Towards the sustainable discovery and development of new antibiotics
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Title
Towards the sustainable discovery and development of new antibiotics
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Journal
Nature Reviews Chemistry
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-08-19
DOI
10.1038/s41570-021-00313-1
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Note: Only part of the references are listed.- Mastering the Gram-Negative Bacterial Barrier – Chemical Approaches to Increase Bacterial Bioavailability of Antibiotics
- (2021) Henni-Karoliina Ropponen et al. ADVANCED DRUG DELIVERY REVIEWS
- Developing synergistic drug combinations to restore antibiotic sensitivity in drug-resistant Mycobacterium tuberculosis
- (2021) Charles Omollo et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties
- (2021) Guoli Xiong et al. NUCLEIC ACIDS RESEARCH
- Highly parallelized droplet cultivation and prioritization of antibiotic producers from natural microbial communities
- (2021) Lisa Mahler et al. eLife
- A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms
- (2021) Christian Schütz et al. Advanced Science
- Mechanism-of-Action Classification of Antibiotics by Global Transcriptome Profiling
- (2020) Aubrie O’Rourke et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Drug-target interaction prediction with tree-ensemble learning and output space reconstruction
- (2020) Konstantinos Pliakos et al. BMC BIOINFORMATICS
- A Deep Learning Approach to Antibiotic Discovery
- (2020) Jonathan M. Stokes et al. CELL
- Bioinformatics Approaches to the Understanding of Molecular Mechanisms in Antimicrobial Resistance
- (2020) Pieter-Jan Van Camp et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Engineering of Streptomyces lividans for heterologous expression of secondary metabolite gene clusters
- (2020) Yousra Ahmed et al. Microbial Cell Factories
- Plant Endophytes and Epiphytes: Burgeoning Sources of Known and “Unknown” Cytotoxic and Antibiotic Agents?
- (2020) David J. Newman et al. PLANTA MEDICA
- Vancomycin Resistance Is Overcome by Conjugation of Polycationic Peptides
- (2020) Florian Umstätter et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- The effect of antibiotics on the gut microbiome: a metagenomics analysis of microbial shift and gut antibiotic resistance in antibiotic treated mice
- (2020) Lei Xu et al. BMC GENOMICS
- The Science of Antibiotic Discovery
- (2020) Kim Lewis CELL
- COVID-19: don't neglect antimicrobial stewardship principles!
- (2020) B.D. Huttner et al. CLINICAL MICROBIOLOGY AND INFECTION
- High quality genome sequences of thirteen Hypoxylaceae (Ascomycota) strengthen the phylogenetic family backbone and enable the discovery of new taxa
- (2020) Daniel Wibberg et al. FUNGAL DIVERSITY
- Bacterial and fungal infections in COVID-19 patients: A matter of concern
- (2020) Pengcheng Zhou et al. INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
- Teicoplanin: an alternative drug for the treatment of COVID-19?
- (2020) Sophie Alexandra Baron et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019
- (2020) David J. Newman et al. JOURNAL OF NATURAL PRODUCTS
- Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
- (2020) Fei Zhou et al. LANCET
- ARTS 2.0: feature updates and expansion of the Antibiotic Resistant Target Seeker for comparative genome mining
- (2020) Mehmet Direnç Mungan et al. NUCLEIC ACIDS RESEARCH
- Therapeutic Potential for Tetracyclines in the Treatment of COVID‐19
- (2020) Mohit Sodhi et al. PHARMACOTHERAPY
- Ca2+-Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids
- (2020) Fabian Grein et al. Nature Communications
- Review on natural products databases: where to find data in 2020
- (2020) Maria Sorokina et al. Journal of Cheminformatics
- Inducible Antibacterial Activity in the Bacillales by Triphenyl Tetrazolium Chloride
- (2020) Laura Sierra-Zapata et al. Scientific Reports
- How covid-19 is accelerating the threat of antimicrobial resistance
- (2020) Jeremy Hsu BMJ-British Medical Journal
- Innovation in AMR – the CARB-X Perspective
- (2020) Richard Alm et al. ACS Infectious Diseases
- The Global Antibiotic Research and Development Partnership (GARDP) Not-for-Profit Model of Antibiotic Development
- (2020) Manica Balasegaram et al. ACS Infectious Diseases
- Urban informal settlements as hotspots of antimicrobial resistance and the need to curb environmental transmission
- (2020) Maya L. Nadimpalli et al. Nature Microbiology
- Metabolic Fingerprinting with Fourier-Transform Infrared (FTIR) Spectroscopy: Towards a High-Throughput Screening Assay for Antibiotic Discovery and Mechanism-of-Action Elucidation
