Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages

Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation

(2016) Ming-Yu Wu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain

(2016) Margherita Brindisi et al.   JOURNAL OF MEDICINAL CHEMISTRY

In silico study of subtilisin-like protease 1 (SUB1) from different Plasmodium species in complex with peptidyl-difluorostatones and characterization of potent pan-SUB1 inhibitors

(2016) Simone Brogi et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

PE_PGRS33 Contributes to Mycobacterium tuberculosis Entry in Macrophages through Interaction with TLR2

(2016) Ivana Palucci et al.   PLoS One

Development of HuperTacrines as Non-Toxic, Cholinesterase Inhibitors for the Potential Treatment of Alzheimer’s Disease

(2015) Mourad Chioua et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Synthetic spirocyclic endoperoxides: new antimalarial scaffolds

(2015) Margherita Brindisi et al.   MedChemComm

8-Hydroxyquinoline: a privileged structure with a broad-ranging pharmacological potential

(2015) Yu'ning Song et al.   MedChemComm

Discovery and Cardioprotective Effects of the First Non-Peptide Agonists of the G Protein-Coupled Prokineticin Receptor-1

(2015) Adeline Gasser et al.   PLoS One

Rational design of the first difluorostatone-based PfSUB1 inhibitors

(2014) Simone Giovani et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor

(2014) Mattia Mori et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Delamanid: A Review of Its Use in Patients with Multidrug-Resistant Tuberculosis

(2014) Hannah A. Blair et al.   DRUGS

Management of patients with multidrug-resistant/extensively drug-resistant tuberculosis in Europe: a TBNET consensus statement

(2014) C. Lange et al.   EUROPEAN RESPIRATORY JOURNAL

Targeting Dopamine D3 and Serotonin 5-HT1A and 5-HT2A Receptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies

(2014) Margherita Brindisi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bedaquiline: A Novel Antitubercular Agent for the Treatment of Multidrug-Resistant Tuberculosis

(2014) Marylee V. Worley et al.   PHARMACOTHERAPY

Virulence factors of theMycobacterium tuberculosiscomplex

(2013) Marina A. Forrellad et al.   Virulence

Functional dissection of protein domains involved in the immunomodulatory properties of PE_PGRS33 ofMycobacterium tuberculosis

(2013) Antonella Zumbo et al.   Pathogens and Disease

Functional characterization of the Mycobacterium tuberculosis zinc metallopeptidase Zmp1 and identification of potential substrates

(2012) Agnese Petrera et al.   BIOLOGICAL CHEMISTRY

Approach for detecting mutagenicity of biodegraded and ozonated pharmaceuticals, metabolites and transformation products from a drinking water perspective

(2012) Stefan Gartiser et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

The mutagenic, DNA-damaging and antioxidative properties of bark and leaf extracts from Coutarea hexandra (Jacq.) K. Schum

(2011) Líria Granato Nunes et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Crystal Structure ofMycobacterium tuberculosisZinc-dependent Metalloprotease-1 (Zmp1), a Metalloprotease Involved in Pathogenicity

(2011) Davide M. Ferraris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

(2011) Diego Sbardella et al.   MOLECULAR ASPECTS OF MEDICINE

Mycobacterium tuberculosis Rv0198c, a putative matrix metalloprotease is involved in pathogenicity

(2011) D.G. Niranjala Muttucumaru et al.   TUBERCULOSIS

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

(2010) Jonathan B. Baell et al.   JOURNAL OF MEDICINAL CHEMISTRY

To bind zinc or not to bind zinc: An examination of innovative approaches to improved metalloproteinase inhibition

(2009) Jennifer A. Jacobsen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Extension of QM/MM docking and its applications to metalloproteins

(2009) Art E. Cho et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Linking Inflammasome Activation and Phagosome Maturation

(2008) Vanja Lazarevic et al.   Cell Host & Microbe

Mycobacterium tuberculosis Prevents Inflammasome Activation

(2008) Sharon S. Master et al.   Cell Host & Microbe