Modulating intracellular pathways to improve non-viral delivery of RNA therapeutics
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Modulating intracellular pathways to improve non-viral delivery of RNA therapeutics
Authors
Keywords
Nucleic acid therapeutics, Nanoparticles, Conjugates, Cellular delivery, Intracellular barriers, Endosomal escape, Intracellular trafficking, Cellular uptake
Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 181, Issue -, Pages 114041
Publisher
Elsevier BV
Online
2021-11-09
DOI
10.1016/j.addr.2021.114041
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Lumasiran: First Approval
- (2021) Lesley J. Scott et al. DRUGS
- How COVID unlocked the power of RNA vaccines
- (2021) Elie Dolgin NATURE
- Vaccinia Virus Protein B18R: Influence on mRNA Immunogenicity and Translation upon Non-Viral Delivery in Different Ocular Cell Types
- (2021) An-Katrien Minnaert et al. Pharmaceutics
- Inclisiran: First Approval
- (2021) Yvette N. Lamb DRUGS
- BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting
- (2021) Noa Dagan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Surfactant Protein B Promotes Cytosolic SiRNA Delivery by Adopting a Virus-like Mechanism of Action
- (2021) Roberta Guagliardo et al. ACS Nano
- Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics: Getting the message across
- (2021) An-Katrien Minnaert et al. ADVANCED DRUG DELIVERY REVIEWS
- The current landscape of nucleic acid therapeutics
- (2021) Jayesh A. Kulkarni et al. Nature Nanotechnology
- A Combinatorial Library of Lipid Nanoparticles for RNA Delivery to Leukocytes
- (2020) Srinivas Ramishetti et al. ADVANCED MATERIALS
- The challenge and prospect of mRNA therapeutics landscape
- (2020) Yuhua Weng et al. BIOTECHNOLOGY ADVANCES
- Golodirsen: First Approval
- (2020) Young-A Heo DRUGS
- L-Type Calcium Channel Blocker Enhances Cellular Delivery and Gene Silencing Potency of Cell-Penetrating Asymmetric siRNAs
- (2020) Jeong Yong Choe et al. MOLECULAR PHARMACEUTICS
- Effect of small molecule signaling in PepFect14 transfection
- (2020) Maxime Gestin et al. PLoS One
- Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA
- (2020) Siddharth Patel et al. Nature Communications
- Cationic Amphiphilic Drugs Boost the Lysosomal Escape of Small Nucleic Acid Therapeutics in a Nanocarrier-Dependent Manner
- (2020) Thijs Van de Vyver et al. ACS Nano
- Endocytosis of Extracellular Vesicles and Release of Their Cargo from Endosomes
- (2020) Bhagyashree S. Joshi et al. ACS Nano
- Co-delivery of NS1 and BMP2 mRNAs to murine pluripotent stem cells leads to enhanced BMP-2 expression and osteogenic differentiation
- (2020) Pinpin Wang et al. Acta Biomaterialia
- Targeted lipid nanoparticles for RNA therapeutics and immunomodulation in leukocytes
- (2020) Nuphar Veiga et al. ADVANCED DRUG DELIVERY REVIEWS
- Protein and mRNA Delivery Enabled by Cholesteryl‐Based Biodegradable Lipidoid Nanoparticles
- (2020) Yamin Li et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Autophagy-inhibiting polymer as an effective nonviral cancer gene therapy vector with inherent apoptosis-sensitizing ability
- (2020) Jiafeng Wang et al. BIOMATERIALS
- Influence of pathogenic stimuli on Müller cell transfection by lipoplexes
- (2020) Karen Peynshaert et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Ubqln4 Facilitates Endoplasmic Reticulum-to-Cytosol Escape of a Nonenveloped Virus during Infection
- (2020) Xiaofang Liu et al. JOURNAL OF VIROLOGY
- A Nanoprimer To Improve the Systemic Delivery of siRNA and mRNA
- (2020) Nell R. M. Saunders et al. NANO LETTERS
- The pandemic pipeline
- (2020) John Hodgson NATURE BIOTECHNOLOGY
- RNA therapeutics on the rise
- (2020) Feng Wang et al. NATURE REVIEWS DRUG DISCOVERY
- Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol
- (2020) Kausik K. Ray et al. NEW ENGLAND JOURNAL OF MEDICINE
- Phosphorothioate modified oligonucleotide–protein interactions
- (2020) Stanley T Crooke et al. NUCLEIC ACIDS RESEARCH
- Imaging small molecule-induced endosomal escape of siRNA
- (2020) Hampus Du Rietz et al. Nature Communications
- Arrayed CRISPR Screening Identifies Novel Targets That Enhance the Productive Delivery of mRNA by MC3-Based Lipid Nanoparticles
- (2020) Douglas Ross-Thriepland et al. SLAS Discovery
- Impact of the endosomal escape activity of cell-penetrating peptides on the endocytic pathway
- (2020) Helena M. Kondow-McConaghy et al. ACS Chemical Biology
- A Thermostable mRNA Vaccine against COVID-19
- (2020) Na-Na Zhang et al. CELL
- Albumin-conjugated drug is irresistible by single gene mutation of endocytic system: Verification by genome-wide CRISPR-Cas9 loss-of-function screens
- (2020) Fang Yuan et al. JOURNAL OF CONTROLLED RELEASE
- Phase 1/2 study of COVID-19 RNA vaccine BNT162b1 in adults
- (2020) Mark J. Mulligan et al. NATURE
- mRNA vaccines: intellectual property landscape
- (2020) Cecilia Martin et al. NATURE REVIEWS DRUG DISCOVERY
- Advances in oligonucleotide drug delivery
- (2020) Thomas C. Roberts et al. NATURE REVIEWS DRUG DISCOVERY
- Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria
- (2020) Manisha Balwani et al. NEW ENGLAND JOURNAL OF MEDICINE
- Amplifying RNA Vaccine Development
- (2020) Deborah H. Fuller et al. NEW ENGLAND JOURNAL OF MEDICINE
- Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates
- (2020) Kizzmekia S. Corbett et al. NEW ENGLAND JOURNAL OF MEDICINE
- An mRNA Vaccine against SARS-CoV-2 — Preliminary Report
- (2020) Lisa A. Jackson et al. NEW ENGLAND JOURNAL OF MEDICINE
- An Alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates
- (2020) Jesse H. Erasmus et al. Science Translational Medicine
- Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice
- (2020) Paul F. McKay et al. Nature Communications
- Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing
- (2020) Tuo Wei et al. Nature Communications
- Increased PIP3 activity blocks nanoparticle mRNA delivery
- (2020) Kalina Paunovska et al. Science Advances
- Resveratrol Enhances mRNA and siRNA Lipid Nanoparticles Primary CLL Cell Transfection
- (2020) Edo Kon et al. Pharmaceutics
- Functional Genomics for Target Identification
- (2020) Davide Gianni et al. SLAS Discovery
- Prospects for RNAi Therapy of COVID-19
- (2020) Hasan Uludağ et al. Frontiers in Bioengineering and Biotechnology
- Nanoparticles containing constrained phospholipids deliver mRNA to liver immune cells in vivo without targeting ligands
- (2020) Zubao Gan et al. Bioengineering & Translational Medicine
- COVID-19 Vaccine Frontrunners and Their Nanotechnology Design
- (2020) Young Hun Chung et al. ACS Nano
- SARS-CoV-2 immunity: review and applications to phase 3 vaccine candidates
- (2020) Gregory A Poland et al. LANCET
- Nanomedicine-Based Approaches for mRNA Delivery
- (2020) Satoshi Uchida et al. MOLECULAR PHARMACEUTICS
- Mist begins to clear for lung delivery of RNA
- (2020) Catherine Shaffer NATURE BIOTECHNOLOGY
- A framework for designing delivery systems
- (2020) Wilson Poon et al. Nature Nanotechnology
- Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates
- (2020) Edward E. Walsh et al. NEW ENGLAND JOURNAL OF MEDICINE
- Paving the Road for RNA Therapeutics
- (2020) Niels Dammes et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Nanotechnology Responses to COVID‐19
- (2020) Eduardo Ruiz‐Hitzky et al. Advanced Healthcare Materials
- Just dose it
- (2020) Twan Lammers NATURE MATERIALS
- Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine
- (2020) Lindsey R. Baden et al. NEW ENGLAND JOURNAL OF MEDICINE
- Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
- (2020) Fernando P. Polack et al. NEW ENGLAND JOURNAL OF MEDICINE
- Zebrafish as a preclinical in vivo screening model for nanomedicines
- (2019) Sandro Sieber et al. ADVANCED DRUG DELIVERY REVIEWS
- The current state and future directions of RNAi-based therapeutics
- (2019) Ryan L. Setten et al. NATURE REVIEWS DRUG DISCOVERY
- Retro-1-Oligonucleotide Conjugates. Synthesis and Biological Evaluation
