A new antibiotic selectively kills Gram-negative pathogens

Identification of conformation-selective nanobodies against the membrane protein insertase BamA by an integrated structural biology approach

(2019) Hundeep Kaur et al.   JOURNAL OF BIOMOLECULAR NMR

A small-molecule inhibitor of BamA impervious to efflux and the outer membrane permeability barrier

(2019) Elizabeth M. Hart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mortality due to KPC carbapenemase-producing Klebsiella pneumoniae infections: Systematic review and meta-analysis

(2018) Jorge A. Ramos-Castañeda et al.   JOURNAL OF INFECTION

Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis

(2018) Evelina Tacconelli et al.   LANCET INFECTIOUS DISEASES

Thermal proteome profiling in bacteria: probing protein state in vivo

(2018) André Mateus et al.   Molecular Systems Biology

C–C bond forming radical SAM enzymes involved in the construction of carbon skeletons of cofactors and natural products

(2018) Kenichi Yokoyama et al.   NATURAL PRODUCT REPORTS

Novel soil bacteria possess diverse genes for secondary metabolite biosynthesis

(2018) Alexander Crits-Christoph et al.   NATURE

Monoclonal antibody targeting the β-barrel assembly machine ofEscherichia coliis bactericidal

(2018) Kelly M. Storek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Refining the Natural Product Repertoire in Entomopathogenic Bacteria

(2018) Nicholas Jay Tobias et al.   TRENDS IN MICROBIOLOGY

Towards Understanding MCR-like Colistin Resistance

(2018) Jian Sun et al.   TRENDS IN MICROBIOLOGY

Sequence-Specific Solution NMR Assignments of the β-Barrel Insertase BamA to Monitor Its Conformational Ensemble at the Atomic Level

(2018) Jean-Baptiste Hartmann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Optimized arylomycins are a new class of Gram-negative antibiotics

(2018) Peter A. Smith et al.   NATURE

Single-pot, solid-phase-enhanced sample preparation for proteomics experiments

(2018) Christopher S. Hughes et al.   Nature Protocols

Predictive compound accumulation rules yield a broad-spectrum antibiotic

(2017) Michelle F. Richter et al.   NATURE

antiSMASH 4.0—improvements in chemistry prediction and gene cluster boundary identification

(2017) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

Systematic review and meta-analysis of mortality of patients infected with carbapenem-resistant Klebsiella pneumoniae

(2017) Liangfei Xu et al.   Annals of Clinical Microbiology and Antimicrobials

Natural product diversity associated with the nematode symbionts Photorhabdus and Xenorhabdus

(2017) Nicholas J. Tobias et al.   Nature Microbiology

Antibacterial drug discovery in the resistance era

(2016) Eric D. Brown et al.   NATURE

Thermal profiling reveals phenylalanine hydroxylase as an off-target of panobinostat

(2016) Isabelle Becher et al.   Nature Chemical Biology

The structure of the  -barrel assembly machinery complex

(2016) J. Bakelar et al.   SCIENCE

Antibiotics, birth mode, and diet shape microbiome maturation during early life

(2016) Nicholas A. Bokulich et al.   Science Translational Medicine

The healthy human microbiome

(2016) Jason Lloyd-Price et al.   Genome Medicine

Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining

(2015) Xiaoyu Tang et al.   ACS Chemical Biology

hybridSPAdes: an algorithm for hybrid assembly of short and long reads

(2015) Dmitry Antipov et al.   BIOINFORMATICS

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

Structure and biosynthesis of a macrocyclic peptide containing an unprecedented lysine-to-tryptophan crosslink

(2015) Kelsey R. Schramma et al.   Nature Chemistry

Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry

(2015) Holger Franken et al.   Nature Protocols

Efficacy of a Ceftazidime-Avibactam Combination in a Murine Model of Septicemia Caused by Enterobacteriaceae Species Producing AmpC or Extended-Spectrum β-Lactamases

(2014) Premavathy Levasseur et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Ultrasensitive proteome analysis using paramagnetic bead technology

(2014) C. S. Hughes et al.   Molecular Systems Biology

Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance

(2014) Andrew M. King et al.   NATURE

Reconstitution of bacterial autotransporter assembly using purified components

(2014) Giselle Roman-Hernandez et al.   eLife

Efforts toward broadening the spectrum of arylomycin antibiotic activity

(2013) Jian Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Platforms for antibiotic discovery

(2013) Kim Lewis   NATURE REVIEWS DRUG DISCOVERY

Phylogeny of Bacteria Isolated from Rhabditis sp. (Nematoda) and Identification of Novel Entomopathogenic Serratia marcescens Strains

(2012) James T. Tambong   CURRENT MICROBIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Bacterial symbionts and natural products

(2011) Jason M. Crawford et al.   CHEMICAL COMMUNICATIONS

ArcS, the Cognate Sensor Kinase in an Atypical Arc System of Shewanella oneidensis MR-1

(2010) J. Lassak et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Functional Reconstitution of an ABC Transporter in Nanodiscs for Use in Electron Paramagnetic Resonance Spectroscopy

(2010) Frances Joan D. Alvarez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reconstitution of Outer Membrane Protein Assembly from Purified Components

(2010) C. L. Hagan et al.   SCIENCE

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Physicochemical Properties of Antibacterial Compounds: Implications for Drug Discovery

(2008) Rosemarie O’Shea et al.   JOURNAL OF MEDICINAL CHEMISTRY