- (2020) Bernardo Ribeiro da Cunha et al. Metabolites
- The microbial coinfection in COVID-19
- (2020) Xi Chen et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Tackling antimicrobial resistance in the COVID-19 pandemic
- (2020) Haileyesus Getahun et al. BULLETIN OF THE WORLD HEALTH ORGANIZATION
- COVID-19 and Antimicrobial Resistance: Parallel and Interacting Health Emergencies
- (2020) Robby Nieuwlaat et al. CLINICAL INFECTIOUS DISEASES
- Bacterial co-infection and secondary infection in patients with COVID-19: a living rapid review and meta-analysis
- (2020) Bradley J. Langford et al. CLINICAL MICROBIOLOGY AND INFECTION
- Inhaled Liposomal Antimicrobial Delivery in Lung Infections
- (2020) Matteo Bassetti et al. DRUGS
- A look at the clinical, economic, and societal impact of antimicrobial resistance in 2020
- (2020) Matteo Bassetti et al. EXPERT OPINION ON PHARMACOTHERAPY
- Host Epigenetics in Intracellular Pathogen Infections
- (2020) Marek Fol et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Needs assessment for novel Gram-negative antibiotics in US hospitals: a retrospective cohort study
- (2020) Jeffrey R Strich et al. LANCET INFECTIOUS DISEASES
- Antimicrobial use, drug-resistant infections and COVID-19
- (2020) Timothy M. Rawson et al. NATURE REVIEWS MICROBIOLOGY
- Biology of antimicrobial resistance and approaches to combat it
- (2020) Sarah M. Schrader et al. Science Translational Medicine
- UK launches subscription style model for antibiotics to encourage new development
- (2020) Elisabeth Mahase BMJ-British Medical Journal
- How to Stimulate and Facilitate Early Stage Antibiotic Discovery
- (2020) Johannes Zuegg et al. ACS Infectious Diseases
- The Antibacterial Research and Development Pipeline Needs Urgent Solutions
- (2020) Peter Beyer et al. ACS Infectious Diseases
- Antibacterial Drugs: The Last Frontier
- (2020) David M. Shlaes ACS Infectious Diseases
- On the Road to Discovering Urgently Needed Antibiotics: So Close Yet So Far Away
- (2020) Wes Kim et al. ACS Infectious Diseases
- Fostering Antibiotic Development through Impact Funding
- (2020) Aleks Engel ACS Infectious Diseases
- Repurposing Modular Polyketide Synthases and Non-ribosomal Peptide Synthetases for Novel Chemical Biosynthesis
- (2020) Soonkyu Hwang et al. Frontiers in Molecular Biosciences
- Machine Learning Applications for Mass Spectrometry-Based Metabolomics
- (2020) Ulf W. Liebal et al. Metabolites
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- (2020) Deanna J. Buehrle et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Evaluation of bacterial co-infections of the respiratory tract in COVID-19 patients admitted to ICU
- (2020) Ehsan Sharifipour et al. BMC INFECTIOUS DISEASES
- Empiric Antibacterial Therapy and Community-onset Bacterial Co-infection in Patients Hospitalized with COVID-19: A Multi-Hospital Cohort Study
- (2020) Valerie M Vaughn et al. CLINICAL INFECTIOUS DISEASES
- Emerging Co-Pathogens: New Delhi Metallo-beta-lactamase producing Enterobacterales Infections in New York City COVID-19 Patients
- (2020) Priya Nori et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Azithromycin for severe COVID-19
- (2020) Catherine E Oldenburg et al. LANCET
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- (2020) Osmar N. Silva et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Combining antibiotics with antivirulence compounds can have synergistic effects and reverse selection for antibiotic resistance in Pseudomonas aeruginosa
- (2020) Chiara Rezzoagli et al. PLOS BIOLOGY
- Bacterial and viral co-infections in patients with severe SARS-CoV-2 pneumonia admitted to a French ICU
- (2020) Damien Contou et al. Annals of Intensive Care
- Amidochelocardin Overcomes Resistance Mechanisms Exerted on Tetracyclines and Natural Chelocardin
- (2020) Fabienne Hennessen et al. Antibiotics-Basel
- Comprehensive prediction of secondary metabolite structure and biological activity from microbial genome sequences
- (2020) Michael A. Skinnider et al. Nature Communications
- Corallopyronin A for short-course anti-wolbachial, macrofilaricidal treatment of filarial infections
- (2020) Andrea Schiefer et al. PLoS Neglected Tropical Diseases
- Research, Innovation, and Policy: An Alliance Combating Antimicrobial Resistance
- (2019) Arjon J. van Hengel et al. TRENDS IN MICROBIOLOGY
- Application of Permeation Enhancers in Oral Delivery of Macromolecules: An Update
- (2019) Sam Maher et al. Pharmaceutics