- (2019) Jordi Agramunt et al. MOLECULES
- mRNA as a Transformative Technology for Vaccine Development to Control Infectious Diseases
- (2019) Giulietta Maruggi et al. MOLECULAR THERAPY
- Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery
- (2019) Piotr S. Kowalski et al. MOLECULAR THERAPY
- Inhibition of the Inflammatory Pathway Enhances Both the in Vitro and in Vivo Transfection Activity of Exogenous in Vitro-Transcribed mRNAs Delivered by Lipid Nanoparticles
- (2019) Takara Ohto et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Systemic mRNA Therapy for the Treatment of Fabry Disease: Preclinical Studies in Wild-Type Mice, Fabry Mouse Model, and Wild-Type Non-human Primates
- (2019) Xuling Zhu et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Nanoparticles Containing Oxidized Cholesterol Deliver mRNA to the Liver Microenvironment at Clinically Relevant Doses
- (2019) Kalina Paunovska et al. ADVANCED MATERIALS
- Penetration and Uptake of Nanoparticles in 3D Tumor Spheroids
- (2019) Aleksandra Tchoryk et al. BIOCONJUGATE CHEMISTRY
- RNAi therapeutic and its innovative biotechnological evolution
- (2019) Yuhua Weng et al. BIOTECHNOLOGY ADVANCES
- Watch What You (Self-) Eat: Autophagic Mechanisms that Modulate Metabolism
- (2019) Vikramjit Lahiri et al. Cell Metabolism
- Cell Subtypes Within the Liver Microenvironment Differentially Interact with Lipid Nanoparticles
- (2019) Cory D. Sago et al. Cellular and Molecular Bioengineering
- mRNA Therapy Improves Metabolic and Behavioral Abnormalities in a Murine Model of Citrin Deficiency
- (2019) Jingsong Cao et al. MOLECULAR THERAPY
- Differential uptake, kinetics and mechanisms of intracellular trafficking of next-generation antisense oligonucleotides across human cancer cell lines
- (2019) Emily Linnane et al. NUCLEIC ACIDS RESEARCH
- Structure of membrane tethers and their role in fusion
- (2019) Christian Ungermann et al. TRAFFIC
- CRISPR screening using an expanded toolkit of autophagy reporters identifies TMEM41B as a novel autophagy factor
- (2019) Christopher J. Shoemaker et al. PLOS BIOLOGY
- Efficient reduction of synthetic mRNA induced immune activation by simultaneous delivery of B18R encoding mRNA
- (2019) Tatjana Michel et al. Journal of Biological Engineering
- Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines
- (2019) Kimberly J. Hassett et al. Molecular Therapy-Nucleic Acids
- Volanesorsen: First Global Approval
- (2019) Julia Paik et al. DRUGS
- Exocytosis - a putative road-block in nanoparticle and nanocomplex mediated gene delivery
- (2019) Ujjwal Ranjan Dahiya et al. JOURNAL OF CONTROLLED RELEASE
- mRNA levels can be reduced by antisense oligonucleotides via no-go decay pathway
- (2019) Xue-hai Liang et al. NUCLEIC ACIDS RESEARCH
- A High‐Throughput Automated Confocal Microscopy Platform for Quantitative Phenotyping of Nanoparticle Uptake and Transport in Spheroids
- (2019) Meritxell B. Cutrona et al. Small
- Regulating intracellular fate of siRNA by endoplasmic reticulum membrane-decorated hybrid nanoplexes
- (2019) Chong Qiu et al. Nature Communications
- Lipid Conjugates Enhance Endosomal Release of Antisense Oligonucleotides Into Cells
- (2019) Shiyu Wang et al. Nucleic Acid Therapeutics
- CRISPR knockout screen implicates three genes in lysosome function
- (2019) Guy M. Lenk et al. Scientific Reports
- Enhancing MicroRNA Activity through Increased Endosomal Release Mediated by Nigericin
- (2019) Esteban A. Orellana et al. Molecular Therapy-Nucleic Acids
- Aminoglycoside Enhances the Delivery of Antisense Morpholino Oligonucleotides In Vitro and in mdx Mice
- (2019) Mingxing Wang et al. Molecular Therapy-Nucleic Acids
- Corona Composition Can Affect the Mechanisms Cells Use to Internalize Nanoparticles
- (2019) Valentina Francia et al. ACS Nano
- Using Large Datasets to Understand Nanotechnology
- (2019) Kalina Paunovska et al. ADVANCED MATERIALS
- Constrained Nanoparticles Deliver siRNA and sgRNA to T Cells In Vivo without Targeting Ligands
- (2019) Melissa P. Lokugamage et al. ADVANCED MATERIALS
- Nanomaterials meet zebrafish: Toxicity evaluation and drug delivery applications
- (2019) Hao-Ran Jia et al. JOURNAL OF CONTROLLED RELEASE
- Repair or Lysophagy: Dealing with Damaged Lysosomes
- (2019) Chrisovalantis Papadopoulos et al. JOURNAL OF MOLECULAR BIOLOGY
- Endocytic Profiling of Cancer Cell Models Reveals Critical Factors Influencing LNP-Mediated mRNA Delivery and Protein Expression
- (2019) Edward J. Sayers et al. MOLECULAR THERAPY
- Three decades of messenger RNA vaccine development
- (2019) Rein Verbeke et al. Nano Today
- Hexose potentiates peptide-conjugated morpholino oligomer efficacy in cardiac muscles of dystrophic mice in an age-dependent manner
- (2019) Gang Han et al. Molecular Therapy-Nucleic Acids
- CS-PEI/Beclin-siRNA Downregulate Multidrug Resistance Proteins and Increase Paclitaxel Therapeutic Efficacy against NSCLC
- (2019) Wangta Liu et al. Molecular Therapy-Nucleic Acids
- Effective In Vivo Topical Delivery of siRNA and Gene Silencing in Intact Corneal Epithelium Using a Modified Cell-Penetrating Peptide
- (2019) Davide Schiroli et al. Molecular Therapy-Nucleic Acids
- Targeting RyR activity boosts antisense exon 44 and 45 skipping in human DMD skeletal or cardiac muscle culture models
- (2019) Florian Barthélémy et al. Molecular Therapy-Nucleic Acids
- Cytosolic Delivery of Macromolecules in Live Human Cells Using the Combined Endosomal Escape Activities of a Small Molecule and Cell Penetrating Peptides
- (2019) Jason Allen et al. ACS Chemical Biology
- Mild Innate Immune Activation Overrides Efficient Nanoparticle‐Mediated RNA Delivery
- (2019) Melissa P. Lokugamage et al. ADVANCED MATERIALS
- Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation
- (2019) John J. Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Endosomal escape enhancing compounds facilitate functional delivery of extracellular vesicle cargo
- (2019) Nikki Heath et al. Nanomedicine
- RNA therapies explained
- (2019) Sarah DeWeerdt NATURE
- The many functions of ESCRTs
- (2019) Marina Vietri et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- A novel and translational role for autophagy in antisense oligonucleotide trafficking and activity
- (2019) Joseph Ochaba et al. NUCLEIC ACIDS RESEARCH
- Tailoring mRNA Vaccine to Balance Innate/Adaptive Immune Response
- (2019) Sergio Linares-Fernández et al. TRENDS IN MOLECULAR MEDICINE
- Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells
- (2019) Marco Maugeri et al. Nature Communications
- In vivo epigenetic CRISPR screen identifies Asf1a as an immunotherapeutic target in Kras-mutant lung adenocarcinoma
- (2019) Fei Li et al. Cancer Discovery
- Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal
- (2019) Jingyue Jia et al. DEVELOPMENTAL CELL
- Ionizable lipid nanoparticles encapsulating barcoded mRNA for accelerated in vivo delivery screening
- (2019) Pedro P.G. Guimaraes et al. JOURNAL OF CONTROLLED RELEASE
- The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs
- (2019) Akin Akinc et al. Nature Nanotechnology
- Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes
- (2019) Xue-hai Liang et al. NUCLEIC ACIDS RESEARCH
- Combined Modality Therapy Based on Hybrid Gold Nanostars Coated with Temperature Sensitive Liposomes to Overcome Paclitaxel-Resistance in Hepatic Carcinoma
- (2019) Hongyan Zhu et al. Pharmaceutics
- On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA
- (2018) Jayesh A. Kulkarni et al. ACS Nano
- Analyzing 2000 in Vivo Drug Delivery Data Points Reveals Cholesterol Structure Impacts Nanoparticle Delivery
- (2018) Kalina Paunovska et al. ACS Nano
- Endosomal Size and Membrane Leakiness Influence Proton Sponge-Based Rupture of Endosomal Vesicles
- (2018) Lotte M. P. Vermeulen et al. ACS Nano
- New Mechanism for Release of Endosomal Contents: Osmotic Lysis via Nigericin-Mediated K+/H+ Exchange
- (2018) Loganathan Rangasamy et al. BIOCONJUGATE CHEMISTRY
- The proton sponge hypothesis: Fable or fact?
- (2018) Lotte M.P. Vermeulen et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- The enigmatic endosome – sorting the ins and outs of endocytic trafficking
- (2018) Naava Naslavsky et al. JOURNAL OF CELL SCIENCE
- Repurposing cationic amphiphilic drugs as adjuvants to induce lysosomal siRNA escape in nanogel transfected cells
- (2018) Freya Joris et al. JOURNAL OF CONTROLLED RELEASE
- A hepatic pDNA delivery system based on an intracellular environment sensitive vitamin E-scaffold lipid-like material with the aid of an anti-inflammatory drug
- (2018) Ryohei Togashi et al. JOURNAL OF CONTROLLED RELEASE
- Dexamethasone prodrugs as potent suppressors of the immunostimulatory effects of lipid nanoparticle formulations of nucleic acids
- (2018) Sam Chen et al. JOURNAL OF CONTROLLED RELEASE
- Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression
- (2018) Jennifer L.S. Willoughby et al. MOLECULAR THERAPY
- A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates
- (2018) Staci Sabnis et al. MOLECULAR THERAPY
- Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates
- (2018) Donald J. Foster et al. MOLECULAR THERAPY
- A Direct Comparison of in Vitro and in Vivo Nucleic Acid Delivery Mediated by Hundreds of Nanoparticles Reveals a Weak Correlation
- (2018) Kalina Paunovska et al. NANO LETTERS
- Lipid Nanoparticle Formulations for Enhanced Co-delivery of siRNA and mRNA
- (2018) Rebecca L. Ball et al. NANO LETTERS
- Methodologies to investigate intracellular barriers for nucleic acid delivery in non-viral gene therapy
- (2018) Lotte M.P. Vermeulen et al. Nano Today
- mRNA vaccines — a new era in vaccinology
- (2018) Norbert Pardi et al. NATURE REVIEWS DRUG DISCOVERY
- Tapping the RNA world for therapeutics
- (2018) Judy Lieberman NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Ammonium and arsenic trioxide are potent facilitators of oligonucleotide function when delivered by gymnosis
- (2018) Xiaowei Zhang et al. NUCLEIC ACIDS RESEARCH
- Structure–activity relationships and cellular mechanism of action of small molecules that enhance the delivery of oligonucleotides
- (2018) Rudolph L Juliano et al. NUCLEIC ACIDS RESEARCH
- Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo
- (2018) Matthew R Hassler et al. NUCLEIC ACIDS RESEARCH
- A stress-induced response complex (SIRC) shuttles miRNAs, siRNAs, and oligonucleotides to the nucleus
- (2018) Daniela Castanotto et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Triggered recruitment of ESCRT machinery promotes endolysosomal repair
- (2018) Michael L. Skowyra et al. SCIENCE
- Efficient cell delivery mediated by lipid-specific endosomal escape of supercharged branched peptides
- (2018) Dakota J. Brock et al. TRAFFIC
- Tapping the RNA world for therapeutics
- (2018) Judy Lieberman NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Endosomal Escape of Antisense Oligonucleotides Internalized by Stabilin Receptors Is Regulated by Rab5C and EEA1 During Endosomal Maturation
- (2018) Colton M. Miller et al. Nucleic Acid Therapeutics
- Modulation of mRNA Translation and Cell Viability by Influenza A Virus Derived Nonstructural Protein 1
- (2018) Yi Liu et al. Nucleic Acid Therapeutics
- Intracellular Trafficking and Endosomal Release of Oligonucleotides: What We Know and What We Don’t
- (2018) R.L. Juliano Nucleic Acid Therapeutics
- GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics
- (2018) Aaron D. Springer et al. Nucleic Acid Therapeutics
- A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing
- (2018) Jonathan D. Finn et al. Cell Reports
- Repurposing Dantrolene for Long-Term Combination Therapy to Potentiate Antisense-Mediated DMD Exon Skipping in the mdx Mouse
- (2018) Derek W. Wang et al. Molecular Therapy-Nucleic Acids
- Long-Term Morpholino Oligomers in Hexose Elicits Long-Lasting Therapeutic Improvements in mdx Mice
- (2018) Gang Han et al. Molecular Therapy-Nucleic Acids
- Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter Mouse
- (2018) Kevin J. Kauffman et al. Molecular Therapy-Nucleic Acids
- Surfactant protein B (SP-B) enhances the cellular siRNA delivery of proteolipid coated nanogels for inhalation therapy
- (2018) Pieterjan Merckx et al. Acta Biomaterialia
- Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts
- (2018) Martin P. Stewart et al. CHEMICAL REVIEWS
- Inotersen: First Global Approval
- (2018) Susan J. Keam DRUGS
- Patisiran: First Global Approval
- (2018) Sheridan M. Hoy DRUGS
- Modifying a Commonly Expressed Endocytic Receptor Retargets Nanoparticles in Vivo
- (2018) Cory D. Sago et al. NANO LETTERS
- Gene-silencing technology gets first drug approval after 20-year wait
- (2018) Heidi Ledford NATURE
- COPII vesicles can affect the activity of antisense oligonucleotides by facilitating the release of oligonucleotides from endocytic pathways
- (2018) Xue-hai Liang et al. NUCLEIC ACIDS RESEARCH
- mRNA transfection by a Xentry-protamine cell-penetrating peptide is enhanced by TLR antagonist E6446
- (2018) Glenn D. Bell et al. PLoS One
- RNAi/CRISPR Screens: from a Pool to a Valid Hit
- (2018) Anne Schuster et al. TRENDS IN BIOTECHNOLOGY
- Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies
- (2018) Norbert Pardi et al. Nature Communications
- Barcoding chemical modifications into nucleic acids improves drug stability in vivo
- (2018) Cory D. Sago et al. Journal of Materials Chemistry B
- Super-resolution Imaging of Proton Sponge-Triggered Rupture of Endosomes and Cytosolic Release of Small Interfering RNA
- (2018) Marcin Wojnilowicz et al. ACS Nano
- Overcoming Endosomal Entrapment in Drug Delivery
- (2018) Dehua Pei et al. BIOCONJUGATE CHEMISTRY
- The Endosomal Escape of Nanoparticles: Toward More Efficient Cellular Delivery
- (2018) Samuel A. Smith et al. BIOCONJUGATE CHEMISTRY
- Endosomal Escape and Cytosolic Penetration of Macromolecules Mediated by Synthetic Delivery Agents
- (2018) Dakota J. Brock et al. BIOCONJUGATE CHEMISTRY
- 3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs
- (2018) Ana S. Nunes et al. BIOTECHNOLOGY AND BIOENGINEERING
- ESCRT‐mediated lysosome repair precedes lysophagy and promotes cell survival
- (2018) Maja Radulovic et al. EMBO JOURNAL
- Translating nanomedicines: Thinking beyond materials? A young investigator's reply to ‘The Novelty Bubble’
- (2018) Dominik Witzigmann et al. JOURNAL OF CONTROLLED RELEASE
- Nanoparticles That Deliver RNA to Bone Marrow Identified by in Vivo Directed Evolution
- (2018) Cory D. Sago et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- mRNA-Based Protein Replacement Therapy for the Heart
- (2018) Ajit Magadum et al. MOLECULAR THERAPY
- mRNA therapeutics deliver a hopeful message
- (2018) Zifu Zhong et al. Nano Today
- Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways
- (2018) Maire F Osborn et al. NUCLEIC ACIDS RESEARCH
- High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing
- (2018) Cory D. Sago et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Membrane Destabilization Induced by Lipid Species Increases Activity of Phosphorothioate-Antisense Oligonucleotides
- (2018) Shiyu Wang et al. Molecular Therapy-Nucleic Acids
- Improvement of In Vivo Expression of Genes Delivered by Self-Amplifying RNA Using Vaccinia Virus Immune Evasion Proteins
- (2017) Tim Beissert et al. HUMAN GENE THERAPY
- Silica nanoparticles induce autophagy dysfunction via lysosomal impairment and inhibition of autophagosome degradation in hepatocytes
- (2017) Ji Wang et al. International Journal of Nanomedicine
- Synthesis and Evaluation of Chloroquine-Containing DMAEMA Copolymers as Efficient Anti-miRNA Delivery Vectors with Improved Endosomal Escape and Antimigratory Activity in Cancer Cells
- (2017) Ying Xie et al. MACROMOLECULAR BIOSCIENCE
- Rab GTPases: master regulators that establish the secretory and endocytic pathways
- (2017) Suzanne R. Pfeffer MOLECULAR BIOLOGY OF THE CELL
- Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate
- (2017) Tracy S. Zimmermann et al. MOLECULAR THERAPY
- 6BIO Enhances Oligonucleotide Activity in Cells: A Potential Combinatorial Anti-androgen Receptor Therapy in Prostate Cancer Cells
- (2017) Xiaowei Zhang et al. MOLECULAR THERAPY
- Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses
- (2017) Kapil Bahl et al. MOLECULAR THERAPY
- Boosting Intracellular Delivery of Lipid Nanoparticle-Encapsulated mRNA
- (2017) Siddharth Patel et al. NANO LETTERS
- Small molecules convey big messages: Boosting non-viral nucleic acid delivery with low molecular weight drugs
- (2017) Freya Joris et al. Nano Today
- Boosting the therapeutic efficiency of nanovectors: exocytosis engineering
- (2017) Stefania Corvaglia et al. Nanoscale
- Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer
- (2017) Ugur Sahin et al. NATURE
- In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target
- (2017) Robert T. Manguso et al. NATURE
- The chemical evolution of oligonucleotide therapies of clinical utility
- (2017) Anastasia Khvorova et al. NATURE BIOTECHNOLOGY
- Cellular uptake and trafficking of antisense oligonucleotides
- (2017) Stanley T Crooke et al. NATURE BIOTECHNOLOGY
- Overcoming cellular barriers for RNA therapeutics
- (2017) Steven F Dowdy NATURE BIOTECHNOLOGY
- Probes & Drugs portal: an interactive, open data resource for chemical biology
- (2017) Ctibor Skuta et al. NATURE METHODS
- Applications of chemogenomic library screening in drug discovery
- (2017) Lyn H. Jones et al. NATURE REVIEWS DRUG DISCOVERY
- A Highly Durable RNAi Therapeutic Inhibitor of PCSK9
- (2017) Kevin Fitzgerald et al. NEW ENGLAND JOURNAL OF MEDICINE
- Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL Cholesterol
- (2017) Kausik K. Ray et al. NEW ENGLAND JOURNAL OF MEDICINE
- Characterizing exogenous mRNA delivery, trafficking, cytoplasmic release and RNA–protein correlations at the level of single cells
- (2017) Jonathan L. Kirschman et al. NUCLEIC ACIDS RESEARCH
- Intra-endosomal trafficking mediated by lysobisphosphatidic acid contributes to intracellular release of phosphorothioate-modified antisense oligonucleotides
- (2017) Shiyu Wang et al. NUCLEIC ACIDS RESEARCH
- 5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo
- (2017) Reka A. Haraszti et al. NUCLEIC ACIDS RESEARCH
- Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates
- (2017) Jayaprakash K. Nair et al. NUCLEIC ACIDS RESEARCH
- Antisense oligonucleotides targeting translation inhibitory elements in 5′ UTRs can selectively increase protein levels
- (2017) Xue-hai Liang et al. NUCLEIC ACIDS RESEARCH
- Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs
- (2017) Xiulong Shen et al. NUCLEIC ACIDS RESEARCH
- Multicellular tumor spheroids: a relevant 3D model for the in vitro preclinical investigation of polymer nanomedicines
- (2017) Gianpiero Lazzari et al. Polymer Chemistry
- Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics
- (2017) James E. Dahlman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lipophilic siRNA targets albumin in situ and promotes bioavailability, tumor penetration, and carrier-free gene silencing
- (2017) Samantha M. Sarett et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effect of removing Kupffer cells on nanoparticle tumor delivery
- (2017) Anthony J. Tavares et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics
- (2017) Nicolas Bertrand et al. Nature Communications
- Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia
- (2017) Ding An et al. Cell Reports
- Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map
- (2017) Ian Smith et al. PLOS BIOLOGY
- The Multifaceted Role of SNARE Proteins in Membrane Fusion
- (2017) Jing Han et al. Frontiers in Physiology
- The Formation of Nanoparticles between Small Interfering RNA and Amphipathic Cell-Penetrating Peptides
- (2017) Ly Pärnaste et al. Molecular Therapy-Nucleic Acids
- Nanobody-Based Delivery Systems for Diagnosis and Targeted Tumor Therapy
- (2017) Yaozhong Hu et al. Frontiers in Immunology
- Role of autophagy in cell-penetrating peptide transfection model
- (2017) Moataz Dowaidar et al. Scientific Reports
- A chloroquine-induced macrophage-preconditioning strategy for improved nanodelivery
- (2017) Joy Wolfram et al. Scientific Reports
- Conjugates of small targeting molecules to non-viral vectors for the mediation of siRNA
- (2016) Defu Zhi et al. Acta Biomaterialia
- Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA
- (2016) Jason B. Miller et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Hydroxychloroquine-conjugated gold nanoparticles for improved siRNA activity
- (2016) F. Perche et al. BIOMATERIALS
- 3D tumor spheroids: an overview on the tools and techniques used for their analysis
- (2016) Elisabete C. Costa et al. BIOTECHNOLOGY ADVANCES
- Therapeutic nucleic acids: current clinical status
- (2016) Kannan Sridharan et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- The Emerging Hallmarks of Cancer Metabolism
- (2016) Natalya N. Pavlova et al. Cell Metabolism
- Design of virus-based nanomaterials for medicine, biotechnology, and energy
- (2016) Amy M. Wen et al. CHEMICAL SOCIETY REVIEWS
- Retro-1 Analogues Differentially Affect Oligonucleotide Delivery and Toxin Trafficking
- (2016) Bing Yang et al. ChemMedChem
- Evading innate immunity in nonviral mRNA delivery: don’t shoot the messenger
- (2016) Joke Devoldere et al. DRUG DISCOVERY TODAY
- Eteplirsen: First Global Approval
- (2016) Yahiya Y. Syed DRUGS
- Comparing exosome-like vesicles with liposomes for the functional cellular delivery of small RNAs
- (2016) Stephan Stremersch et al. JOURNAL OF CONTROLLED RELEASE
- Nanoparticle–liver interactions: Cellular uptake and hepatobiliary elimination
- (2016) Yi-Nan Zhang et al. JOURNAL OF CONTROLLED RELEASE
- Protein Kinase C-α is a Critical Protein for Antisense Oligonucleotide-mediated Silencing in Mammalian Cells
- (2016) Daniela Castanotto et al. MOLECULAR THERAPY
- Glucocorticoid Cell Priming Enhances Transfection Outcomes in Adult Human Mesenchymal Stem Cells
- (2016) Abby M Kelly et al. MOLECULAR THERAPY
- The Niemann-Pick C1 Inhibitor NP3.47 Enhances Gene Silencing Potency of Lipid Nanoparticles Containing siRNA
- (2016) Haitang Wang et al. MOLECULAR THERAPY
- Targeted Delivery of siRNA to Transferrin Receptor Overexpressing Tumor Cells via Peptide Modified Polyethylenimine
