Ammonium and arsenic trioxide are potent facilitators of oligonucleotide function when delivered by gymnosis

FDA-Approved Oligonucleotide Therapies in 2017

(2017) Cy A. Stein et al.   MOLECULAR THERAPY

Longitudinal effect of eteplirsen versus historical control on ambulation in Duchenne muscular dystrophy

(2016) Jerry R. Mendell et al.   ANNALS OF NEUROLOGY

Intrathecal Injections in Children With Spinal Muscular Atrophy

(2016) Manon Haché et al.   JOURNAL OF CHILD NEUROLOGY

Protein Kinase C-α is a Critical Protein for Antisense Oligonucleotide-mediated Silencing in Mammalian Cells

(2016) Daniela Castanotto et al.   MOLECULAR THERAPY

Cellular uptake and intracellular trafficking of oligonucleotides

(2015) R.L. Juliano et al.   ADVANCED DRUG DELIVERY REVIEWS

Ca2+enrichment in culture medium potentiates effect of oligonucleotides

(2015) Shin-ichiro Hori et al.   NUCLEIC ACIDS RESEARCH

High-throughput screening identifies small molecules that enhance the pharmacological effects of oligonucleotides

(2015) B. Yang et al.   NUCLEIC ACIDS RESEARCH

A cytoplasmic pathway for gapmer antisense oligonucleotide-mediated gene silencing in mammalian cells

(2015) Daniela Castanotto et al.   NUCLEIC ACIDS RESEARCH

Development of Therapeutic Splice-Switching Oligonucleotides

(2014) Petra Disterer et al.   HUMAN GENE THERAPY

Sequence motifs associated with hepatotoxicity of locked nucleic acid—modified antisense oligonucleotides

(2014) Andrew D. Burdick et al.   NUCLEIC ACIDS RESEARCH

The small molecule Retro-1 enhances the pharmacological actions of antisense and splice switching oligonucleotides

(2013) Xin Ming et al.   NUCLEIC ACIDS RESEARCH

Dantrolene Enhances Antisense-Mediated Exon Skipping in Human and Mouse Models of Duchenne Muscular Dystrophy

(2012) G. C. Kendall et al.   Science Translational Medicine

Antisense 2′-Deoxy, 2′-Fluoroarabino Nucleic Acid (2′F-ANA) Oligonucleotides: In Vitro Gymnotic Silencers of Gene Expression Whose Potency Is Enhanced by Fatty Acids

(2012) Naira Souleimanian et al.   Molecular Therapy-Nucleic Acids

From an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia

(2011) S.-J. Chen et al.   BLOOD

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes

(2011) Erich Koller et al.   NUCLEIC ACIDS RESEARCH

PML/RARA Oxidation and Arsenic Binding Initiate the Antileukemia Response of As2O3

(2010) Marion Jeanne et al.   CANCER CELL

Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates

(2010) Ellen Marie Straarup et al.   NUCLEIC ACIDS RESEARCH

Arsenic Trioxide Controls the Fate of the PML-RAR  Oncoprotein by Directly Binding PML

(2010) X. W. Zhang et al.   SCIENCE

Altered fatty acid metabolism and composition in cultured astrocytes under hyperammonemic conditions

(2009) Sven Gottschalk et al.   JOURNAL OF NEUROCHEMISTRY

RISC hitches onto endosome trafficking

(2009) Haruhiko Siomi et al.   NATURE CELL BIOLOGY

Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents

(2009) C. A. Stein et al.   NUCLEIC ACIDS RESEARCH

Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia

(2009) J. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides

(2008) R. Juliano et al.   NUCLEIC ACIDS RESEARCH