Drug combinations: a strategy to extend the life of antibiotics in the 21st century

The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification

(2018) Vitaly Sedlyarov et al.   Cell Host & Microbe

Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis

(2018) Evelina Tacconelli et al.   LANCET INFECTIOUS DISEASES

A delicate balance

(2018) Marla Broadfoot   SCIENCE

Systematic analysis of complex genetic interactions

(2018) Elena Kuzmin et al.   SCIENCE

Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics

(2018) Craig R. MacNair et al.   Nature Communications

DeepARG: a deep learning approach for predicting antibiotic resistance genes from metagenomic data

(2018) Gustavo Arango-Argoty et al.   Microbiome

Mutant phenotypes for thousands of bacterial genes of unknown function

(2018) Morgan N. Price et al.   NATURE

Species-specific activity of antibacterial drug combinations

(2018) Ana Rita Brochado et al.   NATURE

Uses of polypills for cardiovascular disease and evidence to date

(2017) Mark D Huffman et al.   LANCET

Opportunities for natural products in 21st century antibiotic discovery

(2017) Gerard D. Wright   NATURAL PRODUCT REPORTS

Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites

(2017) Brett C. Covington et al.   NATURAL PRODUCT REPORTS

Functional annotation of chemical libraries across diverse biological processes

(2017) Jeff S Piotrowski et al.   Nature Chemical Biology

Emerging and evolving concepts in gene essentiality

(2017) Giulia Rancati et al.   NATURE REVIEWS GENETICS

Origins of Combination Therapy for Tuberculosis: Lessons for Future Antimicrobial Development and Application

(2017) Christopher A. Kerantzas et al.   mBio

Synergistic effects of antimicrobial peptide DP7 combined with antibiotics against multidrug-resistant bacteria

(2017) Xiaozhe Wu et al.   Drug Design Development and Therapy

High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance

(2017) Morgan A. Wambaugh et al.   PLOS BIOLOGY

Game Changers: New β-Lactamase Inhibitor Combinations Targeting Antibiotic Resistance in Gram-Negative Bacteria

(2017) Karen Bush   ACS Infectious Diseases

Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance

(2017) Jonathan M. Stokes et al.   Nature Microbiology

Predictive computational phenotyping and biomarker discovery using reference-free genome comparisons

(2016) Alexandre Drouin et al.   BMC GENOMICS

Antimicrobial synergy between carprofen and doxycycline against methicillin-resistant Staphylococcus pseudintermedius ST71

(2016) Rikke Prejh Brochmann et al.   BMC Veterinary Research

History of chemotherapy of leprosy

(2016) Shaik K. Noordeen   CLINICS IN DERMATOLOGY

Hybrid antibiotics – clinical progress and novel designs

(2016) Alastair L. Parkes et al.   Expert Opinion on Drug Discovery

Enhanced identification of synergistic and antagonistic emergent interactions among three or more drugs

(2016) Elif Tekin et al.   Journal of the Royal Society Interface

A robust platform for chemical genomics in bacterial systems

(2016) Shawn French et al.   MOLECULAR BIOLOGY OF THE CELL

Chemogenomics and orthology‐based design of antibiotic combination therapies

(2016) Sriram Chandrasekaran et al.   Molecular Systems Biology

Antibacterial drug discovery in the resistance era

(2016) Eric D. Brown et al.   NATURE

Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

(2016) Mingxun Wang et al.   NATURE BIOTECHNOLOGY

Antimicrobial combinations: Bliss independence and Loewe additivity derived from mechanistic multi-hit models

(2016) Desiree Y. Baeder et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives

(2016) Hanno Sjuts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A global genetic interaction network maps a wiring diagram of cellular function

(2016) M. Costanzo et al.   SCIENCE

TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci

(2016) Sang Ho Lee et al.   Science Translational Medicine

Antibiotic Adjuvants: Rescuing Antibiotics from Resistance

(2016) Gerard D. Wright   TRENDS IN MICROBIOLOGY

Antibacterial Antifolates: From Development through Resistance to the Next Generation

(2016) Alexavier Estrada et al.   Cold Spring Harbor Perspectives in Medicine

β-Lactams and β-Lactamase Inhibitors: An Overview

(2016) Karen Bush et al.   Cold Spring Harbor Perspectives in Medicine

Current status and prospects of HIV treatment

(2016) Tomas Cihlar et al.   Current Opinion in Virology

Reviving Antibiotics: Efflux Pump Inhibitors That Interact with AcrA, a Membrane Fusion Protein of the AcrAB-TolC Multidrug Efflux Pump

(2016) Narges Abdali et al.   ACS Infectious Diseases

Systematic chemical-genetic and chemical-chemical interaction datasets for prediction of compound synergism

(2016) Jan Wildenhain et al.   Scientific Data

Genome-wide CRISPR screen reveals novel host factors required for Staphylococcus aureus α-hemolysin-mediated toxicity

(2016) Sebastian Virreira Winter et al.   Scientific Reports

Suppression of Emergence of Resistance in Pathogenic Bacteria: Keeping Our Powder Dry, Part 2

(2015) G. L. Drusano et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synergistic Effect of Membrane-Active Peptides Polymyxin B and Gramicidin S on Multidrug-Resistant Strains and Biofilms of Pseudomonas aeruginosa

(2015) Marina Berditsch et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Suppression of Emergence of Resistance in Pathogenic Bacteria: Keeping Our Powder Dry, Part 1

(2015) G. L. Drusano et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Targeting the Adaptability of Heterogeneous Aneuploids

(2015) Guangbo Chen et al.   CELL

The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria

(2015) Xian-Zhi Li et al.   CLINICAL MICROBIOLOGY REVIEWS

The challenge of Clostridium difficile infection: Overview of clinical manifestations, diagnostic tools and therapeutic options

(2015) Nynke Postma et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Anthelmintic closantel enhances bacterial killing of polymyxin B against multidrug-resistant Acinetobacter baumannii

(2015) Thien B Tran et al.   JOURNAL OF ANTIBIOTICS

A Hybrid Drug Limits Resistance by Evading the Action of the Multiple Antibiotic Resistance Pathway

(2015) Kathy K. Wang et al.   MOLECULAR BIOLOGY AND EVOLUTION

ESKAPEing the labyrinth of antibacterial discovery

(2015) Ruben Tommasi et al.   NATURE REVIEWS DRUG DISCOVERY

Antibiotic resistance breakers: can repurposed drugs fill the antibiotic discovery void?

(2015) David Brown   NATURE REVIEWS DRUG DISCOVERY

Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase

(2015) Maya A. Farha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multidrug evolutionary strategies to reverse antibiotic resistance

(2015) M. Baym et al.   SCIENCE

An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens

(2015) Nicole Robbins et al.   Cell Reports

Prediction of Synergism from Chemical-Genetic Interactions by Machine Learning

(2015) Jan Wildenhain et al.   Cell Systems

A Broad-Spectrum Antibiofilm Peptide Enhances Antibiotic Action against Bacterial Biofilms

(2014) Fany Reffuveille et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibiotic Adjuvants: Diverse Strategies for Controlling Drug-Resistant Pathogens

(2014) Erin E. Gill et al.   Chemical Biology & Drug Design

A macrophage-stimulating compound from a screen of microbial natural products

(2014) Julie A Perry et al.   JOURNAL OF ANTIBIOTICS

Small-Molecule Suppression of β-Lactam Resistance in Multidrug-Resistant Gram-Negative Pathogens

(2014) Christopher M. Brackett et al.   JOURNAL OF MEDICINAL CHEMISTRY

Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance

(2014) Andrew M. King et al.   NATURE

A community computational challenge to predict the activity of pairs of compounds

(2014) Mukesh Bansal et al.   NATURE BIOTECHNOLOGY

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

(2014) David Cook et al.   NATURE REVIEWS DRUG DISCOVERY

Alternating antibiotic treatments constrain evolutionary paths to multidrug resistance

(2014) Seungsoo Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combination antibiotic therapy for multidrug-resistant Gram-negative bacteria

(2014) Thomas Tängdén   UPSALA JOURNAL OF MEDICAL SCIENCES

Correction: Optimal Drug Synergy in Antimicrobial Treatments

(2014) Joseph Peter Torella et al.   PLoS Computational Biology

Murgocil is a Highly Bioactive Staphylococcal-Specific Inhibitor of the Peptidoglycan Glycosyltransferase Enzyme MurG

(2013) Paul A. Mann et al.   ACS Chemical Biology

Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance

(2013) Peter J. Stogios et al.   BIOCHEMICAL JOURNAL

Discovery of Wall Teichoic Acid Inhibitors as Potential Anti-MRSA β-Lactam Combination Agents

(2013) Hao Wang et al.   CHEMISTRY & BIOLOGY

Antibiotic resistance—the need for global solutions

(2013) Ramanan Laxminarayan et al.   LANCET INFECTIOUS DISEASES

Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation

(2013) Soumaya Zlitni et al.   Nature Chemical Biology

Systems-level antimicrobial drug and drug synergy discovery

(2013) Terry Roemer et al.   Nature Chemical Biology

The Efflux Inhibitor Phenylalanine-Arginine Beta-Naphthylamide (PAβN) Permeabilizes the Outer Membrane of Gram-Negative Bacteria

(2013) Ryan P. Lamers et al.   PLoS One

Combination approaches to combat multidrug-resistant bacteria

(2013) Roberta J. Worthington et al.   TRENDS IN BIOTECHNOLOGY

A Forward Chemical Screen Identifies Antibiotic Adjuvants in Escherichia coli

(2012) Patricia L. Taylor et al.   ACS Chemical Biology

Inhibition of WTA Synthesis Blocks the Cooperative Action of PBPs and Sensitizes MRSA to β-Lactams

(2012) Maya A. Farha et al.   ACS Chemical Biology

Functional Repurposing Revealed by Comparing S. pombe and S. cerevisiae Genetic Interactions

(2012) Adam Frost et al.   CELL

Hierarchical Modularity and the Evolution of Genetic Interactomes across Species

(2012) Colm J. Ryan et al.   MOLECULAR CELL

Recover the lost art of drug discovery

(2012) Kim Lewis   NATURE

Automated design of ligands to polypharmacological profiles

(2012) Jérémy Besnard et al.   NATURE

Modulating immunity as a therapy for bacterial infections

(2012) Robert E. W. Hancock et al.   NATURE REVIEWS MICROBIOLOGY

Small Molecule Suppression of Carbapenem Resistance in NDM-1 Producing Klebsiella pneumoniae

(2012) Roberta J. Worthington et al.   ACS Medicinal Chemistry Letters

A Small Molecule Discrimination Map of the Antibiotic Resistance Kinome

(2011) Tushar Shakya et al.   CHEMISTRY & BIOLOGY

Challenges of Antibacterial Discovery

(2011) L. L. Silver   CLINICAL MICROBIOLOGY REVIEWS

Antibiotic adjuvants: multicomponent anti-infective strategies

(2011) Lindsay Kalan et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole

(2011) M. Spitzer et al.   Molecular Systems Biology

Systematic exploration of synergistic drug pairs

(2011) M. Cokol et al.   Molecular Systems Biology

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

(2011) Linda Ejim et al.   Nature Chemical Biology

Inhibition of Bacterial Multidrug Resistance by Celecoxib, a Cyclooxygenase-2 Inhibitor

(2010) Arunasree M. Kalle et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibiotic Sensitivity Profiles Determined with an Escherichia coli Gene Knockout Collection: Generating an Antibiotic Bar Code

(2010) A. Liu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Chemical Synthesis and Biological Screening of 2-Aminoimidazole-Based Bacterial and Fungal Antibiofilm Agents

(2010) Steven A. Rogers et al.   CHEMBIOCHEM

Three Decades of  -Lactamase Inhibitors

(2010) S. M. Drawz et al.   CLINICAL MICROBIOLOGY REVIEWS

Synergy among antibacterial peptides and between peptides and small-molecule antibiotics

(2010) Marco Cassone et al.   Expert Review of Anti-Infective Therapy

Synthetic lethality: General principles, utility and detection using genetic screens in human cells

(2010) Sebastian M.B. Nijman   FEBS LETTERS

Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe

(2010) Dong-Uk Kim et al.   NATURE BIOTECHNOLOGY

Symbiotic streptomycetes provide antibiotic combination prophylaxis for wasp offspring

(2010) Johannes Kroiss et al.   Nature Chemical Biology

Mechanism of recognition of compounds of diverse structures by the multidrug efflux pump AcrB of Escherichia coli

(2010) Y. Takatsuka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genotype to Phenotype: A Complex Problem

(2010) R. D. Dowell et al.   SCIENCE

Systems approaches and algorithms for discovery of combinatorial therapies

(2009) Jacob D. Feala et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology

Accelerated evolution of resistance in multidrug environments

(2008) M. Hegreness et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes

(2008) S. J. Dixon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Virtual Screening and Experimental Verification to Identify Potential Inhibitors of the ErmC Methyltransferase Responsible for Bacterial Resistance against Macrolide Antibiotics

(2007) Marcin Feder et al.   ChemMedChem