Impact of Two Neuronal Sigma-1 Receptor Modulators, PRE084 and DMT, on Neurogenesis and Neuroinflammation in an Aβ1–42-Injected, Wild-Type Mouse Model of AD

Microglia in Aging and Alzheimer’s Disease: A Comparative Species Review

(2021) Melissa K. Edler et al.   Cells

N,N-Dimethyltryptamine attenuates spreading depolarization and restrains neurodegeneration by sigma-1 receptor activation in the ischemic rat brain

(2021) Írisz Szabó et al.   NEUROPHARMACOLOGY

Neuroinflammation and Neurogenesis in Alzheimer’s Disease and Potential Therapeutic Approaches

(2020) Pi-Shan Sung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bi-phasic dose response in the preclinical and clinical developments of sigma-1 receptor ligands for the treatment of neurodegenerative disorders

(2020) Tangui Maurice   Expert Opinion on Drug Discovery

Sigma ligands as potent inhibitors of Aβ and AβOs in neurons and promising therapeutic agents of Alzheimer's disease

(2020) Wen-Hui Ma et al.   NEUROPHARMACOLOGY

N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo

(2020) Jose A. Morales-Garcia et al.   Translational Psychiatry

Evaluation of the Cytotoxicity of Ayahuasca Beverages

(2020) Ana Y. Simão et al.   MOLECULES

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

(2020) Fangda Leng et al.   Nature Reviews Neurology

Sigma-1 Receptor Activation Induces Autophagy and Increases Proteostasis Capacity In Vitro and In Vivo

(2019) Maximilian Christ et al.   Cells

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

(2019) Elena P. Moreno-Jiménez et al.   NATURE MEDICINE

Anti-inflammatory and cognitive effects of interferon-β1a (IFNβ1a) in a rat model of Alzheimer’s disease

(2019) Giuseppa Mudò et al.   Journal of Neuroinflammation

Chronic, Intermittent Microdoses of the Psychedelic N,N-Dimethyltryptamine (DMT) Produce Positive Effects on Mood and Anxiety in Rodents

(2019) Lindsay P. Cameron et al.   ACS Chemical Neuroscience

Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer’s Disease Patients

(2019) Matthew K. Tobin et al.   Cell Stem Cell

Corrigendum: A Single Dose of 5-MeO-DMT Stimulates Cell Proliferation, Neuronal Survivability, Morphological and Functional Changes in Adult Mice Ventral Dentate Gyrus

(2019) Rafael Vitor Lima da Cruz et al.   Frontiers in Molecular Neuroscience

The Roles of Intracellular Chaperone Proteins, Sigma Receptors, in Parkinson’s Disease (PD) and Major Depressive Disorder (MDD)

(2019) Kai Yang et al.   Frontiers in Pharmacology

Is Alzheimer’s Disease a Neurogenesis Disorder?

(2019) Se Hoon Choi et al.   Cell Stem Cell

Effects of the Pentapeptide P33 on Memory and Synaptic Plasticity in APP/PS1 Transgenic Mice: A Novel Mechanism Presenting the Protein Fe65 as a Target

(2019) Titanilla Szögi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Keeping up with the therapeutic advances in schizophrenia: a review of novel and emerging pharmacological entities

(2019) Amanda Krogmann et al.   CNS SPECTRUMS

Neuronal Sigma-1 Receptors: Signaling Functions and Protective Roles in Neurodegenerative Diseases

(2019) Daniel A. Ryskamp et al.   Frontiers in Neuroscience

Neurogenesis and morphological-neural alterations closely related to amyloid β-peptide (25–35)-induced memory impairment in male rats

(2018) Eleazar Ramírez et al.   NEUROPEPTIDES

Dipentylammonium Binds to the Sigma-1 Receptor and Protects Against Glutamate Toxicity, Attenuates Dopamine Toxicity and Potentiates Neurite Outgrowth in Various Cultured Cell Lines

(2018) James M. Brimson et al.   NEUROTOXICITY RESEARCH

Psychedelics Promote Structural and Functional Neural Plasticity

(2018) Calvin Ly et al.   Cell Reports

Hypothesis: The Psychedelic Ayahuasca Heals Traumatic Memories via a Sigma 1 Receptor-Mediated Epigenetic-Mnemonic Process

(2018) Antonio Inserra   Frontiers in Pharmacology

Sigma Receptors as Endoplasmic Reticulum Stress “Gatekeepers” and their Modulators as Emerging New Weapons in the Fight Against Cancer

(2018) Anna Tesei et al.   Frontiers in Pharmacology

Dark Classics in Chemical Neuroscience: N,N-Dimethyltryptamine (DMT)

