Self-resistance guided genome mining uncovers new topoisomerase inhibitors from myxobacteria

Natural products from myxobacteria: novel metabolites and bioactivities

(2017) J. Herrmann et al.   NATURAL PRODUCT REPORTS

The Antibiotic Resistant Target Seeker (ARTS), an exploration engine for antibiotic cluster prioritization and novel drug target discovery

(2017) Mohammad Alanjary et al.   NUCLEIC ACIDS RESEARCH

PRISM 3: expanded prediction of natural product chemical structures from microbial genomes

(2017) Michael A. Skinnider et al.   NUCLEIC ACIDS RESEARCH

antiSMASH 4.0—improvements in chemistry prediction and gene cluster boundary identification

(2017) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

Discovery of a Phosphonoacetic Acid Derived Natural Product by Pathway Refactoring

(2017) Todd S. Freestone et al.   ACS Synthetic Biology

Resistance Gene-Guided Genome Mining: Serial Promoter Exchanges in Aspergillus nidulans Reveal the Biosynthetic Pathway for Fellutamide B, a Proteasome Inhibitor

(2016) Hsu-Hua Yeh et al.   ACS Chemical Biology

Genome Analysis of the Fruiting Body-Forming Myxobacterium Chondromyces crocatus Reveals High Potential for Natural Product Biosynthesis

(2016) Nestor Zaburannyi et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Cloning and Heterologous Expression of the Grecocycline Biosynthetic Gene Cluster

(2016) Oksana Bilyk et al.   PLoS One

Myxobacteria: Moving, Killing, Feeding, and Surviving Together

(2016) José Muñoz-Dorado et al.   Frontiers in Microbiology

Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining

(2015) Xiaoyu Tang et al.   ACS Chemical Biology

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

Discovery of microbial natural products by activation of silent biosynthetic gene clusters

(2015) Peter J. Rutledge et al.   NATURE REVIEWS MICROBIOLOGY

antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters

(2015) Tilmann Weber et al.   NUCLEIC ACIDS RESEARCH

Cystobactamids: Myxobacterial Topoisomerase Inhibitors Exhibiting Potent Antibacterial Activity

(2014) Sascha Baumann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Squaring up to DNA: pentapeptide repeat proteins and DNA mimicry

(2014) Shama Shah et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Secondary metabolomics: the impact of mass spectrometry-based approaches on the discovery and characterization of microbial natural products

(2014) Daniel Krug et al.   NATURAL PRODUCT REPORTS

Activation and identification of five clusters for secondary metabolites inStreptomyces albus J1074

(2014) Carlos Olano et al.   Microbial Biotechnology

Detection of metabolite induction in fungal co-cultures on solid media by high-throughput differential ultra-high pressure liquid chromatography–time-of-flight mass spectrometry fingerprinting

(2013) Samuel Bertrand et al.   JOURNAL OF CHROMATOGRAPHY A

Application of a Novel Microtitre Plate-Based Assay for the Discovery of New Inhibitors of DNA Gyrase and DNA Topoisomerase VI

(2013) James A. Taylor et al.   PLoS One

Drugging Topoisomerases: Lessons and Challenges

(2012) Yves Pommier   ACS Chemical Biology

Genomics-Driven Discovery of Burkholderic Acid, a Noncanonical, Cryptic Polyketide from Human PathogenicBurkholderiaSpecies

(2012) Jakob Franke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Two Systems for Conditional Gene Expression in Myxococcus xanthus Inducible by Isopropyl- -D-Thiogalactopyranoside or Vanillate

(2012) A. A. Iniesta et al.   JOURNAL OF BACTERIOLOGY

Baeyer–Villiger C–C Bond Cleavage Reaction in Gilvocarcin and Jadomycin Biosynthesis

(2012) Nidhi Tibrewal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pentapeptide-repeat proteins that act as topoisomerase poison resistance factors have a common dimer interface

(2011) Matthew W. Vetting et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Myxoprincomide: A Natural Product from Myxococcus xanthus Discovered by Comprehensive Analysis of the Secondary Metabolome

(2011) Niña Socorro Cortina et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure of QnrB1, a Plasmid-mediated Fluoroquinolone Resistance Factor

(2011) Matthew W. Vetting et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolites from the Induced Expression of Cryptic Single Operons Found in the Genome of Burkholderia pseudomallei

(2011) John B. Biggins et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Completing the puzzle of aurachin biosynthesis in Stigmatella aurantiaca Sg a15

(2011) Dominik Pistorius et al.   Molecular BioSystems

Discovery of 23 Natural Tubulysins from Angiococcus disciformis An d48 and Cystobacter SBCb004

(2010) Yi Chai et al.   CHEMISTRY & BIOLOGY

Oxytetracycline Biosynthesis

(2010) Lauren B. Pickens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclization of aromatic polyketides from bacteria and fungi

(2010) Hui Zhou et al.   NATURAL PRODUCT REPORTS

Biosynthesis of Aromatic Polyketides in Bacteria

(2009) Abhirup Das et al.   ACCOUNTS OF CHEMICAL RESEARCH

Myxobacteria—‘microbial factories’ for the production of bioactive secondary metabolites

(2009) Silke C. Wenzel et al.   Molecular BioSystems

The impact of genomics on the exploitation of the myxobacterial secondary metabolome

(2009) Silke C. Wenzel et al.   NATURAL PRODUCT REPORTS

Biosynthesis and Structures of Cyclomarins and Cyclomarazines, Prenylated Cyclic Peptides of Marine Actinobacterial Origin

(2008) Andrew W. Schultz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli

(2008) W. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA