Nanobody-based cancer therapy of solid tumors

Site-Specific Labeling of Cysteine-Tagged Camelid Single-Domain Antibody-Fragments for Use in Molecular Imaging

(2014) Sam Massa et al.   BIOCONJUGATE CHEMISTRY

In vivonear-infrared fluorescence targeting of T cells: comparison of nanobodies and conventional monoclonal antibodies

(2014) Peter Bannas et al.   Contrast Media & Molecular Imaging

Intein Applications: From Protein Purification and Labeling to Metabolic Control Methods

(2014) David W. Wood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nanobody–photosensitizer conjugates for targeted photodynamic therapy

(2014) Raimond Heukers et al.   Nanomedicine-Nanotechnology Biology and Medicine

A general protocol for the generation of Nanobodies for structural biology

(2014) Els Pardon et al.   Nature Protocols

Targeted Radionuclide Therapy with A 177Lu-labeled Anti-HER2 Nanobody

(2014) Matthias D'Huyvetter et al.   Theranostics

Nanobodies: Natural Single-Domain Antibodies

(2013) Serge Muyldermans   Annual Review of Biochemistry

Targeting hepatocyte growth factor receptor (Met) positive tumor cells using internalizing nanobody-decorated albumin nanoparticles

(2013) Raimond Heukers et al.   BIOMATERIALS

A novel VHH nanobody against the active site (the CA domain) of tumor-associated, carbonic anhydrase isoform IX and its usefulness for cancer diagnosis

(2013) Fatemeh Araste et al.   BIOTECHNOLOGY LETTERS

Anti-c-MET Nanobody®- a new potential drug in multiple myeloma treatment

(2013) Tobias Schmidt Slørdahl et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Rapid optical imaging of human breast tumour xenografts using anti-HER2 VHHs site-directly conjugated to IRDye 800CW for image-guided surgery

(2013) Marta Kijanka et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Nanobodies as novel agents for disease diagnosis and therapy

(2013) Christina G. Siontorou   International Journal of Nanomedicine

Neutralizing Nanobodies Targeting Diverse Chemokines Effectively Inhibit Chemokine Function

(2013) Christophe Blanchetot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Llama-derived Single Variable Domains (Nanobodies) Directed against Chemokine Receptor CXCR7 Reduce Head and Neck Cancer Cell Growthin Vivo

(2013) David Maussang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endocytosis of EGFR requires its kinase activity and N-terminal transmembrane dimerization motif

(2013) R. Heukers et al.   JOURNAL OF CELL SCIENCE

Targeting tumors with nanobodies for cancer imaging and therapy

(2013) Sabrina Oliveira et al.   JOURNAL OF CONTROLLED RELEASE

Efficient growth inhibition of EGFR over-expressing tumor cells by an anti-EGFR nanobody

(2013) Kobra Omidfar et al.   MOLECULAR BIOLOGY REPORTS

Inhibition of Tumor Growth by Targeted Anti-EGFR/IGF-1R Nanobullets Depends on Efficient Blocking of Cell Survival Pathways

(2013) Roy van der Meel et al.   MOLECULAR PHARMACEUTICS

Fluorescent Affibody Peptide Penetration in Glioma Margin Is Superior to Full Antibody

(2013) Kristian Sexton et al.   PLoS One

Delivery of Cancer Therapeutics Using Nanotechnology

(2013) Eun-Kyung Lim et al.   Pharmaceutics

Intrinsically active nanobody-modified polymeric micelles for tumor-targeted combination therapy

(2012) Marina Talelli et al.   BIOMATERIALS

Cell-penetrating anti-GFAP VHH and corresponding fluorescent fusion protein VHH-GFP spontaneously cross the blood-brain barrier and specifically recognize astrocytes: application to brain imaging

(2012) Tengfei Li et al.   FASEB JOURNAL

Nanobody-albumin nanoparticles (NANAPs) for the delivery of a multikinase inhibitor 17864 to EGFR overexpressing tumor cells

(2012) Isil Altintas et al.   JOURNAL OF CONTROLLED RELEASE

Nanobodies Targeting the Hepatocyte Growth Factor: Potential New Drugs for Molecular Cancer Therapy

(2012) M. J. W. D. Vosjan et al.   MOLECULAR CANCER THERAPEUTICS

Odyssey of a cancer nanoparticle: From injection site to site of action

(2012) Joseph W. Nichols et al.   Nano Today

Development of VEGFR2-specific Nanobody Pseudomonas exotoxin A conjugated to provide efficient inhibition of tumor cell growth

(2012) Mahdi Behdani et al.   New Biotechnology

Therapeutic stem cells expressing variants of EGFR-specific nanobodies have antitumor effects

(2012) J. A. J. M. van de Water et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific Cell Targeting with Nanobody Conjugated Branched Gold Nanoparticles for Photothermal Therapy

(2011) Bieke Van de Broek et al.   ACS Nano

Delivery of nanomedicines to extracellular and intracellular compartments of a solid tumor

(2011) Yinghuan Li et al.   ADVANCED DRUG DELIVERY REVIEWS

Preclinical screening of anti-HER2 nanobodies for molecular imaging of breast cancer

(2011) Ilse Vaneycken et al.   FASEB JOURNAL

A biparatopic anti-EGFR nanobody efficiently inhibits solid tumour growth

(2011) Rob C. Roovers et al.   INTERNATIONAL JOURNAL OF CANCER

Nanobody — Shell functionalized thermosensitive core-crosslinked polymeric micelles for active drug targeting

(2011) Marina Talelli et al.   JOURNAL OF CONTROLLED RELEASE

Combined MUC1-specific nanobody-tagged PEG-polyethylenimine polyplex targeting and transcriptional targeting of tBid transgene for directed killing of MUC1 over-expressing tumour cells

(2011) Elham Sadeqzadeh et al.   JOURNAL OF CONTROLLED RELEASE

Tumor-targeted Nanobullets: Anti-EGFR nanobody-liposomes loaded with anti-IGF-1R kinase inhibitor for cancer treatment

(2011) Roy van der Meel et al.   JOURNAL OF CONTROLLED RELEASE

Generation and characterization of a functional Nanobody against the vascular endothelial growth factor receptor-2; angiogenesis cell receptor

(2011) Mahdi Behdani et al.   MOLECULAR IMMUNOLOGY

Oriented conjugates of single-domain antibodies and quantum dots: toward a new generation of ultrasmall diagnostic nanoprobes

(2011) Alyona Sukhanova et al.   Nanomedicine-Nanotechnology Biology and Medicine

Engineered Single-Domain Antibodies with High Protease Resistance and Thermal Stability

(2011) Greg Hussack et al.   PLoS One

Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin

(2010) Marina Talelli et al.   BIOMATERIALS

Localization, mechanism and reduction of renal retention of technetium-99m labeled epidermal growth factor receptor-specific nanobody in mice

(2010) Lea Olive Tchouate Gainkam et al.   Contrast Media & Molecular Imaging

Renal uptake of different radiolabelled peptides is mediated by megalin: SPECT and biodistribution studies in megalin-deficient mice

(2010) Erik Vegt et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Generation of a Family-specific Phage Library of Llama Single Chain Antibody Fragments That Neutralize HIV-1

(2010) Willie W. L. Koh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Downregulation of EGFR by a novel multivalent nanobody-liposome platform

(2010) Sabrina Oliveira et al.   JOURNAL OF CONTROLLED RELEASE

In Vitro Analysis and In Vivo Tumor Targeting of a Humanized, Grafted Nanobody in Mice Using Pinhole SPECT/Micro-CT

(2010) I. Vaneycken et al.   JOURNAL OF NUCLEAR MEDICINE

Delivering nanomedicine to solid tumors

(2010) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling

(2010) J. B. Spangler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sortase-mediated protein ligation: an emerging biotechnology tool for protein modification and immobilisation

(2009) Thomas Proft   BIOTECHNOLOGY LETTERS

Affinity and Avidity in Antibody-Based Tumor Targeting

(2009) Stephen I. Rudnick et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Differential tumor-targeting abilities of three single-domain antibody formats

(2009) Andrea Bell et al.   CANCER LETTERS

Potent antibody drug conjugates for cancer therapy

(2009) Peter D Senter   CURRENT OPINION IN CHEMICAL BIOLOGY

 -arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7

(2009) S. Rajagopal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Visualization of Heterogeneous Extravascular Distribution of Trastuzumab in Human Epidermal Growth Factor Receptor Type 2 Overexpressing Xenografts

(2008) J. H.E. Baker et al.   CLINICAL CANCER RESEARCH

General Strategy to Humanize a Camelid Single-domain Antibody and Identification of a Universal Humanized Nanobody Scaffold

(2008) Cécile Vincke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EGF induces coalescence of different lipid rafts

(2008) E. G. Hofman et al.   JOURNAL OF CELL SCIENCE

Monoclonal Antibodies in Cancer Therapy: 25 Years of Progress

(2008) Robert K. Oldham et al.   JOURNAL OF CLINICAL ONCOLOGY

Comparison of the Biodistribution and Tumor Targeting of Two 99mTc-Labeled Anti-EGFR Nanobodies in Mice, Using Pinhole SPECT/Micro-CT

(2008) L. O. T. Gainkam et al.   JOURNAL OF NUCLEAR MEDICINE

Improved tumor targeting of anti-epidermal growth factor receptor Nanobodies through albumin binding: taking advantage of modular Nanobody technology

(2008) B. M. Tijink et al.   MOLECULAR CANCER THERAPEUTICS

SPECT Imaging with 99mTc-Labeled EGFR-Specific Nanobody for In Vivo Monitoring of EGFR Expression

(2008) Lieven Huang et al.   MOLECULAR IMAGING AND BIOLOGY

Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats

(2008) Michelle Longmire et al.   Nanomedicine

Camelid immunoglobulins and nanobody technology

(2008) S. Muyldermans et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Single-domain antibody fragments with high conformational stability

(2002) Mireille Dumoulin et al.   PROTEIN SCIENCE