Discovery of Investigational Drug CT1812, an Antagonist of the Sigma-2 Receptor Complex for Alzheimer’s Disease

Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer's disease modification

(2021) Nicholas J. Izzo et al.   Alzheimers & Dementia

Alzheimer’s protection effect of A673T mutation may be driven by lower Aβ oligomer binding affinity

(2020) Colleen S. Limegrover et al.   JOURNAL OF NEUROCHEMISTRY

Systematic and standardized comparison of reported Amyloid-β receptors for sufficiency, affinity, and Alzheimer’s disease relevance

(2019) Levi M. Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular Receptors of Amyloid β Oligomers (AβOs) in Alzheimer’s Disease

(2018) Barbara Mroczko et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

(2018) Erika N. Cline et al.   JOURNAL OF ALZHEIMERS DISEASE

Natural-Products-Inspired Use of the gem-Dimethyl Group in Medicinal Chemistry

(2017) Tanaji T. Talele   JOURNAL OF MEDICINAL CHEMISTRY

Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease

(2017) Bitna Yi et al.   JOURNAL OF NEUROCHEMISTRY

Identification of the gene that codes for the σ2receptor

(2017) Assaf Alon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Investigation of miscellaneous hERG inhibition in large diverse compound collection using automated patch-clamp assay

(2016) Hai-bo Yu et al.   ACTA PHARMACOLOGICA SINICA

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate

(2016) Ting Yang et al.   JOURNAL OF NEUROSCIENCE

Prediction of hERG Liability - Using SVM Classification, Bootstrapping and Jackknifing

(2016) Hongmao Sun et al.   Molecular Informatics

Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis

(2015) Kirsten L. Viola et al.   ACTA NEUROPATHOLOGICA

Sigma-2 Receptor Ligands: Neurobiological Effects

(2015) Lin Guo et al.   CURRENT MEDICINAL CHEMISTRY

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease

(2015) Sergio T. Ferreira et al.   Frontiers in Cellular Neuroscience

Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration

(2015) Peng Liu et al.   Cell Reports

In Vivo Application of beta Amyloid Oligomers: A Simple Tool to Evaluate Mechanisms of Action and New Therapeutic Approaches

(2015) Claudia Balducci et al.   CURRENT PHARMACEUTICAL DESIGN

Alzheimer's Disease-Like Pathology Induced by Amyloid-β Oligomers in Nonhuman Primates

(2014) Leticia Forny-Germano et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers II: Sigma-2/PGRMC1 Receptors Mediate Abeta 42 Oligomer Binding and Synaptotoxicity

(2014) Nicholas J. Izzo et al.   PLoS One

Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers I: Abeta 42 Oligomer Binding to Specific Neuronal Receptors Is Displaced by Drug Candidates That Improve Cognitive Deficits

(2014) Nicholas J. Izzo et al.   PLoS One

Human LilrB2 Is a  -Amyloid Receptor and Its Murine Homolog PirB Regulates Synaptic Plasticity in an Alzheimer's Model

(2013) T. Kim et al.   SCIENCE

The case for soluble Aβ oligomers as a drug target in Alzheimer's disease

(2013) Franz Hefti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Sigma-2 ligands induce tumour cell death by multiple signalling pathways

(2012) C Zeng et al.   BRITISH JOURNAL OF CANCER

Thy1-hAPPLond/Swe+mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function

(2012) Mehrdad Faizi et al.   Brain and Behavior

Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site

(2011) Jinbin Xu et al.   Nature Communications

Minocycline Recovers MTT-Formazan Exocytosis Impaired by Amyloid Beta Peptide

(2010) Peter Kreutzmann et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Synthesis and Applications oftert-Butanesulfinamide

(2010) MaryAnn T. Robak et al.   CHEMICAL REVIEWS

Picomolar Amyloid-  Positively Modulates Synaptic Plasticity and Memory in Hippocampus

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE