Systematic evaluation of antibody-mediated siRNA delivery using an industrial platform of THIOMAB–siRNA conjugates

An Antimesothelin-Monomethyl Auristatin E Conjugate with Potent Antitumor Activity in Ovarian, Pancreatic, and Mesothelioma Models

(2014) S. J. Scales et al.   MOLECULAR CANCER THERAPEUTICS

Site-Specific Antibody–Polymer Conjugates for siRNA Delivery

(2013) Hua Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

First-in-Humans Trial of an RNA Interference Therapeutic Targeting VEGF and KSP in Cancer Patients with Liver Involvement

(2013) Josep Tabernero et al.   Cancer Discovery

Real-time quantification of antibody–short interfering RNA conjugate in serum by antigen capture reverse transcription–polymerase chain reaction

(2012) Martha Tan et al.   ANALYTICAL BIOCHEMISTRY

Antibody-Drug Conjugates in Cancer Therapy

(2012) Eric L. Sievers et al.   Annual Review of Medicine

Antibody-Conjugated Nanoparticles for Therapeutic Applications

(2012) M. M. Cardoso et al.   CURRENT MEDICINAL CHEMISTRY

Anti-Her2 single-chain antibody mediated DNMTs-siRNA delivery for targeted breast cancer therapy

(2012) Shuang Dou et al.   JOURNAL OF CONTROLLED RELEASE

Delivery of chemo-sensitizing siRNAs to HER2+-breast cancer cells using RNA aptamers

(2012) Kristina W. Thiel et al.   NUCLEIC ACIDS RESEARCH

Targeted Delivery of PLK1-siRNA by ScFv Suppresses Her2+ Breast Cancer Growth and Metastasis

(2012) Y.-d. Yao et al.   Science Translational Medicine

An Antibody-Drug Conjugate Targeting the Endothelin B Receptor for the Treatment of Melanoma

(2011) J. Asundi et al.   CLINICAL CANCER RESEARCH

Cargo sorting to lysosome-related organelles regulates siRNA-mediated gene silencing

(2011) Dinari A. Harris et al.   JOURNAL OF CELL BIOLOGY

Current prospects for RNA interference-based therapies

(2011) Beverly L. Davidson et al.   NATURE REVIEWS GENETICS

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Silencing by small RNAs is linked to endosomal trafficking

(2009) Young Sik Lee et al.   NATURE CELL BIOLOGY

Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity

(2009) Derrick J. Gibbings et al.   NATURE CELL BIOLOGY

Targeting HER2-Positive Breast Cancer with Trastuzumab-DM1, an Antibody-Cytotoxic Drug Conjugate

(2008) G. D. Lewis Phillips et al.   CANCER RESEARCH

T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice

(2008) Priti Kumar et al.   CELL

Rapid identification of reactive cysteine residues for site-specific labeling of antibody-Fabs

(2008) Jagath R. Junutula et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Localization of Double-stranded Small Interfering RNA to Cytoplasmic Processing Bodies Is Ago2 Dependent and Results in Up-Regulation of GW182 and Argonaute-2

(2008) Aarti Jagannath et al.   MOLECULAR BIOLOGY OF THE CELL

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

(2008) Jagath R Junutula et al.   NATURE BIOTECHNOLOGY