Recent Advances in Anti-virulence Therapeutic Strategies With a Focus on Dismantling Bacterial Membrane Microdomains, Toxin Neutralization, Quorum-Sensing Interference and Biofilm Inhibition

Development of Molecularly Imprinted Polymers To Block Quorum Sensing and Inhibit Bacterial Biofilm Formation

(2018) Luyao Ma et al.   ACS Applied Materials & Interfaces

Neutralizing Alpha-Toxin Accelerates Healing of Staphylococcus aureus -Infected Wounds in Nondiabetic and Diabetic Mice

(2018) Roger V. Ortines et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro and In Vivo Activity of Peptidomimetic Compounds That Target the Periodontal Pathogen Porphyromonas gingivalis

(2018) Jinlian Tan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of biofilm formation by chemical uncoupler, 3, 3′, 4′, 5-tetrachlorosalicylanilide (TCS): From the perspective of quorum sensing and biofilm related genes

(2018) Xiaochi Feng et al.   BIOCHEMICAL ENGINEERING JOURNAL

α-Toxin Induces Platelet Aggregation and Liver Injury during Staphylococcus aureus Sepsis

(2018) Bas G.J. Surewaard et al.   Cell Host & Microbe

Lactam hybrid analogues of solonamide B and autoinducing peptides as potent S. aureus AgrC antagonists

(2018) Anna Mette Hansen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Subinhibitory Concentrations of Prim-O-Glucosylcimifugin Decrease the Expression of Alpha-Hemolysin in Staphylococcus aureus (USA300)

(2018) Ouyang Ping et al.   Evidence-based Complementary and Alternative Medicine

Enzymatic dispersal of dual-species biofilms carrying Listeria monocytogenes and other associated food industry bacteria

(2018) C.H. Puga et al.   FOOD CONTROL

Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin Disease

(2018) Mara Baldry et al.   JOURNAL OF INFECTIOUS DISEASES

Exploring the impact of parthenolide as anti-quorum sensing and anti-biofilm agent against Pseudomonas aeruginosa

(2018) Manmohit Kalia et al.   LIFE SCIENCES

In Silico and in Vitro-Guided Identification of Inhibitors of Alkylquinolone-Dependent Quorum Sensing in Pseudomonas aeruginosa

(2018) Fadi Soukarieh et al.   MOLECULES

Protein-mediated anti-adhesion surface against oral bacteria

(2018) Xi Liu et al.   Nanoscale

Quorum-Sensing Systems as Targets for Antivirulence Therapy

(2018) Tom Defoirdt   TRENDS IN MICROBIOLOGY

Staphylococcus aureus and Atopic Dermatitis: A Complex and Evolving Relationship

(2018) Joan A. Geoghegan et al.   TRENDS IN MICROBIOLOGY

Eriodictyol protects against Staphylococcus aureus-induced lung cell injury by inhibiting alpha-hemolysin expression

(2018) He Xuewen et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

A Biofilm Matrix-Associated Protease Inhibitor Protects Pseudomonas aeruginosa from Proteolytic Attack

(2018) Boo Shan Tseng et al.   mBio

Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform

(2018) Xiaogang Wang et al.   Nature Communications

Designer cells programming quorum-sensing interference with microbes

(2018) Ferdinand Sedlmayer et al.   Nature Communications

Linear peptidomimetics as potent antagonists of Staphylococcus aureus agr quorum sensing

(2018) Georgia Karathanasi et al.   Scientific Reports

Characterization of AiiK, an AHL lactonase, from Kurthia huakui LAM0618T and its application in quorum quenching on Pseudomonas aeruginosa PAO1

(2018) Weiwei Dong et al.   Scientific Reports

Terrein is an inhibitor of quorum sensing and c-di-GMP in Pseudomonas aeruginosa: a connection between quorum sensing and c-di-GMP

(2018) Bomin Kim et al.   Scientific Reports

Combination Therapy Strategy of Quorum Quenching Enzyme and Quorum Sensing Inhibitor in Suppressing Multiple Quorum Sensing Pathways of P. aeruginosa

(2018) July Fong et al.   Scientific Reports

PvdQ Quorum Quenching Acylase Attenuates Pseudomonas aeruginosa Virulence in a Mouse Model of Pulmonary Infection

