein-Induced Tubule Formation in Lipid Bilayers

(2011) Anjan P. Pandey et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Accumulation and distribution of α-synuclein and ubiquitin in the CNS of Gaucher disease mouse models

(2011) Y.H. Xu et al.   MOLECULAR GENETICS AND METABOLISM

Lipid Pathway Alterations in Parkinson's Disease Primary Visual Cortex

(2011) Danni Cheng et al.   PLoS One

Serum Cholesterol and the Progression of Parkinson's Disease: Results from DATATOP

(2011) Xuemei Huang et al.   PLoS One

CNS expression of glucocerebrosidase corrects  -synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy

(2011) S. P. Sardi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Synuclein sequesters arachidonic acid to modulate SNARE-mediated exocytosis

(2010) Frédéric Darios et al.   EMBO REPORTS

Membrane Curvature Induction and Tubulation Are Common Features of Synucleins and Apolipoproteins

(2010) Jobin Varkey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adsorption of α-Synuclein on Lipid Bilayers: Modulating the Structure and Stability of Protein Assemblies

(2010) Farzin Haque et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

Alpha-synuclein, lipids and Parkinson’s disease

(2010) Violeta Ruipérez et al.   PROGRESS IN LIPID RESEARCH

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Clustering of α -Synuclein on Supported Lipid Bilayers: Role of Anionic Lipid, Protein, and Divalent Ion Concentration

(2009) Anjan P. Pandey et al.   BIOPHYSICAL JOURNAL

Multiple Tight Phospholipid-Binding Modes of α-Synuclein Revealed by Solution NMR Spectroscopy

(2009) Christina R. Bodner et al.   JOURNAL OF MOLECULAR BIOLOGY

Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: A biological link between Gaucher disease and parkinsonism

(2009) Amy B. Manning-Boğ et al.   NEUROTOXICOLOGY

An Analytical Solution to the Kinetics of Breakable Filament Assembly

(2009) T. P. J. Knowles et al.   SCIENCE

N-terminal region of α-synuclein is essential for the fatty acid-induced oligomerization of the molecules

(2008) Hiroki Karube et al.   FEBS LETTERS

Update of the LIPID MAPS comprehensive classification system for lipids

(2008) Eoin Fahy et al.   JOURNAL OF LIPID RESEARCH

Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and α-synuclein in human neuroblastoma SH-SY5Y cells

(2008) Jaya Prasanthi Rantham Prabhakara et al.   JOURNAL OF NEUROCHEMISTRY

Phenotype, diagnosis, and treatment of Gaucher's disease

(2008) Gregory A Grabowski   LANCET

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Gene–gene interaction between heme oxygenase-1 and liver X receptor-β and Alzheimer's disease risk

(2008) Jon Infante et al.   NEUROBIOLOGY OF AGING

Total cholesterol and the risk of Parkinson disease

(2008) G. Hu et al.   NEUROLOGY

Regulation of α-synuclein expression by liver X receptor ligands in vitro

(2008) Danni Cheng et al.   NEUROREPORT

Dietary fats, cholesterol and iron as risk factors for Parkinson's disease

(2008) Karen M. Powers et al.   PARKINSONISM & RELATED DISORDERS

Intracellular cholesterol modifies the ERAD of glucocerebrosidase in Gaucher disease patients☆

(2007) Idit Ron et al.   MOLECULAR GENETICS AND METABOLISM