Modification and de novo design of non-ribosomal peptide synthetases using specific assembly points within condensation domains

De novo design and engineering of non-ribosomal peptide synthetases

(2017) Kenan A. J. Bozhüyük et al.   Nature Chemistry

Biosynthetic engineering of nonribosomal peptide synthetases

(2016) Hajo Kries   JOURNAL OF PEPTIDE SCIENCE

Recent advances in engineering nonribosomal peptide assembly lines

(2016) M. Winn et al.   NATURAL PRODUCT REPORTS

A structural model for multimodular NRPS assembly lines

(2016) Mohamed A. Marahiel   NATURAL PRODUCT REPORTS

Polyketide synthase and non-ribosomal peptide synthetase thioesterase selectivity: logic gate or a victim of fate?

(2016) Mark E. Horsman et al.   NATURAL PRODUCT REPORTS

Structure Elucidation and Activity of Kolossin A, theD-/L-Pentadecapeptide Product of a Giant Nonribosomal Peptide Synthetase

(2015) Helge B. Bode et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Portability of the thiolation domain in recombinant pyoverdine non-ribosomal peptide synthetases

(2015) Mark J. Calcott et al.   BMC MICROBIOLOGY

“Click Chemistry” for the Simple Determination of Fatty-Acid Uptake and Degradation: Revising the Role of Fatty-Acid Transporters

(2015) Alexander J. Pérez et al.   CHEMBIOCHEM

Solid-Phase Enrichment and Analysis of Azide-Labeled Natural Products: Fishing Downstream of Biochemical Pathways

(2015) Alexander J. Pérez et al.   CHEMISTRY-A EUROPEAN JOURNAL

The re-emergence of natural products for drug discovery in the genomics era

(2015) Alan L. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

Reprogramming Nonribosomal Peptide Synthetases for “Clickable” Amino Acids

(2014) Hajo Kries et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biosynthesis of Novel Pyoverdines by Domain Substitution in a Nonribosomal Peptide Synthetase of Pseudomonas aeruginosa

(2014) Mark J. Calcott et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Genetic manipulation of non-ribosomal peptide synthetases to generate novel bioactive peptide products

(2014) Mark J. Calcott et al.   BIOTECHNOLOGY LETTERS

Rapid Determination of the Amino Acid Configuration of Xenotetrapeptide

(2014) Carsten Kegler et al.   CHEMBIOCHEM

Yeast Homologous Recombination Cloning Leading to the Novel Peptides Ambactin and Xenolindicin

(2014) Olivia Schimming et al.   CHEMBIOCHEM

Insect-Specific Production of New GameXPeptides inPhotorhabdus luminescensTTO1, Widespread Natural Products in Entomopathogenic Bacteria

(2014) Friederike I. Nollmann et al.   CHEMBIOCHEM

Characterisation of Taxlllaids A-G; Natural Products fromXenorhabdus indica

(2014) Max Kronenwerth et al.   CHEMISTRY-A EUROPEAN JOURNAL

Creating functional engineered variants of the single-module non-ribosomal peptide synthetase IndC by T domain exchange

(2014) Ralf Beer et al.   Molecular BioSystems

Combating Multidrug-Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials

(2013) Kieron M. G. O'Connell et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Crystal Structures of the First Condensation Domain of CDA Synthetase Suggest Conformational Changes during the Synthetic Cycle of Nonribosomal Peptide Synthetases

(2013) Kristjan Bloudoff et al.   JOURNAL OF MOLECULAR BIOLOGY

Neutral Loss Fragmentation Pattern Based Screening for Arginine-Rich Natural Products in Xenorhabdus and Photorhabdus

(2012) Sebastian W. Fuchs et al.   ANALYTICAL CHEMISTRY

Merging Chemical Synthesis and Biosynthesis: A New Chapter in the Total Synthesis of Natural Products and Natural Product Libraries

(2012) Andreas Kirschning et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Introduction of a Non-Natural Amino Acid into a Nonribosomal Peptide Antibiotic by Modification of Adenylation Domain Specificity

(2012) Jenny Thirlway et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Determination of the Absolute Configuration of Peptide Natural Products by Using Stable Isotope Labeling and Mass Spectrometry

(2012) Helge B. Bode et al.   CHEMISTRY-A EUROPEAN JOURNAL

Improving known classes of antibiotics: an optimistic approach for the future

(2012) Karen Bush   CURRENT OPINION IN PHARMACOLOGY

Combinatorial Biosynthesis of Cyclic Lipopeptide Antibiotics: A Model for Synthetic Biology To Accelerate the Evolution of Secondary Metabolite Biosynthetic Pathways

(2012) Richard H. Baltz   ACS Synthetic Biology

Structure elucidation and biosynthesis of lysine-rich cyclic peptides in Xenorhabdus nematophila

(2011) Sebastian W. Fuchs et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Diversity of Monomers in Nonribosomal Peptides: towards the Prediction of Origin and Biological Activity

(2010) S. Caboche et al.   JOURNAL OF BACTERIOLOGY

Gene Expression Enabling Synthetic Diversification of Natural Products: Chemogenetic Generation of Pacidamycin Analogs

(2010) Abhijeet Deb Roy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

(2009) Ellen M. Sletten et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Adenylation Enzyme Characterization Using γ -18O4-ATP Pyrophosphate Exchange

(2009) Vanessa V. Phelan et al.   CHEMISTRY & BIOLOGY

Nonribosomal Peptide Synthetases Involved in the Production of Medically Relevant Natural Products

(2008) Elizabeth A. Felnagle et al.   MOLECULAR PHARMACEUTICS

Crystal Structure of the Termination Module of a Nonribosomal Peptide Synthetase

(2008) A. Tanovic et al.   SCIENCE