Vaccinia Virus Protein B18R: Influence on mRNA Immunogenicity and Translation upon Non-Viral Delivery in Different Ocular Cell Types

Inhibition of the Inflammatory Pathway Enhances Both the in Vitro and in Vivo Transfection Activity of Exogenous in Vitro-Transcribed mRNAs Delivered by Lipid Nanoparticles

(2019) Takara Ohto et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Efficient reduction of synthetic mRNA induced immune activation by simultaneous delivery of B18R encoding mRNA

(2019) Tatjana Michel et al.   Journal of Biological Engineering

Lipid nanoparticles for delivery of messenger RNA to the back of the eye

(2019) Siddharth Patel et al.   JOURNAL OF CONTROLLED RELEASE

Non-viral delivery of chemically modified mRNA to the retina: Subretinal versus intravitreal administration

(2019) Joke Devoldere et al.   JOURNAL OF CONTROLLED RELEASE

Gene Therapy in Retinal Dystrophies

(2019) Ziccardi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tailoring mRNA Vaccine to Balance Innate/Adaptive Immune Response

(2019) Sergio Linares-Fernández et al.   TRENDS IN MOLECULAR MEDICINE

Messenger RNA translation enhancement by immune evasion proteins: a comparative study between EKB (vaccinia virus) and NS1 (influenza A virus)

(2019) Yi Liu et al.   Scientific Reports

Seeing the Light after 25 Years of Retinal Gene Therapy

(2018) Ivana Trapani et al.   TRENDS IN MOLECULAR MEDICINE

Gene therapy in inherited retinal degenerative diseases, a review

(2018) Vitor K. L. Takahashi et al.   OPHTHALMIC GENETICS

mRNA therapeutics deliver a hopeful message

(2018) Zifu Zhong et al.   Nano Today

Improvement of In Vivo Expression of Genes Delivered by Self-Amplifying RNA Using Vaccinia Virus Immune Evasion Proteins

(2017) Tim Beissert et al.   HUMAN GENE THERAPY

Taking Stock of Retinal Gene Therapy: Looking Back and Moving Forward

(2017) Jean Bennett   MOLECULAR THERAPY

The Role of Interferons in Inflammation and Inflammasome Activation

(2017) Nataša Kopitar-Jerala   Frontiers in Immunology

Vectors and Gene Delivery to the Retina

(2017) Arthur Planul et al.   Annual Review of Vision Science

Recombinant Vaccinia virus-coded interferon inhibitor B18R: Expression, refolding and a use in a mammalian expression system with a RNA-vector

(2017) Yuriy G. Kim et al.   PLoS One

Evading innate immunity in nonviral mRNA delivery: don’t shoot the messenger

(2016) Joke Devoldere et al.   DRUG DISCOVERY TODAY

IL-1β Induces IL-6 production in retinal Müller cells predominantly through the activation of P38 MAPK/NF-κB signaling pathway

(2015) Xiufen Liu et al.   EXPERIMENTAL CELL RESEARCH

Müller glia as an important source of cytokines and inflammatory factors present in the gliotic retina during proliferative vitreoretinopathy

(2015) K. Eastlake et al.   GLIA

Efficient Reprogramming of Human Fibroblasts and Blood-Derived Endothelial Progenitor Cells Using Nonmodified RNA for Reprogramming and Immune Evasion

(2015) Marco Alexander Poleganov et al.   HUMAN GENE THERAPY

A detailed three-step protocol for live imaging of intracellular traffic in polarized primary porcine RPE monolayers

(2014) Kimberly A. Toops et al.   EXPERIMENTAL EYE RESEARCH

The Herpes Simplex Virus 1 Virion Host Shutoff Protein Enhances Translation of Viral Late mRNAs by Preventing mRNA Overload

(2014) B. Dauber et al.   JOURNAL OF VIROLOGY

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

Non-viral vectors for gene-based therapy

(2014) Hao Yin et al.   NATURE REVIEWS GENETICS

Fixing problems with cell lines

(2014) Jon R. Lorsch et al.   SCIENCE

Efficient Generation of Human iPSCs by a Synthetic Self-Replicative RNA

(2013) Naohisa Yoshioka et al.   Cell Stem Cell

Muller Glia in Retinal Innate Immunity: A Perspective on Their Roles in Endophthalmitis

(2013) Ashok Kumar et al.   CRITICAL REVIEWS IN IMMUNOLOGY

Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction

(2013) Lior Zangi et al.   NATURE BIOTECHNOLOGY

Reprogramming human fibroblasts to pluripotency using modified mRNA

(2013) Pankaj K Mandal et al.   Nature Protocols

BAY11 enhances OCT4 synthetic mRNA expression in adult human skin cells

(2013) Jason P Awe et al.   Stem Cell Research & Therapy

The cytotoxic and immunogenic hurdles associated with non-viral mRNA-mediated reprogramming of human fibroblasts

(2012) Katharina Drews et al.   BIOMATERIALS

Mechanism of inhibition of lipopolysaccharide-induced interferon-β production by 2-aminopurine

(2012) Tsuyoshi Sugiyama et al.   MOLECULAR IMMUNOLOGY

Feeder-Free Derivation of Human Induced Pluripotent Stem Cells with Messenger RNA

(2012) Luigi Warren et al.   Scientific Reports

TLR2 Mediates the Innate Response of Retinal Muller Glia to Staphylococcus aureus

(2011) N. Shamsuddin et al.   JOURNAL OF IMMUNOLOGY

Mechanism of Endosomal TLR Inhibition by Antimalarial Drugs and Imidazoquinolines

(2011) A. Kuznik et al.   JOURNAL OF IMMUNOLOGY

Neutrophils and interferon-α-producing cells: who produces interferon in lupus?

(2011) Patrice Decker   ARTHRITIS RESEARCH & THERAPY

Type I interferons: diversity of sources, production pathways and effects on immune responses

(2011) Melissa Swiecki et al.   Current Opinion in Virology

Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA

(2010) Luigi Warren et al.   Cell Stem Cell