- Home
- Publications
- Publication Search
- Publication Details
Title
Applications of chemogenomic library screening in drug discovery
Authors
Keywords
-
Journal
NATURE REVIEWS DRUG DISCOVERY
Volume 16, Issue 4, Pages 285-296
Publisher
Springer Nature
Online
2017-01-20
DOI
10.1038/nrd.2016.244
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Drug-induced adverse events prediction with the LINCS L1000 data
- (2016) Zichen Wang et al. BIOINFORMATICS
- A Landscape of Pharmacogenomic Interactions in Cancer
- (2016) Francesco Iorio et al. CELL
- Cereblon and its downstream substrates as molecular targets of immunomodulatory drugs
- (2016) Takumi Ito et al. INTERNATIONAL JOURNAL OF HEMATOLOGY
- EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen
- (2016) Susanne Scheipl et al. JOURNAL OF PATHOLOGY
- Identification and Validation of Small Molecules That Enhance Recombinant Adeno-associated Virus Transduction following High-Throughput Screens
- (2016) Sarah C. Nicolson et al. JOURNAL OF VIROLOGY
- Reproducibility: Team up with industry
- (2016) Aled Edwards NATURE
- Reproducible pharmacogenomic profiling of cancer cell line panels
- (2016) Peter M. Haverty et al. NATURE
- Augmented efficacy of brentuximab vedotin combined with ruxolitinib and/or Navitoclax in a murine model of human Hodgkin’s lymphoma
- (2016) Wei Ju et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Open PHACTS computational protocols for in silico target validation of cellular phenotypic screens: knowing the knowns
- (2016) D. Digles et al. MedChemComm
- Chemogenomic Profiling of Endogenous PARK2 Expression Using a Genome-Edited Coincidence Reporter
- (2015) Samuel A. Hasson et al. ACS Chemical Biology
- The novel mechanism of lenalidomide activity
- (2015) E. C. Fink et al. BLOOD
- The Concise Guide to PHARMACOLOGY 2015/16: Overview
- (2015) Stephen PH Alexander et al. BRITISH JOURNAL OF PHARMACOLOGY
- Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes
- (2015) Stuart L. Schreiber et al. CELL
- Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells
- (2015) Chen Yu et al. Cell Stem Cell
- Pharmacological and Protein Profiling Suggests Venetoclax (ABT-199) as Optimal Partner with Ibrutinib in Chronic Lymphocytic Leukemia
- (2015) F. Cervantes-Gomez et al. CLINICAL CANCER RESEARCH
- Phenotype-driven chemical screening in zebrafish for compounds that inhibit collective cell migration identifies multiple pathways potentially involved in metastatic invasion
- (2015) V. E. Gallardo et al. Disease Models & Mechanisms
- CETSA: a target engagement assay with potential to transform drug discovery
- (2015) Annika Jenmalm Jensen et al. Future Medicinal Chemistry
- Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain
- (2015) John S. Tokarski et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Targeting cancer with kinase inhibitors
- (2015) Stefan Gross et al. JOURNAL OF CLINICAL INVESTIGATION
- Choosing the Right Tool for the Job: RNAi, TALEN, or CRISPR
- (2015) Michael Boettcher et al. MOLECULAR CELL
- A chemical-genetic interaction map of small molecules using high-throughput imaging in cancer cells
- (2015) M. Breinig et al. Molecular Systems Biology
- Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines
- (2015) Jungseog Kang et al. NATURE BIOTECHNOLOGY
- Comprehensive characterization of the Published Kinase Inhibitor Set
- (2015) Jonathan M Elkins et al. NATURE BIOTECHNOLOGY
- Functional genomics to uncover drug mechanism of action
- (2015) Sebastian M B Nijman Nature Chemical Biology
- The promise and peril of chemical probes
- (2015) Cheryl H Arrowsmith et al. Nature Chemical Biology
- Preclinical target validation using patient-derived cells
- (2015) Aled M. Edwards et al. NATURE REVIEWS DRUG DISCOVERY
- Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs
- (2015) Maire F. Osborn et al. NUCLEIC ACIDS RESEARCH
- Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia
- (2015) A Eriksson et al. Blood Cancer Journal
- Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset
- (2015) B. Seashore-Ludlow et al. Cancer Discovery
- Proscillaridin A is cytotoxic for glioblastoma cell lines and controls tumor xenograft growth in vivo
- (2015) Emilie Denicolaï et al. Oncotarget
- Distant Polypharmacology among MLP Chemical Probes
- (2014) Albert A. Antolín et al. ACS Chemical Biology
- Niclosamide Inhibits Androgen Receptor Variants Expression and Overcomes Enzalutamide Resistance in Castration-Resistant Prostate Cancer
- (2014) C. Liu et al. CLINICAL CANCER RESEARCH
- Seeding Collaborations to Advance Kinase Science with the GSK Published Kinase Inhibitor Set (PKIS)
- (2014) David Drewry et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Advances in multiparameter optimization methods forde novodrug design
- (2014) Matthew Segall Expert Opinion on Drug Discovery
- Chemistry: Chemical con artists foil drug discovery
- (2014) Jonathan Baell et al. NATURE
- Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms
- (2014) Nicole C Kleinstreuer et al. NATURE BIOTECHNOLOGY
- Targeting bromodomains: epigenetic readers of lysine acetylation
- (2014) Panagis Filippakopoulos et al. NATURE REVIEWS DRUG DISCOVERY
- BioAssay Research Database (BARD): chemical biology and probe-development enabled by structured metadata and result types
- (2014) E.A. Howe et al. NUCLEIC ACIDS RESEARCH
- A High-Throughput Assay for Small Molecule Destabilizers of the KRAS Oncoprotein
- (2014) Joseph Carver et al. PLoS One
- High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell–like diffuse large B-cell lymphoma cells
- (2014) Lesley A. Mathews Griner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Composition and applications of focus libraries to phenotypic assays
- (2014) Anne Mai Wassermann et al. Frontiers in Pharmacology
- Identification of potent Yes1 kinase inhibitors using a library screening approach
- (2013) Paresma R. Patel et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- An Interactive Resource to Identify Cancer Genetic and Lineage Dependencies Targeted by Small Molecules
- (2013) Amrita Basu et al. CELL
- TAK1 Inhibition in the DFG-Out Conformation
- (2013) Iain Kilty et al. Chemical Biology & Drug Design
- Contributions of Molecular Properties to Drug Promiscuity
- (2013) Ákos Tarcsay et al. JOURNAL OF MEDICINAL CHEMISTRY
- A novel approach applying a chemical biology strategy in phenotypic screening reveals pathway-selective regulators of histone 3 K27 tri-methylation
- (2013) Yan Liu et al. Molecular BioSystems
- Target identification and mechanism of action in chemical biology and drug discovery
- (2013) Monica Schenone et al. Nature Chemical Biology
- Target validation using chemical probes
- (2013) Mark E Bunnage et al. Nature Chemical Biology
- ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system
- (2013) Sigrun Polier et al. Nature Chemical Biology
- Profile of the GSK Published Protein Kinase Inhibitor Set Across ATP-Dependent and-Independent Luciferases: Implications for Reporter-Gene Assays
- (2013) Patricia Dranchak et al. PLoS One
- Transcriptomic analysis of genetically defined autism candidate genes reveals common mechanisms of action
- (2013) Thomas A Lanz et al. Molecular Autism
- Systems Pharmacology to Predict Drug Toxicity: Integration Across Levels of Biological Organization
- (2012) Jane P.F. Bai et al. Annual Review of Pharmacology and Toxicology
- Causal reasoning on biological networks: interpreting transcriptional changes
- (2012) Leonid Chindelevitch et al. BIOINFORMATICS
- Morphobase, an Encyclopedic Cell Morphology Database, and Its Use for Drug Target Identification
- (2012) Yushi Futamura et al. CHEMISTRY & BIOLOGY
- Modern Phenotypic Drug Discovery Is a Viable, Neoclassic Pharma Strategy
- (2012) Jonathan A. Lee et al. JOURNAL OF MEDICINAL CHEMISTRY
- Phenotype-based high-content chemical library screening identifies statins as inhibitors of in vivo lymphangiogenesis
- (2012) M. M. P. Schulz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of false positives in “HTS hits to lead”: The application of Bayesian models in HTS triage to rapidly deliver a series of selective TRPV4 antagonists
- (2012) Sarah E. Skerratt et al. MedChemComm
- Chemical Genetics–Based Target Identification in Drug Discovery
- (2011) Feng Cong et al. Annual Review of Pharmacology and Toxicology
- Chemoproteomic approaches to drug target identification and drug profiling
- (2011) Marcus Bantscheff et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Design and Synthesis of Inhaled p38 Inhibitors for the Treatment of Chronic Obstructive Pulmonary Disease
- (2011) David S. Millan et al. JOURNAL OF MEDICINAL CHEMISTRY
- Small Molecules Targeting Hepatitis C Virus-Encoded NS5A Cause Subcellular Redistribution of Their Target: Insights into Compound Modes of Action
- (2011) P. Targett-Adams et al. JOURNAL OF VIROLOGY
- Too many roads not taken
- (2011) Aled M. Edwards et al. NATURE
- Getting pharmaceutical R&D back on target
- (2011) Mark E Bunnage Nature Chemical Biology
- Drug screening in a zebrafish model of Duchenne muscular dystrophy
- (2011) G. Kawahara et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Cell-Based High-Content Screening Assay Reveals Activators and Inhibitors of Cancer Cell Invasion
- (2011) M. Quintavalle et al. Science Signaling
- Apparent activity in high-throughput screening: origins of compound-dependent assay interference
- (2010) Natasha Thorne et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy
- (2010) C. M. Adamo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An in vivo chemical library screen in Xenopus tadpoles reveals novel pathways involved in angiogenesis and lymphangiogenesis
- (2009) R. E. Kalin et al. BLOOD
- AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance
- (2009) Thomas O'Hare et al. CANCER CELL
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started