- Lower ototoxicity and absence of hidden hearing loss point to gentamicin C1a and apramycin as promising antibiotics for clinical use
- (2019) Masaaki Ishikawa et al. Scientific Reports
- Interplay between β-lactamases and new β-lactamase inhibitors
- (2019) Karen Bush et al. NATURE REVIEWS MICROBIOLOGY
- Drug combinations: a strategy to extend the life of antibiotics in the 21st century
- (2019) Mike Tyers et al. NATURE REVIEWS MICROBIOLOGY
- Reversing Resistance to Counter Antimicrobial Resistance in the World Health Organisation's Critical Priority of Most Dangerous Pathogens
- (2019) Henrietta Venter BIOSCIENCE REPORTS
- Engineering Atypical Tetracycline Formation in Amycolatopsis sulphurea for the Production of Modified Chelocardin Antibiotics
- (2019) Tadeja Lukežič et al. ACS Chemical Biology
- Horizontal Cell Biology: Monitoring Global Changes of Protein Interaction States with the Proteome-Wide Cellular Thermal Shift Assay (CETSA)
- (2019) Lingyun Dai et al. Annual Review of Biochemistry
- Exploitation of Antibiotic Resistance as a Novel Drug Target: Development of a β-Lactamase-Activated Antibacterial Prodrug
- (2019) Lindsay E. Evans et al. JOURNAL OF MEDICINAL CHEMISTRY
- β-Lactamases and β-Lactamase Inhibitors in the 21st Century
- (2019) Catherine L. Tooke et al. JOURNAL OF MOLECULAR BIOLOGY
- antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline
- (2019) Kai Blin et al. NUCLEIC ACIDS RESEARCH
- Recent Advances in Anti-virulence Therapeutic Strategies With a Focus on Dismantling Bacterial Membrane Microdomains, Toxin Neutralization, Quorum-Sensing Interference and Biofilm Inhibition
- (2019) Osmel Fleitas Martínez et al. Frontiers in Cellular and Infection Microbiology
- Elaborations on Corallopyronin A as a Novel Treatment Strategy Against Genital Chlamydial Infections
- (2019) Nathalie Loeper et al. Frontiers in Microbiology
- Non-traditional Antibacterial Therapeutic Options and Challenges
- (2019) Ursula Theuretzbacher et al. Cell Host & Microbe
- The Evolution and Ecology of Bacterial Warfare
- (2019) Elisa T. Granato et al. CURRENT BIOLOGY
- Antibiotic Resistance Breakers: Current Approaches and Future Directions
- (2019) Mark Laws et al. FEMS MICROBIOLOGY REVIEWS
- The amazing potential of fungi: 50 ways we can exploit fungi industrially
- (2019) Kevin D. Hyde et al. FUNGAL DIVERSITY
- Taming the beast: Interplay between gut small molecules and enteric pathogens
- (2019) Aman Kumar et al. INFECTION AND IMMUNITY
- Modification and de novo design of non-ribosomal peptide synthetases using specific assembly points within condensation domains
- (2019) Kenan A. J. Bozhüyük et al. Nature Chemistry
- Designing development programs for non-traditional antibacterial agents
- (2019) John H. Rex et al. Nature Communications
- Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics
- (2019) Yu Zong et al. Nature Communications
- Development of a novel cultivation technique for uncultured soil bacteria
- (2019) Dhiraj Kumar Chaudhary et al. Scientific Reports
- Assembling a plug-and-play production line for combinatorial biosynthesis of aromatic polyketides in Escherichia coli
- (2019) Matthew Cummings et al. PLOS BIOLOGY
- A Review of the Microbial Production of Bioactive Natural Products and Biologics
- (2019) Janette V. Pham et al. Frontiers in Microbiology
- Toward Autonomous Antibiotic Discovery
- (2019) Cesar de la Fuente-Nunez mSystems
- Antibiotic Pollution in the Environment: From Microbial Ecology to Public Policy
- (2019) Susanne A. Kraemer et al. Microorganisms
- MolNetEnhancer: Enhanced Molecular Networks by Integrating Metabolome Mining and Annotation Tools
- (2019) Madeleine Ernst et al. Metabolites
- Potent LpxC Inhibitors with In Vitro Activity Against Multi-Drug Resistant Pseudomonas aeruginosa
- (2019) Kevin M. Krause et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Synergistic interactions of phytochemicals with antimicrobial agents: Potential strategy to counteract drug resistance
- (2019) Muhammad Ayaz et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Drug Syntheses Beyond the Rule of 5
- (2019) Mohit Tyagi et al. CHEMISTRY-A EUROPEAN JOURNAL
- Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety
- (2019) Frederick Cohen et al. ChemMedChem
- All-Assay-Max2 pQSAR: Activity Predictions as Accurate as Four-Concentration IC50s for 8558 Novartis Assays
- (2019) Eric J. Martin et al. Journal of Chemical Information and Modeling
- Production optimization and biosynthesis revision of corallopyronin A, a potent anti-filarial antibiotic
- (2019) Domen Pogorevc et al. METABOLIC ENGINEERING
- Siderophore–Antibiotic Conjugate Design: New Drugs for Bad Bugs?
- (2019) Negash et al. MOLECULES
- Immuno-oncology drug development goes global
- (2019) Jia Xin Yu et al. NATURE REVIEWS DRUG DISCOVERY
- Antibiotic resistance and epigenetics: more to it than meets the eye
- (2019) Dipannita Ghosh et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- The drivers of antibiotic use and misuse: the development and investigation of a theory driven community measure
- (2019) Mitchell K. Byrne et al. BMC PUBLIC HEALTH
- Flexible Fragment Growing Boosts Potency of Quorum‐Sensing Inhibitors against Pseudomonas aeruginosa Virulence
- (2019) Michael Zender et al. ChemMedChem
- Antibiotics: past, present and future
- (2019) Matthew I Hutchings et al. CURRENT OPINION IN MICROBIOLOGY
- Strategies to Overcome Antimicrobial Resistance (AMR) Making Use of Non-Essential Target Inhibitors: A Review
- (2019) Annunziato INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A new antibiotic selectively kills Gram-negative pathogens
- (2019) Yu Imai et al. NATURE
- A shot in the arm for new antibiotics
- (2019) Kevin Outterson NATURE BIOTECHNOLOGY
- Antibiotic development — economic, regulatory and societal challenges
- (2019) Christine Årdal et al. NATURE REVIEWS MICROBIOLOGY
- The global preclinical antibacterial pipeline
- (2019) Ursula Theuretzbacher et al. NATURE REVIEWS MICROBIOLOGY
- The Natural Products Atlas: An Open Access Knowledge Base for Microbial Natural Products Discovery
- (2019) Jeffrey A. van Santen et al. ACS Central Science
- CRAGE enables rapid activation of biosynthetic gene clusters in undomesticated bacteria
- (2019) Gaoyan Wang et al. Nature Microbiology
- Machine learning approaches and databases for prediction of drug–target interaction: a survey paper
- (2019) Maryam Bagherian et al. BRIEFINGS IN BIOINFORMATICS
- Semisynthesis and biological evaluation of amidochelocardin derivatives as broad-spectrum antibiotics
- (2019) Charlotte Grandclaudon et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Rethinking drug design in the artificial intelligence era
- (2019) Petra Schneider et al. NATURE REVIEWS DRUG DISCOVERY
- A New Artificial Urine Protocol to Better Imitate Human Urine
- (2019) Neslihan Sarigul et al. Scientific Reports
- Zebrafish and Galleria mellonella: Models to Identify the Subsequent Infection and Evaluate the Immunological Differences in Different Klebsiella pneumoniae Intestinal Colonization Strains
- (2019) Xiucai Zhang et al. Frontiers in Microbiology
- METLIN: A Technology Platform for Identifying Knowns and Unknowns
- (2018) Carlos Guijas et al. ANALYTICAL CHEMISTRY
- Thinking outside the box - novel antibacterials to tackle the resistance crisis
- (2018) Markus Lakemeyer et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Orientia tsutsugamushi Is Highly Susceptible to the RNA Polymerase Switch Region Inhibitor Corallopyronin A In Vitro and In Vivo
- (2018) Fredericke Kock et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Antibiotic discovery: combining isolation chip (iChip) technology and co-culture technique
- (2018) Adil Farooq Lodhi et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- A Map of Protein-Metabolite Interactions Reveals Principles of Chemical Communication
- (2018) Ilaria Piazza et al. CELL
- Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages
- (2018) Marco Paolino et al. ChemMedChem
- Siderophore–antibiotic conjugates: exploiting iron uptake to deliver drugs into bacteria
- (2018) I.J. Schalk CLINICAL MICROBIOLOGY AND INFECTION
- Translation of innovative chemistry into screening libraries: an exemplar partnership from the European Lead Factory
- (2018) Remy Morgentin et al. DRUG DISCOVERY TODAY
- Discovery and development of new antibacterial drugs: learning from experience?
- (2018) Nicole Jackson et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Glycomimetic, Orally Bioavailable LecB Inhibitors Block Biofilm Formation of Pseudomonas aeruginosa
- (2018) Roman Sommer et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Novel soil bacteria possess diverse genes for secondary metabolite biosynthesis
- (2018) Alexander Crits-Christoph et al. NATURE
- Genome-wide mutant profiling predicts the mechanism of a Lipid II binding antibiotic
- (2018) Marina Santiago et al. Nature Chemical Biology
- Chemoproteomics and Chemical Probes for Target Discovery
- (2018) Gerard Drewes et al. TRENDS IN BIOTECHNOLOGY
- Self-resistance guided genome mining uncovers new topoisomerase inhibitors from myxobacteria
- (2018) Fabian Panter et al. Chemical Science
- Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria
- (2018) Mark A. T. Blaskovich et al. Nature Communications
- Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria
- (2018) Thomas Hoffmann et al. Nature Communications
- The anti-mycobacterial activity of the cytochrome bcc inhibitor Q203 can be enhanced by small-molecule inhibition of cytochrome bd
- (2018) Ping Lu et al. Scientific Reports
- Fluoroquinolone use and risk of aortic aneurysm and dissection: nationwide cohort study
- (2018) Björn Pasternak et al. BMJ-British Medical Journal
- Fluoroquinolone use and risk of aortic aneurysm and dissection: nationwide cohort study
- (2018) Björn Pasternak et al. BMJ-British Medical Journal
- In Vitro Model of the Gram-Negative Bacterial Cell Envelope for Investigation of Anti-Infective Permeation Kinetics
- (2018) Florian Graef et al. ACS Infectious Diseases
- Predicting Human Pharmacokinetics: Physiologically Based Pharmacokinetic Modeling and In Silico ADME Prediction in Early Drug Discovery
- (2018) Jian Shi et al. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
- Effective inhibition of rifampicin-resistant Chlamydia trachomatis by the novel DNA-dependent RNA polymerase inhibitor corallopyronin A
- (2018) Kensuke Shima et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Wastewater treatment plant resistomes are shaped by bacterial composition, genetic exchange, and upregulated expression in the effluent microbiomes
- (2018) Feng Ju et al. ISME Journal
- Polypharmacology by Design: A Medicinal Chemist’s Perspective on Multitargeting Compounds
- (2018) Ewgenij Proschak et al. JOURNAL OF MEDICINAL CHEMISTRY
- Generation of a cluster-free Streptomyces albus chassis strains for improved heterologous expression of secondary metabolite clusters
- (2018) Maksym Myronovskyi et al. METABOLIC ENGINEERING
- Amycomicin is a potent and specific antibiotic discovered with a targeted interaction screen
- (2018) Gleb Pishchany et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- High-resolution NMR studies of antibiotics in cellular membranes
- (2018) João Medeiros-Silva et al. Nature Communications
- Pathoblockers or antivirulence drugs as a new option for the treatment of bacterial infections
- (2018) Matthew B Calvert et al. Beilstein Journal of Organic Chemistry
- Targeting the Pseudomonas quinolone signal quorum sensing system for the discovery of novel anti-infective pathoblockers
- (2018) Christian Schütz et al. Beilstein Journal of Organic Chemistry
- Serine integrase recombinational engineering (SIRE): A versatile toolbox for genome editing
- (2018) Nico Snoeck et al. BIOTECHNOLOGY AND BIOENGINEERING
- Reaching toward underexplored targets in antibacterial drug design
- (2018) Marko Jukič et al. DRUG DEVELOPMENT RESEARCH
- Impact of antimicrobial therapy on the gut microbiome
- (2018) Amira A Bhalodi et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- The role played by drug efflux pumps in bacterial multidrug resistance
- (2017) Mohsen Chitsaz et al. Essays in Biochemistry
- CRISPR-Cas9 technology: applications in genome engineering, development of sequence-specific antimicrobials, and future prospects
- (2017) César de la Fuente-Núñez et al. Integrative Biology
- Iron Metabolism and the Inflammatory Response
- (2017) Ana C. Martins et al. IUBMB LIFE
- Large-scale preparation of key building blocks for the manufacture of fully synthetic macrolide antibiotics
- (2017) Philip C Hogan et al. JOURNAL OF ANTIBIOTICS
- Incentivising innovation in antibiotic drug discovery and development: progress, challenges and next steps
- (2017) Victoria L Simpkin et al. JOURNAL OF ANTIBIOTICS
- Beyond the Rule of 5: Lessons Learned from AbbVie’s Drugs and Compound Collection
- (2017) David A. DeGoey et al. JOURNAL OF MEDICINAL CHEMISTRY
- Substituted N-Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery
- (2017) Elisa Azzali et al. JOURNAL OF MEDICINAL CHEMISTRY
- Database for Rapid Dereplication of Known Natural Products Using Data from MS and Fast NMR Experiments
- (2017) Carlos L. Zani et al. JOURNAL OF NATURAL PRODUCTS
- Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases
- (2017) Esther Schönauer et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Rational synthetic pathway refactoring of natural products biosynthesis in actinobacteria
- (2017) Gao-Yi Tan et al. METABOLIC ENGINEERING
- Heterologous production of myxobacterial α-pyrone antibiotics in Myxococcus xanthus
- (2017) Hilda Sucipto et al. METABOLIC ENGINEERING
- Antibiotics and specialized metabolites from the human microbiota
- (2017) Walaa K. Mousa et al. NATURAL PRODUCT REPORTS
- Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights
- (2017) J. Masschelein et al. NATURAL PRODUCT REPORTS
- Symbiosis-inspired approaches to antibiotic discovery
- (2017) Navid Adnani et al. NATURAL PRODUCT REPORTS
- Predictive compound accumulation rules yield a broad-spectrum antibiotic
- (2017) Michelle F. Richter et al. NATURE
- A communal catalogue reveals Earth’s multiscale microbial diversity
- (2017) Luke R. Thompson et al. NATURE
- Measuring protein structural changes on a proteome-wide scale using limited proteolysis-coupled mass spectrometry
- (2017) Simone Schopper et al. Nature Protocols
- The commensal lifestyle of Staphylococcus aureus and its interactions with the nasal microbiota
- (2017) Bernhard Krismer et al. NATURE REVIEWS MICROBIOLOGY
- ExoCET: exonuclease in vitro assembly combined with RecET recombination for highly efficient direct DNA cloning from complex genomes
- (2017) Hailong Wang et al. NUCLEIC ACIDS RESEARCH
- Regulation of the AcrAB-TolC efflux pump in Enterobacteriaceae
- (2017) Natasha Weston et al. RESEARCH IN MICROBIOLOGY
- Antibody–Antibiotic Conjugates: A Novel Therapeutic Platform against Bacterial Infections
- (2017) Sanjeev Mariathasan et al. TRENDS IN MOLECULAR MEDICINE
- Molecular Networking As a Drug Discovery, Drug Metabolism, and Precision Medicine Strategy
- (2017) Robert A. Quinn et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Multidrug-resistant gonorrhea: A research and development roadmap to discover new medicines
- (2017) Emilie Alirol et al. PLOS MEDICINE
- Liposomal Formulations in Clinical Use: An Updated Review
- (2017) Upendra Bulbake et al. Pharmaceutics
- Deciphering the mode of action of cell wall-inhibiting antibiotics using metabolic labeling of growing peptidoglycan in Streptococcus pyogenes
- (2017) Atsushi Sugimoto et al. Scientific Reports
- Antibiotic treatment for Tuberculosis induces a profound dysbiosis of the microbiome that persists long after therapy is completed
- (2017) Matthew F. Wipperman et al. Scientific Reports
- Revisiting unexploited antibiotics in search of new antibacterial drug candidates: the case of γ-actinorhodin
- (2017) Nada M. Nass et al. Scientific Reports
- Rapid Inhibition Profiling in Bacillus subtilis to Identify the Mechanism of Action of New Antimicrobials
- (2016) Anne Lamsa et al. ACS Chemical Biology
- BDDCS, the Rule of 5 and drugability
- (2016) Leslie Z. Benet et al. ADVANCED DRUG DELIVERY REVIEWS
- Rule of five in 2015 and beyond: Target and ligand structural limitations, ligand chemistry structure and drug discovery project decisions
- (2016) Christopher A. Lipinski ADVANCED DRUG DELIVERY REVIEWS
- High-Throughput Single-Cell Cultivation on Microfluidic Streak Plates
- (2016) Cheng-Ying Jiang et al. APPLIED AND ENVIRONMENTAL MICROBIOLOGY
- Animal models in the pharmacokinetic/pharmacodynamic evaluation of antimicrobial agents
- (2016) Miao Zhao et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Characterization and prediction of the mechanism of action of antibiotics through NMR metabolomics
- (2016) Verena Hoerr et al. BMC MICROBIOLOGY
- Polypharmacology in Drug Discovery: A Review from Systems Pharmacology Perspective
- (2016) Wenjuan Zhang et al. CURRENT PHARMACEUTICAL DESIGN
- Innovation in the pharmaceutical industry: New estimates of R&D costs
- (2016) Joseph A. DiMasi et al. JOURNAL OF HEALTH ECONOMICS
- Novel Strategies for the Treatment of Pseudomonas aeruginosa Infections
- (2016) Stefanie Wagner et al. JOURNAL OF MEDICINAL CHEMISTRY
- Antibiotic reimbursement in a model delinked from sales: a benchmark-based worldwide approach
- (2016) John H Rex et al. LANCET INFECTIOUS DISEASES
- Validation of Early Human Dose Prediction: A Key Metric for Compound Progression in Drug Discovery
- (2016) Ken M. Page MOLECULAR PHARMACEUTICS
- Chemical proteomics approaches for identifying the cellular targets of natural products
- (2016) M. H. Wright et al. NATURAL PRODUCT REPORTS
- New tools for reconstruction and heterologous expression of natural product biosynthetic gene clusters
- (2016) Yunzi Luo et al. NATURAL PRODUCT REPORTS
- Human commensals producing a novel antibiotic impair pathogen colonization
- (2016) Alexander Zipperer et al. NATURE
- Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking
- (2016) Mingxun Wang et al. NATURE BIOTECHNOLOGY
- Assembly and clustering of natural antibiotics guides target identification
- (2016) Chad W Johnston et al. Nature Chemical Biology
- Scaling laws predict global microbial diversity
- (2016) Kenneth J. Locey et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- How well can in vitro data predict in vivo effects of chemicals? Rodent carcinogenicity as a case study
- (2016) Louis Anthony (Tony) Cox et al. REGULATORY TOXICOLOGY AND PHARMACOLOGY
- Mechanisms of bacterial persistence during stress and antibiotic exposure
- (2016) Alexander Harms et al. SCIENCE
- Antibiotic-Induced Changes in the Intestinal Microbiota and Disease
- (2016) Simone Becattini et al. TRENDS IN MOLECULAR MEDICINE
- Endless resistance. Endless antibiotics?
- (2016) Jed F. Fisher et al. MedChemComm
- Persister formation in Staphylococcus aureus is associated with ATP depletion
- (2016) Brian P. Conlon et al. Nature Microbiology
- Construction of a New Class of Tetracycline Lead Structures with Potent Antibacterial Activity through Biosynthetic Engineering
- (2015) Urška Lešnik et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Pharmacodynamic Profiling of a Siderophore-Conjugated Monocarbam in Pseudomonas aeruginosa: Assessing the Risk for Resistance and Attenuated Efficacy
- (2015) Aryun Kim et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Target-Based Identification of Whole-Cell Active Inhibitors of Biotin Biosynthesis in Mycobacterium tuberculosis
- (2015) Sae Woong Park et al. CHEMISTRY & BIOLOGY
- Target Based Drug Design - A Reality in Virtual Sphere
- (2015) Saroj Verma et al. CURRENT MEDICINAL CHEMISTRY
- The Joint European Compound Library: boosting precompetitive research
- (2015) Jérémy Besnard et al. DRUG DISCOVERY TODAY
- Benefit of Retraining pKa Models Studied Using Internally Measured Data
- (2015) Peter Gedeck et al. Journal of Chemical Information and Modeling
- Culture-independent discovery of natural products from soil metagenomes
- (2015) Micah Katz et al. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- Insights into Structure–Activity Relationships of Bacterial RNA Polymerase Inhibiting Corallopyronin Derivatives
- (2015) Till F. Schäberle et al. JOURNAL OF NATURAL PRODUCTS
- Facilitating quality control for spectra assignments of small organic molecules: nmrshiftdb2 - a free in-house NMR database with integrated LIMS for academic service laboratories
- (2015) Stefan Kuhn et al. MAGNETIC RESONANCE IN CHEMISTRY
- A new antibiotic kills pathogens without detectable resistance
- (2015) Losee L. Ling et al. NATURE
- Computational approaches to natural product discovery
- (2015) Marnix H Medema et al. Nature Chemical Biology
- The promise and peril of chemical probes
- (2015) Cheryl H Arrowsmith et al. Nature Chemical Biology
- Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry
- (2015) Holger Franken et al. Nature Protocols
- Urinary tract infections: epidemiology, mechanisms of infection and treatment options
- (2015) Ana L. Flores-Mireles et al. NATURE REVIEWS MICROBIOLOGY
- Dereplication strategies in natural product research: How many tools and methodologies behind the same concept?
- (2015) Jane Hubert et al. PHYTOCHEMISTRY REVIEWS
- Socially mediated induction and suppression of antibiosis during bacterial coexistence
- (2015) Monica I. Abrudan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting DnaN for tuberculosis therapy using novel griselimycins
- (2015) A. Kling et al. SCIENCE
- Deoxynybomycins inhibit mutant DNA gyrase and rescue mice infected with fluoroquinolone-resistant bacteria
- (2015) Elizabeth I. Parkinson et al. Nature Communications
- Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research
- (2015) Norman Moullan et al. Cell Reports
- The Evolving Role of Chemical Synthesis in Antibacterial Drug Discovery
- (2014) Peter M. Wright et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Machine-Learning Techniques Applied to Antibacterial Drug Discovery
- (2014) Jacob D. Durrant et al. Chemical Biology & Drug Design
- Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates
- (2014) Bradley Croy Doak et al. CHEMISTRY & BIOLOGY
- Mining the Metabiome: Identifying Novel Natural Products from Microbial Communities
- (2014) Aleksandr Milshteyn et al. CHEMISTRY & BIOLOGY
- Natural Product Synthesis at the Interface of Chemistry and Biology
- (2014) Jiyong Hong CHEMISTRY-A EUROPEAN JOURNAL
- Polymeric Nanoparticle Technologies for Oral Drug Delivery
- (2014) Eric M. Pridgen et al. Clinical Gastroenterology and Hepatology
- Genomic tools to profile antibiotic mode of action
- (2014) Silvia T. Cardona et al. CRITICAL REVIEWS IN MICROBIOLOGY
- Integrative Approaches for Predicting In Vivo Effects of Chemicals from their Structural Descriptors and the Results of Short-Term Biological Assays
- (2014) Yen Low et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Dereplication of microbial extracts and related analytical technologies
- (2014) Tatsuya Ito et al. JOURNAL OF ANTIBIOTICS
- Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance
- (2014) Andrew M. King et al. NATURE
- High-throughput platform for the discovery of elicitors of silent bacterial gene clusters
- (2014) M. R. Seyedsayamdost PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Gene-targeted microfluidic cultivation validated by isolation of a gut bacterium listed in Human Microbiome Project's Most Wanted taxa
- (2014) Liang Ma et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Discovery and preclinical development of new antibiotics
