Melatonin Enhances Cisplatin and Radiation Cytotoxicity in Head and Neck Squamous Cell Carcinoma by Stimulating Mitochondrial ROS Generation, Apoptosis, and Autophagy

Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation

(2018) Ying-Qiang Shen et al.   JOURNAL OF PINEAL RESEARCH

Autophagy Modulation in Cancer: Current Knowledge on Action and Therapy

(2018) Mija Marinković et al.   Oxidative Medicine and Cellular Longevity

Cancer Radiosensitizers

(2018) Hao Wang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Oral Mucositis: Melatonin Gel an Effective New Treatment

(2017) Ahmed Abdel Moneim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Impact of Premature Senescence on Radiosensitivity Measured by High Throughput Cell-Based Assays

(2017) Razmik Mirzayans et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis

(2017) Russel Reiter et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin enhances neural stem cell differentiation and engraftment by increasing mitochondrial function

(2017) Miguel Mendivil-Perez et al.   JOURNAL OF PINEAL RESEARCH

Senescent cells: an emerging target for diseases of ageing

(2017) Bennett G. Childs et al.   NATURE REVIEWS DRUG DISCOVERY

Melatonin protects rats from radiotherapy-induced small intestine toxicity

(2017) Beatriz Fernández-Gil et al.   PLoS One

DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity

(2017) Claire Vanpouille-Box et al.   Nature Communications

Activation of apoptosis signalling pathways by reactive oxygen species

(2016) Maureen Redza-Dutordoir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Caspases Connect Cell-Death Signaling to Organismal Homeostasis

(2016) Lorenzo Galluzzi et al.   IMMUNITY

Melatonin as an antioxidant: under promises but over delivers

(2016) Russel J. Reiter et al.   JOURNAL OF PINEAL RESEARCH

Permeabilized myocardial fibers as model to detect mitochondrial dysfunction during sepsis and melatonin effects without disruption of mitochondrial network

(2016) Carolina Doerrier et al.   MITOCHONDRION

Ischaemic conditioning and reperfusion injury

(2016) Derek J. Hausenloy et al.   Nature Reviews Cardiology

The telomere proteins in tumorigenesis and clinical outcomes of oral squamous cell carcinoma

(2016) Y. Benhamou et al.   ORAL ONCOLOGY

Melatonin enhances sensitivity to fluorouracil in oesophageal squamous cell carcinoma through inhibition of Erk and Akt pathway

(2016) Yun-Xin Lu et al.   Cell Death & Disease

Melatonin as a potential anticarcinogen for non-small-cell lung cancer

(2016) Zhiqiang Ma et al.   Oncotarget

Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells

(2015) P. Plaimee et al.   CELL PROLIFERATION

Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis

(2015) A. H. Chourasia et al.   EMBO REPORTS

Melatonin sensitizes human breast cancer cells to ionizing radiation by downregulating proteins involved in double-strand DNA break repair

(2015) Carolina Alonso-González et al.   JOURNAL OF PINEAL RESEARCH

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Natural and therapy-induced immunosurveillance in breast cancer

(2015) Guido Kroemer et al.   NATURE MEDICINE

Extrapineal melatonin: sources, regulation, and potential functions

(2014) Darío Acuña-Castroviejo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis

(2014) Francisco Ortiz et al.   JOURNAL OF PINEAL RESEARCH

Melatonin: Exceeding Expectations

(2014) Russel J. Reiter et al.   PHYSIOLOGY

Metabolic control of cell death

(2014) D. R. Green et al.   SCIENCE

Antioxidants Accelerate Lung Cancer Progression in Mice

(2014) V. I. Sayin et al.   Science Translational Medicine

Cell death stages in single apoptotic and necrotic cells monitored by Raman microspectroscopy

(2014) Eva Brauchle et al.   Scientific Reports

A Mitochondrial Switch Promotes Tumor Metastasis

(2014) Paolo E. Porporato et al.   Cell Reports

Metabolic targets for cancer therapy

(2013) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Cisplatin Induces a Mitochondrial-ROS Response That Contributes to Cytotoxicity Depending on Mitochondrial Redox Status and Bioenergetic Functions

(2013) Rossella Marullo et al.   PLoS One

Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration

(2012) Rhonda M. Perciavalle et al.   NATURE CELL BIOLOGY

Mitochondria: master regulators of danger signalling

(2012) Lorenzo Galluzzi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Intracellular ATP Levels Are a Pivotal Determinant of Chemoresistance in Colon Cancer Cells

(2011) Y. Zhou et al.   CANCER RESEARCH

Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations

(2011) Carmen Venegas et al.   JOURNAL OF PINEAL RESEARCH

Uncoupling protein-2 knockdown mediates the cytotoxic effects of cisplatin

(2010) Francisca M. Santandreu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Bcl-2 Inhibitors: Targeting Mitochondrial Apoptotic Pathways in Cancer Therapy

(2009) M. H. Kang et al.   CLINICAL CANCER RESEARCH

Identification of cisplatin-resistance related genes in head and neck squamous cell carcinoma

(2009) Yukio Yamano et al.   INTERNATIONAL JOURNAL OF CANCER

Synergistic antitumor effect of melatonin with several chemotherapeutic drugs on human Ewing sarcoma cancer cells: potentiation of the extrinsic apoptotic pathway

(2009) Sara Casado-Zapico et al.   JOURNAL OF PINEAL RESEARCH

PHASE-CONTRAST MICROSCOPY STUDIES OF EARLY CISPLATIN-INDUCED MORPHOLOGICAL CHANGES OF MALIGNANT MESOTHELIOMA CELLS AND THE CORRESPONDENCE TO INDUCED APOPTOSIS

(2008) Veronica Janson et al.   EXPERIMENTAL LUNG RESEARCH