(2018) Lindsay P. Cameron et al.   ACS Chemical Neuroscience

Sigma-1 Receptor-Modulated Neuroinflammation in Neurological Diseases

(2018) Jia Jia et al.   Frontiers in Cellular Neuroscience

A Single Dose of 5-MeO-DMT Stimulates Cell Proliferation, Neuronal Survivability, Morphological and Functional Changes in Adult Mice Ventral Dentate Gyrus

(2018) Rafael Vitor Lima da Cruz et al.   Frontiers in Molecular Neuroscience

N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function

(2018) Steven A. Barker   Frontiers in Neuroscience

New approaches for the treatment of Alzheimer’s disease

(2018) Paul V. Fish et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

N,N-dimethyltryptamine and the pineal gland: Separating fact from myth

(2017) David E Nichols   JOURNAL OF PSYCHOPHARMACOLOGY

The Sigma-1 Receptor Antagonist, S1RA, Reduces Stroke Damage, Ameliorates Post-Stroke Neurological Deficits and Suppresses the Overexpression of MMP-9

(2017) Pilar Sánchez-Blázquez et al.   MOLECULAR NEUROBIOLOGY

β-Amyloid and the Pathomechanisms of Alzheimer’s Disease: A Comprehensive View

(2017) Botond Penke et al.   MOLECULES

The role of astrocytes in amyloid production and Alzheimer's disease

(2017) Georgia R. Frost et al.   Open Biology

Involvement of Astrocytes in Alzheimer’s Disease from a Neuroinflammatory and Oxidative Stress Perspective

(2017) Rodrigo E. González-Reyes et al.   Frontiers in Molecular Neuroscience

Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT

(2017) Vanja Dakic et al.   Scientific Reports

Neuropharmacology of N,N-dimethyltryptamine

(2016) Theresa M. Carbonaro et al.   BRAIN RESEARCH BULLETIN

Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens

(2016) Anna Rickli et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Early Changes in Hippocampal Neurogenesis in Transgenic Mouse Models for Alzheimer’s Disease

(2016) M. S. Unger et al.   MOLECULAR NEUROBIOLOGY

Crystal structure of the human σ1 receptor

(2016) Hayden R. Schmidt et al.   NATURE

Dimethyltryptamine (DMT): a biochemical Swiss Army knife in neuroinflammation and neuroprotection?

(2016) Attila Szabo et al.   Neural Regeneration Research

Nootropics with potential to (re)build neuroarchitecture

(2016) Kyoko Koshibu   Neural Regeneration Research

The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems

(2016) Tsung-Ping Su et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Endogenous Hallucinogen and Trace Amine N,N-Dimethyltryptamine (DMT) Displays Potent Protective Effects against Hypoxia via Sigma-1 Receptor Activation in Human Primary iPSC-Derived Cortical Neurons and Microglia-Like Immune Cells

(2016) Attila Szabo et al.   Frontiers in Neuroscience

Sigma-1 Receptor Agonism Promotes Mechanical Allodynia After Priming the Nociceptive System with Capsaicin

(2016) J. M. Entrena et al.   Scientific Reports

The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease

(2015) Myles R. Minter et al.   JOURNAL OF NEUROCHEMISTRY

The involvement of the sigma-1 receptor in neurodegeneration and neurorestoration

(2015) Karsten Ruscher et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Sigma-1 (σ1) receptor deficiency reduces β-amyloid25–35-induced hippocampal neuronal cell death and cognitive deficits through suppressing phosphorylation of the NMDA receptor NR2B

(2015) Jun Yin et al.   NEUROPHARMACOLOGY

Adult Neurogenesis in Neurodegenerative Diseases: Figure 1.

(2015) Beate Winner et al.   Cold Spring Harbor Perspectives in Biology

Psychedelics and Immunomodulation: Novel Approaches and Therapeutic Opportunities

(2015) Attila Szabo   Frontiers in Immunology

Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism

(2014) Veronica Francardo et al.   BRAIN

Amyloid β-Peptide 1–42 Modulates the Proliferation of Mouse Neural Stem Cells: Upregulation of Fucosyltransferase IX and Notch Signaling

(2014) Yutaka Itokazu et al.   MOLECULAR NEUROBIOLOGY

Psychedelic N,N-Dimethyltryptamine and 5-Methoxy-N,N-Dimethyltryptamine Modulate Innate and Adaptive Inflammatory Responses through the Sigma-1 Receptor of Human Monocyte-Derived Dendritic Cells

(2014) Attila Szabo et al.   PLoS One

Sigma 1 receptor activation regulates brain-derived neurotrophic factor through NR2A-CaMKIV-TORC1 pathway to rescue the impairment of learning and memory induced by brain ischaemia/reperfusion

(2014) Qian Xu et al.   PSYCHOPHARMACOLOGY

Intrahippocampal injection of Aβ1-42inhibits neurogenesis and down-regulates IFN-γ and NF-κB expression in hippocampus of adult mouse brain

(2013) Meige Zheng et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

A possibly sigma-1 receptor mediated role of dimethyltryptamine in tissue protection, regeneration, and immunity

(2013) Ede Frecska et al.   JOURNAL OF NEURAL TRANSMISSION

Role of Neuroinflammation in Adult Neurogenesis and Alzheimer Disease: Therapeutic Approaches

(2013) Almudena Fuster-Matanzo et al.   MEDIATORS OF INFLAMMATION

Amyloid β Peptides Promote Autophagy-Dependent Differentiation of Mouse Neural Stem Cells

(2013) Maria B. Fonseca et al.   MOLECULAR NEUROBIOLOGY

Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation

(2013) Marco Peviani et al.   NEUROBIOLOGY OF DISEASE

Sigma-1 Receptor Chaperone at the ER-Mitochondrion Interface Mediates the Mitochondrion-ER-Nucleus Signaling for Cellular Survival

(2013) Tomohisa Mori et al.   PLoS One

The Neuropsychological Profile of Alzheimer Disease

(2013) S. Weintraub et al.   Cold Spring Harbor Perspectives in Medicine

Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning

(2013) Briony J. Catlow et al.   EXPERIMENTAL BRAIN RESEARCH

The effect of ageing on neurogenesis and oxidative stress in the APPswe/PS1deltaE9 mouse model of Alzheimer's disease

(2012) Alison Hamilton et al.   BRAIN RESEARCH

Neuroprotective effects of the sigma-1 receptor ligand PRE-084 against excitotoxic perinatal brain injury in newborn mice

(2012) E. Griesmaier et al.   EXPERIMENTAL NEUROLOGY

3,6′-Dithiothalidomide, a new TNF-α synthesis inhibitor, attenuates the effect of Aβ1-42 intracerebroventricular injection on hippocampal neurogenesis and memory deficit

(2012) Isabella Russo et al.   JOURNAL OF NEUROCHEMISTRY

Neurogenic abnormalities in Alzheimer's disease differ between stages of neurogenesis and are partly related to cholinergic pathology

(2012) Elaine K. Perry et al.   NEUROBIOLOGY OF DISEASE

Autonomic, Neuroendocrine, and Immunological Effects of Ayahuasca

(2011) Rafael G. dos Santos et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Sigma Receptor Agonist 2-(4-Morpholinethyl)1 Phenylcyclohexanecarboxylate (Pre084) Increases GDNF and BiP Expression and Promotes Neuroprotection after Root Avulsion Injury

(2011) Clara Penas et al.   JOURNAL OF NEUROTRAUMA

Adult hippocampal neurogenesis and its role in Alzheimer's disease

(2011) Yangling Mu et al.   Molecular Neurodegeneration

Amyloid-β oligomers stimulate microglia through a tyrosine kinase dependent mechanism

(2011) Gunjan Dhawan et al.   NEUROBIOLOGY OF AGING

The cholinergic system, sigma-1 receptors and cognition

(2010) Aren van Waarde et al.   BEHAVIOURAL BRAIN RESEARCH

Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer’s disease-linked APPswe/PS1ΔE9 mice

(2010) Yuan-Shih Hu et al.   FASEB JOURNAL

Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice

(2010) Michael Demars et al.   JOURNAL OF NEUROSCIENCE RESEARCH

DHEA prevents Aβ25–35-impaired survival of newborn neurons in the dentate gyrus through a modulation of PI3K-Akt-mTOR signaling

(2010) Liang Li et al.   NEUROPHARMACOLOGY

Sigma-1 Receptors Regulate Bcl-2 Expression by Reactive Oxygen Species-Dependent Transcriptional Regulation of Nuclear Factor  B

(2009) J. Meunier et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Predicting new molecular targets for known drugs

(2009) Michael J. Keiser et al.   NATURE

Controlled in situ preparation of Aβ(1–42) oligomers from the isopeptide “iso-Aβ(1–42)”, physicochemical and biological characterization

(2009) Zsolt Bozso et al.   PEPTIDES

The Hallucinogen N,N-Dimethyltryptamine (DMT) Is an Endogenous Sigma-1 Receptor Regulator

(2009) D. Fontanilla et al.   SCIENCE

Low density of sigma1 receptors in early Alzheimer’s disease

(2008) Masahiro Mishina et al.   ANNALS OF NUCLEAR MEDICINE

Aβ40 promotes neuronal cell fate in neural progenitor cells

(2008) Y Chen et al.   CELL DEATH AND DIFFERENTIATION

The anti-amnesic and neuroprotective effects of donepezil against amyloid β25-35 peptide-induced toxicity in mice involve an interaction with the σ1 receptor

(2006) J Meunier et al.   BRITISH JOURNAL OF PHARMACOLOGY