Pridopidine activates neuroprotective pathways impaired in Huntington Disease

The effects of sigma (σ1) receptor-selective ligands on muscarinic receptor antagonist-induced cognitive deficits in mice

(2015) Maninder Malik et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sigma-1 receptor is involved in degradation of intranuclear inclusions in a cellular model of Huntington's disease

(2015) Yasuo Miki et al.   NEUROBIOLOGY OF DISEASE

Pridopidine selectively occupies sigma-1 rather than dopamine D2 receptors at behaviorally active doses

(2015) Kristoffer Sahlholm et al.   PSYCHOPHARMACOLOGY

Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism

(2014) Veronica Francardo et al.   BRAIN

Deficiency of Ube3a in Huntington's disease mice brain increases aggregate load and accelerates disease pathology

(2014) Megha Maheshwari et al.   HUMAN MOLECULAR GENETICS

Effects of PB190 and PB212, new σ receptor ligands, on glucocorticoid receptor-mediated gene transcription in LMCAT cells

(2014) Grażyna Skuza et al.   Pharmacological Reports

A randomized, double-blind, placebo-controlled trial of pridopidine in Huntington's disease

(2013)   MOVEMENT DISORDERS

Multisource ascertainment of Huntington disease in Canada: Prevalence and population at risk

(2013) Emily R. Fisher et al.   MOVEMENT DISORDERS

Imbalance of p75NTR/TrkB protein expression in Huntington’s disease: implication for neuroprotective therapies

(2013) V Brito et al.   Cell Death & Disease

Dopamine D1 Receptors, Regulation of Gene Expression in the Brain, and Neurodegeneration

(2012) Jean Lud Cadet et al.   CNS & Neurological Disorders-Drug Targets

The dopamine stabilizers ACR16 and (−)-OSU6162 display nanomolar affinities at the σ-1 receptor

(2012) K Sahlholm et al.   MOLECULAR PSYCHIATRY

Glucocorticoid receptors recruit the CaMKIIα-BDNF-CREB pathways to mediate memory consolidation

(2012) Dillon Y Chen et al.   NATURE NEUROSCIENCE

Association between a variant of the sigma-1 receptor gene and Alzheimer's disease

(2012) Ágnes Fehér et al.   NEUROSCIENCE LETTERS

Sigma-1 receptor chaperones regulate the secretion of brain-derived neurotrophic factor

(2012) Michiko Fujimoto et al.   SYNAPSE

A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis

(2011) Amr Al-Saif et al.   ANNALS OF NEUROLOGY

Genetic Polymorphisms in Sigma-1 Receptor and Apolipoprotein E Interact to Influence the Severity of Alzheimers Disease

(2011) Yue Huang et al.   Current Alzheimer Research

Evidence for antimanic efficacy of glycogen synthase kinase-3 (GSK3) inhibitors in a strain-specific model of acute mania

(2011) Mikhail Kalinichev et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Pridopidine for the treatment of motor function in patients with Huntington's disease (MermaiHD): a phase 3, randomised, double-blind, placebo-controlled trial

(2011) Justo Garcia de Yebenes et al.   LANCET NEUROLOGY

The Physiology, Signaling, and Pharmacology of Dopamine Receptors

(2011) J.-M. Beaulieu et al.   PHARMACOLOGICAL REVIEWS

BDNF-trkB signaling in late life cognitive decline and Alzheimer’s disease

(2011) Hoau-Yan Wang et al.   Translational Neuroscience

Sigma nonopioid intracellular receptor 1 mutations cause frontotemporal lobar degeneration-motor neuron disease

(2010) Agnes A. Luty et al.   ANNALS OF NEUROLOGY

BDNF Overexpression in the Forebrain Rescues Huntington's Disease Phenotypes in YAC128 Mice

(2010) Y. Xie et al.   JOURNAL OF NEUROSCIENCE

The dopaminergic stabilizers pridopidine (ACR16) and (−)-OSU6162 display dopamine D2 receptor antagonism and fast receptor dissociation properties

(2009) Tino Dyhring et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Short-Term Striatal Gene Expression Responses to Brain-Derived Neurotrophic Factor Are Dependent on MEK and ERK Activation

(2009) Ozgun Gokce et al.   PLoS One

Glucocorticoid receptor interaction with TrkB promotes BDNF-triggered PLC-  signaling for glutamate release via a glutamate transporter

(2009) T. Numakawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Large-scale analysis of glucocorticoid target genes in rat hypothalamus

(2008) Hirohito Sato et al.   JOURNAL OF NEUROCHEMISTRY

Activation of Trk neurotrophin receptors by glucocorticoids provides a neuroprotective effect

(2008) F. Jeanneteau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA