Characterizing exogenous mRNA delivery, trafficking, cytoplasmic release and RNA–protein correlations at the level of single cells

Strategies for modulating innate immune activation and protein production of in vitro transcribed mRNAs

(2016) Kristin H. Loomis et al.   Journal of Materials Chemistry B

Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown

(2015) Anders Wittrup et al.   NATURE BIOTECHNOLOGY

Post-transcriptional Regulation of Programmed Cell Death 4 (PDCD4) mRNA by the RNA-binding Proteins Human Antigen R (HuR) and T-cell Intracellular Antigen 1 (TIA1)

(2014) Callie P. Wigington et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multi-Level Kinetic Model of mRNA Delivery via Transfection of Lipoplexes

(2014) Thomas S. Ligon et al.   PLoS One

Combining Single RNA Sensitive Probes with Subdiffraction-Limited and Live-Cell Imaging Enables the Characterization of Virus Dynamics in Cells

(2013) Eric Alonas et al.   ACS Nano

Transmembrane routes of cationic liposome-mediated gene delivery using human throat epidermis cancer cells

(2013) Shaohui Cui et al.   BIOTECHNOLOGY LETTERS

Eukaryotic Stress Granules Are Cleared by Autophagy and Cdc48/VCP Function

(2013) J. Ross Buchan et al.   CELL

Single-cell mRNA transfection studies: Delivery, kinetics and statistics by numbers

(2013) Carolin Leonhardt et al.   Nanomedicine-Nanotechnology Biology and Medicine

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

(2013) Gaurav Sahay et al.   NATURE BIOTECHNOLOGY

In situ detection of individual mRNA molecules and protein complexes or post-translational modifications using padlock probes combined with the in situ proximity ligation assay

(2013) Irene Weibrecht et al.   Nature Protocols

Characterization of mRNA-Cytoskeleton Interactions In Situ Using FMTRIP and Proximity Ligation

(2013) Jeenah Jung et al.   PLoS One

Human Respiratory Syncytial Virus Nucleoprotein and Inclusion Bodies Antagonize the Innate Immune Response Mediated by MDA5 and MAVS

(2012) A. W. Lifland et al.   JOURNAL OF VIROLOGY

Quantifying RNA–protein interactions in situ using modified-MTRIPs and proximity ligation

(2012) Jeenah Jung et al.   NUCLEIC ACIDS RESEARCH

Developing mRNA-vaccine technologies

(2012) Thomas Schlake et al.   RNA Biology

Spatial Relationships between Markers for Secretory and Endosomal Machinery in Human Cytomegalovirus-Infected Cells versus Those in Uninfected Cells

(2011) S. Das et al.   JOURNAL OF VIROLOGY

Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

(2011) Michael S D Kormann et al.   NATURE BIOTECHNOLOGY

Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

(2011) Katalin Karikó et al.   NUCLEIC ACIDS RESEARCH

Nucleoside modifications in RNA limit activation of 2'-5'-oligoadenylate synthetase and increase resistance to cleavage by RNase L

(2011) B. R. Anderson et al.   NUCLEIC ACIDS RESEARCH

Characterizing mRNA Interactions with RNA Granules during Translation Initiation Inhibition

(2011) Chiara Zurla et al.   PLoS One

Protein expression from exogenous mRNA: Uptake by receptor-mediated endocytosis and trafficking via the lysosomal pathway

(2011) Christina Lorenz et al.   RNA Biology

RNA helical imperfections regulate activation of the protein kinase PKR: Effects of bulge position, size, and geometry

(2011) L. A. Heinicke et al.   RNA

Dynamics of Native β-actin mRNA Transport in the Cytoplasm

(2011) Aaron W. Lifland et al.   TRAFFIC

Single Molecule Sensitive Multivalent Polyethylene Glycol Probes for RNA Imaging

(2010) Aaron W. Lifland et al.   BIOCONJUGATE CHEMISTRY

Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA

(2010) Luigi Warren et al.   Cell Stem Cell

Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation

(2010) Bart R. Anderson et al.   NUCLEIC ACIDS RESEARCH

Making the message clear: visualizing mRNA localization

(2010) Timothy T. Weil et al.   TRENDS IN CELL BIOLOGY

Eukaryotic Stress Granules: The Ins and Outs of Translation

(2009) J. Ross Buchan et al.   MOLECULAR CELL

PKR and the ribosome compete for mRNA

(2009) Rebecca Toroney et al.   Nature Chemical Biology

Single molecule–sensitive probes for imaging RNA in live cells

(2009) Philip J Santangelo et al.   NATURE METHODS

Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay

(2008) Ola Söderberg et al.   METHODS

Imaging individual mRNA molecules using multiple singly labeled probes

(2008) Arjun Raj et al.   NATURE METHODS

Nucleoside modifications modulate activation of the protein kinase PKR in an RNA structure-specific manner

(2008) S. R. Nallagatla et al.   RNA

Stress granules: the Tao of RNA triage

(2008) Paul Anderson et al.   TRENDS IN BIOCHEMICAL SCIENCES