Amidochelocardin Overcomes Resistance Mechanisms Exerted on Tetracyclines and Natural Chelocardin

Over-expression of RamA, which regulates production of the MDR efflux pump AcrAB-TolC, increases mutation rate and influences drug-resistance phenotype.

(2020) Elizabeth M. Grimsey et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

(2020) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Mechanism of Eravacycline Resistance in Clinical Enterococcus faecalis Isolates From China

(2020) Zewen Wen et al.   Frontiers in Microbiology

Eravacycline susceptibility was impacted by genetic mutation of 30S ribosome subunits, and branched-chain amino acid transport system II carrier protein, Na/Pi cotransporter family protein in Staphylococcus aureus

(2020) Zhanwen Wang et al.   BMC MICROBIOLOGY

The Clinical Significance of High Antimicrobial Resistance in Community-Acquired Urinary Tract Infections

(2020) Maria G. Zavala-Cerna et al.   Canadian Journal of Infectious Diseases & Medical Microbiology

Mechanism of eravacycline resistance in Acinetobacter baumannii mediated by a deletion mutation in the sensor kinase adeS, leading to elevated expression of the efflux pump AdeABC

(2020) Yue Shi et al.   INFECTION GENETICS AND EVOLUTION

Tetracycline-inactivating enzymes from environmental, human commensal, and pathogenic bacteria cause broad-spectrum tetracycline resistance

(2020) Andrew J. Gasparrini et al.   Communications Biology

Engineering Atypical Tetracycline Formation in Amycolatopsis sulphurea for the Production of Modified Chelocardin Antibiotics

(2019) Tadeja Lukežič et al.   ACS Chemical Biology

Omadacycline: a novel aminomethylcycline

(2019) Rodrigo M Burgos et al.   Infection and Drug Resistance

Antibiotics: past, present and future

(2019) Matthew I Hutchings et al.   CURRENT OPINION IN MICROBIOLOGY

In vitro Activity and Heteroresistance of Omadacycline Against Clinical Staphylococcus aureus Isolates From China Reveal the Impact of Omadacycline Susceptibility by Branched-Chain Amino Acid Transport System II Carrier Protein, Na/Pi Cotransporter Family Protein, and Fibronectin-Binding Protein

(2019) Bing Bai et al.   Frontiers in Microbiology

Semisynthesis and biological evaluation of amidochelocardin derivatives as broad-spectrum antibiotics

(2019) Charlotte Grandclaudon et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Tetracycline-Inactivating Enzymes

(2018) Jana L. Markley et al.   Frontiers in Microbiology

Fluoroquinolone Restriction as an Effective Antimicrobial Stewardship Intervention

(2018) Kimberly C. Claeys et al.   Current Infectious Disease Reports

The pSG5-based thermosensitive vector family for genome editing and gene expression in actinomycetes

(2018) Günther Muth   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Urinary Tract Infections

(2018) Rachel Millner et al.   PEDIATRIC CLINICS OF NORTH AMERICA

ABySS 2.0: resource-efficient assembly of large genomes using a Bloom filter

(2017) Shaun D. Jackman et al.   GENOME RESEARCH

DnrI of Streptomyces peucetius binds to the resistance genes, drrAB and drrC but is activated by daunorubicin

(2017) Francis Prija et al.   JOURNAL OF BASIC MICROBIOLOGY

Multi-drug-resistant Gram-negative bacteria causing urinary tract infections: a review

(2017) Annarita Mazzariol et al.   JOURNAL OF CHEMOTHERAPY

Regulation of the AcrAB-TolC efflux pump in Enterobacteriaceae

(2017) Natasha Weston et al.   RESEARCH IN MICROBIOLOGY

Dual mechanism of action of the atypical tetracycline chelocardin

(2016) Jennifer J. Stepanek et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Current perspectives on tigecycline resistance in Enterobacteriaceae: susceptibility testing issues and mechanisms of resistance

(2016) Spyros Pournaras et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Step-Wise Increase in Tigecycline Resistance in Klebsiella pneumoniae Associated with Mutations in ramR, lon and rpsJ

(2016) Li Fang et al.   PLoS One

Construction of a New Class of Tetracycline Lead Structures with Potent Antibacterial Activity through Biosynthetic Engineering

(2015) Urška Lešnik et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Urinary tract infections: epidemiology, mechanisms of infection and treatment options

(2015) Ana L. Flores-Mireles et al.   NATURE REVIEWS MICROBIOLOGY

Tetracycline antibiotics and resistance mechanisms

(2014) Fabian Nguyen et al.   BIOLOGICAL CHEMISTRY

Current and future treatment options for infections caused by multidrug-resistant Gram-negative pathogens

(2014) Garyphallia Poulakou et al.   Future Microbiology

Structure of the AcrAB–TolC multidrug efflux pump

(2014) Dijun Du et al.   NATURE

A new strategy to fight antimicrobial resistance: the revival of old antibiotics

(2014) Nadim Cassir et al.   Frontiers in Microbiology

Developing new antibacterials through natural product research

(2013) Herbert A Kirst   Expert Opinion on Drug Discovery

Clinical relevance of the ESKAPE pathogens

(2013) Jack N Pendleton et al.   Expert Review of Anti-Infective Therapy

RamA, which controls expression of the MDR efflux pump AcrAB-TolC, is regulated by the Lon protease

(2013) V. Ricci et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Identification of the chelocardin biosynthetic gene cluster from Amycolatopsis sulphurea: a platform for producing novel tetracycline antibiotics

(2013) T. Lukezic et al.   MICROBIOLOGY-SGM

Effect of Transcriptional Activators SoxS, RobA, and RamA on Expression of Multidrug Efflux Pump AcrAB-TolC in Enterobacter cloacae

(2012) Astrid Pérez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Geneious Basic: An integrated and extendable desktop software platform for the organization and analysis of sequence data

(2012) M. Kearse et al.   BIOINFORMATICS

Antibiotics produced by Streptomyces

(2012) Rudi Emerson de Lima Procópio et al.   Brazilian Journal of Infectious Diseases

In Vitro Selection oframRandsoxRMutants Overexpressing Efflux Systems by Fluoroquinolones as Well as Cefoxitin in Klebsiella pneumoniae

(2011) Suzanne Bialek-Davenet et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Revisiting “Older” Antimicrobials in the Era of Multidrug Resistance

(2011) Jason M Pogue et al.   PHARMACOTHERAPY

ramR Mutations in Clinical Isolates of Klebsiella pneumoniae with Reduced Susceptibility to Tigecycline

(2010) M. Hentschke et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Daunorubicin efflux in Streptomyces peucetius modulates biosynthesis by feedback regulation

(2010) Padmanabhan Srinivasan et al.   FEMS MICROBIOLOGY LETTERS

Drug transport mechanism of the AcrB efflux pump

(2009) Klaas M. Pos   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Decreased fluoroquinolone susceptibility in mutants of Salmonella serovars other than Typhimurium: detection of novel mutations involved in modulated expression of ramA and soxS

(2009) C. Kehrenberg et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Multiple Regulatory Pathways Associated with High-Level Ciprofloxacin and Multidrug Resistance in Salmonella enterica Serovar Enteritidis: Involvement of ramA and Other Global Regulators

(2008) E. O'Regan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

ramR Mutations Involved in Efflux-Mediated Multidrug Resistance in Salmonella enterica Serovar Typhimurium

(2008) Y. M. Abouzeed et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES