Visualization of self-delivering hydrophobically modified siRNA cellular internalization

siRNA Conjugates Carrying Sequentially Assembled Trivalent N-Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in Hepatocytes

(2015) Shigeo Matsuda et al.   ACS Chemical Biology

Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides

(2015) Richard S. Geary et al.   ADVANCED DRUG DELIVERY REVIEWS

Hepatocyte-Specific Delivery of siRNAs Conjugated to Novel Non-nucleosidic TrivalentN-Acetylgalactosamine Elicits Robust Gene Silencing in Vivo

(2015) Kallanthottathil G. Rajeev et al.   CHEMBIOCHEM

Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown

(2015) Anders Wittrup et al.   NATURE BIOTECHNOLOGY

An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia

(2015) Alfica Sehgal et al.   NATURE MEDICINE

Knocking down disease: a progress report on siRNA therapeutics

(2015) Anders Wittrup et al.   NATURE REVIEWS GENETICS

DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing

(2015) Kazutaka Nishina et al.   Nature Communications

Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain

(2015) Julia F Alterman et al.   Molecular Therapy-Nucleic Acids

Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

(2014) Jayaprakash K. Nair et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing

(2013) Lukas Stalder et al.   EMBO JOURNAL

Novel Hydrophobically Modified Asymmetric RNAi Compounds (sd-rxRNA) Demonstrate Robust Efficacy in the Eye

(2013) Michael Byrne et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Preclinical development of siRNA therapeutics: Towards the match between fundamental science and engineered systems

(2013) M. Videira et al.   Nanomedicine-Nanotechnology Biology and Medicine

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

(2013) Jerome Gilleron et al.   NATURE BIOTECHNOLOGY

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

(2013) Gaurav Sahay et al.   NATURE BIOTECHNOLOGY

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

The interactions of amphiphilic antisense oligonucleotides with serum proteins and their effects on in vitro silencing activity

(2012) Arnaud E. Felber et al.   BIOMATERIALS

Effect of cycloheximide on epidermal growth factor receptor trafficking and signaling

(2012) Morten P. Oksvold et al.   FEBS LETTERS

Gαs promotes EEA1 endosome maturation and shuts down proliferative signaling through interaction with GIV (Girdin)

(2012) Anthony O. Beas et al.   MOLECULAR BIOLOGY OF THE CELL

Analysis of synaptic vesicle endocytosis in synaptosomes by high-content screening

(2012) James A Daniel et al.   Nature Protocols

Rabenosyn-5 defines the fate of the transferrin receptor following clathrin-mediated endocytosis

(2012) D. M. Navaroli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dye selection for live cell imaging of intact siRNA

(2011) Markus Hirsch et al.   BIOLOGICAL CHEMISTRY

MARCH ubiquitin ligases alter the itinerary of clathrin-independent cargo from recycling to degradation

(2011) Craig A. Eyster et al.   MOLECULAR BIOLOGY OF THE CELL

Efficient In Vivo Delivery of siRNA Into Brain Capillary Endothelial Cells Along With Endogenous Lipoprotein

(2011) Hiroya Kuwahara et al.   MOLECULAR THERAPY

Carrier-free cellular uptake and the gene-silencing activity of the lipophilic siRNAs is strongly affected by the length of the linker between siRNA and lipophilic group

(2011) Natalya S. Petrova et al.   NUCLEIC ACIDS RESEARCH

Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes

(2011) Erich Koller et al.   NUCLEIC ACIDS RESEARCH

Regarding the Amazing Choreography of Clathrin Coats

(2011) Linton M. Traub   PLOS BIOLOGY

Scavenger Receptors Mediate Cellular Uptake of Polyvalent Oligonucleotide-Functionalized Gold Nanoparticles

(2010) Pinal C. Patel et al.   BIOCONJUGATE CHEMISTRY

Endosomal escape pathways for delivery of biologicals

(2010) Amir K. Varkouhi et al.   JOURNAL OF CONTROLLED RELEASE

Systems survey of endocytosis by multiparametric image analysis

(2010) Claudio Collinet et al.   NATURE

Spatial control of EGF receptor activation by reversible dimerization on living cells

(2010) Inhee Chung et al.   NATURE

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Lipid-like materials for low-dose, in vivo gene silencing

(2010) K. T. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative evaluation of siRNA delivery in vivo

(2010) Y. Pei et al.   RNA

A Phosphoinositide Switch Controls the Maturation and Signaling Properties of APPL Endosomes

(2009) Roberto Zoncu et al.   CELL

Common and distinct roles for the binding partners Rabenosyn-5 and Vps45 in the regulation of endocytic trafficking in mammalian cells

(2009) Juliati Rahajeng et al.   EXPERIMENTAL CELL RESEARCH

Sequential signaling in plasma-membrane domains during macropinosome formation in macrophages

(2009) S. Yoshida et al.   JOURNAL OF CELL SCIENCE

Internalization and intracellular sorting of the EGF receptor: a model for understanding the mechanisms of receptor trafficking

(2009) I. H. Madshus et al.   JOURNAL OF CELL SCIENCE

A Novel Mechanism Is Involved in Cationic Lipid-Mediated Functional siRNA Delivery

(2009) James J. Lu et al.   MOLECULAR PHARMACEUTICS

Silencing by small RNAs is linked to endosomal trafficking

(2009) Young Sik Lee et al.   NATURE CELL BIOLOGY

Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity

(2009) Derrick J. Gibbings et al.   NATURE CELL BIOLOGY

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Chemically modified siRNA: tools and applications

(2008) J WATTS et al.   DRUG DISCOVERY TODAY

Endocytosis and intracellular trafficking of ErbBs

(2008) Alexander Sorkin et al.   EXPERIMENTAL CELL RESEARCH

Sorting of EGF and transferrin at the plasma membrane and by cargo-specific signaling to EEA1-enriched endosomes

(2008) D. Leonard et al.   JOURNAL OF CELL SCIENCE

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

ARAP1 Regulates Endocytosis of EGFR

(2008) Hye-Young Yoon et al.   TRAFFIC