An Alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates

Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle

(2020) Hongzhou Lu et al.   JOURNAL OF MEDICAL VIROLOGY

A novel coronavirus outbreak of global health concern

(2020) Chen Wang et al.   LANCET

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

(2020) Michael Letko et al.   Nature Microbiology

The outbreak of SARS-CoV-2 pneumonia calls for viral vaccines

(2020) Weilong Shang et al.   npj Vaccines

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

(2020) Alba Grifoni et al.   CELL

The COVID-19 vaccine development landscape

(2020) Tung Thanh Le et al.   NATURE REVIEWS DRUG DISCOVERY

Development of an inactivated vaccine candidate for SARS-CoV-2

(2020) Qiang Gao et al.   SCIENCE

DNA vaccine protection against SARS-CoV-2 in rhesus macaques

(2020) Jingyou Yu et al.   SCIENCE

Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion

(2019) Alexandra C. Walls et al.   CELL

Evaluating size-dependent relaxivity of PEGylated-USPIOs to develop gadolinium-free T1 contrast agents for vascular imaging

(2018) Amit P. Khandhar et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Iron Oxide Nanoparticles-Based Vaccine Delivery for Cancer Treatment

(2018) Yi Zhao et al.   MOLECULAR PHARMACEUTICS

Self-Amplifying RNA Vaccines Give Equivalent Protection against Influenza to mRNA Vaccines but at Much Lower Doses

(2018) Annette B. Vogel et al.   MOLECULAR THERAPY

Therapeutic conserved elements (CE) DNA vaccine induces strong T-cell responses against highly conserved viral sequences during simian-human immunodeficiency virus infection

(2018) Paul Munson et al.   Human Vaccines & Immunotherapeutics

A Nanostructured Lipid Carrier for Delivery of a Replicating Viral RNA Provides Single, Low-Dose Protection against Zika

(2018) Jesse H. Erasmus et al.   MOLECULAR THERAPY

Mucosal T Helper 17 and T Regulatory Cell Homeostasis Correlate with Acute Simian Immunodeficiency Virus Viremia and Responsiveness to Antiretroviral Therapy in Macaques

(2018) Megan A. O'Connor et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Heterologous Immunization With Defined RNA and Subunit Vaccines Enhances T Cell Responses That Protect Against Leishmania donovani

(2018) Malcolm S. Duthie et al.   Frontiers in Immunology

Evaluation of PEG-coated iron oxide nanoparticles as blood pool tracers for preclinical magnetic particle imaging

(2017) A. P. Khandhar et al.   Nanoscale

High-performance iron oxide nanoparticles for magnetic particle imaging – guided hyperthermia (hMPI)

(2016) Lisa M. Bauer et al.   Nanoscale

Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues

(2016) Saeid Zanganeh et al.   Nature Nanotechnology

SARS-like WIV1-CoV poised for human emergence

(2016) Vineet D. Menachery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Memory T cell responses targeting the SARS coronavirus persist up to 11 years post-infection

(2016) Oi-Wing Ng et al.   VACCINE

Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus

(2015) Davide Corti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phase I study of alphaviral vector (AVX701) in colorectal cancer patients: comparison of immune responses in stage III and stage IV patients

(2015) Michael A Morse et al.   Journal for ImmunoTherapy of Cancer

Squalene emulsion potentiates the adjuvant activity of the TLR4 agonist, GLA, via inflammatory caspases, IL-18, and IFN-γ

(2014) Anthony L. Desbien et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Self-replicating alphavirus RNA vaccines

(2014) Karl Ljungberg et al.   Expert Review of Vaccines

T cell-mediated immune response to respiratory coronaviruses

(2014) Rudragouda Channappanavar et al.   IMMUNOLOGIC RESEARCH

Severe Acute Respiratory Syndrome-Associated Coronavirus Vaccines Formulated with Delta Inulin Adjuvants Provide Enhanced Protection while Ameliorating Lung Eosinophilic Immunopathology

(2014) Yoshikazu Honda-Okubo et al.   JOURNAL OF VIROLOGY

Virus-Specific Memory CD8 T Cells Provide Substantial Protection from Lethal Severe Acute Respiratory Syndrome Coronavirus Infection

(2014) R. Channappanavar et al.   JOURNAL OF VIROLOGY

Targeting antigens to CD180 rapidly induces antigen-specific IgG, affinity maturation, and immunological memory

(2013) Jay W. Chaplin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The adjuvant effect of MF59 is due to the oil-in-water emulsion formulation, none of the individual components induce a comparable adjuvant effect

(2013) Samuele Calabro et al.   VACCINE

Sensing of RNA Viruses: a Review of Innate Immune Receptors Involved in Recognizing RNA Virus Invasion

(2012) S. Jensen et al.   JOURNAL OF VIROLOGY

Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

(2012) Chien-Te Tseng et al.   PLoS One

Lack of Peripheral Memory B Cell Responses in Recovered Patients with Severe Acute Respiratory Syndrome: A Six-Year Follow-Up Study

(2011) F. Tang et al.   JOURNAL OF IMMUNOLOGY

T Cell Responses Are Required for Protection from Clinical Disease and for Virus Clearance in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice

(2010) J. Zhao et al.   JOURNAL OF VIROLOGY

The spike protein of SARS-CoV — a target for vaccine and therapeutic development

(2009) Lanying Du et al.   NATURE REVIEWS MICROBIOLOGY

Randomized, double-blind, Phase 1 trial of an alphavirus replicon vaccine for cytomegalovirus in CMV seronegative adult volunteers

(2009) David I. Bernstein et al.   VACCINE

Structural Basis for Potent Cross-Neutralizing Human Monoclonal Antibody Protection against Lethal Human and Zoonotic Severe Acute Respiratory Syndrome Coronavirus Challenge

(2008) B. Rockx et al.   JOURNAL OF VIROLOGY