Pridopidine Promotes Synaptogenesis and Reduces Spatial Memory Deficits in the Alzheimer’s Disease APP/PS1 Mouse Model

The redox language in neurodegenerative diseases: oxidative post-translational modifications by hydrogen peroxide

(2021) Yew Mun Lee et al.   Cell Death & Disease

Calcium Dyshomeostasis in Alzheimer’s Disease Pathogenesis

(2021) Roberta Cascella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuronal Hyperexcitability in APPSWE/PS1dE9 Mouse Models of Alzheimer’s Disease

(2021) Luisa Müller et al.   JOURNAL OF ALZHEIMERS DISEASE

Atrophy of lacunosum moleculare layer is important for learning and memory in APP/PS1 transgenic mice

(2021) Yi Zhang et al.   NEUROREPORT

NMDA and AMPA receptors dysregulation in Alzheimer's disease

(2021) Parvin Babaei   EUROPEAN JOURNAL OF PHARMACOLOGY

PRE-084 as a tool to uncover potential therapeutic applications for selective sigma-1 receptor activation

(2020) Zeinab Y. Motawe et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1G93A Model

(2019) Ariel Ionescu et al.   Cell Death & Disease

The Role of PI3K/Akt and ERK in Neurodegenerative Disorders

(2019) Sachchida Nand Rai et al.   NEUROTOXICITY RESEARCH

Pridopidine Induces Functional Neurorestoration Via the Sigma-1 Receptor in a Mouse Model of Parkinson’s Disease

(2019) Veronica Francardo et al.   Neurotherapeutics

Mitochondria- and Oxidative Stress-Targeting Substances in Cognitive Decline-Related Disorders: From Molecular Mechanisms to Clinical Evidence

(2019) Imane Lejri et al.   Oxidative Medicine and Cellular Longevity

Synapse loss and progress of Alzheimer’s disease -A network model

(2019) G. Kashyap et al.   Scientific Reports

Neuronal Sigma-1 Receptors: Signaling Functions and Protective Roles in Neurodegenerative Diseases

(2019) Daniel A. Ryskamp et al.   Frontiers in Neuroscience

Mutational Analysis of Sigma-1 Receptor’s Role in Synaptic Stability

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Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging

(2018) Efstathios S. Gonos et al.   Aging-US

Roles for Arc in metabotropic glutamate receptor-dependent LTD and synapse elimination: Implications in health and disease

(2018) Julia R. Wilkerson et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

Amyloid-β Peptides are Generated in Mitochondria-Associated Endoplasmic Reticulum Membranes

(2018) Bernadette Schreiner et al.   JOURNAL OF ALZHEIMERS DISEASE

Fluoxetine Delays the Cognitive Function Decline and Synaptic Changes in a Transgenic Mouse Model of Early Alzheimer's Disease

(2018) Chun-ni Zhou et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Safety and efficacy of pridopidine in patients with Huntington's disease (PRIDE-HD): a phase 2, randomised, placebo-controlled, multicentre, dose-ranging study

(2018) Ralf Reilmann et al.   LANCET NEUROLOGY

Pridopidine stabilizes mushroom spines in mouse models of Alzheimer's disease by acting on the sigma-1 receptor

(2018) Daniel Ryskamp et al.   NEUROBIOLOGY OF DISEASE

Alzheimer's disease

(2017) C. A. Lane et al.   EUROPEAN JOURNAL OF NEUROLOGY

Role of Glutamate and NMDA Receptors in Alzheimer’s Disease

(2017) Rui Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Tale of the Good and the Bad Cdk5: Remodeling of the Actin Cytoskeleton in the Brain

(2017) Kavita Shah et al.   MOLECULAR NEUROBIOLOGY

The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease

(2017) Daniel Ryskamp et al.   NEUROBIOLOGY OF DISEASE

Dendritic spines: Morphological building blocks of memory

(2017) Menahem Segal   NEUROBIOLOGY OF LEARNING AND MEMORY

Spine Dynamics: Are They All the Same?

(2017) Kalen P. Berry et al.   NEURON

Sigma 1 receptor activation modifies intracellular calcium exchange in the G93A hSOD1 ALS model

(2017) Vedrana Tadić et al.   NEUROSCIENCE

Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases

(2017) Michael G. Erkkinen et al.   Cold Spring Harbor Perspectives in Biology

Role of Oxidative Stress in the Progression of Alzheimer's Disease

(2017) Rukhsana Sultana et al.   JOURNAL OF ALZHEIMERS DISEASE

Dendritic Spine Pathology in Neurodegenerative Diseases

(2016) Jochen Herms et al.   Annual Review of Pathology-Mechanisms of Disease

Mechanisms of tau and Aβ-induced excitotoxicity

(2016) Susanne P. Pallo et al.   BRAIN RESEARCH

Early synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors

(2016) Silvia Viana da Silva et al.   Nature Communications

Role of Immediate-Early Genes in Synaptic Plasticity and Neuronal Ensembles Underlying the Memory Trace

