Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs

High-throughput screening identifies small molecules that enhance the pharmacological effects of oligonucleotides

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Structure–Activity Relationship Study around Guanabenz Identifies Two Derivatives Retaining Antiprion Activity but Having Lost α2-Adrenergic Receptor Agonistic Activity

(2014) Phu hai Nguyen et al.   ACS Chemical Neuroscience

A Bifurcated Proteoglycan Binding Small Molecule Carrier for siRNA Delivery

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Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

(2014) Jayaprakash K. Nair et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight

(2014) James E. Dahlman et al.   Nature Nanotechnology

Guanabenz, which enhances the unfolded protein response, ameliorates mutant SOD1-induced amyotrophic lateral sclerosis

(2014) Lijun Wang et al.   NEUROBIOLOGY OF DISEASE

Guanabenz delays the onset of disease symptoms, extends lifespan, improves motor performance and attenuates motor neuron loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis

(2014) H.-Q. Jiang et al.   NEUROSCIENCE

Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

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The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing

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Novel Hydrophobically Modified Asymmetric RNAi Compounds (sd-rxRNA) Demonstrate Robust Efficacy in the Eye

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Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

(2013) Jerome Gilleron et al.   NATURE BIOTECHNOLOGY

The small molecule Retro-1 enhances the pharmacological actions of antisense and splice switching oligonucleotides

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Dendrimers as Carriers for siRNA Delivery and Gene Silencing: A Review

(2013) Jiangyu Wu et al.   TheScientificWorldJOURNAL

siRNA Delivery: From Lipids to Cell-penetrating Peptides and Their Mimics

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Sustained translational repression by eIF2α-P mediates prion neurodegeneration

(2012) Julie A. Moreno et al.   NATURE

Exploring the Interaction Between siRNA and the SMoC Biomolecule Transporters: Implications for Small Molecule-Mediated Delivery of siRNA

(2011) Matt Gooding et al.   Chemical Biology & Drug Design

Current prospects for RNA interference-based therapies

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Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis

(2011) P. Tsaytler et al.   SCIENCE

Combinatorial Approach to Determine Functional Group Effects on Lipidoid-Mediated siRNA Delivery

(2010) Kerry P. Mahon et al.   BIOCONJUGATE CHEMISTRY

RNA interference in vitro and in vivo using an arginine peptide/siRNA complex system

(2010) Sung Wook Kim et al.   JOURNAL OF CONTROLLED RELEASE

Endosomal escape pathways for delivery of biologicals

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The promises and pitfalls of RNA-interference-based therapeutics

(2009) Daniela Castanotto et al.   NATURE

A New Potent Secondary Amphipathic Cell–penetrating Peptide for siRNA Delivery Into Mammalian Cells

(2008) Laurence Crombez et al.   MOLECULAR THERAPY

Antihypertensive Drug Guanabenz Is Active In Vivo against both Yeast and Mammalian Prions

(2008) Déborah Tribouillard-Tanvier et al.   PLoS One