Cholinesterase inhibitor rivastigmine enhances nerve growth factor-induced neurite outgrowth in PC12 cells via sigma-1 and sigma-2 receptors

Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease

(2017) Bitna Yi et al.   JOURNAL OF NEUROCHEMISTRY

Clinical practice with anti-dementia drugs: A revised (third) consensus statement from the British Association for Psychopharmacology

(2017) John T O’Brien et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Identification of the gene that codes for the σ2receptor

(2017) Assaf Alon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems

(2016) Tsung-Ping Su et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Sigma-1 receptor directly interacts with Rac1-GTPase in the brain mitochondria

(2015) Nino Natsvlishvili et al.   BMC BIOCHEMISTRY

Scopolamine and Depression: A Role for Muscarinic Antagonism?

(2014) Helge Hasselmann   CNS & Neurological Disorders-Drug Targets

Inhibition of Nerve Growth Factor-Induced Neurite Outgrowth from PC12 Cells by Dexamethasone: Signaling Pathways through the Glucocorticoid Receptor and Phosphorylated Akt and ERK1/2

(2014) Kazuki Terada et al.   PLoS One

Nicotinic Acetylcholine Receptors Containing the α7-Like Subunit Mediate Contractions of Muscles Responsible for Space Positioning of the Snail, Helix pomatia L. Tentacle

(2014) Tibor Kiss et al.   PLoS One

Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers I: Abeta 42 Oligomer Binding to Specific Neuronal Receptors Is Displaced by Drug Candidates That Improve Cognitive Deficits

(2014) Nicholas J. Izzo et al.   PLoS One

A review on cholinesterase inhibitors for Alzheimer’s disease

(2013) Preet Anand et al.   ARCHIVES OF PHARMACAL RESEARCH

Chemical, Pharmacological, and in vitro Metabolic Stability Studies on Enantiomerically Pure RC-33 Compounds: Promising Neuroprotective Agents Acting as σ1Receptor Agonists

(2013) Daniela Rossi et al.   ChemMedChem

Quinazolin-4-one Derivatives as Selective Histone Deacetylase-6 Inhibitors for the Treatment of Alzheimer’s Disease

(2013) Chao-Wu Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site

(2011) Jinbin Xu et al.   Nature Communications

Roles of Nicotinic Receptors in Acetylcholinesterase Inhibitor-Induced Neuroprotection and Nicotinic Receptor Up-Regulation

(2009) Yuki Takada-Takatori et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells

(2009) Giuseppe Cassano et al.   CELL CALCIUM

Pharmacology and Therapeutic Potential of Sigma1 Receptor Ligands

(2009) E. Cobos et al.   Current Neuropharmacology

Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression

(2008) Wayne C. Drevets et al.   Brain Structure & Function

Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by donepezil: Role of sigma-1 receptors and IP3 receptors

(2008) Tamaki Ishima et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The anti-amnesic and neuroprotective effects of donepezil against amyloid β25-35 peptide-induced toxicity in mice involve an interaction with the σ1 receptor

(2006) J Meunier et al.   BRITISH JOURNAL OF PHARMACOLOGY