High-throughput screening identifies small molecules that enhance the pharmacological effects of oligonucleotides
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
High-throughput screening identifies small molecules that enhance the pharmacological effects of oligonucleotides
Authors
Keywords
-
Journal
NUCLEIC ACIDS RESEARCH
Volume 43, Issue 4, Pages 1987-1996
Publisher
Oxford University Press (OUP)
Online
2015-02-07
DOI
10.1093/nar/gkv060
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Advances in targeted delivery of small interfering RNA using simple bioconjugates
- (2014) Christoffer Nielsen et al. Expert Opinion on Drug Delivery
- Nanotoxicity: a key obstacle to clinical translation of siRNA-based nanomedicine
- (2014) Hui Yi Xue et al. Nanomedicine
- RNAi Therapies: Drugging the Undruggable
- (2014) S. Y. Wu et al. Science Translational Medicine
- Molecular Parameters of siRNA–Cell Penetrating Peptide Nanocomplexes for Efficient Cellular Delivery
- (2013) Alexander H. van Asbeck et al. ACS Nano
- Conjugation with Receptor-Targeted Histidine-Rich Peptides Enhances the Pharmacological Effectiveness of Antisense Oligonucleotides
- (2013) Osamu Nakagawa et al. BIOCONJUGATE CHEMISTRY
- Albumin-based nanoconjugates for targeted delivery of therapeutic oligonucleotides
- (2013) Xin Ming et al. BIOMATERIALS
- First-in-human Phase I study of EZN-4176, a locked nucleic acid antisense oligonucleotide to exon 4 of the androgen receptor mRNA in patients with castration-resistant prostate cancer
- (2013) D Bianchini et al. BRITISH JOURNAL OF CANCER
- Rab GTPase regulation of membrane identity
- (2013) Suzanne R Pfeffer CURRENT OPINION IN CELL BIOLOGY
- siRNA delivery: from basics to therapeutic applications
- (2013) Vladimir Torchilin Frontiers in Bioscience-Landmark
- Clinical Trials Using Antisense Oligonucleotides in Duchenne Muscular Dystrophy
- (2013) Taeyoung Koo et al. HUMAN GENE THERAPY
- A Nobel Prize for membrane traffic: Vesicles find their journey’s end
- (2013) Ira Mellman et al. JOURNAL OF CELL BIOLOGY
- Recent advances in delivery of drug–nucleic acid combinations for cancer treatment
- (2013) Jing Li et al. JOURNAL OF CONTROLLED RELEASE
- Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape
- (2013) Jerome Gilleron et al. NATURE BIOTECHNOLOGY
- Delivery materials for siRNA therapeutics
- (2013) Rosemary Kanasty et al. NATURE MATERIALS
- Regulatory watch: Antisense approval provides boost to the field
- (2013) Man Tsuey Tse NATURE REVIEWS DRUG DISCOVERY
- Safety and Efficacy of RNAi Therapy for Transthyretin Amyloidosis
- (2013) Teresa Coelho et al. NEW ENGLAND JOURNAL OF MEDICINE
- The small molecule Retro-1 enhances the pharmacological actions of antisense and splice switching oligonucleotides
- (2013) Xin Ming et al. NUCLEIC ACIDS RESEARCH
- Cellular trafficking determines the exon skipping activity of Pip6a-PMO in mdx skeletal and cardiac muscle cells
- (2013) T. Lehto et al. NUCLEIC ACIDS RESEARCH
- Lipid Sorting and Multivesicular Endosome Biogenesis
- (2013) C. Bissig et al. Cold Spring Harbor Perspectives in Biology
- Nucleic Acid Delivery: The Missing Pieces of the Puzzle?
- (2012) Juliane Nguyen et al. ACCOUNTS OF CHEMICAL RESEARCH
- Targeting receptor-mediated endocytotic pathways with nanoparticles: Rationale and advances
- (2012) Shi Xu et al. ADVANCED DRUG DELIVERY REVIEWS
- The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo
- (2012) Hiroshi Maeda et al. ADVANCED DRUG DELIVERY REVIEWS
- Fluorescent Peptide–PNA Chimeras for Imaging Monoamine Oxidase A mRNA in Neuronal Cells
- (2012) Dalip Sethi et al. BIOCONJUGATE CHEMISTRY
- Structure and nuclease resistance of 2′,4′-constrained 2′-O-methoxyethyl (cMOE) and 2′-O-ethyl (cEt) modified DNAs
- (2012) Pradeep S. Pallan et al. CHEMICAL COMMUNICATIONS
- RNA-Based Therapeutics: Current Progress and Future Prospects
- (2012) John C. Burnett et al. CHEMISTRY & BIOLOGY
- Biochemical regulation of the inflammasome
- (2012) Jennifer K. Dowling et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Development of a High-Throughput Assay for Identifying Inhibitors of TBK1 and IKKε
- (2012) Jessica E. Hutti et al. PLoS One
- Self-Assembling Peptide-Based Nanoparticles for siRNA Delivery in Primary Cell Lines
- (2012) Sébastien Deshayes et al. Small
- A practical guide to evaluating colocalization in biological microscopy
- (2011) Kenneth W. Dunn et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- High-Throughput Screening for RecA Inhibitors Using a Transcreener Adenosine 5′-O-Diphosphate Assay
- (2011) Eliza J.R. Peterson et al. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
- Multivalent Cyclic RGD Conjugates for Targeted Delivery of Small Interfering RNA
- (2011) Md. Rowshon Alam et al. BIOCONJUGATE CHEMISTRY
- Cellular Uptake and Intracellular Trafficking of Antisense and siRNA Oligonucleotides
- (2011) Rudolph L. Juliano et al. BIOCONJUGATE CHEMISTRY
- Locked vs. unlocked nucleic acids (LNA vs. UNA): contrasting structures work towards common therapeutic goals
- (2011) Meghan A. Campbell et al. CHEMICAL SOCIETY REVIEWS
- The ESCRT Pathway
- (2011) William M. Henne et al. DEVELOPMENTAL CELL
- Silencing disease genes in the laboratory and the clinic
- (2011) Jonathan K Watts et al. JOURNAL OF PATHOLOGY
- Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes
- (2011) Erich Koller et al. NUCLEIC ACIDS RESEARCH
- Retrograde Transport: Two (or More) Roads Diverged in an Endosomal Tree?
- (2011) Ludger Johannes et al. TRAFFIC
- At the Crossroads of Chemistry and Cell Biology: Inhibiting Membrane Traffic by Small Molecules
- (2011) Lisa Kleist et al. TRAFFIC
- RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform
- (2010) C. Frank Bennett et al. Annual Review of Pharmacology and Toxicology
- Inhibition of Retrograde Transport Protects Mice from Lethal Ricin Challenge
- (2010) Bahne Stechmann et al. CELL
- Cationic nanosystems for the delivery of small interfering ribonucleic acid therapeutics: a focus on toxicogenomics
- (2010) Saghir Akhtar Expert Opinion on Drug Metabolism & Toxicology
- Endosomal escape pathways for delivery of biologicals
- (2010) Amir K. Varkouhi et al. JOURNAL OF CONTROLLED RELEASE
- Identification of Non-Peptide Malignant Brain Tumor (MBT) Repeat Antagonists by Virtual Screening of Commercially Available Compounds
- (2010) Dmitri Kireev et al. JOURNAL OF MEDICINAL CHEMISTRY
- Targeted Intracellular Delivery of Antisense Oligonucleotides via Conjugation with Small-Molecule Ligands
- (2010) Osamu Nakagawa et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms
- (2010) Akin Akinc et al. MOLECULAR THERAPY
- Targeted delivery of RNAi therapeutics for cancer therapy
- (2010) Jun Li et al. Nanomedicine
- Smart siRNA delivery systems based on polymeric nanoassemblies and nanoparticles
- (2010) Atsushi Tamura et al. Nanomedicine
- Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
- (2010) Mark E. Davis et al. NATURE
- Anti-tumor activity of splice-switching oligonucleotides
- (2010) John A. Bauman et al. NUCLEIC ACIDS RESEARCH
- Intracellular delivery of an antisense oligonucleotide via endocytosis of a G protein-coupled receptor
- (2010) Xin Ming et al. NUCLEIC ACIDS RESEARCH
- Mechanisms of Endocytosis
- (2009) Gary J. Doherty et al. Annual Review of Biochemistry
- Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers
- (2009) Patrick Midoux et al. BRITISH JOURNAL OF PHARMACOLOGY
- Biological Barriers to Therapy with Antisense and siRNA Oligonucleotides
- (2009) R. Juliano et al. MOLECULAR PHARMACEUTICS
- In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses
- (2009) Marcin Kortylewski et al. NATURE BIOTECHNOLOGY
- Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors
- (2009) Justin P Dassie et al. NATURE BIOTECHNOLOGY
- Knocking down barriers: advances in siRNA delivery
- (2009) Kathryn A. Whitehead et al. NATURE REVIEWS DRUG DISCOVERY
- The Biological Effect of an Antisense Oligonucleotide Depends on Its Route of Endocytosis and Trafficking
- (2009) Md. Rowshon Alam et al. OLIGONUCLEOTIDES
- Transport of Dicationic Drugs Pentamidine and Furamidine by Human Organic Cation Transporters
- (2008) X. Ming et al. DRUG METABOLISM AND DISPOSITION
- Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis
- (2008) Md Rowshon Alam et al. NUCLEIC ACIDS RESEARCH
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More