Culture-independent discovery of natural products from soil metagenomes

Targeted Metagenomics: Finding Rare Tryptophan Dimer Natural Products in the Environment

(2015) Fang-Yuan Chang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors

(2015) Jeremy G. Owen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters

(2015) Daniel Montiel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Socially mediated induction and suppression of antibiosis during bacterial coexistence

(2015) Monica I. Abrudan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global biogeographic sampling of bacterial secondary metabolism

(2015) Zachary Charlop-Powers et al.   eLife

Targeted metagenomics as a tool to tap into marine natural product diversity for the discovery and production of drug candidates

(2015) Marla Trindade et al.   Frontiers in Microbiology

Arixanthomycins A–C: Phylogeny-Guided Discovery of Biologically Active eDNA-Derived Pentangular Polyphenols

(2014) Hahk-Soo Kang et al.   ACS Chemical Biology

Characterization of an Environmental DNA-Derived Gene Cluster that Encodes the Bisindolylmaleimide Methylarcyriarubin

(2014) Fang-Yuan Chang et al.   CHEMBIOCHEM

eSNaPD: A Versatile, Web-Based Bioinformatics Platform for Surveying and Mining Natural Product Biosynthetic Diversity from Metagenomes

(2014) Boojala Vijay B. Reddy et al.   CHEMISTRY & BIOLOGY

Mining the Metabiome: Identifying Novel Natural Products from Microbial Communities

(2014) Aleksandr Milshteyn et al.   CHEMISTRY & BIOLOGY

The Chemical Arsenal of Burkholderia pseudomallei Is Essential for Pathogenicity

(2014) John B. Biggins et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mining Soil Metagenomes to Better Understand the Evolution of Natural Product Structural Diversity: Pentangular Polyphenols as a Case Study

(2014) Hahk-Soo Kang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An environmental bacterial taxon with a large and distinct metabolic repertoire

(2014) Micheal C. Wilson et al.   NATURE

Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont

(2014) Toshiyuki Wakimoto et al.   Nature Chemical Biology

Chemical-biogeographic survey of secondary metabolism in soil

(2014) Z. Charlop-Powers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A

(2014) Kazuya Yamanaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation and identification of five clusters for secondary metabolites inStreptomyces albus J1074

(2014) Carlos Olano et al.   Microbial Biotechnology

Arimetamycin A: Improving Clinically Relevant Families of Natural Products through Sequence-Guided Screening of Soil Metagenomes

(2013) Hahk-Soo Kang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deep sequencing of non-ribosomal peptide synthetases and polyketide synthases from the microbiomes of Australian marine sponges

(2013) Jason N Woodhouse et al.   ISME Journal

Discovery and Synthetic Refactoring of Tryptophan Dimer Gene Clusters from the Environment

(2013) Fang-Yuan Chang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers

(2013) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

Alternative Sigma Factor Over-Expression Enables Heterologous Expression of a Type II Polyketide Biosynthetic Pathway in Escherichia coli

(2013) David Cole Stevens et al.   PLoS One

Discovery of indolotryptoline antiproliferative agents by homology-guided metagenomic screening

(2013) F.-Y. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metagenomic natural product discovery in lichen provides evidence for a family of biosynthetic pathways in diverse symbioses

(2013) A. Kampa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products

(2013) J. G. Owen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Refactoring the Silent Spectinabilin Gene Cluster Using a Plug-and-Play Scaffold

(2013) Zengyi Shao et al.   ACS Synthetic Biology

Selective Enrichment of Environmental DNA Libraries for Genes Encoding Nonribosomal Peptides and Polyketides by Phosphopantetheine Transferase-Dependent Complementation of Siderophore Biosynthesis

(2012) Zachary Charlop-Powers et al.   ACS Chemical Biology

Natural Product Biosynthetic Gene Diversity in Geographically Distinct Soil Microbiomes

(2012) Boojala Vijay B. Reddy et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Proteasome Inhibitors: An Expanding Army Attacking a Unique Target

(2012) Alexei F. Kisselev et al.   CHEMISTRY & BIOLOGY

Biocatalysts and small molecule products from metagenomic studies

(2012) Hala A Iqbal et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Tetarimycin A, an MRSA-Active Antibiotic Identified through Induced Expression of Environmental DNA Gene Clusters

(2012) Dimitris Kallifidas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Natural Product Domain Seeker NaPDoS: A Phylogeny Based Bioinformatic Tool to Classify Secondary Metabolite Gene Diversity