- (2016) Yuran Xie et al. MOLECULES
- Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy
- (2016) Lena M. Kranz et al. NATURE
- CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes
- (2016) Bastiaan Evers et al. NATURE BIOTECHNOLOGY
- Translation efficiency of mRNAs is increased by antisense oligonucleotides targeting upstream open reading frames
- (2016) Xue-hai Liang et al. NATURE BIOTECHNOLOGY
- Mechanism of hard-nanomaterial clearance by the liver
- (2016) Kim M. Tsoi et al. NATURE MATERIALS
- Single-cell multimodal profiling reveals cellular epigenetic heterogeneity
- (2016) Lih Feng Cheow et al. NATURE METHODS
- Parallel single-cell sequencing links transcriptional and epigenetic heterogeneity
- (2016) Christof Angermueller et al. NATURE METHODS
- Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse
- (2016) Ye Zhang et al. NEURON
- Enhanced non-viral gene delivery by coordinated endosomal release and inhibition of β-tubulin deactylase
- (2016) Yoon Khei Ho et al. NUCLEIC ACIDS RESEARCH
- Visualization of self-delivering hydrophobically modified siRNA cellular internalization
- (2016) Socheata Ly et al. NUCLEIC ACIDS RESEARCH
- Splice-switching antisense oligonucleotides as therapeutic drugs
- (2016) Mallory A. Havens et al. NUCLEIC ACIDS RESEARCH
- The delivery of therapeutic oligonucleotides
- (2016) Rudolph L. Juliano NUCLEIC ACIDS RESEARCH
- Development of a Quantitative BRET Affinity Assay for Nucleic Acid-Protein Interactions
- (2016) Timothy A. Vickers et al. PLoS One
- Hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice
- (2016) Gang Han et al. Nature Communications
- Pharmacokinetic and Pharmacodynamic Investigations of ION-353382, a Model Antisense Oligonucleotide: Using Alpha-2-Macroglobulin and Murinoglobulin Double-Knockout Mice
- (2016) Colby S. Shemesh et al. Nucleic Acid Therapeutics
- Intrathecal delivery of frataxin mRNA encapsulated in lipid nanoparticles to dorsal root ganglia as a potential therapeutic for Friedreich’s ataxia
- (2016) Joseph F. Nabhan et al. Scientific Reports
- Analysis of nanoparticle delivery to tumours
- (2016) Stefan Wilhelm et al. Nature Reviews Materials
- Role of Intermediate Filaments in Vesicular Traffic
- (2016) Azzurra Margiotta et al. Cells
- The intracellular trafficking mechanism of Lipofectamine-based transfection reagents and its implication for gene delivery
- (2016) Francesco Cardarelli et al. Scientific Reports
- A systematic High-Content Screening microscopy approach reveals key roles for Rab33b, OATL1 and Myo6 in nanoparticle trafficking in HeLa cells
- (2016) Angela Panarella et al. Scientific Reports
- Simultaneous delivery of Paclitaxel and Bcl-2 siRNA via pH-Sensitive liposomal nanocarrier for the synergistic treatment of melanoma
- (2016) Teegala Lakshminarayan Reddy et al. Scientific Reports
- siRNA Conjugates Carrying Sequentially Assembled Trivalent N-Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in Hepatocytes
- (2015) Shigeo Matsuda et al. ACS Chemical Biology
- Systemic Gene Silencing in Primary T Lymphocytes Using Targeted Lipid Nanoparticles
- (2015) Srinivas Ramishetti et al. ACS Nano
- Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides
- (2015) Richard S. Geary et al. ADVANCED DRUG DELIVERY REVIEWS
- Antisense oligonucleotides in therapy for neurodegenerative disorders
- (2015) Melvin M. Evers et al. ADVANCED DRUG DELIVERY REVIEWS
- Viral Vectors for Gene Therapy: Translational and Clinical Outlook
- (2015) Melissa A. Kotterman et al. Annual Review of Biomedical Engineering
- Co-delivery of hydrophobic paclitaxel and hydrophilic AURKA specific siRNA by redox-sensitive micelles for effective treatment of breast cancer
- (2015) Tingjie Yin et al. BIOMATERIALS
- Efficient Intracellular Delivery of Native Proteins
- (2015) Diego S. D’Astolfo et al. CELL
- Hollow Inorganic Nanoparticles as Efficient Carriers for siRNA Delivery: A Comprehensive Review
- (2015) Jaleh Varshosaz et al. CURRENT PHARMACEUTICAL DESIGN
- High-content analysis for drug delivery and nanoparticle applications
- (2015) David J. Brayden et al. DRUG DISCOVERY TODAY
- ER-endosome contact sites: molecular compositions and functions
- (2015) C. Raiborg et al. EMBO JOURNAL
- Modified mRNA as an alternative to plasmid DNA (pDNA) for transcript replacement and vaccination therapy
- (2015) Hyewon Youn et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Efficient Reprogramming of Human Fibroblasts and Blood-Derived Endothelial Progenitor Cells Using Nonmodified RNA for Reprogramming and Immune Evasion
- (2015) Marco Alexander Poleganov et al. HUMAN GENE THERAPY
- Paclitaxel tumor priming promotes delivery and transfection of intravenous lipid-siRNA in pancreatic tumors
- (2015) Jie Wang et al. JOURNAL OF CONTROLLED RELEASE
- Improved intracellular delivery of peptide- and lipid-nanoplexes by natural glycosides
- (2015) Alexander Weng et al. JOURNAL OF CONTROLLED RELEASE
- Nanobody conjugated PLGA nanoparticles for active targeting of African Trypanosomiasis
- (2015) José L. Arias et al. JOURNAL OF CONTROLLED RELEASE
- Going beyond the liver: Progress and challenges of targeted delivery of siRNA therapeutics
- (2015) Cornelia Lorenzer et al. JOURNAL OF CONTROLLED RELEASE
- Modulating Polyplex-Mediated Gene Transfection by Small-Molecule Regulators of Autophagy
- (2015) Xiao Zhong et al. MOLECULAR PHARMACEUTICS
- Nanobody-based cancer therapy of solid tumors
- (2015) Marta Kijanka et al. Nanomedicine
- Lessons in simplicity that should shape the future of drug delivery
- (2015) Koen Raemdonck et al. NATURE BIOTECHNOLOGY
- Antisense oligonucleotide–directed inhibition of nonsense-mediated mRNA decay
- (2015) Tomoki T Nomakuchi et al. NATURE BIOTECHNOLOGY
- Principles of nanoparticle design for overcoming biological barriers to drug delivery
- (2015) Elvin Blanco et al. NATURE BIOTECHNOLOGY
- Integrated genome and transcriptome sequencing of the same cell
- (2015) Siddharth S Dey et al. NATURE BIOTECHNOLOGY
- Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown
- (2015) Anders Wittrup et al. NATURE BIOTECHNOLOGY
- Knocking down disease: a progress report on siRNA therapeutics
- (2015) Anders Wittrup et al. NATURE REVIEWS GENETICS
- High-throughput functional genomics using CRISPR–Cas9
- (2015) Ophir Shalem et al. NATURE REVIEWS GENETICS
- Identification of siRNA delivery enhancers by a chemical library screen
- (2015) Jerome Gilleron et al. NUCLEIC ACIDS RESEARCH
- Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs
- (2015) Maire F. Osborn et al. NUCLEIC ACIDS RESEARCH
- High-throughput screening identifies small molecules that enhance the pharmacological effects of oligonucleotides
- (2015) B. Yang et al. NUCLEIC ACIDS RESEARCH
- A cytoplasmic pathway for gapmer antisense oligonucleotide-mediated gene silencing in mammalian cells
- (2015) Daniela Castanotto et al. NUCLEIC ACIDS RESEARCH
- Histone-targeted Polyplexes Avoid Endosomal Escape and Enter the Nucleus During Postmitotic Redistribution of ER Membranes
- (2015) Nikki L Ross et al. Molecular Therapy-Nucleic Acids
- Pharmacology of L-type Calcium Channels: Novel Drugs for Old Targets?
- (2015) Jorg Striessnig et al. Current Molecular Pharmacology
- The Importance of Membrane Defects—Lessons from Simulations
- (2014) W. F. Drew Bennett et al. ACCOUNTS OF CHEMICAL RESEARCH
- Niemann-Pick C1 Affects the Gene Delivery Efficacy of Degradable Polymeric Nanoparticles
- (2014) Ahmed A. Eltoukhy et al. ACS Nano
- Direct cytosolic siRNA delivery by reconstituted high density lipoprotein for target-specific therapy of tumor angiogenesis
- (2014) Yang Ding et al. BIOMATERIALS
- A Hierarchical Map of Regulatory Genetic Interactions in Membrane Trafficking
- (2014) Prisca Liberali et al. CELL
- A Bifurcated Proteoglycan Binding Small Molecule Carrier for siRNA Delivery
- (2014) Matt Gooding et al. Chemical Biology & Drug Design
- Principles of membrane tethering and fusion in endosome and lysosome biogenesis
- (2014) Daniel Kümmel et al. CURRENT OPINION IN CELL BIOLOGY
- Autophagy Induced by Calcium Phosphate Precipitates Targets Damaged Endosomes
- (2014) Xi Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lysosomal capturing of cytoplasmic injected nanoparticles by autophagy: An additional barrier to non viral gene delivery
- (2014) Katrien Remaut et al. JOURNAL OF CONTROLLED RELEASE
- Tumor priming enhances siRNA delivery and transfection in intraperitoneal tumors
- (2014) Jie Wang et al. JOURNAL OF CONTROLLED RELEASE
- Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing
- (2014) Jayaprakash K. Nair et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Recent developments in the co-delivery of siRNA and small molecule anticancer drugs for cancer treatment
- (2014) Manju Saraswathy et al. Materials Today
- Intracellular delivery of nanomaterials: How to catch endosomal escape in the act
- (2014) Thomas F. Martens et al. Nano Today
- Enhancing endosomal escape for nanoparticle mediated siRNA delivery
- (2014) Da Ma Nanoscale
- Chemistry: Chemical con artists foil drug discovery
- (2014) Jonathan Baell et al. NATURE
- Time to deliver
- (2014) NATURE BIOTECHNOLOGY
- Microfluidic organs-on-chips
- (2014) Sangeeta N Bhatia et al. NATURE BIOTECHNOLOGY
- Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects
- (2014) Bin Shen et al. NATURE METHODS
- mRNA-based therapeutics — developing a new class of drugs
- (2014) Ugur Sahin et al. NATURE REVIEWS DRUG DISCOVERY
- Non-viral vectors for gene-based therapy
- (2014) Hao Yin et al. NATURE REVIEWS GENETICS
- Systematic evaluation of antibody-mediated siRNA delivery using an industrial platform of THIOMAB–siRNA conjugates
- (2014) Trinna L. Cuellar et al. NUCLEIC ACIDS RESEARCH
- Identification of the endosomal sorting complex required for transport-I (ESCRT-I) as an important modulator of anti-miR uptake by cancer cells
- (2014) Timothy R. Wagenaar et al. NUCLEIC ACIDS RESEARCH
- TCP1 complex proteins interact with phosphorothioate oligonucleotides and can co-localize in oligonucleotide-induced nuclear bodies in mammalian cells
- (2014) Xue-hai Liang et al. NUCLEIC ACIDS RESEARCH
- Aganirsen Antisense Oligonucleotide Eye Drops Inhibit Keratitis-Induced Corneal Neovascularization and Reduce Need for Transplantation
- (2014) Claus Cursiefen et al. OPHTHALMOLOGY
- Cytoplasmic HIV-1 RNA is mainly transported by diffusion in the presence or absence of Gag protein
- (2014) Jianbo Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lipid compartmentalization in the endosome system
- (2014) Françoise Hullin-Matsuda et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Endosome maturation, transport and functions
- (2014) Cameron C. Scott et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Retromer: A Master Conductor of Endosome Sorting
- (2014) C. Burd et al. Cold Spring Harbor Perspectives in Biology
- Clathrin-Independent Pathways of Endocytosis
- (2014) S. Mayor et al. Cold Spring Harbor Perspectives in Biology
- Mechanism of Ca2+-triggered ESCRT assembly and regulation of cell membrane repair
- (2014) Luana L. Scheffer et al. Nature Communications
- Cellular Uptake and Intracellular Trafficking of Oligonucleotides: Implications for Oligonucleotide Pharmacology
- (2014) R.L. Juliano et al. Nucleic Acid Therapeutics
- Phosphorothioates, Essential Components of Therapeutic Oligonucleotides
- (2014) Fritz Eckstein Nucleic Acid Therapeutics
- Multicellular Tumor Spheroids as a Model for Assessing Delivery of Oligonucleotides in Three Dimensions
- (2014) Kyle Carver et al. Molecular Therapy-Nucleic Acids
- Exocytosis of nanoparticles from cells: Role in cellular retention and toxicity
- (2013) Ramin Sakhtianchi et al. ADVANCES IN COLLOID AND INTERFACE SCIENCE
- Is Cancer a Metabolic Disease?
- (2013) Hilary A. Coller AMERICAN JOURNAL OF PATHOLOGY
- Autophagy and formation of tubulovesicular autophagosomes provide a barrier against nonviral gene delivery
- (2013) Rebecca Roberts et al. Autophagy
- Efficient Generation of Human iPSCs by a Synthetic Self-Replicative RNA
- (2013) Naohisa Yoshioka et al. Cell Stem Cell
- The journey of the organelle: teamwork and regulation in intracellular transport
- (2013) Kari Barlan et al. CURRENT OPINION IN CELL BIOLOGY
- Mipomersen Sodium: First Global Approval
- (2013) Philip Hair et al. DRUGS
- The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing
- (2013) Lukas Stalder et al. EMBO JOURNAL
- Retrograde transport of protein toxins through the Golgi apparatus
- (2013) Kirsten Sandvig et al. HISTOCHEMISTRY AND CELL BIOLOGY
- Endosomal escape kinetics of mesoporous silica-based system for efficient siRNA delivery
- (2013) Mingqi Wang et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Intracellular processing of immunostimulatory CpG–siRNA: Toll-like receptor 9 facilitates siRNA dicing and endosomal escape
- (2013) Sergey Nechaev et al. JOURNAL OF CONTROLLED RELEASE
- Reversal of Lung Cancer Multidrug Resistance by pH-Responsive Micelleplexes Mediating Co-Delivery of siRNA and Paclitaxel
- (2013) Haijun Yu et al. MACROMOLECULAR BIOSCIENCE
- RNAi-mediated inhibition of apoptosis fails to prevent cationic nanoparticle-induced cell death in cultured cells
- (2013) Mariana G Bexiga et al. Nanomedicine
- Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape
- (2013) Jerome Gilleron et al. NATURE BIOTECHNOLOGY
- Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling
- (2013) Gaurav Sahay et al. NATURE BIOTECHNOLOGY
- Delivery materials for siRNA therapeutics
- (2013) Rosemary Kanasty et al. NATURE MATERIALS
- Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface
- (2013) Anna Salvati et al. Nature Nanotechnology
- Organization of the ER–Golgi interface for membrane traffic control
- (2013) Federica Brandizzi et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The small molecule Retro-1 enhances the pharmacological actions of antisense and splice switching oligonucleotides
- (2013) Xin Ming et al. NUCLEIC ACIDS RESEARCH
- Robust RNAi enhancement via human Argonaute-2 overexpression from plasmids, viral vectors and cell lines
- (2013) Kathleen Börner et al. NUCLEIC ACIDS RESEARCH
- PKC Activation in Niemann Pick C1 Cells Restores Subcellular Cholesterol Transport
- (2013) Farshad Tamari et al. PLoS One
- ALIX and the multivesicular endosome: ALIX in Wonderland
- (2013) Christin Bissig et al. TRENDS IN CELL BIOLOGY
- Lipid Sorting and Multivesicular Endosome Biogenesis
- (2013) C. Bissig et al. Cold Spring Harbor Perspectives in Biology
- BAY11 enhances OCT4 synthetic mRNA expression in adult human skin cells
- (2013) Jason P Awe et al. Stem Cell Research & Therapy
- In Vitro–In Vivo Translation of Lipid Nanoparticles for Hepatocellular siRNA Delivery
- (2012) Kathryn A. Whitehead et al. ACS Nano
- Polymeric Nucleic Acid Vehicles Exploit Active Interorganelle Trafficking Mechanisms
- (2012) Katye M. Fichter et al. ACS Nano
- High-Speed Imaging of Rab Family Small GTPases Reveals Rare Events in Nanoparticle Trafficking in Living Cells
- (2012) Peter Sandin et al. ACS Nano
- Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo
- (2012) Muthusamy Jayaraman et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Roles for Actin Assembly in Endocytosis
- (2012) Olivia L. Mooren et al. Annual Review of Biochemistry
- Fluorescence Fluctuation Spectroscopy Enables Quantitative Imaging of Single mRNAs in Living Cells
- (2012) Bin Wu et al. BIOPHYSICAL JOURNAL
- The mTOR Signalling Pathway in Human Cancer
- (2012) Helena Pópulo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- On the cellular processing of non-viral nanomedicines for nucleic acid delivery: Mechanisms and methods
- (2012) Dries Vercauteren et al. JOURNAL OF CONTROLLED RELEASE
- Regulation by L-Type Calcium Channels of Endocytosis: An Overview
- (2012) Juliana M. Rosa et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Polyplexes Traffic through Caveolae to the Golgi and Endoplasmic Reticulum en Route to the Nucleus
- (2012) Meghan J. Reilly et al. MOLECULAR PHARMACEUTICS
- A human genome-wide screen for regulators of clathrin-coated vesicle formation reveals an unexpected role for the V-ATPase
- (2012) Patrycja Kozik et al. NATURE CELL BIOLOGY
- Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway
- (2012) Jeremy C. Simpson et al. NATURE CELL BIOLOGY
- Endocytosis and Signaling: Cell Logistics Shape the Eukaryotic Cell Plan
- (2012) Sara Sigismund et al. PHYSIOLOGICAL REVIEWS
- Dantrolene Enhances Antisense-Mediated Exon Skipping in Human and Mouse Models of Duchenne Muscular Dystrophy
- (2012) G. C. Kendall et al. Science Translational Medicine
- Involvement of Lysosomal Exocytosis in the Excretion of Mesoporous Silica Nanoparticles and Enhancement of the Drug Delivery Effect by Exocytosis Inhibition
- (2012) Rolando E. Yanes et al. Small
- Annexin A2 binds to endosomes following organelle destabilization by particulate wear debris
- (2012) Brian Scharf et al. Nature Communications
- Antisense 2′-Deoxy, 2′-Fluoroarabino Nucleic Acid (2′F-ANA) Oligonucleotides: In Vitro Gymnotic Silencers of Gene Expression Whose Potency Is Enhanced by Fatty Acids
- (2012) Naira Souleimanian et al. Molecular Therapy-Nucleic Acids
- Overcoming Endosomal Barrier by Amphotericin B-Loaded Dual pH-Responsive PDMA-b-PDPA Micelleplexes for siRNA Delivery
- (2011) Haijun Yu et al. ACS Nano
- Dynamic Colocalization Microscopy To Characterize Intracellular Trafficking of Nanomedicines
- (2011) Dries Vercauteren et al. ACS Nano
- Simultaneous Delivery of siRNA and Paclitaxel via a “Two-in-One” Micelleplex Promotes Synergistic Tumor Suppression
- (2011) Tian-Meng Sun et al. ACS Nano
- Gold Nanoparticles Induce Autophagosome Accumulation through Size-Dependent Nanoparticle Uptake and Lysosome Impairment
- (2011) Xiaowei Ma et al. ACS Nano
- Calcium entry through slow-inactivating L-type calcium channels preferentially triggers endocytosis rather than exocytosis in bovine chromaffin cells
- (2011) Juliana M. Rosa et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Exploring the Interaction Between siRNA and the SMoC Biomolecule Transporters: Implications for Small Molecule-Mediated Delivery of siRNA
- (2011) Matt Gooding et al. Chemical Biology & Drug Design
- Clathrin-independent endocytosis: mechanisms and function
- (2011) Kirsten Sandvig et al. CURRENT OPINION IN CELL BIOLOGY
- Endosome maturation
- (2011) Jatta Huotari et al. EMBO JOURNAL
- Protein kinase A inhibition modulates the intracellular routing of gene delivery vehicles in HeLa cells, leading to productive transfection
- (2011) Zia ur Rehman et al. JOURNAL OF CONTROLLED RELEASE
- Non-degradative intracellular trafficking of highly compacted polymeric DNA nanoparticles
- (2011) Anthony J. Kim et al. JOURNAL OF CONTROLLED RELEASE
- Mechanism of Endosomal TLR Inhibition by Antimalarial Drugs and Imidazoquinolines
- (2011) A. Kuznik et al. JOURNAL OF IMMUNOLOGY
- Effects of Lipofectamine 2000/siRNA Complexes on Autophagy in Hepatoma Cells
- (2011) Robert H. Mo et al. MOLECULAR BIOTECHNOLOGY
- Uptake, Efficacy, and Systemic Distribution of Naked, Inhaled Short Interfering RNA (siRNA) and Locked Nucleic Acid (LNA) Antisense
- (2011) Sterghios A Moschos et al. MOLECULAR THERAPY
- Endocytosis and intracellular transport of nanoparticles: Present knowledge and need for future studies
- (2011) Tore-Geir Iversen et al. Nano Today
- Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes
- (2011) Erich Koller et al. NUCLEIC ACIDS RESEARCH
- Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo
- (2011) Samir EL Andaloussi et al. NUCLEIC ACIDS RESEARCH
- Role of Rab GTPases in Membrane Traffic and Cell Physiology
- (2011) Alex H. Hutagalung et al. PHYSIOLOGICAL REVIEWS
- Effects of Transport Inhibitors on the Cellular Uptake of Carboxylated Polystyrene Nanoparticles in Different Cell Lines
- (2011) Tiago dos Santos et al. PLoS One
- Mannose receptor polyubiquitination regulates endosomal recruitment of p97 and cytosolic antigen translocation for cross-presentation
- (2011) M. Zehner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Retrograde Transport: Two (or More) Roads Diverged in an Endosomal Tree?