- (2014) Diarmaid Hughes et al. UPSALA JOURNAL OF MEDICAL SCIENCES
- Design, synthesis and investigation on the structure–activity relationships of N-substituted 2-aminothiazole derivatives as antitubercular agents
- (2013) Marco Pieroni et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Cloning and Analysis of the Planosporicin Lantibiotic Biosynthetic Gene Cluster of Planomonospora alba
- (2013) E. J. Sherwood et al. JOURNAL OF BACTERIOLOGY
- Discovery and Biophysical Characterization of 2-Amino-oxadiazoles as Novel Antagonists of PqsR, an Important Regulator of Pseudomonas aeruginosa Virulence
- (2013) Michael Zender et al. JOURNAL OF MEDICINAL CHEMISTRY
- Identification of the chelocardin biosynthetic gene cluster from Amycolatopsis sulphurea: a platform for producing novel tetracycline antibiotics
- (2013) T. Lukezic et al. MICROBIOLOGY-SGM
- Side effects of antibiotics during bacterial infection: Mitochondria, the main target in host cell
- (2013) Rochika Singh et al. MITOCHONDRION
- Industrial natural product chemistry for drug discovery and development
- (2013) Armin Bauer et al. NATURAL PRODUCT REPORTS
- Bacterial cytological profiling rapidly identifies the cellular pathways targeted by antibacterial molecules
- (2013) P. Nonejuie et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Engineered Streptomyces avermitilis Host for Heterologous Expression of Biosynthetic Gene Cluster for Secondary Metabolites
- (2013) Mamoru Komatsu et al. ACS Synthetic Biology
- Applications of Human Pharmacokinetic Prediction in First-in-Human Dose Estimation
- (2012) Peng Zou et al. AAPS Journal
- Chemical Inhibitors of the Type Three Secretion System: Disarming Bacterial Pathogens
- (2012) Miles C. Duncan et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- A Glutathione-Dependent Detoxification System Is Required for Formaldehyde Resistance and Optimal Survival of Neisseria meningitidis in Biofilms
- (2012) Nathan H. Chen et al. ANTIOXIDANTS & REDOX SIGNALING
- Understanding efflux in Gram-negative bacteria: opportunities for drug discovery
- (2012) Herbert P Schweizer Expert Opinion on Drug Discovery
- Corallopyronin A Specifically Targets and Depletes Essential Obligate Wolbachia Endobacteria From Filarial Nematodes In Vivo
- (2012) Andrea Schiefer et al. JOURNAL OF INFECTIOUS DISEASES
- Molecular Determinants of AcrB-Mediated Bacterial Efflux Implications for Drug Discovery
- (2012) John I. Manchester et al. JOURNAL OF MEDICINAL CHEMISTRY
- Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology
- (2012) Rainer Wilcken et al. JOURNAL OF MEDICINAL CHEMISTRY
- Exploiting Adaptive Laboratory Evolution of Streptomyces clavuligerus for Antibiotic Discovery and Overproduction
- (2012) Pep Charusanti et al. PLoS One
- Polypharmacology: drug discovery for the future
- (2012) A Srinivas Reddy et al. Expert Review of Clinical Pharmacology
- Novel classes of antibiotics or more of the same?
- (2011) Anthony RM Coates et al. BRITISH JOURNAL OF PHARMACOLOGY
- Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance
- (2011) A.-P. Magiorakos et al. CLINICAL MICROBIOLOGY AND INFECTION
- Principles of early drug discovery
- (2010) JP Hughes et al. BRITISH JOURNAL OF PHARMACOLOGY
- Antibacterials from the Sea
- (2010) Chambers C. Hughes et al. CHEMISTRY-A EUROPEAN JOURNAL
- How to improve R&D productivity: the pharmaceutical industry's grand challenge
- (2010) Steven M. Paul et al. NATURE REVIEWS DRUG DISCOVERY
- Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters
- (2010) Juan Pablo Gomez-Escribano et al. Microbial Biotechnology
- A Balancing Act: Efflux/Influx in Mycobacterial Drug Resistance
- (2009) G. E. Louw et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success
- (2009) Frank Lovering et al. JOURNAL OF MEDICINAL CHEMISTRY
- CD-Spectroscopy As a Powerful Tool for Investigating the Mode of Action of Unmodified Drugs in Live Cells
- (2009) Lutz F. Tietze et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Evolution of a Fourth Generation Catalyst for the Amination and Thioetherification of Aryl Halides
- (2008) John F. Hartwig ACCOUNTS OF CHEMICAL RESEARCH
- Membrane Permeability and Regulation of Drug “Influx and Efflux” in Enterobacterial Pathogens
- (2008) Anne Davin-Regli et al. CURRENT DRUG TARGETS
- Physicochemical Properties of Antibacterial Compounds: Implications for Drug Discovery
- (2008) Rosemarie O’Shea et al. JOURNAL OF MEDICINAL CHEMISTRY
- A Robust Platform for the Synthesis of New Tetracycline Antibiotics
- (2008) Cuixiang Sun et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Transcription inactivation through local refolding of the RNA polymerase structure
- (2008) Georgiy A. Belogurov et al. NATURE
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