Large-scale preparation of key building blocks for the manufacture of fully synthetic macrolide antibiotics

A platform for the discovery of new macrolide antibiotics

(2016) Ian B. Seiple et al.   NATURE

An Efficient Directed Claisen Reaction Allows for Rapid Construction of 5,6-Disubstituted 1,3-Dioxin-4-ones

(2015) Andrew Myers et al.   SYNTHESIS-STUTTGART

Stereocontrolled Synthesis ofsyn-β-Hydroxy-α-Amino Acids by Direct Aldolization of Pseudoephenamine Glycinamide

(2014) Ian B. Seiple et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure-Activity Relationships and Mechanism of Action of Macrolides Derived from Erythromycin as Antibacterial Agents

(2013) Jian-Hua Liang et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Practical Asymmetric Synthesis of a Chiral Piperazinone Derivative

(2013) Mark McLaughlin et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Pseudoephenamine: A Practical Chiral Auxiliary for Asymmetric Synthesis

(2012) Marvin R. Morales et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dynamic kinetic resolution in the stereoselective synthesis of 4,5-diaryl cyclic sulfamidates by using chiral rhodium-catalyzed asymmetric transfer hydrogenation

(2011) Juae Han et al.   CHEMICAL COMMUNICATIONS

CEM-101, a novel fluoroketolide: antimicrobial activity against a diverse collection of Gram-positive and Gram-negative bacteria

(2009) Shannon D. Putnam et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Lithium Diisopropylamide-Mediated Ortholithiations: Lithium Chloride Catalysis

(2009) Lekha Gupta et al.   JOURNAL OF ORGANIC CHEMISTRY

Streptococcus pneumoniae: Does Antimicrobial Resistance Matter?

(2009) Joseph Lynch et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE