ARTS 2.0: feature updates and expansion of the Antibiotic Resistant Target Seeker for comparative genome mining

A Deep Learning Approach to Antibiotic Discovery

(2020) Jonathan M. Stokes et al.   CELL

antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline

(2019) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

A deep learning genome-mining strategy for biosynthetic gene cluster prediction

(2019) Geoffrey D Hannigan et al.   NUCLEIC ACIDS RESEARCH

A computational framework to explore large-scale biosynthetic diversity

(2019) Jorge C. Navarro-Muñoz et al.   Nature Chemical Biology

The Natural Products Atlas: An Open Access Knowledge Base for Microbial Natural Products Discovery

(2019) Jeffrey A. van Santen et al.   ACS Central Science

Self-Resistance of Natural Product Producers: Past, Present, and Future Focusing on Self-Resistant Protein Variants

(2018) Khaled H. Almabruk et al.   ACS Chemical Biology

Thailandamide: a fatty acid synthesis antibiotic that is co-expressed with a resistant target gene.

(2018) Christopher E. Wozniak et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

ASTRAL-III: polynomial time species tree reconstruction from partially resolved gene trees

(2018) Chao Zhang et al.   BMC BIOINFORMATICS

Future Directions of Marine Myxobacterial Natural Product Discovery Inferred from Metagenomics

(2018) Ronald Garcia et al.   Marine Drugs

Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action

(2018) Yan Yan et al.   NATURE

The antiSMASH database version 2: a comprehensive resource on secondary metabolite biosynthetic gene clusters

(2018) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

The Antibiotic Resistant Target Seeker (ARTS), an exploration engine for antibiotic cluster prioritization and novel drug target discovery

(2017) Mohammad Alanjary et al.   NUCLEIC ACIDS RESEARCH

PRISM 3: expanded prediction of natural product chemical structures from microbial genomes

(2017) Michael A. Skinnider et al.   NUCLEIC ACIDS RESEARCH

The evolution of genome mining in microbes – a review

(2016) Nadine Ziemert et al.   NATURAL PRODUCT REPORTS

Lifemap: Exploring the Entire Tree of Life

(2016) Damien M. de Vienne   PLOS BIOLOGY

A new view of the tree of life

(2016) Laura A. Hug et al.   Nature Microbiology

Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining

(2015) Xiaoyu Tang et al.   ACS Chemical Biology

Production of the Bengamide Class of Marine Natural Products in Myxobacteria: Biosynthesis and Structure-Activity Relationships

(2015) Silke C. Wenzel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The re-emergence of natural products for drug discovery in the genomics era

(2015) Alan L. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

HGTree: database of horizontally transferred genes determined by tree reconciliation

(2015) Hyeonsoo Jeong et al.   NUCLEIC ACIDS RESEARCH

Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation

(2015) Nuala A. O'Leary et al.   NUCLEIC ACIDS RESEARCH

In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazolinone assembly

(2015) Yi-Ling Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Directed natural product biosynthesis gene cluster capture and expression in the model bacterium Bacillus subtilis

(2015) Yongxin Li et al.   Scientific Reports

Ornithine Transcarbamylase ArgK Plays a Dual role for the Self-defense of Phaseolotoxin Producing Pseudomonas syringae pv. phaseolicola

(2015) Li chen et al.   Scientific Reports

Targeted metagenomics as a tool to tap into marine natural product diversity for the discovery and production of drug candidates

(2015) Marla Trindade et al.   Frontiers in Microbiology

Cystobactamids: Myxobacterial Topoisomerase Inhibitors Exhibiting Potent Antibacterial Activity

(2014) Sascha Baumann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters

(2014) Peter Cimermancic et al.   CELL

Multilocus Sequence Typing Reveals Evidence of Homologous Recombination Linked to Antibiotic Resistance in the Genus Salinispora

(2013) Kelle C. Freel et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Natural products: A continuing source of novel drug leads

(2013) Gordon M. Cragg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Microbial genome mining for accelerated natural products discovery: is a renaissance in the making?

(2013) Brian O. Bachmann et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Identifying producers of antibacterial compounds by screening for antibiotic resistance

(2013) Maulik N Thaker et al.   NATURE BIOTECHNOLOGY

DEG 10, an update of the database of essential genes that includes both protein-coding genes and noncoding genomic elements: Table 1.

(2013) Hao Luo et al.   NUCLEIC ACIDS RESEARCH

Myxobacterium-Produced Antibiotic TA (Myxovirescin) Inhibits Type II Signal Peptidase

(2012) Yao Xiao et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

TIGRFAMs and Genome Properties in 2013

(2012) Daniel H. Haft et al.   NUCLEIC ACIDS RESEARCH

Phylogeny and molecular signatures for the phylum Thermotogae and its subgroups

(2011) Radhey S. Gupta et al.   ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY

The Kalimantacin/Batumin Biosynthesis Operon Encodes a Self-Resistance Isoform of the FabI Bacterial Target

(2010) Wesley Mattheus et al.   CHEMISTRY & BIOLOGY

Caldilinea tarbellica sp. nov., a filamentous, thermophilic, anaerobic bacterium isolated from a deep hot aquifer in the Aquitaine Basin

(2010) P. Gregoire et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

Myxobacterial secondary metabolites: bioactivities and modes-of-action

(2010) Kira J. Weissman et al.   NATURAL PRODUCT REPORTS

Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin

(2009) Laura C. Wieland Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Andrimid producers encode an acetyl-CoA carboxyltransferase subunit resistant to the action of the antibiotic

(2008) X. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA