Dose-dependent sigma-1 receptor occupancy by donepezil in rat brain can be assessed with 11C-SA4503 and microPET

Small-Animal PET with a  -Ligand, 11C-SA4503, Detects Spontaneous Pituitary Tumors in Aged Rats

(2013) N. K. Ramakrishnan et al.   JOURNAL OF NUCLEAR MEDICINE

Safety, tolerability and pharmacokinetics of single and multiple doses of a novel sigma-1 receptor antagonist in three randomized phase I studies

(2012) Montserrat Abadias et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Concurrent administration of atypical antipsychotics and donepezil: drug interaction study in rats

(2012) Ramakrishna Nirogi et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Involvement of the sigma1 receptor in the antidepressant-like effects of fluvoxamine in the forced swimming test in comparison with the effects elicited by paroxetine

(2012) Yumi Sugimoto et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pharmacological Interaction With the Sigma1 (σ1)-Receptor in the Acute Behavioral Effects of Antidepressants

(2011) Vanessa Villard et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Dopamine D2 Occupancy as a Biomarker for Antipsychotics: Quantifying the Relationship with Efficacy and Extrapyramidal Symptoms

(2010) Rik de Greef et al.   AAPS Journal

The cholinergic system, sigma-1 receptors and cognition

(2010) Aren van Waarde et al.   BEHAVIOURAL BRAIN RESEARCH

Sigma Receptors in Oncology: Therapeutic and Diagnostic Applications of Sigma Ligands

(2010) Aren van Waarde et al.   CURRENT PHARMACEUTICAL DESIGN

Pharmacokinetic and Pharmacodynamic Properties of Cholinesterase Inhibitors Donepezil, Tacrine, and Galantamine in Aged and Young Lister Hooded Rats

(2010) C. W. Goh et al.   DRUG METABOLISM AND DISPOSITION

Phencyclidine-induced cognitive deficits in mice are ameliorated by subsequent subchronic administration of donepezil: Role of sigma-1 receptors

(2009) Shinsui Kunitachi et al.   BRAIN RESEARCH

High occupancy of σ1 receptors in the human brain after single oral administration of donepezil: a positron emission tomography study using [11C]SA4503

(2009) Masatomo Ishikawa et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Measuring Drug Occupancy in the Absence of a Reference Region: The Lassen Plot Re-Visited

(2009) Vincent J Cunningham et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Procognitive 5-HT6 antagonists in the rat forced swimming test: Potential therapeutic utility in mood disorders associated with Alzheimer's disease

(2009) Kazufumi Hirano et al.   LIFE SCIENCES