Elucidating Role of Reactive Oxygen Species (ROS) in Cisplatin Chemotherapy: A Focus on Molecular Pathways and Possible Therapeutic Strategies

GSH triggered intracellular aggregated-cisplatin-loaded iron oxide nanoparticles for overcoming cisplatin resistance in nasopharyngeal carcinoma

(2021) Naveen Kumar Bejjanki et al.   JOURNAL OF BIOMATERIALS APPLICATIONS

Resveratrol’s Anti-Cancer Effects through the Modulation of Tumor Glucose Metabolism

(2021) Aranka Brockmueller et al.   Cancers

Melatonin increases the anticancer potential of doxorubicin in Caco‐2 colorectal cancer cells

(2021) Mahdieh Farhoudi Sefidan Jadid et al.   ENVIRONMENTAL TOXICOLOGY

Synergistic Roles of Curcumin in Sensitising the Cisplatin Effect on a Cancer Stem Cell-Like Population Derived from Non-Small Cell Lung Cancer Cell Lines

(2021) Nazilah Abdul Satar et al.   MOLECULES

Berberine-photodynamic therapy sensitizes melanoma cells to cisplatin-induced apoptosis through ROS-mediated P38 MAPK pathways

(2021) Xiaotong Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Curcumin Efficacy in a Serum/glucose Deprivation-induced Neuronal PC12 Injury Model

(2021) Tahereh Farkhondeh et al.   Current Molecular Pharmacology

Small in Size, but Large in Action: microRNAs as Potential Modulators of PTEN in Breast and Lung Cancers

(2021) Asal Jalal Abadi et al.   Biomolecules

Curcumin and cardiovascular diseases: Focus on cellular targets and cascades

(2021) Ali Mohammad Pourbagher-Shahri et al.   BIOMEDICINE & PHARMACOTHERAPY

Enhancing the chemosensitivity of HepG2 cells towards cisplatin by organoselenium pseudopeptides

(2021) Saad Shaaban et al.   BIOORGANIC CHEMISTRY

Biomedical application of chitosan-based nanoscale delivery systems: Potential usefulness in siRNA delivery for cancer therapy

(2021) Milad Ashrafizadeh et al.   CARBOHYDRATE POLYMERS

Nrf2 signaling pathway in cisplatin chemotherapy: Potential involvement in organ protection and chemoresistance

(2021) Sepideh Mirzaei et al.   PHARMACOLOGICAL RESEARCH

Long non-coding RNAs in the doxorubicin resistance of cancer cells

(2021) Saeed Ashrafizaveh et al.   CANCER LETTERS

Regulation of Nuclear Factor-KappaB (NF-κB) signaling pathway by non-coding RNAs in cancer: Inhibiting or promoting carcinogenesis?

(2021) Sepideh Mirzaei et al.   CANCER LETTERS

Self-assembled peptide and protein nanostructures for anti-cancer therapy: Targeted delivery, stimuli-responsive devices and immunotherapy

(2021) Masoud Delfi et al.   Nano Today

Resibufogenin inhibited colorectal cancer cell growth and tumorigenesis through triggering ferroptosis and ROS production mediated by GPX4 inactivation

(2020) Lian‐Dong Shen et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

DDX3 modulates cisplatin resistance in OSCC through ALKBH5-mediated m6A-demethylation of FOXM1 and NANOG

(2020) Omprakash Shriwas et al.   APOPTOSIS

ROS-mediated miR-21-5p regulates the proliferation and apoptosis of Cr(VI)-exposed L02 hepatocytes via targeting PDCD4

(2020) Yujing Zhang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Sodium butyrate inhibits migration and induces AMPK‐mTOR pathway‐dependent autophagy and ROS‐mediated apoptosis via the miR‐139‐5p/Bmi‐1 axis in human bladder cancer cells

(2020) Feifan Wang et al.   FASEB JOURNAL

AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells

(2020) Maria L. Lotsberg et al.   Journal of Thoracic Oncology

CtBP1 transactivates RAD51 and confers cisplatin resistance to breast cancer cells

(2020) Yu Deng et al.   MOLECULAR CARCINOGENESIS

Curcumin Delivery Mediated by Bio-Based Nanoparticles: A Review

(2020) Mahshid Moballegh Nasery et al.   MOLECULES

Overexpression miR-486-3p Promoted by Allicin Enhances Temozolomide Sensitivity in Glioblastoma Via Targeting MGMT

(2020) Henggang Wu et al.   NEUROMOLECULAR MEDICINE

Elevated Glutathione Peroxidase 2 Expression Promotes Cisplatin Resistance in Lung Adenocarcinoma

(2020) He Du et al.   Oxidative Medicine and Cellular Longevity

Inhibition of TRIM32 Induced by miR-519d Increases the Sensitivity of Colorectal Cancer Cells to Cisplatin

(2020) Xueliang Su et al.   OncoTargets and Therapy

Bruceine D induces lung cancer cell apoptosis and autophagy via the ROS/MAPK signaling pathway in vitro and in vivo

(2020) Jiangjiang Fan et al.   Cell Death & Disease

Clarithromycin inhibits autophagy in colorectal cancer by regulating the hERG1 potassium channel interaction with PI3K

(2020) Giulia Petroni et al.   Cell Death & Disease

Propofol Improves Sensitivity of Lung Cancer Cells to Cisplatin and Its Mechanism

(2020) Yunfeng Huang et al.   MEDICAL SCIENCE MONITOR

Cancer-associated fibroblasts promote immunosuppression by inducing ROS-generating monocytic MDSCs in lung squamous cell carcinoma

(2020) Handan Xiang et al.   Cancer Immunology Research

Sphingosine 1-Phosphate Receptor 2 Induces Otoprotective Responses to Cisplatin Treatment

(2020) Wei Wang et al.   Cancers

Licochalcone D Induces ROS-Dependent Apoptosis in Gefitinib-Sensitive or Resistant Lung Cancer Cells by Targeting EGFR and MET

(2020) Ha-Na Oh et al.   Biomolecules

RIP1 promotes proliferation through G2/M checkpoint progression and mediates cisplatin-induced apoptosis and necroptosis in human ovarian cancer cells

(2020) Xue-lian Zheng et al.   ACTA PHARMACOLOGICA SINICA

Compensatory combination of romidepsin with gemcitabine and cisplatin to effectively and safely control urothelial carcinoma

(2020) Pawat Pattarawat et al.   BRITISH JOURNAL OF CANCER

Insight into the role of p62 in the cisplatin resistant mechanisms of ovarian cancer

(2020) Xiao-Yu Yan et al.   Cancer Cell International

NRF2 as a regulator of cell metabolism and inflammation in cancer

(2020) Feng He et al.   CARCINOGENESIS

The multifaceted role of reactive oxygen species in tumorigenesis

(2020) Anuradha Kirtonia et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Long Noncoding RNA KIF9-AS1 Regulates Transforming Growth Factor-β and Autophagy Signaling to Enhance Renal Cell Carcinoma Chemoresistance via microRNA-497-5p

(2020) Yichen Jin et al.   DNA AND CELL BIOLOGY

ROS and oncogenesis with special reference to EMT and stemness

(2020) Ritam Chatterjee et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

ROS enhances the cytotoxicity of cisplatin by inducing apoptosis and autophagy in tongue squamous cell carcinoma cells

(2020) Dan-Feng Xue et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The role of SIRT2 in cancer: a novel therapeutic target

(2020) Guangyuan Chen et al.   INTERNATIONAL JOURNAL OF CANCER

Curcumin and Colorectal Cancer: From Basic to Clinical Evidences

(2020) Maria Pricci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosome-Delivered c-Met siRNA Could Reverse Chemoresistance to Cisplatin in Gastric Cancer

(2020) Qiumo Zhang et al.   International Journal of Nanomedicine

Imiquimod-induced ROS production disrupts the balance of mitochondrial dynamics and increases mitophagy in skin cancer cells

(2020) Kai-Cheng Chuang et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Allicin enhances the radiosensitivity of colorectal cancer cells via inhibition of NF‐κB signaling pathway

(2020) Wen‐liang Huang et al.   JOURNAL OF FOOD SCIENCE

Chlorpyrifos induces the apoptosis and necroptosis of L8824 cells through the ROS/PTEN/PI3K/AKT axis

(2020) Lanqiao Wang et al.   JOURNAL OF HAZARDOUS MATERIALS

The Synergistic Antitumor Effect of 5-Fluorouracil Combined with Allicin against Lung and Colorectal Carcinoma Cells

(2020) Adrian Bogdan Țigu et al.   MOLECULES

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Plumbagin Enhances the Anticancer Efficacy of Cisplatin by Increasing Intracellular ROS in Human Tongue Squamous Cell Carcinoma

(2020) Danfeng Xue et al.   Oxidative Medicine and Cellular Longevity

Autophagy-modulating phytochemicals in cancer therapeutics: Current evidences and future perspectives

(2020) Srimanta Patra et al.   SEMINARS IN CANCER BIOLOGY

Irinotecan Induces Autophagy-Dependent Apoptosis and Positively Regulates ROS-Related JNK- and P38-MAPK Pathways in Gastric Cancer Cells

(2020) Qingyun Zhu et al.   OncoTargets and Therapy

Propofol induces ROS‑mediated intrinsic apoptosis and migration in triple‑negative breast cancer cells

(2020) Hao Wang et al.   Oncology Letters

High cholesterol induces apoptosis and autophagy through the ROS-activated AKT/FOXO1 pathway in tendon-derived stem cells

(2020) Kaiqun Li et al.   Stem Cell Research & Therapy

Nrf2 and Ferroptosis: A New Research Direction for Neurodegenerative Diseases

(2020) Xiaohua Song et al.   Frontiers in Neuroscience

Kaempferol ameliorates Cisplatin induced nephrotoxicity by modulating oxidative stress, inflammation and apoptosis via ERK and NF-κB pathways

(2020) Zhu Wang et al.   AMB Express

FoxM1-dependent and fatty acid oxidation-mediated ROS modulation is a cell-intrinsic drug resistance mechanism in cancer stem-like cells

(2020) Hae-Ji Choi et al.   Redox Biology

Delivery of MutT homolog 1 inhibitor by functionalized graphene oxide nanoparticles for enhanced chemo-photodynamic therapy triggers cell death in osteosarcoma

(2020) Xin Huang et al.   Acta Biomaterialia

Role of amino acids in regulation of ROS balance in cancer

(2020) Emilie Jaune-Pons et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Cytosolic and mitochondrial ROS production resulted in apoptosis induction in breast cancer cells treated with Crocin: The role of FOXO3a, PTEN and AKT signaling

(2020) Ahmad Nasimian et al.   BIOCHEMICAL PHARMACOLOGY

IQGAP1 promotes anoikis resistance and metastasis through Rac1-dependent ROS accumulation and activation of Src/FAK signalling in hepatocellular carcinoma

(2020) Chun-fen Mo et al.   BRITISH JOURNAL OF CANCER

SNHG16 promotes tumorigenesis and cisplatin resistance by regulating miR-338-3p/PLK4 pathway in neuroblastoma cells

(2020) Zhaoying Xu et al.   Cancer Cell International

Role of the MUC1‐C oncoprotein in the acquisition of cisplatin resistance by urothelial carcinoma

(2020) Keisuke Shigeta et al.   CANCER SCIENCE

Exopolysaccharide from Cryptococcus heimaeyensis S20 induces autophagic cell death in non‐small cell lung cancer cells via ROS/p38 and ROS/ERK signalling

(2020) Yao Hao et al.   CELL PROLIFERATION

Structure of LINC00511‐siRNA‐conjugated nanobubbles and improvement of cisplatin sensitivity on triple negative breast cancer

(2020) Bolin Wu et al.   FASEB JOURNAL

Metformin enhances the sensitivity of colorectal cancer cells to cisplatin through ROS-mediated PI3K/Akt signaling pathway

(2020) Pei Zhang et al.   GENE

Association of the Epithelial–Mesenchymal Transition (EMT) with Cisplatin Resistance

(2020) Milad Ashrafizadeh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling

(2020) Boris Y. Shorning et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Deoxyshikonin inhibits cisplatin resistance of non–small‐cell lung cancer cells by repressing Akt‐mediated ABCB1 expression and function

(2020) Suhong Zhang et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

SIRT2, a direct target of miR‐212‐5p, suppresses the proliferation and metastasis of colorectal cancer cells

(2020) Feng Du et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Long noncoding RNA LEF1‐AS1 acts as a microRNA‐10a‐5p regulator to enhance MSI1 expression and promote chemoresistance in hepatocellular carcinoma cells through activating AKT signaling pathway