- (2011) Ludger Johannes et al. TRAFFIC
- Dynamics of Native β-actin mRNA Transport in the Cytoplasm
- (2011) Aaron W. Lifland et al. TRAFFIC
- Correction: Old World Arenaviruses Enter the Host Cell via the Multivesicular Body and Depend on the Endosomal Sorting Complex Required for Transport
- (2011) Giulia Pasqual et al. PLoS Pathogens
- Induction of genuine autophagy by cationic lipids in mammalian cells
- (2010) Na Man et al. Autophagy
- The influence of mediators of intracellular trafficking on transgene expression efficacy of polymer–plasmid DNA complexes
- (2010) Sutapa Barua et al. BIOMATERIALS
- Inhibition of Retrograde Transport Protects Mice from Lethal Ricin Challenge
- (2010) Bahne Stechmann et al. CELL
- Identification of the Switch in Early-to-Late Endosome Transition
- (2010) Dmitry Poteryaev et al. CELL
- Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA
- (2010) Luigi Warren et al. Cell Stem Cell
- Multisubunit Tethering Complexes and Their Role in Membrane Fusion
- (2010) Cornelia Bröcker et al. CURRENT BIOLOGY
- Gateways for the intracellular access of nanocarriers: a review of receptor-mediated endocytosis mechanisms and of strategies in receptor targeting
- (2010) Noha M Zaki et al. Expert Opinion on Drug Delivery
- Down-modulation of cancer targets using locked nucleic acid (LNA)-based antisense oligonucleotides without transfection
- (2010) Y Zhang et al. GENE THERAPY
- Revisiting caveolin trafficking: the end of the caveosome: Figure 1.
- (2010) Robert G. Parton et al. JOURNAL OF CELL BIOLOGY
- Caveolin-1 is ubiquitinated and targeted to intralumenal vesicles in endolysosomes for degradation
- (2010) Arnold Hayer et al. JOURNAL OF CELL BIOLOGY
- The life of an mRNA in space and time
- (2010) Y. Ben-Ari et al. JOURNAL OF CELL SCIENCE
- Endocytosis of nanomedicines
- (2010) Gaurav Sahay et al. JOURNAL OF CONTROLLED RELEASE
- Small Molecule Modifiers of MicroRNA miR-122 Function for the Treatment of Hepatitis C Virus Infection and Hepatocellular Carcinoma
- (2010) Douglas D. Young et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Poly(glycoamidoamine) Vehicles Promote pDNA Uptake through Multiple Routes and Efficient Gene Expression via Caveolae-Mediated Endocytosis
- (2010) Patrick M. McLendon et al. MOLECULAR PHARMACEUTICS
- Guanine Analogues Enhance Antisense Oligonucleotide-induced Exon Skipping in Dystrophin Gene In Vitro and In Vivo
- (2010) Yihong Hu et al. MOLECULAR THERAPY
- Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms
- (2010) Akin Akinc et al. MOLECULAR THERAPY
- Systems survey of endocytosis by multiparametric image analysis
- (2010) Claudio Collinet et al. NATURE
- Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells
- (2010) Jason M. Kinchen et al. NATURE
- Delivering nanomedicine to solid tumors
- (2010) Rakesh K. Jain et al. Nature Reviews Clinical Oncology
- Intracellular delivery of an antisense oligonucleotide via endocytosis of a G protein-coupled receptor
- (2010) Xin Ming et al. NUCLEIC ACIDS RESEARCH
- Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation
- (2010) Bart R. Anderson et al. NUCLEIC ACIDS RESEARCH
- Enhanced Gene and siRNA Delivery by Polycation-Modified Mesoporous Silica Nanoparticles Loaded with Chloroquine
- (2010) Shanta Raj Bhattarai et al. PHARMACEUTICAL RESEARCH
- Mechanisms of Endocytosis
- (2009) Gary J. Doherty et al. Annual Review of Biochemistry
- Methodological considerations for assessing autophagy modulators: A study with calcium phosphate precipitates
- (2009) Sovan Sarkar et al. Autophagy
- Identifying druggable disease-modifying gene products
- (2009) Scott J Dixon et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Single-molecule imaging of β-actin mRNAs in the cytoplasm of a living cell
- (2009) Mai Yamagishi et al. EXPERIMENTAL CELL RESEARCH
- Biochemical Isolation and Characterization of the Tubulovesicular LC3-positive Autophagosomal Compartment
- (2009) Wentao Gao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Efficient polyethylenimine-mediated gene delivery proceeds via a caveolar pathway in HeLa cells
- (2009) Nathan P. Gabrielson et al. JOURNAL OF CONTROLLED RELEASE
- The Effect of Chemical Modification and Nanoparticle Formulation on Stability and Biodistribution of siRNA in Mice
- (2009) Shan Gao et al. MOLECULAR THERAPY
- Evaluation of Efficacy, Biodistribution, and Inflammation for a Potent siRNA Nanoparticle: Effect of Dexamethasone Co-treatment
- (2009) Marc T Abrams et al. MOLECULAR THERAPY
- The Use of Inhibitors to Study Endocytic Pathways of Gene Carriers: Optimization and Pitfalls
- (2009) Dries Vercauteren et al. MOLECULAR THERAPY
- RISC hitches onto endosome trafficking
- (2009) Haruhiko Siomi et al. NATURE CELL BIOLOGY
- Silencing by small RNAs is linked to endosomal trafficking
- (2009) Young Sik Lee et al. NATURE CELL BIOLOGY
- Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity
- (2009) Derrick J. Gibbings et al. NATURE CELL BIOLOGY
- Rab GTPases as coordinators of vesicle traffic
- (2009) Harald Stenmark NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The Biological Effect of an Antisense Oligonucleotide Depends on Its Route of Endocytosis and Trafficking
- (2009) Md. Rowshon Alam et al. OLIGONUCLEOTIDES
- Evaluations of combination MDR-1 gene silencing and paclitaxel administration in biodegradable polymeric nanoparticle formulations to overcome multidrug resistance in cancer cells
- (2008) Sunita Yadav et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Enhancement of RNAi by a small molecule antibiotic enoxacin
- (2008) Qiangzhe Zhang et al. CELL RESEARCH
- Membrane traffic in the secretory pathway
- (2008) J. Malsam et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Function and dysfunction of the PI system in membrane trafficking
- (2008) Mariella Vicinanza et al. EMBO JOURNAL
- Modified pectin-based carrier for gene delivery: Cellular barriers in gene delivery course
- (2008) Tali Katav et al. JOURNAL OF CONTROLLED RELEASE
- Microtubule Acetylation Through HDAC6 Inhibition Results in Increased Transfection Efficiency
- (2008) Erin E Vaughan et al. MOLECULAR THERAPY
- Efficient In Vivo Delivery of siRNA to the Liver by Conjugation of α-Tocopherol
- (2008) Kazutaka Nishina et al. MOLECULAR THERAPY
- A small molecule enhances RNA interference and promotes microRNA processing
- (2008) Ge Shan et al. NATURE BIOTECHNOLOGY
- Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis
- (2008) Md Rowshon Alam et al. NUCLEIC ACIDS RESEARCH
- Biochemical Investigation of Active Intracellular Transport of Polymeric Gene-Delivery Vectors
- (2007) David M. Drake et al. JOURNAL OF PHARMACEUTICAL SCIENCES
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started