(2018) Putri D. Utari et al.   Frontiers in Cellular and Infection Microbiology

A Small Molecule-Screening Pipeline to Evaluate the Therapeutic Potential of 2-Aminoimidazole Molecules Against Clostridium difficile

(2018) Rajani Thanissery et al.   Frontiers in Microbiology

Quorum Sensing-Regulated Phenol-Soluble Modulins Limit Persister Cell Populations in Staphylococcus aureus

(2018) Martin S. Bojer et al.   Frontiers in Microbiology

Oral Biofilm Formation on Different Materials for Dental Implants

(2018) Thalisson S. O. Silva et al.   Jove-Journal of Visualized Experiments

Receptor-Based Peptides for Inhibition of Leukotoxin Activity

(2018) Eric Krueger et al.   ACS Infectious Diseases

Enzyme targets for drug design of new anti-virulence therapeutics

(2018) Charlene M Kahler et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Impact of endotracheal tube biofilm and respiratory secretions on airway resistance and mechanics of breathing in a neonatal lung model

(2018) Kaitlin M. Kenaley et al.   JOURNAL OF APPLIED PHYSIOLOGY

Propolis potentiates the effect of cranberry (Vaccinium macrocarpon) in reducing the motility and the biofilm formation of uropathogenic Escherichia coli

(2018) Jérémy Ranfaing et al.   PLoS One

2-Aminobenzimidazoles as antibiofilm agents against Salmonella enterica serovar Typhimurium

(2018) William M. Huggins et al.   MedChemComm

Structural and Biochemical Characterization of AaL, a Quorum Quenching Lactonase with Unusual Kinetic Properties

(2018) Celine Bergonzi et al.   Scientific Reports

Small-molecule AgrA inhibitors F12 and F19 act as antivirulence agents against Gram-positive pathogens

(2018) Michael Greenberg et al.   Scientific Reports

Coumarin Reduces Virulence and Biofilm Formation in Pseudomonas aeruginosa by Affecting Quorum Sensing, Type III Secretion and C-di-GMP Levels

(2018) Yunhui Zhang et al.   Frontiers in Microbiology

Subinhibitory concentrations of resveratrol reduce alpha-hemolysin production in Staphylococcus aureus isolates by downregulating saeRS

(2018) Jingjing Duan et al.   Emerging Microbes & Infections

Inhibition of Lipopolysaccharide- and Lipoprotein-Induced Inflammation by Antitoxin Peptide Pep19-2.5

(2018) Lena Heinbockel et al.   Frontiers in Immunology

Targeting the Pseudomonas quinolone signal quorum sensing system for the discovery of novel anti-infective pathoblockers

(2018) Christian Schütz et al.   Beilstein Journal of Organic Chemistry

Catechin-mediated restructuring of a bacterial toxin inhibits activity

(2018) En Hyung Chang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Quorum sensing inhibitors as antipathogens: biotechnological applications

(2018) Vipin Chandra Kalia et al.   BIOTECHNOLOGY ADVANCES

Identification of a Small Molecule Anti-biofilm Agent Against Salmonella enterica

(2018) Jasmine Moshiri et al.   Frontiers in Microbiology

Inhibition of alpha-hemolysin expression by resveratrol attenuates Staphylococcus aureus virulence

(2018) Feng Tang et al.   MICROBIAL PATHOGENESIS

Flavonoids SuppressPseudomonas aeruginosaVirulence through Allosteric Inhibition of Quorum-sensing Receptors

(2017) Jon E. Paczkowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting of Streptococcus mutans Biofilms by a Novel Small Molecule Prevents Dental Caries and Preserves the Oral Microbiome

(2017) S.S. Garcia et al.   JOURNAL OF DENTAL RESEARCH

CRISPR-based genome editing of clinically important Escherichia coli SE15 isolated from indwelling urinary catheters of patients

(2017) Sangrim Kang et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Sclareol Protects Staphylococcus aureus-Induced Lung Cell Injury via Inhibiting Alpha-Hemolysin Expression

(2017) Ping Ouyang et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Reducing Virulence and Biofilm of Pseudomonas aeruginosa by Potential Quorum Sensing Inhibitor Carotenoid: Zeaxanthin

(2017) Barış Gökalsın et al.   MICROBIAL ECOLOGY

Inhibition of quorum sensing-controlled biofilm formation in Pseudomonas aeruginosa by quorum-sensing inhibitors

(2017) Ellappan Kalaiarasan et al.   MICROBIAL PATHOGENESIS

Discovery of potent inhibitors targeting Vibrio harveyi LuxR through shape and e-pharmacophore based virtual screening and its biological evaluation

(2017) Sundaraj Rajamanikandan et al.   MICROBIAL PATHOGENESIS

Inhibition of quorum sensing related virulence factors of Pseudomonas aeruginosa by pyridoxal lactohydrazone

(2017) Azam Heidari et al.   MICROBIAL PATHOGENESIS

Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance

(2017) Seth W. Dickey et al.   NATURE REVIEWS DRUG DISCOVERY

aBiofilm: a resource of anti-biofilm agents and their potential implications in targeting antibiotic drug resistance

(2017) Akanksha Rajput et al.   NUCLEIC ACIDS RESEARCH

Pharmacological Targeting of the Host–Pathogen Interaction: Alternatives to Classical Antibiotics to Combat Drug-Resistant Superbugs

(2017) Jason Munguia et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Pseudomonas aeruginosa Alters Staphylococcus aureus Sensitivity to Vancomycin in a Biofilm Model of Cystic Fibrosis Infection

(2017) Giulia Orazi et al.   mBio

Tuning of the Lethal Response to Multiple Stressors with a Single-Site Mutation during Clinical Infection by Staphylococcus aureus

(2017) Krishan Kumar et al.   mBio

Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models

(2017) In Young Hwang et al.   Nature Communications

VLP-based vaccine induces immune control of Staphylococcus aureus virulence regulation

(2017) Seth M. Daly et al.   Scientific Reports

Pseudomonas aeruginosa exoproducts determine antibiotic efficacy against Staphylococcus aureus

(2017) Lauren Radlinski et al.   PLOS BIOLOGY

Flotillin scaffold activity contributes to type VII secretion system assembly in Staphylococcus aureus

(2017) Benjamin Mielich-Süss et al.   PLoS Pathogens

Bacterial toxins: Offensive, defensive, or something else altogether?

(2017) Justine K. Rudkin et al.   PLoS Pathogens

Activity of Bacteriophages in Removing Biofilms of Pseudomonas aeruginosa Isolates from Chronic Rhinosinusitis Patients

(2017) Stephanie A. Fong et al.   Frontiers in Cellular and Infection Microbiology

CRISPR Interference (CRISPRi) Inhibition of luxS Gene Expression in E. coli: An Approach to Inhibit Biofilm

(2017) Azna Zuberi et al.   Frontiers in Cellular and Infection Microbiology

Chalcone Attenuates Staphylococcus aureus Virulence by Targeting Sortase A and Alpha-Hemolysin

(2017) Bing Zhang et al.   Frontiers in Microbiology

Kaempferol Inhibits the Primary Attachment Phase of Biofilm Formation in Staphylococcus aureus

(2017) Di Ming et al.   Frontiers in Microbiology

Aii810, a Novel Cold-Adapted N-Acylhomoserine Lactonase Discovered in a Metagenome, Can Strongly Attenuate Pseudomonas aeruginosa Virulence Factors and Biofilm Formation

(2017) Xinjiong Fan et al.   Frontiers in Microbiology

Mycobacterium abscessus subsp. abscessus Is Capable of Degrading Pseudomonas aeruginosa Quinolone Signals

(2017) Franziska S. Birmes et al.   Frontiers in Microbiology

In-depth Profiling of MvfR-Regulated Small Molecules in Pseudomonas aeruginosa after Quorum Sensing Inhibitor Treatment

(2017) Giuseppe Allegretta et al.   Frontiers in Microbiology

Effect of Quorum Quenching Lactonase in Clinical Isolates of Pseudomonas aeruginosa and Comparison with Quorum Sensing Inhibitors

(2017) Assia Guendouze et al.   Frontiers in Microbiology

Statins: antimicrobial resistance breakers or makers?

(2017) Humphrey H.T. Ko et al.   PeerJ

Pitfalls associated with evaluating enzymatic quorum quenching activity: the case of MomL and its effect on Pseudomonas aeruginosa and Acinetobacter baumannii biofilms

(2017) Yunhui Zhang et al.   PeerJ

Pseudomonas aeruginosa LasR·DNA Binding Is Directly Inhibited by Quorum Sensing Antagonists

(2017) Emma G. Suneby et al.   ACS Infectious Diseases

Quorum sensing network in clinical strains of A. baumannii: AidA is a new quorum quenching enzyme

(2017) María López et al.   PLoS One

Application of Dual Inhibition Concept within Looped Autoregulatory Systems toward Antivirulence Agents against Pseudomonas aeruginosa Infections

(2016) Andreas Thomann et al.   ACS Chemical Biology

Structure–Function Analyses of a Staphylococcus epidermidis Autoinducing Peptide Reveals Motifs Critical for AgrC-type Receptor Modulation

(2016) Tian Yang et al.   ACS Chemical Biology

Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in Pseudomonas aeruginosa

(2016) Cheng Ji et al.   ACS Chemical Biology

Critical Role of Alpha-Toxin and Protective Effects of Its Neutralization by a Human Antibody in Acute Bacterial Skin and Skin Structure Infections

(2016) Vien T. M. Le et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular Docking, Molecular Dynamics Simulations, Computational Screening to Design Quorum Sensing Inhibitors Targeting LuxP of Vibrio harveyi and Its Biological Evaluation

(2016) Sundaraj Rajamanikandan et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Penicillin V acylases from gram-negative bacteria degrade N-acylhomoserine lactones and attenuate virulence in Pseudomonas aeruginosa

(2016) Avinash Vellore Sunder et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

1,2,3-Triazole-based inhibitors of Porphyromonas gingivalis adherence to oral streptococci and biofilm formation

(2016) Pravin C. Patil et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Fine-Tuning Covalent Inhibition of Bacterial Quorum Sensing

(2016) Neri Amara et al.   CHEMBIOCHEM

Auto Poisoning of the Respiratory Chain by a Quorum-Sensing-Regulated Molecule Favors Biofilm Formation and Antibiotic Tolerance

(2016) Ronen Hazan et al.   CURRENT BIOLOGY

Considerations and caveats in anti-virulence drug development

(2016) Damien Maura et al.   CURRENT OPINION IN MICROBIOLOGY

Antisense locked nucleic acids targetingagrAinhibit quorum sensing and pathogenesis of community-associated methicillin-resistantStaphylococcus aureus

(2016) F. Da et al.   JOURNAL OF APPLIED MICROBIOLOGY

What's on the Outside Matters: The Role of the Extracellular Polymeric Substance of Gram-negative Biofilms in Evading Host Immunity and as a Target for Therapeutic Intervention

(2016) John S. Gunn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PqsBC, a Condensing Enzyme in the Biosynthesis of thePseudomonas aeruginosaQuinolone Signal

(2016) Steffen Lorenz Drees et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Implementation of Rapid Molecular Infectious Disease Diagnostics: the Role of Diagnostic and Antimicrobial Stewardship

(2016) Kevin Messacar et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Truncated Autoinducing Peptides as Antagonists of Staphylococcus lugdunensis Quorum Sensing

(2016) Christopher P. Gordon et al.   JOURNAL OF MEDICINAL CHEMISTRY

Context matters: The importance of dimerization-induced conformation of the LukGH leukocidin of Staphylococcus aureus for the generation of neutralizing antibodies

(2016) Adriana Badarau et al.   mAbs

Inhibitory effects of antibiofilm compound 1 againstStaphylococcus aureusbiofilms

(2016) Looniva Shrestha et al.   MICROBIOLOGY AND IMMUNOLOGY

Biofilms: an emergent form of bacterial life

(2016) Hans-Curt Flemming et al.   NATURE REVIEWS MICROBIOLOGY

Quorum sensing signal–response systems in Gram-negative bacteria

(2016) Kai Papenfort et al.   NATURE REVIEWS MICROBIOLOGY

Evaluation of ethyl N-(2-phenethyl) carbamate analogues as biofilm inhibitors of methicillin resistant Staphylococcus aureus

(2016) Matthew D. Stephens et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

New frontiers for anti-biofilm drug development

(2016) Suzana M. Ribeiro et al.   PHARMACOLOGY & THERAPEUTICS

Bacterial strategies of resistance to antimicrobial peptides

(2016) Hwang-Soo Joo et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The agr Inhibitors Solonamide B and Analogues Alter Immune Responses to Staphylococccus aureus but Do Not Exhibit Adverse Effects on Immune Cell Functions

(2016) Mara Baldry et al.   PLoS One

IVIG-mediated protection against necrotizing pneumonia caused by MRSA

(2016) Binh An Diep et al.   Science Translational Medicine

Staphylococcus aureus α toxin potentiates opportunistic bacterial lung infections

(2016) Taylor S. Cohen et al.   Science Translational Medicine

Dracorhodin Perochlorate attenuates Staphylococcus aureus USA300 virulence by decreasing α-toxin expression

(2016) Yumin Liu et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Discovery of new diketopiperazines inhibiting Burkholderia cenocepacia quorum sensing in vitro and in vivo

(2016) Viola C. Scoffone et al.   Scientific Reports

Targeting Staphylococcus aureus Toxins: A Potential form of Anti-Virulence Therapy

(2016) Cin Kong et al.   Toxins

Is Quorum Sensing Interference a Viable Alternative to Treat Pseudomonas aeruginosa Infections?

(2016) Rodolfo García-Contreras   Frontiers in Microbiology

The SaeRS Two‐Component System of Staphylococcus aureus

(2016) Qian Liu et al.   Genes

The role of 2,4-dihydroxyquinoline (DHQ) inPseudomonas aeruginosapathogenicity

(2016) Jordon D. Gruber et al.   PeerJ

Plasmid transfer in biofilms: a perspective on limitations and opportunities

(2016) Thibault Stalder et al.   npj Biofilms and Microbiomes

Quorum-Quenching and Matrix-Degrading Enzymes in Multilayer Coatings Synergistically Prevent Bacterial Biofilm Formation on Urinary Catheters

(2015) Kristina Ivanova et al.   ACS Applied Materials & Interfaces

Engineered nanoparticles mimicking cell membranes for toxin neutralization

(2015) Ronnie H. Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

Ultrashort Antimicrobial Peptides with Antiendotoxin Properties

(2015) Ya-Han Chih et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

ω-Hydroxyemodin Limits Staphylococcus aureus Quorum Sensing-Mediated Pathogenesis and Inflammation

(2015) Seth M. Daly et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Rhodococcus erythropolis BG43 Genes Mediating Pseudomonas aeruginosa Quinolone Signal Degradation and Virulence Factor Attenuation

(2015) Christine Müller et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Retrocyclins neutralize bacterial toxins by potentiating their unfolding

(2015) Elena Kudryashova et al.   BIOCHEMICAL JOURNAL

Defensive remodeling: How bacterial surface properties and biofilm formation promote resistance to antimicrobial peptides

(2015) Reut Nuri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Synthesis, quorum sensing inhibition and docking studies of 1,5-dihydropyrrol-2-ones

(2015) Wai-Kean Goh et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of 4-(alkyloxy)-6-methyl-2H-pyran-2-one derivatives as quorum sensing inhibitors

(2015) Suzie Park et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting virulence not viability in the search for future antibacterials

(2015) Begoña Heras et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Synergistic Action of Staphylococcus aureus α-Toxin on Platelets and Myeloid Lineage Cells Contributes to Lethal Sepsis

(2015) Michael E. Powers et al.   Cell Host & Microbe

Potent and Selective Modulation of the RhlR Quorum Sensing Receptor by Using Non-native Ligands: An Emerging Target for Virulence Control inPseudomonas aeruginosa

(2015) Nora R. Eibergen et al.   CHEMBIOCHEM

Small Molecule Inhibitors of Clostridium difficile Toxin B-Induced Cellular Damage

(2015) John Tam et al.   CHEMISTRY & BIOLOGY

Catechol-based substrates of chalcone synthase as a scaffold for novel inhibitors of PqsD

(2015) Giuseppe Allegretta et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Exploring the chemical space of ureidothiophene-2-carboxylic acids as inhibitors of the quorum sensing enzyme PqsD from Pseudomonas aeruginosa

(2015) J. Henning Sahner et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Investigational therapies targeting quorum-sensing for the treatment ofStaphylococcus aureusinfections

(2015) Burhan A Khan et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Zingerone silences quorum sensing and attenuates virulence of Pseudomonas aeruginosa

(2015) Lokender Kumar et al.   FITOTERAPIA

Exploration of Modulated Genetic Circuits Governing Virulence Determinants in Staphylococcus aureus

(2015) Rekha Arya et al.   INDIAN JOURNAL OF MICROBIOLOGY

Potential Emergence of Multi-quorum Sensing Inhibitor Resistant (MQSIR) Bacteria

(2015) Shikha Koul et al.   INDIAN JOURNAL OF MICROBIOLOGY

Neutralization of Clostridium difficile Toxin B Mediated by Engineered Lactobacilli That Produce Single-Domain Antibodies

(2015) Kasper Krogh Andersen et al.   INFECTION AND IMMUNITY

A new small molecule inhibitsStreptococcus mutansbiofilmsin vitroandin vivo

(2015) W. Pan et al.   JOURNAL OF APPLIED MICROBIOLOGY

Quorum quenching enzymes

(2015) Susanne Fetzner   JOURNAL OF BIOTECHNOLOGY

Pseudomonas aeruginosa Biofilm Infections: Community Structure, Antimicrobial Tolerance and Immune Response

(2015) Morten Rybtke et al.   JOURNAL OF MOLECULAR BIOLOGY

Small Molecule Disruption of Quorum Sensing Cross-Regulation in Pseudomonas aeruginosa Causes Major and Unexpected Alterations to Virulence Phenotypes

(2015) Michael A. Welsh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novel Linear Polymers Able to Inhibit Bacterial Quorum Sensing

(2015) Eliana Cavaleiro PhD et al.   MACROMOLECULAR BIOSCIENCE

Exploring the Existence of Lipid Rafts in Bacteria

(2015) Marc Bramkamp et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Hybrids of acylated homoserine lactone and nitric oxide donors as inhibitors of quorum sensing and virulence factors in Pseudomonas aeruginosa

(2015) Samuel K. Kutty et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Differential Expression and Roles of Staphylococcus aureus Virulence Determinants during Colonization and Disease

(2015) Amy Jenkins et al.   mBio

Campylobacter jejuni biofilms contain extracellular DNA and are sensitive to DNase I treatment

(2015) Helen L. Brown et al.   Frontiers in Microbiology

High variability in quorum quenching and growth inhibition by furanone C-30 inPseudomonas aeruginosaclinical isolates from cystic fibrosis patients

(2015) Rodolfo García-Contreras et al.   Pathogens and Disease

Structure-Based Design and Biological Evaluation of Triphenyl Scaffold-Based Hybrid Compounds as Hydrolytically Stable Modulators of a LuxR-Type Quorum Sensing Receptor

(2015) Matthew C. O’Reilly et al.   ACS Infectious Diseases

Biosynthesis of Squalene from Farnesyl Diphosphate in Bacteria: Three Steps Catalyzed by Three Enzymes

(2015) Jian-Jung Pan et al.   ACS Central Science

A novel bacteriophage cocktail reduces and dispersesPseudomonas aeruginosabiofilms under static and flow conditions

(2015) Diana R. Alves et al.   Microbial Biotechnology

Metabolic plasticity for isoprenoid biosynthesis in bacteria: Figure 1

(2015) Jordi Pérez-Gil et al.   BIOCHEMICAL JOURNAL

Castanea sativa (European Chestnut) Leaf Extracts Rich in Ursene and Oleanene Derivatives Block Staphylococcus aureus Virulence and Pathogenesis without Detectable Resistance

(2015) Cassandra L. Quave et al.   PLoS One

The Small Molecule DAM Inhibitor, Pyrimidinedione, Disrupts Streptococcus pneumoniae Biofilm Growth In Vitro

(2015) Mukesh Kumar Yadav et al.   PLoS One

Mechanistic analysis of a synthetic inhibitor of the Pseudomonas aeruginosa LasI quorum-sensing signal synthase

(2015) O. Lidor et al.   Scientific Reports

Inhibition of Salmonella enterica Biofilm Formation Using Small-Molecule Adenosine Mimetics

(2014) Jacob A. Koopman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

MomL, a Novel Marine-DerivedN-Acyl Homoserine Lactonase from Muricauda olearia

(2014) Kaihao Tang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Structural and Functional Analysis of Bacillus subtilis YisP Reveals a Role of Its Product in Biofilm Production

(2014) Xinxin Feng et al.   CHEMISTRY & BIOLOGY

Benzamidobenzoic acids as potent PqsD inhibitors for the treatment of Pseudomonas aeruginosa infections

(2014) Stefan Hinsberger et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Five birds, one stone: Neutralization of α-hemolysin and 4 bi-component leukocidins ofStaphylococcus aureuswith a single human monoclonal antibody

(2014) Harald Rouha et al.   mAbs

Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice

(2014) Brian D Henry et al.   NATURE BIOTECHNOLOGY

Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases

(2014) Robert J Citorik et al.   NATURE BIOTECHNOLOGY

Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials

(2014) David Bikard et al.   NATURE BIOTECHNOLOGY

Coumarins reduce biofilm formation and the virulence of Escherichia coli O157:H7

(2014) Jin-Hyung Lee et al.   PHYTOMEDICINE

Impact of Campylobacter jejuni cj0268c Knockout Mutation on Intestinal Colonization, Translocation, and Induction of Immunopathology in Gnotobiotic IL-10 Deficient Mice

(2014) Markus M. Heimesaat et al.   PLoS One

Inhaled Lactonase Reduces Pseudomonas aeruginosa Quorum Sensing and Mortality in Rat Pneumonia

(2014) Sami Hraiech et al.   PLoS One

Development of a Mimotope Vaccine Targeting the Staphylococcus aureus Quorum Sensing Pathway

(2014) John P. O’Rourke et al.   PLoS One

Selective Chemical Inhibition of agr Quorum Sensing in Staphylococcus aureus Promotes Host Defense with Minimal Impact on Resistance

(2014) Erin K. Sully et al.   PLoS Pathogens

The hierarchy quorum sensing network in Pseudomonas aeruginosa

(2014) Jasmine Lee et al.   Protein & Cell

The Increasingly Complex Mechanism of HMG-CoA Reductase

(2013) Brandon E. Haines et al.   ACCOUNTS OF CHEMICAL RESEARCH

Efficacy of AiiM, anN-Acylhomoserine Lactonase, against Pseudomonas aeruginosa in a Mouse Model of Acute Pneumonia

(2013) Yohei Migiyama et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

High-Sensitivity Monoclonal Antibodies Specific for Homoserine Lactones Protect Mice from Lethal Pseudomonas aeruginosa Infections

(2013) Soumya Palliyil et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The End of an Old Hypothesis: The Pseudomonas Signaling Molecules 4-Hydroxy-2-Alkylquinolines Derive from Fatty Acids, Not 3-Ketofatty Acids

(2013) Carlos Eduardo Dulcey et al.   CHEMISTRY & BIOLOGY

The Role of Innate Immunity in Promoting SaeR/S-Mediated Virulence in Staphylococcus aureus

(2013) Oliwia W. Zurek et al.   Journal of Innate Immunity

Exploiting Quorum Sensing To Confuse Bacterial Pathogens

(2013) B. LaSarre et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Flotillins functionally organize the bacterial membrane

(2013) Juri Niño Bach et al.   MOLECULAR MICROBIOLOGY

A Quorum Sensing Small Volatile Molecule Promotes Antibiotic Tolerance in Bacteria

(2013) Yok-Ai Que et al.   PLoS One

The Campylobacter jejuni Cj0268c Protein Is Required for Adhesion and Invasion In Vitro

(2013) A. Malik Tareen et al.   PLoS One

A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation

(2013) C. T. O'Loughlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resistance to the quorum-quenching compounds brominated furanone C-30 and 5-fluorouracil inPseudomonas aeruginosaclinical isolates

(2013) Rodolfo García-Contreras et al.   Pathogens and Disease

Nosocomial outbreak of carbapenem-resistant Enterobacter cloacae highlighting the interspecies transferability of the blaOXA-48 gene in the gut flora

(2012) L. Cremet et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Strain-Specific Transfer of Antibiotic Resistance from an Environmental Plasmid to Foodborne Pathogens

(2012) Eva Van Meervenne et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Structure-Based Design and Screen of Novel Inhibitors for Class II 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase from Streptococcus Pneumoniae

(2012) Ding Li et al.   Journal of Chemical Information and Modeling

Lipopolysaccharide Neutralization by Antimicrobial Peptides: A Gambit in the Innate Host Defense Strategy

(2012) David Pulido et al.   Journal of Innate Immunity

Validation of PqsD as an Anti-biofilm Target in Pseudomonas aeruginosa by Development of Small-Molecule Inhibitors

(2012) Michael P. Storz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Isoprenoid biosynthesis in bacterial pathogens

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