(2020) Jun Gao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

PKM2 inhibition may reverse therapeutic resistance to transarterial chemoembolization in hepatocellular carcinoma

(2020) Sean P. Martin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

HIF-1α-dependent miR-424 induction confers cisplatin resistance on bladder cancer cells through down-regulation of pro-apoptotic UNC5B and SIRT4

(2020) Meng Yu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Mitochondrial APE1 promotes cisplatin resistance by downregulating ROS in osteosarcoma

(2020) Yufeng Liu et al.   ONCOLOGY REPORTS

Disulfiram potentiates docetaxel cytotoxicity in breast cancer cells through enhanced ROS and autophagy

(2020) K. Laxmi Swetha et al.   Pharmacological Reports

The Complex Interplay between Antioxidants and ROS in Cancer

(2020) Isaac S. Harris et al.   TRENDS IN CELL BIOLOGY

miR‑140‑3p enhances cisplatin sensitivity and attenuates stem cell‑like properties through repressing Wnt/β‑catenin signaling in lung adenocarcinoma cells

(2020) Shuoming Wu et al.   Experimental and Therapeutic Medicine

Combination Therapy of Lung Cancer Using Layer-by-Layer Cisplatin Prodrug and Curcumin Co-Encapsulated Nanomedicine

(2020) Yuan Hong et al.   Drug Design Development and Therapy

EFHD2 contributes to non-small cell lung cancer cisplatin resistance by the activation of NOX4-ROS-ABCC1 axis

(2020) Chi-Chen Fan et al.   Redox Biology

Acquisition of Cisplatin Resistance Shifts Head and Neck Squamous Cell Carcinoma Metabolism toward Neutralization of Oxidative Stress

(2020) Wangjie Yu et al.   Cancers

Flavonoids against the Warburg phenotype—concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism

(2020) Marek Samec et al.   EPMA Journal

Role of microRNA/Epithelial-to-Mesenchymal Transition Axis in the Metastasis of Bladder Cancer

(2020) Milad Ashrafizadeh et al.   Biomolecules

The Phytochemical Indicaxanthin Synergistically Enhances Cisplatin-Induced Apoptosis in HeLa Cells via Oxidative Stress-Dependent p53/p21waf1 Axis

(2020) Mario Allegra et al.   Biomolecules

Ascorbate sensitizes human osteosarcoma cells to the cytostatic effects of cisplatin

(2020) Naohiro Oka et al.   Pharmacology Research & Perspectives

Bufalin inhibits ovarian carcinoma via targeting mTOR/HIF‐α pathway

(2020) Shan Su et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

MiR-27a-3p overexpression mitigates inflammation and apoptosis of lipopolysaccharides-induced alveolar epithelial cells by targeting FOXO3 and suppressing the activation of NAPDH/ROS

(2020) Jian Shang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Aconitase 2 sensitizes MCF-7 cells to cisplatin eliciting p53-mediated apoptosis in a ROS-dependent manner

(2020) Fabio Ciccarone et al.   BIOCHEMICAL PHARMACOLOGY

Effective treatment of drug-resistant lung cancer via a nanogel capable of reactivating cisplatin and enhancing early apoptosis

(2020) Min Sun et al.   BIOMATERIALS

Lidocaine alleviates cisplatin resistance and inhibits migration of MGC-803/DDP cells through decreasing miR-10b

(2020) Xiaomin Zhang et al.   CELL CYCLE

The effect of miRNA and autophagy on colorectal cancer

(2020) Jiali Long et al.   CELL PROLIFERATION

Pt(IV) pro-drugs with an axial HDAC inhibitor demonstrate multimodal mechanisms involving DNA damage and apoptosis independent of cisplatin resistance in A2780/A2780cis cells

(2020) Awatif Rashed Z. Almotairy et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Oroxylin A reverses hypoxia-induced cisplatin resistance through inhibiting HIF-1α mediated XPC transcription

(2020) Yunyao Liu et al.   ONCOGENE

MAP30 protein from Momordica charantia is therapeutic and has synergic activity with cisplatin against ovarian cancer in vivo by altering metabolism and inducing ferroptosis

(2020) David W Chan et al.   PHARMACOLOGICAL RESEARCH

Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2/HO-1 axis in EGFR wild-type non-small-cell lung cancer

(2020) Jian-Shu Lou et al.   PHYTOMEDICINE

MiR-140 Resensitizes Cisplatin-Resistant NSCLC Cells to Cisplatin Treatment Through the SIRT1/ROS/JNK Pathway

(2020) Zhilai Lin et al.   OncoTargets and Therapy

Chaetomugilin J Enhances Apoptosis in Human Ovarian Cancer A2780 Cells Induced by Cisplatin Through Inhibiting Pink1/Parkin Mediated Mitophagy

(2020) Xiaoqing Hu et al.   OncoTargets and Therapy

Isodeoxyelephantopin Inactivates Thioredoxin Reductase 1 and Activates ROS-Mediated JNK Signaling Pathway to Exacerbate Cisplatin Effectiveness in Human Colon Cancer Cells

(2020) Lin Hong et al.   Frontiers in Cell and Developmental Biology

STK35 Is Ubiquitinated by NEDD4L and Promotes Glycolysis and Inhibits Apoptosis Through Regulating the AKT Signaling Pathway, Influencing Chemoresistance of Colorectal Cancer

(2020) Haojun Yang et al.   Frontiers in Cell and Developmental Biology

Curcumin’s Beneficial Effects on Neuroblastoma: Mechanisms, Challenges, and Potential Solutions

(2020) Kevin Zhai et al.   Biomolecules

Targeting Hypoxia-Inducible Factor-1-Mediated Metastasis for Cancer Therapy

(2020) Zhaowu Ma et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation and function of autophagy in pancreatic cancer

(2020) Jingbo Li et al.   Autophagy

Axl and Mertk receptors cooperate to promote breast cancer progression by combined oncogenic signaling and evasion of host anti-tumor immunity

(2020) Viralkumar Davra et al.   CANCER RESEARCH

PGC1α regulates mitochondrial oxidative phosphorylation involved in cisplatin resistance in ovarian cancer cells via nucleo-mitochondrial transcriptional feedback

(2020) Luyan Shen et al.   EXPERIMENTAL CELL RESEARCH

Rhus coriaria L. (Sumac) Demonstrates Oncostatic Activity in the Therapeutic and Preventive Model of Breast Carcinoma

(2020) Peter Kubatka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PI3K/AKT/mTOR signaling in gastric cancer: Epigenetics and beyond

(2020) Sadegh Fattahi et al.   LIFE SCIENCES

Injectable in situ forming thermo-responsive graphene based hydrogels for cancer chemo-photothermal therapy and NIR light-enhanced antibacterial applications

(2020) Rita Lima-Sousa et al.   Materials Science & Engineering C-Materials for Biological Applications

Knockdown of TRAP1 promotes cisplatin-induced apoptosis by promoting the ROS-dependent mitochondrial dysfunction in lung cancer cells

(2020) Xiaowei Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

LncRNA MIR4435-2HG mediates cisplatin resistance in HCT116 cells by regulating Nrf2 and HO-1

(2020) Ping Luo et al.   PLoS One

SLAMF1 Promotes Methotrexate Resistance via Activating Autophagy in Choriocarcinoma Cells

(2020) Dazun Shi et al.   Cancer Management and Research

Paraoxonase-2 Silencing Enhances Sensitivity of A375 Melanoma Cells to Treatment with Cisplatin

(2020) Roberto Campagna et al.   Antioxidants

Lung cancer cells and their sensitivity/resistance to cisplatin chemotherapy: Role of microRNAs and upstream mediators

(2020) Milad Ashrafizadeh et al.   CELLULAR SIGNALLING

Cadmium and molybdenum co-induce pyroptosis via ROS/PTEN/PI3K/AKT axis in duck renal tubular epithelial cells

(2020) Caiying Zhang et al.   ENVIRONMENTAL POLLUTION

Polyphenol-cisplatin complexation forming core-shell nanoparticles with improved tumor accumulation and dual-responsive drug release for enhanced cancer chemotherapy

(2020) Jiajia Xiang et al.   JOURNAL OF CONTROLLED RELEASE

Stable W/O/W multiple nanoemulsion encapsulating natural tocotrienols and caffeic acid with cisplatin synergistically treated cancer cell lines (A549 and HEP G2) and reduced toxicity on normal cell line (HEK 293)

(2020) Revathi Raviadaran et al.   Materials Science & Engineering C-Materials for Biological Applications

Metformin enhances anti-cancer effects of cisplatin in meningioma through AMPK-mTOR signaling pathways

(2020) Liemei Guo et al.   Molecular Therapy-Oncolytics

Casticin-Induced Inhibition of Cell Growth and Survival Are Mediated through the Dual Modulation of Akt/mTOR Signaling Cascade

(2019) Jong Lee et al.   Cancers

FBXW7 in Cancer: What Has Been Unraveled Thus Far?

(2019) Bethsebie Lalduhsaki Sailo et al.   Cancers

Melatonin Enhances Cisplatin and Radiation Cytotoxicity in Head and Neck Squamous Cell Carcinoma by Stimulating Mitochondrial ROS Generation, Apoptosis, and Autophagy

(2019) Beatriz I. Fernandez-Gil et al.   Oxidative Medicine and Cellular Longevity

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

KLF4 sensitizes the colon cancer cell HCT-15 to cisplatin by altering the expression of HMGB1 and hTERT

(2019) Suresh Singh Yadav et al.   LIFE SCIENCES

A high-throughput drug screen identifies auranofin as a potential sensitizer of cisplatin in small cell lung cancer

(2019) Xiaoli Liu et al.   INVESTIGATIONAL NEW DRUGS

Vitamin D and its low calcemic analogs modulate the anticancer properties of cisplatin and dacarbazine in the human melanoma A375 cell line

(2019) Anna Piotrowska et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The Induction of Ferroptosis by Impairing STAT3/Nrf2/GPx4 Signaling Enhances the Sensitivity of Osteosarcoma Cells to Cisplatin

(2019) Qiang Liu et al.   CELL BIOLOGY INTERNATIONAL

Targeting autophagy using natural compounds for cancer prevention and therapy

(2019) Shuo Deng et al.   CANCER

MiR-124 sensitizes cisplatin-induced cytotoxicity against CD133+ hepatocellular carcinoma cells by targeting SIRT1/ROS/JNK pathway

(2019) Yunxiuxiu Xu et al.   Aging-US

Disulfiram modulates ROS accumulation and overcomes synergistically cisplatin resistance in breast cancer cell lines

(2019) Zhi Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

Cisplatin resistance involves a metabolic reprogramming through ROS and PGC-1α in NSCLC which can be overcome by OXPHOS inhibition

(2019) Alberto Cruz-Bermúdez et al.   FREE RADICAL BIOLOGY AND MEDICINE

Emodin, a natural anthraquinone, suppresses liver cancer in vitro and in vivo by regulating VEGFR2 and miR-34a

(2019) Jianguo Bai et al.   INVESTIGATIONAL NEW DRUGS

Inositol-triphosphate 3-kinase B confers cisplatin resistance by regulating NOX4-dependent redox balance

(2019) Chaoyun Pan et al.   JOURNAL OF CLINICAL INVESTIGATION

Synthesis, biological evaluation and in silico studies of novel N-substituted phthalazine sulfonamide compounds as potent carbonic anhydrase and acetylcholinesterase inhibitors

(2019) Cüneyt Türkeş et al.   BIOORGANIC CHEMISTRY

A Novel hMTR4‐PDIA3P1‐miR‐125/124‐TRAF6 Regulatory Axis and Its Function in NF‐ K B Signaling and Chemoresistance

(2019) Chen Xie et al.   HEPATOLOGY

Inhibition of tumor propellant glutathione peroxidase 4 induces ferroptosis in cancer cells and enhances anticancer effect of cisplatin

(2019) Xuefei Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mitochondrial fission causes cisplatin resistance under hypoxic conditions via ROS in ovarian cancer cells

(2019) Youngjin Han et al.   ONCOGENE

Downregulation of MUTYH contributes to cisplatin‑resistance of esophageal squamous cell carcinoma cells by promoting Twist‑mediated EMT

(2019) Yanxia Guo et al.   ONCOLOGY REPORTS

Loss of Scribble confers cisplatin resistance during NSCLC chemotherapy via Nox2/ROS and Nrf2/PD-L1 signaling

(2019) Na Wang et al.   EBioMedicine

SIRT5 Promotes Cisplatin Resistance in Ovarian Cancer by Suppressing DNA Damage in a ROS-Dependent Manner via Regulation of the Nrf2/HO-1 Pathway

(2019) Xiaodan Sun et al.   Frontiers in Oncology

Dual-targeting antitumor conjugates derived from platinum(IV) prodrugs and microtubule inhibitor CA-4 significantly exhibited potent ability to overcome cisplatin resistance

(2019) Xiaochao Huang et al.   BIOORGANIC CHEMISTRY

A reactive oxygen species scoring system predicts cisplatin sensitivity and prognosis in ovarian cancer patients

(2019) Chaoyang Sun et al.   BMC CANCER

Cisplatin induces chemoresistance through the PTGS2-mediated anti-apoptosis in gastric cancer

(2019) Xiao-mian Lin et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Targeting the Kynurenine Pathway for the Treatment of Cisplatin-Resistant Lung Cancer

(2019) Dan J. M. Nguyen et al.   MOLECULAR CANCER RESEARCH

Ketogenic Diet Combined With Melatonin Overcomes Cisplatin and Vincrisitne Drug Resistance in Breast Carcinoma Syngraft

(2019) Wamidh H. Talib   NUTRITION

α-Hederin Increases The Apoptosis Of Cisplatin-Resistant Gastric Cancer Cells By Activating Mitochondrial Pathway In Vivo And Vitro

(2019) Yinghui Liu et al.   OncoTargets and Therapy

Direct impact of cisplatin on mitochondria induces ROS production that dictates cell fate of ovarian cancer cells

(2019) Markus Kleih et al.   Cell Death & Disease

β‑elemene enhances cisplatin‑induced apoptosis in bladder cancer cells through the ROS‑AMPK signaling pathway

(2019) Daoju Gan et al.   Oncology Letters

Clarithromycin synergizes with cisplatin to inhibit ovarian cancer growth in vitro and in vivo

(2019) Bo Zhou et al.   Journal of Ovarian Research

Curcumin enhances cisplatin-induced human laryngeal squamous cancer cell death through activation of TRPM2 channel and mitochondrial oxidative stress

(2019) Sinem Gökçe Kütük et al.   Scientific Reports

Piperlongumine Inhibits Akt Phosphorylation to Reverse Resistance to Cisplatin in Human Non-Small Cell Lung Cancer Cells via ROS Regulation

(2019) Chao Zhang et al.   Frontiers in Pharmacology

Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements

(2019) Vaishali Aggarwal et al.   Biomolecules

Graphene Oxide Promotes Cancer Metastasis through Associating with Plasma Membrane To Promote TGF-β Signaling-Dependent Epithelial–Mesenchymal Transition

(2019) Jianqiang Zhu et al.   ACS Nano

Olean-28,13b-olide 2 plays a role in cisplatin-mediated apoptosis and reverses cisplatin resistance in human lung cancer through multiple signaling pathways

(2019) Bin Zhu et al.   BIOCHEMICAL PHARMACOLOGY

Combining α-Hederin with cisplatin increases the apoptosis of gastric cancer in vivo and in vitro via mitochondrial related apoptosis pathway

(2019) Huan Deng et al.   BIOMEDICINE & PHARMACOTHERAPY

Cisplatin-stimulated macrophages promote ovarian cancer migration via the CCL20-CCR6 axis

(2019) Wan Liu et al.   CANCER LETTERS

A concise review on cancer treatment methods and delivery systems

(2019) Elham Bidram et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Natural borneol sensitizes human glioma cells to cisplatin-induced apoptosis by triggering ROS-mediated oxidative damage and regulation of MAPKs and PI3K/AKT pathway

(2019) Wen-qiang Cao et al.   PHARMACEUTICAL BIOLOGY

Farnesol abrogates epithelial to mesenchymal transition process through regulating Akt/mTOR pathway

(2019) Jong Hyun Lee et al.   PHARMACOLOGICAL RESEARCH

SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis

(2019) Kai Su Greene et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PRDX2 protects against oxidative stress induced by H. pylori and promotes resistance to cisplatin in gastric cancer

(2019) Sen Wang et al.   Redox Biology

Macrovipecetin, a C-type lectin from Macrovipera lebetina venom, inhibits proliferation migration and invasion of SK-MEL-28 human melanoma cells and enhances their sensitivity to cisplatin

(2018) Manel B. Hammouda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

DUOXA1-mediated ROS production promotes cisplatin resistance by activating ATR-Chk1 pathway in ovarian cancer

(2018) Yunxiao Meng et al.   CANCER LETTERS

Formononetin-induced oxidative stress abrogates the activation of STAT3/5 signaling axis and suppresses the tumor growth in multiple myeloma preclinical model

(2018) Chulwon Kim et al.   CANCER LETTERS

ABT737 reverses cisplatin resistance by targeting glucose metabolism of human ovarian cancer cells

(2018) Yunjie Xu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Cisplatin and curcumin co-loaded nano-liposomes for the treatment of hepatocellular carcinoma

(2018) Yao Cheng et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Targeting activator protein 1 signaling pathway by bioactive natural agents: Possible therapeutic strategy for cancer prevention and intervention

(2018) Devesh Tewari et al.   PHARMACOLOGICAL RESEARCH

Triple action Pt(iv) derivatives of cisplatin: a new class of potent anticancer agents that overcome resistance

(2018) Emanuele Petruzzella et al.   Chemical Science

Miltirone‑induced apoptosis in cisplatin‑resistant lung cancer cells through upregulation of p53 signaling pathways

(2018) Zhongcheng Zhu   Oncology Letters

Cisplatin and Pemetrexed Activate AXL and AXL Inhibitor BGB324 Enhances Mesothelioma Cell Death from Chemotherapy

(2018) Derek B. Oien et al.   Frontiers in Pharmacology

Role of ROS and Nutritional Antioxidants in Human Diseases

(2018) Zewen Liu et al.   Frontiers in Physiology

Targeting colorectal cancer cell metabolism through development of cisplatin and metformin nano-cubosomes

(2018) Mona M. Saber et al.   BMC CANCER

KLF4, a miR-32-5p targeted gene, promotes cisplatin-induced apoptosis by upregulating BIK expression in prostate cancer

(2018) Lu Zhang et al.   Cell Communication and Signaling

Dauricine upregulates the chemosensitivity of hepatocellular carcinoma cells: Role of repressing glycolysis via miR-199a:HK2/PKM2 modulation

(2018) Wei Li et al.   FOOD AND CHEMICAL TOXICOLOGY

Asteriscus graveolens Extract in Combination with Cisplatin/Etoposide/Doxorubicin Suppresses Lymphoma Cell Growth through Induction of Caspase-3 Dependent Apoptosis

(2018) Zainab Tayeh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Thioredoxin Confers Intrinsic Resistance to Cytostatic Drugs in Human Glioma Cells

(2018) Bodo Haas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oleuropein induces apoptosis via abrogating NF-κB activation cascade in estrogen receptor-negative breast cancer cells

(2018) Lian Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mitochondria in innate immune signaling

(2018) Balaji Banoth et al.   Translational Research

Intricate role of mitochondrial lipid in mitophagy and mitochondrial apoptosis: its implication in cancer therapeutics

(2018) Prakash P. Praharaj et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Modulating ROS to overcome multidrug resistance in cancer

(2018) Qingbin Cui et al.   DRUG RESISTANCE UPDATES

Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer

(2018) Daiha Shin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Suppression of SESN1 reduces cisplatin and hyperthermia resistance through increasing reactive oxygen species (ROS) in human maxillary cancer cells

(2018) Norihiko Narita et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Activated Integrated Stress Response Induced by Salubrinal Promotes Cisplatin Resistance in Human Gastric Cancer Cells via Enhanced xCT Expression and Glutathione Biosynthesis

(2018) Sheng-Fan Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SIRT5-mediated deacetylation of LDHB promotes autophagy and tumorigenesis in colorectal cancer

(2018) Liang Shi et al.   Molecular Oncology

Targeting STAT3 and oxidative phosphorylation in oncogene-addicted tumors

(2018) Matilda Lee et al.   Redox Biology

Ophiopogonin D, a Steroidal Glycoside Abrogates STAT3 Signaling Cascade and Exhibits Anti-Cancer Activity by Causing GSH/GSSG Imbalance in Lung Carcinoma

(2018) Jong Lee et al.   Cancers

Cisplatin Loaded Multiwalled Carbon Nanotubes Induce Resistance in Triple Negative Breast Cancer Cells

(2018) Madalina Badea et al.   Pharmaceutics

Melatonin increases human cervical cancer HeLa cells apoptosis induced by cisplatin via inhibition of JNK/Parkin/mitophagy axis

(2017) Li Chen et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Metformin increases sensitivity of osteosarcoma stem cells to cisplatin by inhibiting expression of PKM2

(2017) Depeng Shang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Neferine Potentiates the Antitumor Effect of Cisplatin in Human Lung Adenocarcinoma Cells Via a Mitochondria-Mediated Apoptosis Pathway

(2017) Kalai Selvi Sivalingam et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cisplatin triggers cancer stem cell enrichment in platinum-resistant cells through NF-κB-TNFα-PIK3CA loop

(2017) Bhushan Thakur et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Synergic prooxidant, apoptotic and TRPV1 channel activator effects of alpha-lipoic acid and cisplatin in MCF-7 breast cancer cells

(2017) Gökhan Nur et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Ethaselen: a novel organoselenium anticancer agent targeting thioredoxin reductase 1 reverses cisplatin resistance in drug-resistant K562 cells by inducing apoptosis

(2017) Suo-fu Ye et al.   Journal of Zhejiang University-SCIENCE B

Abrus agglutinin promotes irreparable DNA damage by triggering ROS generation followed by ATM-p73 mediated apoptosis in oral squamous cell carcinoma

(2017) Niharika Sinha et al.   MOLECULAR CARCINOGENESIS

Uncaria tomentosa Leaves Decoction Modulates Differently ROS Production in Cancer and Normal Cells, and Effects Cisplatin Cytotoxicity

(2017) Anita Kośmider et al.   MOLECULES

Hederagenin Induces Apoptosis in Cisplatin-Resistant Head and Neck Cancer Cells by Inhibiting the Nrf2-ARE Antioxidant Pathway

(2017) Eun Hye Kim et al.   Oxidative Medicine and Cellular Longevity

Bioenergetics of acquired cisplatin resistant H1299 non-small cell lung cancer and P31 mesothelioma cells

(2017) Fintan Geoghegan et al.   Oncotarget

Enhanced antitumor efficacy of cisplatin for treating ovarian cancer in vitro and in vivo via transferrin binding

(2017) Huifang Peng et al.   Oncotarget

A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma

(2017) Xiaoyun Dai et al.   Oncotarget

MiR-519d impedes cisplatin-resistance in breast cancer stem cells by down-regulating the expression of MCL-1

(2017) Qing Xie et al.   Oncotarget

Telomerase reverse transcriptase promotes chemoresistance by suppressing cisplatin-dependent apoptosis in osteosarcoma cells

(2017) Zhengpei Zhang et al.   Scientific Reports

Bu-Zhong-Yi-Qi Decoction, the Water Extract of Chinese Traditional Herbal Medicine, Enhances Cisplatin Cytotoxicity in A549/DDP Cells through Induction of Apoptosis and Autophagy

(2017) Ning Yu et al.   Biomed Research International

Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis

(2017) Jong-Lyel Roh et al.   Redox Biology

Autophagy inhibitor chloroquine increases sensitivity to cisplatin in QBC939 cholangiocarcinoma cells by mitochondrial ROS

(2017) Xianzhi Qu et al.   PLoS One

Knockdown of HIF-1α by siRNA-expressing plasmid delivered by attenuated Salmonella enhances the antitumor effects of cisplatin on prostate cancer

(2017) Junlian Gu et al.   Scientific Reports

Emodin Enhances the Chemosensitivity of Endometrial Cancer by Inhibiting ROS-Mediated Cisplatin-resistance

(2017) Ning Ding et al.   Anti-Cancer Agents in Medicinal Chemistry

Co-Delivery of Cisplatin Prodrug and Chlorin e6 by Mesoporous Silica Nanoparticles for Chemo-Photodynamic Combination Therapy to Combat Drug Resistance

(2016) Wei Zhang et al.   ACS Applied Materials & Interfaces

Nimbolide-Induced Oxidative Stress Abrogates STAT3 Signaling Cascade and Inhibits Tumor Growth in Transgenic Adenocarcinoma of Mouse Prostate Model

(2016) Jingwen Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeting Nrf2 with wogonin overcomes cisplatin resistance in head and neck cancer

(2016) Eun Hye Kim et al.   APOPTOSIS

Enhancement of cisplatin-induced colon cancer cells apoptosis by shikonin, a natural inducer of ROS in vitro and in vivo

(2016) Guodong He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Emodin enhances cisplatin-induced cytotoxicity in human bladder cancer cells through ROS elevation and MRP1 downregulation

(2016) Xinxing Li et al.   BMC CANCER

Reactive oxygen species-mediated synergistic and preferential induction of cell death and reduction of clonogenic resistance in breast cancer cells by combined cisplatin and FK228

(2016) Lenora Ann Pluchino et al.   CANCER LETTERS

Activation of mitochondrial oxidation by PDK2 inhibition reverses cisplatin resistance in head and neck cancer

(2016) Jong-Lyel Roh et al.   CANCER LETTERS

Cisplatin and resveratrol induce apoptosis and autophagy following oxidative stress in malignant mesothelioma cells

(2016) Yoon-Jin Lee et al.   FOOD AND CHEMICAL TOXICOLOGY

Cisplatin–Protein Interactions: Unexpected Drug Binding to N-Terminal Amine and Lysine Side Chains

(2016) Irene Russo Krauss et al.   INORGANIC CHEMISTRY

A Novel Polyphenol Conjugate Sensitizes Cisplatin-Resistant Head and Neck Cancer Cells to Cisplatin via Nrf2 Inhibition

(2016) E. H. Kim et al.   MOLECULAR CANCER THERAPEUTICS

Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome

(2016) Sergey V. Melnikov et al.   NUCLEIC ACIDS RESEARCH

Gallic acid induces apoptosis and enhances the anticancer effects of cisplatin in human small cell lung cancer H446 cell line via the ROS-dependent mitochondrial apoptotic pathway

(2016) RUIXUAN WANG et al.   ONCOLOGY REPORTS

Immunomodulatory proteins FIP-gts and chloroquine induce caspase-independent cell death via autophagy for resensitizing cisplatin-resistant urothelial cancer cells

(2016) I-Lun Hsin et al.   PHYTOMEDICINE

ROS Generation in Peroxisomes and its Role in Cell Signaling

(2016) Luis A. del Río et al.   PLANT AND CELL PHYSIOLOGY

Trisubstituted-Imidazoles Induce Apoptosis in Human Breast Cancer Cells by Targeting the Oncogenic PI3K/Akt/mTOR Signaling Pathway

(2016) Chakrabhavi Dhananjaya Mohan et al.   PLoS One

Circulatory zinc transport is controlled by distinct interdomain sites on mammalian albumins

(2016) Katarzyna B. Handing et al.   Chemical Science

Mitochondrial dysfunction enhances cisplatin resistance in human gastric cancer cells via the ROS-activated GCN2-eIF2α-ATF4-xCT pathway

(2016) Sheng-Fan Wang et al.   Oncotarget

Curcumin potentiates antitumor activity of cisplatin in bladder cancer cell lines via ROS-mediated activation of ERK1/2

(2016) Bong Hee Park et al.   Oncotarget

New bipyridine gold(III) dithiocarbamate-containing complexes exerted a potent anticancer activity against cisplatin-resistant cancer cells independent of p53 status

(2016) Muhammad Altaf et al.   Oncotarget

Yu Ping Feng San reverses cisplatin-induced multi-drug resistance in lung cancer cells via regulating drug transporters and p62/TRAF6 signalling

(2016) Jian-Shu Lou et al.   Scientific Reports

Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives

(2016) Pei Shi Ong et al.   Frontiers in Pharmacology

Hypoxia and metabolic adaptation of cancer cells

(2016) K L Eales et al.   Oncogenesis

Gaussian Mixture Model-Based Ensemble Kalman Filtering for State and Parameter Estimation for a PMMA Process

(2016) Ruoxia Li et al.   Processes

Ruthenium(II) Complexes with 2-Phenylimidazo[4,5-f][1,10]phenanthroline Derivatives that Strongly Combat Cisplatin-Resistant Tumor Cells

(2016) Leli Zeng et al.   Scientific Reports

PKC-δ/PKC-α activity balance regulates the lethal effects of cisplatin

(2015) Antonella Muscella et al.   BIOCHEMICAL PHARMACOLOGY

Isorhamnetin augments the anti-tumor effect of capeciatbine through the negative regulation of NF-κB signaling cascade in gastric cancer

(2015) Kanjoormana A. Manu et al.   CANCER LETTERS

Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells

(2015) P. Plaimee et al.   CELL PROLIFERATION

NBM-T-BMX-OS01, an Osthole Derivative, Sensitizes Human Lung Cancer A549 Cells to Cisplatin through AMPK-Dependent Inhibition of ERK and Akt Pathway

(2015) Tian-Jun Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

New mechanisms for old drugs: Insights into DNA-unrelated effects of platinum compounds and drug resistance determinants

(2015) Laura Gatti et al.   DRUG RESISTANCE UPDATES

Brown algae phlorotannins enhance the tumoricidal effect of cisplatin and ameliorate cisplatin nephrotoxicity

(2015) Yeong-In Yang et al.   GYNECOLOGIC ONCOLOGY

Melatonin sensitizes human cervical cancer HeLa cells to cisplatin-induced cytotoxicity and apoptosis: effects on oxidative stress and DNA fragmentation

(2015) Roberto Pariente et al.   JOURNAL OF PINEAL RESEARCH

Approach for chemosensitization of cisplatin-resistant ovarian cancer by cucurbitacin B

(2015) Fardous F. El-Senduny et al.   TUMOR BIOLOGY

Suppression of Chloride Channel 3 Expression Facilitates Sensitivity of Human Glioma U251 Cells to Cisplatin Through Concomitant Inhibition of Akt and Autophagy

(2014) Jing Su et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Dual Oxidase Maturation factor 1 (DUOXA1) overexpression increases reactive oxygen species production and inhibits murine muscle satellite cell differentiation

(2014) Shelley DE Sandiford et al.   Cell Communication and Signaling

Extrapineal melatonin: sources, regulation, and potential functions

(2014) Darío Acuña-Castroviejo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeting Cancer Cells via the Reactive Oxygen Species-Mediated Unfolded Protein Response with a Novel Synthetic Polyphenol Conjugate

(2014) S. Y. Shin et al.   CLINICAL CANCER RESEARCH

p62/SQSTM1 is involved in cisplatin resistance in human ovarian cancer cells via the Keap1-Nrf2-ARE system

(2014) MEIHUI XIA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

TRAP1 Regulates Proliferation, Mitochondrial Function, and Has Prognostic Significance in NSCLC

(2014) Jackeline Agorreta et al.   MOLECULAR CANCER RESEARCH

Synergistic Induction of Apoptosis by Methylseleninic Acid and Cisplatin, The Role of ROS-ERK/AKT-p53 Pathway

(2014) Yibo Zhang et al.   MOLECULAR PHARMACEUTICS

The Akt inhibitor MK-2206 enhances the cytotoxicity of paclitaxel (Taxol) and cisplatin in ovarian cancer cells

(2014) Ying-Hsi Lin et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Zinc protoporphyrin IX enhances chemotherapeutic response of hepatoma cells to cisplatin

(2014) Yang-Sui Liu   WORLD JOURNAL OF GASTROENTEROLOGY

MiR-519d represses ovarian cancer cell proliferation and enhances cisplatin-mediated cytotoxicity in vitro by targeting XIAP

(2014) Yingxin Pang et al.   OncoTargets and Therapy

Systems biology of cisplatin resistance: past, present and future

(2014) L Galluzzi et al.   Cell Death & Disease

Emodin Augments Cisplatin Cytotoxicity in Platinum-Resistant Ovarian Cancer Cells via ROS-Dependent MRP1 Downregulation

(2014) Jun Ma et al.   Biomed Research International

Nanoscale Drug Delivery Platforms Overcome Platinum-Based Resistance in Cancer Cells Due to Abnormal Membrane Protein Trafficking

(2013) Xue Xue et al.   ACS Nano

An anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell survival proteins

(2013) Aruljothi Subramaniam et al.   APOPTOSIS

Roles of Chk1 in cell biology and cancer therapy

(2013) Youwei Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

p53 restoration can overcome cisplatin resistance through inhibition of Akt as well as induction of Bax

(2013) CHAE WON KIM et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Curcumin-loaded nanoparticles induce apoptotic cell death through regulation of the function of MDR1 and reactive oxygen species in cisplatin-resistant CAR human oral cancer cells

(2013) PEI-YING CHANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B-regulated gene products

(2013) Kanjoormana A. Manu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Resistance to paclitxel in breast carcinoma cells requires a quality control of mitochondrial antiapoptotic proteins by TRAP1

(2013) Francesca Maddalena et al.   Molecular Oncology

Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases

(2013) Stephen L. Archer   NEW ENGLAND JOURNAL OF MEDICINE

Emodin Suppresses Migration and Invasion through the Modulation of CXCR4 Expression in an Orthotopic Model of Human Hepatocellular Carcinoma

(2013) Kanjoormana Aryan Manu et al.   PLoS One

PERK/eIF2  signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS

(2013) K. M. Rouschop et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel method for speciation of Pt in human serum incubated with cisplatin, oxaliplatin and carboplatin by conjoint liquid chromatography on monolithic disks with UV and ICP-MS detection

(2013) Anže Martinčič et al.   TALANTA

Cisplatin resistance by induction of aldo-keto reductase family 1 member C2 in human bladder cancer cells

(2013) AKITOMI SHIRATO et al.   Oncology Letters

Triptolide avoids cisplatin resistance and induces apoptosis via the reactive oxygen species/nuclear factor-κB pathway in SKOV3PT platinum-resistant human ovarian cancer cells

(2013) YAN-YING ZHONG et al.   Oncology Letters

Antioxidative properties of paraoxonase 2 in intestinal epithelial cells

(2012) Louis-Philippe Précourt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Synergistic cytotoxic action of cisplatin and withaferin A on ovarian cancer cell lines

(2012) Sham S. Kakar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AMPK and GCN2–ATF4 signal the repression of mitochondria in colon cancer cells

(2012) Inmaculada Martínez-Reyes et al.   BIOCHEMICAL JOURNAL

Enhancement of cisplatin cytotoxicity by benzyl isothiocyanate in HL-60 cells

(2012) Younghyun Lee et al.   FOOD AND CHEMICAL TOXICOLOGY

Molecular mechanism of indomethacin-induced gastropathy

(2012) Sudhir K. Yadav et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Relationship of Thioredoxin-1 and Cisplatin Resistance: Its Impact on ROS and Oxidative Metabolism in Lung Cancer Cells

(2012) M. Wangpaichitr et al.   MOLECULAR CANCER THERAPEUTICS

Mitochondrial dynamics in neurodegeneration

(2012) Kie Itoh et al.   TRENDS IN CELL BIOLOGY

The Human Paraoxonase Gene Cluster As a Target in the Treatment of Atherosclerosis

(2011) Zhi-Gang She et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative stress modulates heme synthesis and induces peroxiredoxin-2 as a novel cytoprotective response in  -thalassemic erythropoiesis

(2011) L. De Franceschi et al.   HAEMATOLOGICA

Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia

(2011) Aude Carreau et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Proteomic Analyses of Sirt1-Mediated Cisplatin Resistance in OSCC Cell Line

(2011) Ping Xiong et al.   PROTEIN JOURNAL

Paraoxonase 2 (PON2) in the mouse central nervous system: A neuroprotective role?

(2011) Gennaro Giordano et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Transcriptional up-regulation of SOD1 by CEBPD: A potential target for cisplatin resistant human urothelial carcinoma cells

(2010) Tzyh-Chyuan Hour et al.   BIOCHEMICAL PHARMACOLOGY

Dual oxidase, hydrogen peroxide and thyroid diseases

(2010) Hidemi Ohye et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Comparative hydrolysis and plasma protein binding of cis-platin and carboplatin in human plasma in vitro

(2010) Melani Sooriyaarachchi et al.   Metallomics

ATR: a master conductor of cellular responses to DNA replication stress

(2010) Rachel Litman Flynn et al.   TRENDS IN BIOCHEMICAL SCIENCES

Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress

(2009) Hee-Yeon Cho et al.   CANCER LETTERS

N′1,N′3-Dimethyl-N′1,N′3-bis(phenylcarbonothioyl) Propanedihydrazide (Elesclomol) Selectively Kills Cisplatin Resistant Lung Cancer Cells through Reactive Oxygen Species (ROS)

(2009) Medhi Wangpaichitr et al.   Cancers

Suppression of Nrf2-driven heme oxygenase-1 enhances the chemosensitivity of lung cancer A549 cells toward cisplatin

(2007) Hak-Ryul Kim et al.   LUNG CANCER