(2012) Nadine Ziemert et al.   PLoS One

Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides

(2012) M. F. Freeman et al.   SCIENCE

Geographic Distribution of Secondary Metabolite Genes in the Marine Actinomycete Salinispora arenicola

(2011) Anna Edlund et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Accessing the Hidden Majority of Marine Natural Products through Metagenomics

(2011) Mohamed S. Donia et al.   CHEMBIOCHEM

Isolation and Characterization of a Novel Tannase from a Metagenomic Library

(2011) Jian Yao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Nonlinear electrophoresis for purification of soil DNA for metagenomics

(2011) Katja Engel et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Cloning and Characterization of an Environmental DNA-Derived Gene Cluster That Encodes the Biosynthesis of the Antitumor Substance BE-54017

(2011) Fang-Yuan Chang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A close relationship between primary nucleotides sequence structure and the composition of functional genes in the genome of prokaryotes

(2011) Juan A.L. Garcia et al.   MOLECULAR PHYLOGENETICS AND EVOLUTION

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

(2011) Marnix H. Medema et al.   NUCLEIC ACIDS RESEARCH

Functional analysis of environmental DNA-derived type II polyketide synthases reveals structurally diverse secondary metabolites

(2011) Z. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

(2011) L. Laureti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expanding Small-Molecule Functional Metagenomics through Parallel Screening of Broad-Host-Range Cosmid Environmental DNA Libraries in Diverse Proteobacteria

(2010) J. W. Craig et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Product-Induced Gene Expression, a Product-Responsive Reporter Assay Used To Screen Metagenomic Libraries for Enzyme-Encoding Genes

(2010) T. Uchiyama et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Sequence-Based Analysis of Secondary-Metabolite Biosynthesis in Marine Actinobacteria

(2010) E. A. Gontang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A novel metagenome-derived β-galactosidase: gene cloning, overexpression, purification and characterization

(2010) Kui Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Cloning large natural product gene clusters from the environment: Piecing environmental DNA gene clusters back together with TAR

(2010) Jeffrey H. Kim et al.   BIOPOLYMERS

Gram negative shuttle BAC vector for heterologous expression of metagenomic libraries

(2010) Kavita S. Kakirde et al.   GENE

Prospecting Metagenomic Enzyme Subfamily Genes for DNA Family Shuffling by a Novel PCR-based Approach

(2010) Qiuyan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fluostatins Produced by the Heterologous Expression of a TAR Reassembled Environmental DNA Derived Type II PKS Gene Cluster

(2010) Zhiyang Feng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tailoring Enzyme-Rich Environmental DNA Clones: A Source of Enzymes for Generating Libraries of Unnatural Natural Products

(2010) Jacob J. Banik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solution Structure of Polytheonamide B, a Highly Cytotoxic Nonribosomal Polypeptide from Marine Sponge

(2010) Toshiyuki Hamada et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Natural Products from Environmental DNA Hosted inRalstonia metallidurans

(2009) Jeffrey W. Craig et al.   ACS Chemical Biology

An Environmental DNA-Derived Type II Polyketide Biosynthetic Pathway Encodes the Biosynthesis of the Pentacyclic Polyketide Erdacin

(2009) Ryan W. King et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Natural products and drug discovery. Can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia?

(2009) Hong-Fang Ji et al.   EMBO REPORTS

A plasmid RK2-based broad-host-range cloning vector useful for transfer of metagenomic libraries to a variety of bacterial species

(2009) Trine Aakvik et al.   FEMS MICROBIOLOGY LETTERS

Chemical biology of natural indolocarbazole products: 30 years since the discovery of staurosporine

(2009) Hirofumi Nakano et al.   JOURNAL OF ANTIBIOTICS

Nonlinear electrophoretic response yields a unique parameter for separation of biomolecules

(2009) J. Pel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recovery, Purification, and Cloning of High-Molecular-Weight DNA from Soil Microorganisms

(2008) M. R. Liles et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Joining the Army of Proteasome Inhibitors

(2008) Alexei F. Kisselev   CHEMISTRY & BIOLOGY

Natural products to drugs: natural product-derived compounds in clinical trials

(2008) Mark S. Butler   NATURAL PRODUCT REPORTS

ClustScan : an integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures

(2008) Antonio Starcevic et al.   NUCLEIC ACIDS RESEARCH

Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary

(2008) J. J. Banik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA