CRAGE enables rapid activation of biosynthetic gene clusters in undomesticated bacteria

Combined Approach of Backbone Amide Linking and On-Resin N-Methylation for the Synthesis of Bioactive and Metabolically Stable Peptides

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Engineered integrative and conjugative elements for efficient and inducible DNA transfer to undomesticated bacteria

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Methionine-Containing Rhabdopeptide/Xenortide-like Peptides from Heterologous Expression of the Biosynthetic Gene Cluster kj12ABC in Escherichia coli

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Microbiome-Modulated Metabolites at the Interface of Host Immunity

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Chromosomal position effect influences the heterologous expression of genes and biosynthetic gene clusters in Streptomyces albus J1074

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Commensal bacteria make GPCR ligands that mimic human signalling molecules

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1,003 reference genomes of bacterial and archaeal isolates expand coverage of the tree of life

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A scalable platform to identify fungal secondary metabolites and their gene clusters

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Lateral Gene Transfer Dynamics in the Ancient Bacterial Genus Streptomyces

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Effect of Genomic Integration Location on Heterologous Protein Expression and Metabolic Engineering in E. coli

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The Global Regulators Lrp, LeuO, and HexA Control Secondary Metabolism in Entomopathogenic Bacteria

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Natural product diversity associated with the nematode symbionts Photorhabdus and Xenorhabdus

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Transformation-associated recombination (TAR) cloning for genomics studies and synthetic biology

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Natural Product Discovery through Improved Functional Metagenomics in Streptomyces

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Entomopathogenic bacteria use multiple mechanisms for bioactive peptide library design

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Synthetic biology to access and expand nature's chemical diversity

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A Fast and Practical Yeast Transformation Method Mediated by Escherichia coli Based on a Trans-Kingdom Conjugal Transfer System: Just Mix Two Cultures and Wait One Hour

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Genomic charting of ribosomally synthesized natural product chemical space facilitates targeted mining

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Natural Products and the Gene Cluster Revolution

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Structure Elucidation and Activity of Kolossin A, theD-/L-Pentadecapeptide Product of a Giant Nonribosomal Peptide Synthetase

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Rational and efficient site-directed mutagenesis of adenylation domain alters relative yields of luminmide derivatives in vivo

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Simple “On-Demand” Production of Bioactive Natural Products

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Translating biosynthetic gene clusters into fungal armor and weaponry

(2015) Nancy P Keller   Nature Chemical Biology

Reinvigorating natural product combinatorial biosynthesis with synthetic biology

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Horizontal gene transfer: building the web of life

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Discovery of microbial natural products by activation of silent biosynthetic gene clusters

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antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters

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IMG-ABC: A Knowledge Base To Fuel Discovery of Biosynthetic Gene Clusters and Novel Secondary Metabolites

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Rapid Quantification of Mutant Fitness in Diverse Bacteria by Sequencing Randomly Bar-Coded Transposons

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Yeast Homologous Recombination Cloning Leading to the Novel Peptides Ambactin and Xenolindicin

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Insect-Specific Production of New GameXPeptides inPhotorhabdus luminescensTTO1, Widespread Natural Products in Entomopathogenic Bacteria

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Engineering complex biological systems in bacteria through recombinase-assisted genome engineering

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Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora

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Implementation of stable and complex biological systems through recombinase-assisted genome engineering

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Refactoring the Silent Spectinabilin Gene Cluster Using a Plug-and-Play Scaffold

(2013) Zengyi Shao et al.   ACS Synthetic Biology

Synthesis of szentiamide, a depsipeptide from entomopathogenicXenorhabdus szentirmaiiwith activity againstPlasmodium falciparum

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Quantifying Homologous Replacement of Loci between Haloarchaeal Species

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Luminmycins A–C, Cryptic Natural Products from Photorhabdus luminescens Identified by Heterologous Expression in Escherichia coli

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Production of Cytotoxic Glidobactins/Luminmycins by Photorhabdus asymbiotica in Liquid Media and Live Crickets

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Heterologous expression of a Photorhabdus luminescens syrbactin-like gene cluster results in production of the potent proteasome inhibitor glidobactin A

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Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting

(2012) Jun Fu et al.   NATURE BIOTECHNOLOGY

Microbial life in the phyllosphere

(2012) Julia A. Vorholt   NATURE REVIEWS MICROBIOLOGY

One-shot NMR analysis of microbial secretions identifies highly potent proteasome inhibitor

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An Engineered Microbial Platform for Direct Biofuel Production from Brown Macroalgae

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A Single Promoter Inversion Switches Photorhabdus Between Pathogenic and Mutualistic States

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Improvement of Transformation Efficiency by Strategic Circumvention of Restriction Barriers in Streptomyces griseus

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MZmine 2: Modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data

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Integrating prokaryotes and eukaryotes: DNA transposases in light of structure

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Integrative and conjugative elements: mosaic mobile genetic elements enabling dynamic lateral gene flow

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Entomopathogenic bacteria as a source of secondary metabolites

(2009) Helge B Bode   CURRENT OPINION IN CHEMICAL BIOLOGY

Dre recombinase, like Cre, is a highly efficient site-specific recombinase in E. coli, mammalian cells and mice

(2009) K. Anastassiadis et al.   Disease Models & Mechanisms

Redesigning Enzymes Based on Adaptive Evolution for Optimal Function in Synthetic Metabolic Pathways

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