Pathophysiology and Diagnosis of ALS: Insights from Advances in Neurophysiological Techniques

Amyotrophic lateral sclerosis diagnostic index

(2019) Nimeshan Geevasinga et al.   NEUROLOGY

Relative preservation of triceps over biceps strength in upper limb-onset ALS: the ‘split elbow’

(2019) Roaya Khalaf et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Split elbow sign: more evidence for the importance of cortical dysfunction in ALS

(2019) Steve Vucic   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Short-interval intracortical inhibition: Comparison between conventional and threshold-tracking techniques

(2018) Gintaute Samusyte et al.   Brain Stimulation

6. ALS disability is predicted by a shift in the balance between short latency facilitatory and inhibitory circuits

(2018) Mehdi A.J. van den Bos et al.   CLINICAL NEUROPHYSIOLOGY

Primary lateral sclerosis and the amyotrophic lateral sclerosis–frontotemporal dementia spectrum

(2018) Smriti Agarwal et al.   JOURNAL OF NEUROLOGY

Physiological Processes Underlying Short Interval Intracortical Facilitation in the Human Motor Cortex

(2018) Mehdi A. J. Van den Bos et al.   Frontiers in Neuroscience

Imbalance of cortical facilitatory and inhibitory circuits underlies hyperexcitability in ALS

(2018) Mehdi A.J. Van den Bos et al.   NEUROLOGY

Cortical hyperexcitability and disease spread in amyotrophic lateral sclerosis

(2017) P. Menon et al.   EUROPEAN JOURNAL OF NEUROLOGY

Brain functional connectome abnormalities in amyotrophic lateral sclerosis are associated with disability and cortical hyperexcitability

(2017) N. Geevasinga et al.   EUROPEAN JOURNAL OF NEUROLOGY

Cortical influences drive amyotrophic lateral sclerosis

(2017) Andrew Eisen et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Motor neurone disease: progress and challenges

(2017) Thanuja Dharmadasa et al.   MEDICAL JOURNAL OF AUSTRALIA

Awaji criteria improves the diagnostic sensitivity in amyotrophic lateral sclerosis: A systematic review using individual patient data

(2016) Nimeshan Geevasinga et al.   CLINICAL NEUROPHYSIOLOGY

Hyperactive somatostatin interneurons contribute to excitotoxicity in neurodegenerative disorders

(2016) Wen Zhang et al.   NATURE NEUROSCIENCE

Pathophysiological and diagnostic implications of cortical dysfunction in ALS

(2016) Nimeshan Geevasinga et al.   Nature Reviews Neurology

Diagnostic criteria in amyotrophic lateral sclerosis

(2016) Nimeshan Geevasinga et al.   NEUROLOGY

Motor cortical function determines prognosis in sporadic ALS

(2016) Kazumoto Shibuya et al.   NEUROLOGY

Transcranial Magnetic Stimulation for the Assessment of Neurodegenerative Disease

(2016) Steve Vucic et al.   Neurotherapeutics

Cortical contributions to the flail leg syndrome: Pathophysiological insights

(2016) Parvathi Menon et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Riluzole exerts transient modulating effects on cortical and axonal hyperexcitability in ALS

(2016) Nimeshan Geevasinga et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Corticospinal Motor Neurons Are Susceptible to Increased ER Stress and Display Profound Degeneration in the Absence of UCHL1 Function

(2015) Javier H. Jara et al.   CEREBRAL CORTEX

Altered Functionality, Morphology, and Vesicular Glutamate Transporter Expression of Cortical Motor Neurons from a Presymptomatic Mouse Model of Amyotrophic Lateral Sclerosis

(2015) L. Saba et al.   CEREBRAL CORTEX

Cortical hyperexcitability precedes lower motor neuron dysfunction in ALS

(2015) Parvathi Menon et al.   CLINICAL NEUROPHYSIOLOGY

Non-invasive electrical and magnetic stimulation of the brain, spinal cord, roots and peripheral nerves: Basic principles and procedures for routine clinical and research application. An updated report from an I.F.C.N. Committee

(2015) P.M. Rossini et al.   CLINICAL NEUROPHYSIOLOGY

TMS and drugs revisited 2014

(2015) Ulf Ziemann et al.   CLINICAL NEUROPHYSIOLOGY

Cortical excitability changes distinguish the motor neuron disease phenotypes from hereditary spastic paraplegia

(2015) N. Geevasinga et al.   EUROPEAN JOURNAL OF NEUROLOGY

Dissociated lower limb muscle involvement in amyotrophic lateral sclerosis

(2015) Neil G. Simon et al.   JOURNAL OF NEUROLOGY

Motor Cortex Layer V Pyramidal Neurons Exhibit Dendritic Regression, Spine Loss, and Increased Synaptic Excitation in the Presymptomatic hSOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis

(2015) M. J. Fogarty et al.   JOURNAL OF NEUROSCIENCE

Sensitivity and specificity of threshold tracking transcranial magnetic stimulation for diagnosis of amyotrophic lateral sclerosis: a prospective study

(2015) Parvathi Menon et al.   LANCET NEUROLOGY

Human endogenous retrovirus-K contributes to motor neuron disease

(2015) Wenxue Li et al.   Science Translational Medicine

Cortical Function in Asymptomatic Carriers and Patients WithC9orf72Amyotrophic Lateral Sclerosis

(2015) Nimeshan Geevasinga et al.   JAMA Neurology

Axonal Ion Channel Dysfunction inC9orf72Familial Amyotrophic Lateral Sclerosis

(2015) Nimeshan Geevasinga et al.   JAMA Neurology

Amyotrophic lateral sclerosis: a long preclinical period?

(2014) A. Eisen et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study

(2014) Ammar Al-Chalabi et al.   LANCET NEUROLOGY

Cortical Dysfunction Underlies the Development of the Split-Hand in Amyotrophic Lateral Sclerosis

(2014) Parvathi Menon et al.   PLoS One

Advances in treating amyotrophic lateral sclerosis: insights from pathophysiological studies

(2014) Steve Vucic et al.   TRENDS IN NEUROSCIENCES

Retrograde labeling, transduction, and genetic targeting allow cellular analysis of corticospinal motor neurons: implications in health and disease

(2014) Javier H. Jara et al.   Frontiers in Neuroanatomy

Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons

(2014) Brian J. Wainger et al.   Cell Reports

Cortical hyperexcitability and the split-hand plus phenomenon: Pathophysiological insights in ALS

(2014) Jong Seok Bae et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Study of motor asymmetry in ALS indicates an effect of limb dominance on onset and spread of weakness, and an important role for upper motor neurons

(2014) Matthew S. Devine et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Early intrinsic hyperexcitability does not contribute to motoneuron degeneration in amyotrophic lateral sclerosis

(2014) Félix Leroy et al.   eLife

Riluzole exerts central and peripheral modulating effects in amyotrophic lateral sclerosis

(2013) Steve Vucic et al.   BRAIN

ALS pathophysiology: Insights from the split-hand phenomenon

(2013) Parvathi Menon et al.   CLINICAL NEUROPHYSIOLOGY

Pathophysiological insights into ALS with C9ORF72 expansions

(2013) K. L. Williams et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Neuroprotection through Excitability and mTOR Required in ALS Motoneurons to Delay Disease and Extend Survival

(2013) Smita Saxena et al.   NEURON

Effects of lacosamide and carbamazepine on human motor cortex excitability: A double-blind, placebo-controlled transcranial magnetic stimulation study

(2013) Nicolas Lang et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Awaji Criteria for the Diagnosis of Amyotrophic Lateral Sclerosis

(2012) João Costa et al.   ARCHIVES OF NEUROLOGY

Handedness and the excitability of cortical inhibitory circuits

(2012) Campbell S. Reid et al.   BEHAVIOURAL BRAIN RESEARCH

Transcranial Direct Current Stimulation Effects on the Excitability of Corticospinal Axons of the Human Cerebral Cortex

(2012) Vincenzo Di Lazzaro et al.   Brain Stimulation

Transcranial magnetic stimulation and amyotrophic lateral sclerosis: pathophysiological insights

(2012) Steve Vucic et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

AAV2 mediated retrograde transduction of corticospinal motor neurons reveals initial and selective apical dendrite degeneration in ALS

(2012) Javier H. Jara et al.   NEUROBIOLOGY OF DISEASE

Split-hand plus sign in ALS: Differential involvement of the flexor pollicis longus and intrinsic hand muscles

(2012) Parvathi Menon et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

I-wave origin and modulation

(2011) V. Di Lazzaro et al.   Brain Stimulation

Cortical excitability distinguishes ALS from mimic disorders

(2011) Steve Vucic et al.   CLINICAL NEUROPHYSIOLOGY

Carbamazepine reduces short-interval interhemispheric inhibition in healthy humans

(2011) Martin Sommer et al.   CLINICAL NEUROPHYSIOLOGY

Corticospinal Motor Neurons and Related Subcerebral Projection Neurons Undergo Early and Specific Neurodegeneration in hSOD1G93A Transgenic ALS Mice

(2011) P. H. Ozdinler et al.   JOURNAL OF NEUROSCIENCE

Fasciculation potentials in amyotrophic lateral sclerosis and the diagnostic yield of the Awaji algorithm

(2011) Mana Higashihara et al.   MUSCLE & NERVE

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

(2011) Amanda M Haidet-Phillips et al.   NATURE BIOTECHNOLOGY

Concordance between site of onset and limb dominance in amyotrophic lateral sclerosis

(2010) M. R. Turner et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Cortical excitability in hereditary motor neuronopathy with pyramidal signs: comparison with ALS

(2009) S Vucic et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Upregulation of persistent sodium conductances in familial ALS

(2009) S. Vucic et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

ALS motor phenotype heterogeneity, focality, and spread: Deconstructing motor neuron degeneration

(2009) J. M. Ravits et al.   NEUROLOGY

Redox Regulation of Multidrug Resistance in Cancer Chemotherapy: Molecular Mechanisms and Therapeutic Opportunities

(2008) Macus Tien Kuo   ANTIOXIDANTS & REDOX SIGNALING

Cortical hyperexcitability may precede the onset of familial amyotrophic lateral sclerosis

(2008) Steve Vucic et al.   BRAIN

Cortical excitability testing distinguishes Kennedy’s disease from amyotrophic lateral sclerosis

(2008) Steve Vucic et al.   CLINICAL NEUROPHYSIOLOGY

Electrodiagnostic criteria for diagnosis of ALS

(2008) Mamede de Carvalho et al.   CLINICAL NEUROPHYSIOLOGY

Increased persistent sodium current determines cortical hyperexcitability in a genetic model of amyotrophic lateral sclerosis

(2008) Massimo Pieri et al.   EXPERIMENTAL NEUROLOGY

Biomarkers in amyotrophic lateral sclerosis

(2008) Martin R Turner et al.   LANCET NEUROLOGY

Dissociated small hand muscle atrophy in amyotrophic lateral sclerosis: Frequency, extent, and specificity

(2008) Satoshi Kuwabara et al.   MUSCLE & NERVE

The clinical diagnostic utility of transcranial magnetic stimulation: Report of an IFCN committee

(2007) Robert Chen et al.   CLINICAL NEUROPHYSIOLOGY