Resveratrol Enhances mRNA and siRNA Lipid Nanoparticles Primary CLL Cell Transfection

Imaging small molecule-induced endosomal escape of siRNA

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Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

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Antiproliferative and apoptotic effects of caffeic acid on SK-Mel-28 human melanoma cancer cells

(2019) Luana Paula Pelinson et al.   MOLECULAR BIOLOGY REPORTS

STAT3-induced SMYD3 transcription enhances chronic lymphocytic leukemia cell growth in vitro and in vivo

(2019) Fujia Lin et al.   INFLAMMATION RESEARCH

Therapeutic mRNA delivery to leukocytes

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Lipid Nanoparticle Technology for Clinical Translation of siRNA Therapeutics

(2019) Jayesh A. Kulkarni et al.   ACCOUNTS OF CHEMICAL RESEARCH

Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells

(2019) Marco Maugeri et al.   Nature Communications

On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA

(2018) Jayesh A. Kulkarni et al.   ACS Nano

Endosomal Size and Membrane Leakiness Influence Proton Sponge-Based Rupture of Endosomal Vesicles

(2018) Lotte M. P. Vermeulen et al.   ACS Nano

Rationale for assessing the therapeutic potential of resveratrol in hematological malignancies

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Transferrin-targeted, resveratrol-loaded liposomes for the treatment of glioblastoma

(2018) Aditi Jhaveri et al.   JOURNAL OF CONTROLLED RELEASE

A modular platform for targeted RNAi therapeutics

(2018) Ranit Kedmi et al.   Nature Nanotechnology

Evolution of CLL treatment — from chemoimmunotherapy to targeted and individualized therapy

(2018) Jan A. Burger et al.   Nature Reviews Clinical Oncology

Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

(2018) David Adams et al.   NEW ENGLAND JOURNAL OF MEDICINE

Progress and challenges towards targeted delivery of cancer therapeutics

(2018) Daniel Rosenblum et al.   Nature Communications

Lipid Nanoparticles Enabling Gene Therapies: From Concepts to Clinical Utility

(2018) Jayesh A. Kulkarni et al.   Nucleic Acid Therapeutics

Heat shock protein 27 promotes cell cycle progression by down-regulating E2F transcription factor 4 and retinoblastoma family protein p130

(2018) Ah-Mee Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alnylam launches era of RNAi drugs

(2018) Ken Garber   NATURE BIOTECHNOLOGY

An RNA toolbox for cancer immunotherapy

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Non-viral Delivery of Nucleic Acids: Insight Into Mechanisms of Overcoming Intracellular Barriers

(2018) Mikhail Durymanov et al.   Frontiers in Pharmacology

Regulatory watch: FDA new drug approvals in Q3 2018

(2018) Lisa Urquhart   NATURE REVIEWS DRUG DISCOVERY

The Role of Resveratrol in Cancer Therapy

(2017) Jeong-Hyeon Ko et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ibrutinib modulates the immunosuppressive CLL microenvironment through STAT3-mediated suppression of regulatory B-cell function and inhibition of the PD-1/PD-L1 pathway

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Current perspectives on the role of chemotherapy in chronic lymphocytic leukemia

(2017) Clemens-Martin Wendtner et al.   LEUKEMIA & LYMPHOMA

Curcumin inhibits cancer progression through regulating expression of microRNAs

(2017) Siying Zhou et al.   TUMOR BIOLOGY

CD44: More than a mere stem cell marker

(2016) I. Morath et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Natural polyphenols: An overview

(2016) Munawar Abbas et al.   INTERNATIONAL JOURNAL OF FOOD PROPERTIES

Trends in survival of chronic lymphocytic leukemia patients in Germany and the USA in the first decade of the twenty-first century

(2016) Dianne Pulte et al.   Journal of Hematology & Oncology

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

(2016) András Kotschy et al.   NATURE

Enhancing Endosomal Escape for Intracellular Delivery of Macromolecular Biologic Therapeutics

(2016) Peter Lönn et al.   Scientific Reports

Harnessing RNAi-based nanomedicines for therapeutic gene silencing in B-cell malignancies

(2015) Shiri Weinstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of CD44 in the Pathophysiology of Chronic Lymphocytic Leukemia

(2015) Julia Christine Gutjahr et al.   Frontiers in Immunology

Chronic Lymphocytic Leukemia

(2014) Chadi Nabhan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Resveratrol has anti-leukemic activity associated with decreased O-GlcNAcylated proteins

(2013) Jelena Tomic et al.   EXPERIMENTAL HEMATOLOGY

Resveratrol and quercetin-induced apoptosis of human 232B4 chronic lymphocytic leukemia cells by activation of caspase-3 and cell cycle arrest

(2013) Aysun Adan Gokbulut et al.   Hematology

Advances in Lipid Nanoparticles for siRNA Delivery

(2013) Yuen Tam et al.   Pharmaceutics

Regulation of the cell cycle via mitochondrial gene expression and energy metabolism in HeLa cells

(2012) W. Xiong et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Resveratrol increases rate of apoptosis caused by purine analogues in malignant lymphocytes of chronic lymphocytic leukemia

(2010) Monika Podhorecka et al.   ANNALS OF HEMATOLOGY

STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells

(2010) I. Hazan-Halevy et al.   BLOOD

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

(2010) Akin Akinc et al.   MOLECULAR THERAPY

Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers

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