Chemical Inhibitors of the Type Three Secretion System: Disarming Bacterial Pathogens

New equine antitoxins to botulinum neurotoxins serotypes A and B

(2012) D. Li et al.   BIOLOGICALS

Pre-clinical pharmacokinetics and anti-chlamydial activity of salicylidene acylhydrazide inhibitors of bacterial type III secretion

(2012) Tofeeq Ur-Rehman et al.   JOURNAL OF ANTIBIOTICS

Structural Characterisation of Tpx from Yersinia pseudotuberculosis Reveals Insights into the Binding of Salicylidene Acylhydrazide Compounds

(2012) Mads Gabrielsen et al.   PLoS One

Novel classes of antibiotics or more of the same?

(2011) Anthony RM Coates et al.   BRITISH JOURNAL OF PHARMACOLOGY

Making Space for Anti-Infective Drug Discovery

(2011) Carl Nathan   Cell Host & Microbe

Identification of Bacterial Target Proteins for the Salicylidene Acylhydrazide Class of Virulence-blocking Compounds

(2011) Dai Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protection of Mice From a Chlamydia trachomatis Vaginal Infection Using a Salicylidene Acylhydrazide, a Potential Microbicide

(2011) A. Slepenkin et al.   JOURNAL OF INFECTIOUS DISEASES

An image-based 384-well high-throughput screening method for the discovery of biofilm inhibitors in Vibrio cholerae

(2011) Kelly C. Peach et al.   Molecular BioSystems

Fix the antibiotics pipeline

(2011) Matthew A. Cooper et al.   NATURE

Identification of Small-Molecule Inhibitors of Yersinia pestis Type III Secretion System YscN ATPase

(2011) Wieslaw Swietnicki et al.   PLoS One

Biogenesis, Regulation, and Targeting of the Type III Secretion System

(2011) Thierry Izoré et al.   STRUCTURE

Point-of-care nucleic acid testing for infectious diseases

(2011) Angelika Niemz et al.   TRENDS IN BIOTECHNOLOGY

Identification and Characterization of Small-Molecule Inhibitors of Yop Translocation in Yersinia pseudotuberculosis

(2010) D. E. Harmon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discovery and Characterization of Inhibitors of Pseudomonas aeruginosa Type III Secretion

(2010) D. Aiello et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The type III secretion injectisome, a complex nanomachine for intracellular ‘toxin’ delivery

(2010) Guy R. Cornelis   BIOLOGICAL CHEMISTRY

Statistical molecular design of a focused salicylidene acylhydrazide library and multivariate QSAR of inhibition of type III secretion in the Gram-negative bacterium Yersinia

(2010) Markus K. Dahlgren et al.   BIOORGANIC & MEDICINAL CHEMISTRY

ROS-inhibitory activity of YopE is required for full virulence of Yersinia in mice

(2010) Warangkhana Songsungthong et al.   CELLULAR MICROBIOLOGY

Routine use of point-of-care tests: usefulness and application in clinical microbiology

(2010) O. Clerc et al.   CLINICAL MICROBIOLOGY AND INFECTION

Diagnosing infections—current and anticipated technologies for point-of-care diagnostics and home-based testing

(2010) L. Bissonnette et al.   CLINICAL MICROBIOLOGY AND INFECTION

Antivirulence drugs to target bacterial secretion systems

(2010) Christian Baron   CURRENT OPINION IN MICROBIOLOGY

Antibiotic use and inflammatory bowel diseases in childhood

(2010) A. Hviid et al.   GUT

Distinct CCR2+Gr1+Cells Control Growth of theYersinia pestisΔyopMMutant in Liver and Spleen during Systemic Plague

(2010) Zhan Ye et al.   INFECTION AND IMMUNITY

Small Molecule Inhibitors of LcrF, a Yersinia pseudotuberculosis Transcription Factor, Attenuate Virulence and Limit Infection in a Murine Pneumonia Model

(2010) L. K. Garrity-Ryan et al.   INFECTION AND IMMUNITY

The many faces of the YopM effector from plague causative bacterium Yersinia pestis and its implications for host immune modulation

(2010) Venkataramanan Soundararajan et al.   Innate Immunity

A small-molecule inhibitor of the bacterial type III secretion system protects against in vivo infection with Citrobacter rodentium

(2010) Kyota Kimura et al.   JOURNAL OF ANTIBIOTICS

Timing is everything: the regulation of type III secretion

(2009) Janet E. Deane et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Animal Rule and Emerging Infections: The Role of Clinical Pharmacology in Determining an Effective Dose

(2009) K L Bergman   CLINICAL PHARMACOLOGY & THERAPEUTICS

Translocated effectors of Yersinia

(2009) Hiroyuki Matsumoto et al.   CURRENT OPINION IN MICROBIOLOGY

Salicylidene acylhydrazide-mediated inhibition of type III secretion system-1 in Salmonella enterica serovar Typhimurium is associated with iron restriction and can be reversed by free iron

(2009) Abigail N. Layton et al.   FEMS MICROBIOLOGY LETTERS

Characterization of the Effects of Salicylidene Acylhydrazide Compounds on Type III Secretion in Escherichia coli O157:H7

(2009) J. J. Tree et al.   INFECTION AND IMMUNITY

Guadinomines, Type III Secretion System Inhibitors, Produced by Streptomyces sp. K01-0509

(2009) Masato Iwatsuki et al.   JOURNAL OF ANTIBIOTICS

N-Hydroxybenzimidazole Inhibitors of the Transcription Factor LcrF inYersinia: Novel Antivirulence Agents

(2009) Oak K. Kim et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting Type III Secretion in Yersinia pestis

(2008) N. J. Pan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

An Inhibitor of Gram-Negative Bacterial Virulence Protein Secretion

(2008) Heather B. Felise et al.   Cell Host & Microbe

EspC translocation into epithelial cells by enteropathogenicEscherichia colirequires a concerted participation of type V and III secretion systems

(2008) Jorge E. Vidal et al.   CELLULAR MICROBIOLOGY

Piecing together the Type III injectisome of bacterial pathogens

(2008) Trevor F Moraes et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Transfer of antimicrobial resistance plasmids from Klebsiella pneumoniae to Escherichia coli in the mouse intestine

(2008) S. Schjorring et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Small-Molecule Type III Secretion System Inhibitors Block Assembly of the Shigella Type III Secreton

(2008) A. K. J. Veenendaal et al.   JOURNAL OF BACTERIOLOGY

Decreased Diversity of the Fecal Microbiome in RecurrentClostridium difficile–Associated Diarrhea

(2008) Ju Young Chang et al.   JOURNAL OF INFECTIOUS DISEASES

Virulence blockers as alternatives to antibiotics: type III secretion inhibitors against Gram-negative bacteria

(2008) P. Keyser et al.   JOURNAL OF INTERNAL MEDICINE

Antibiotics and Antibiotic Resistance Genes in Natural Environments

(2008) J. L. Martinez   SCIENCE