(2016) Keiichiro Minatohara et al.   Frontiers in Molecular Neuroscience

Compromised MAPK signaling in human diseases: an update

(2015) Eun Kyung Kim et al.   ARCHIVES OF TOXICOLOGY

Astrocyte/neuron ratio and its importance on glutamate toxicity: an in vitro voltammetric study

(2015) Ahmet Hacimuftuoglu et al.   CYTOTECHNOLOGY

Sex Dimorphism Profile of Alzheimer’s Disease-Type Pathologies in an APP/PS1 Mouse Model

(2015) Shu-Sheng Jiao et al.   NEUROTOXICITY RESEARCH

Sigma-1 receptor regulates Tau phosphorylation and axon extension by shaping p35 turnover via myristic acid

(2015) Shang-Yi A. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pridopidine selectively occupies sigma-1 rather than dopamine D2 receptors at behaviorally active doses

(2015) Kristoffer Sahlholm et al.   PSYCHOPHARMACOLOGY

Gene expression parallels synaptic excitability and plasticity changes in Alzheimer’s disease

(2015) Carlos A. Saura et al.   Frontiers in Cellular Neuroscience

GSK3β Inhibition Promotes Synaptogenesis in Drosophila and Mammalian Neurons

(2015) Germán Cuesto et al.   PLoS One

Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease

(2014) Cassia R. Overk et al.   BIOCHEMICAL PHARMACOLOGY

Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism

(2014) Veronica Francardo et al.   BRAIN

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

(2014) Tara L. Spires-Jones et al.   NEURON

Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer’s disease

(2014) Yasuko Kitagishi et al.   Alzheimers Research & Therapy

Learning improvement after PI3K activation correlates with de novo formation of functional small spines

(2014) Lilian Enriquez-Barreto et al.   Frontiers in Molecular Neuroscience

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

NMDA receptor-mediated excitotoxicity depends on the coactivation of synaptic and extrasynaptic receptors

(2013) X Zhou et al.   Cell Death & Disease

A New Player in the “Synaptopathy” of Alzheimer’s Disease – Arc/Arg 3.1

(2013) Talitha L. Kerrigan et al.   Frontiers in Neurology

The dopamine stabilizers ACR16 and (−)-OSU6162 display nanomolar affinities at the σ-1 receptor

(2012) K Sahlholm et al.   MOLECULAR PSYCHIATRY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Impaired Performance of Female APP/PS1 Mice in the Morris Water Maze Is Coupled with Increased A� Accumulation and Microglial Activation

(2012) J.J. Gallagher et al.   Neurodegenerative Diseases

Synaptic plasticity in depression: Molecular, cellular and functional correlates

(2012) W.N. Marsden   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

PI3K-PKB/Akt Pathway

(2012) B. A. Hemmings et al.   Cold Spring Harbor Perspectives in Biology

Phosphoinositide-3-Kinase Activation Controls Synaptogenesis and Spinogenesis in Hippocampal Neurons

(2011) G. Cuesto et al.   JOURNAL OF NEUROSCIENCE

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

(2011) Michelle C. Mendoza et al.   TRENDS IN BIOCHEMICAL SCIENCES

Molecular mechanisms of neurodegeneration in Alzheimer's disease

(2010) L. Crews et al.   HUMAN MOLECULAR GENETICS

Synthesis and Evaluation of a Set of 4-Phenylpiperidines and 4-Phenylpiperazines as D2Receptor Ligands and the Discovery of the Dopaminergic Stabilizer 4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine (Huntexil, Pridopidine, ACR16)

(2010) Fredrik Pettersson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Amyloid   Induces the Morphological Neurodegenerative Triad of Spine Loss, Dendritic Simplification, and Neuritic Dystrophies through Calcineurin Activation

(2010) H.-Y. Wu et al.   JOURNAL OF NEUROSCIENCE

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

The synapsins: Key actors of synapse function and plasticity

(2010) F. Cesca et al.   PROGRESS IN NEUROBIOLOGY

Flavonoids and cognition: The molecular mechanisms underlying their behavioural effects

(2009) Jeremy P.E. Spencer et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The dopaminergic stabilizers pridopidine (ACR16) and (−)-OSU6162 display dopamine D2 receptor antagonism and fast receptor dissociation properties

(2009) Tino Dyhring et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Immediate Early Gene Arc/Arg3.1: Regulation, Mechanisms, and Function

(2008) C. R. Bramham et al.   JOURNAL OF NEUROSCIENCE

Episodic memory deficits are not related to altered glutamatergic synaptic transmission and plasticity in the CA1 hippocampus of the APPswe/PS1ΔE9-deleted transgenic mice model of β-amyloidosis

(2008) Arturas Volianskis et al.   NEUROBIOLOGY OF AGING

An unambiguous assay for the cloned human sigma1 receptor reveals high affinity interactions with dopamine D4 receptor selective compounds and a distinct structure–affinity relationship for butyrophenones

(2007) Ivan T. Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY