SIRT5 Promotes Cisplatin Resistance in Ovarian Cancer by Suppressing DNA Damage in a ROS-Dependent Manner via Regulation of the Nrf2/HO-1 Pathway

Emerging Roles for SIRT5 in Metabolism and Cancer

(2018) Lauren R. Bringman-Rodenbarger et al.   ANTIOXIDANTS & REDOX SIGNALING

Tissue distribution, subcellular localization, and enzymatic activity analysis of human SIRT5 isoforms

(2018) Yipeng Du et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CDK2 positively regulates aerobic glycolysis by suppressing SIRT5 in gastric cancer

(2018) Zhenyong Tang et al.   CANCER SCIENCE

Functions of the sirtuin deacylase SIRT5 in normal physiology and pathobiology

(2018) Surinder Kumar et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer

(2018) Xiu‐Fei Chen et al.   EMBO REPORTS

SIRT5 and post-translational protein modifications: A potential therapeutic target for myocardial ischemia-reperfusion injury with regard to mitochondrial dynamics and oxidative metabolism

(2018) Rongjun Zou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Theaflavin-3,3′-Digallate Enhances the Inhibitory Effect of Cisplatin by Regulating the Copper Transporter 1 and Glutathione in Human Ovarian Cancer Cells

(2018) Haibo Pan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glutathione in Ovarian Cancer: A Double-Edged Sword

(2018) Sofia Nunes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glutathione metabolism in cancer progression and treatment resistance

(2018) Ankita Bansal et al.   JOURNAL OF CELL BIOLOGY

SIRT5 as a biomarker for response to anthracycline-taxane-based neoadjuvant chemotherapy in triple-negative breast cancer

(2018) Lu Xu et al.   ONCOLOGY REPORTS

Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner

(2018) Yun-Qian Wang et al.   Nature Communications

Targeting a Sirt5-Positive Subpopulation Overcomes Multidrug Resistance in Wild-Type Kras Colorectal Carcinomas

(2018) ZunGuo Du et al.   Cell Reports

Sirtuin 5 overexpression attenuates glucolipotoxicity-induced pancreatic β cells apoptosis and dysfunction

(2018) Yue Wang et al.   EXPERIMENTAL CELL RESEARCH

Sirt5 is dispensable for Braf V600E -mediated cutaneous melanoma development and growth in vivo

(2018) Hyeongsun Moon et al.   EXPERIMENTAL DERMATOLOGY

SIRT5-mediated deacetylation of LDHB promotes autophagy and tumorigenesis in colorectal cancer

(2018) Liang Shi et al.   Molecular Oncology

ROS and the DNA damage response in cancer

(2018) Upadhyayula Sai Srinivas et al.   Redox Biology

NAD + dependent deacetylase Sirtuin 5 rescues the innate inflammatory response of endotoxin tolerant macrophages by promoting acetylation of p65

(2017) Kewei Qin et al.   JOURNAL OF AUTOIMMUNITY

Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2

(2017) Xiaoyan Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

SIRT5 promotes cell proliferation and invasion in hepatocellular carcinoma by targeting E2F1

(2017) Liang Chang et al.   Molecular Medicine Reports

SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense

(2016) Lisha Zhou et al.   EMBO REPORTS

Sirtuin 5 is Anti-apoptotic and Anti-oxidative in Cultured SH-EP Neuroblastoma Cells

(2016) Fengyi Liang et al.   NEUROTOXICITY RESEARCH

The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance

(2016) A. L. Furfaro et al.   Oxidative Medicine and Cellular Longevity

Cancer drug resistance: redox resetting renders a way

(2016) Yuan Liu et al.   Oncotarget

Desuccinylation of pyruvate kinase M2 by SIRT5 contributes to antioxidant response and tumor growth

(2016) Ye Xiangyun et al.   Oncotarget

The Essential Role of H19 Contributing to Cisplatin Resistance by Regulating Glutathione Metabolism in High-Grade Serous Ovarian Cancer

(2016) Zhi-Guo Zheng et al.   Scientific Reports

SIRT5 regulation of ammonia-induced autophagy and mitophagy

(2015) Lucia Polletta et al.   Autophagy

Cisplatin resistance in human cervical, ovarian and lung cancer cells

(2015) Jianli Chen et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

SIRT5 prevents cigarette smoke extract-induced apoptosis in lung epithelial cells via deacetylation of FOXO3

(2015) Yongfeng Wang et al.   CELL STRESS & CHAPERONES

Association of HO-1 and BRCA1 Is Critical for the Maintenance of Cellular Homeostasis in Prostate Cancer

(2015) E. Labanca et al.   MOLECULAR CANCER RESEARCH

NADP+-IDH Mutations Promote Hypersuccinylation that Impairs Mitochondria Respiration and Induces Apoptosis Resistance

(2015) Feng Li et al.   MOLECULAR CELL

Assessing sirtuin expression in endometrial carcinoma and non-neoplastic endometrium

(2015) Carla Bartosch et al.   Oncotarget

SUN2 exerts tumor suppressor functions by suppressing the Warburg effect in lung cancer

(2015) Xiao-bin Lv et al.   Scientific Reports

Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5

(2014) Minjia Tan et al.   Cell Metabolism

Ovarian Cancer Cell Line Panel (OCCP): Clinical Importance of In Vitro Morphological Subtypes

(2014) Corine M. Beaufort et al.   PLoS One

SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer

(2014) Weidong Lu et al.   TUMOR BIOLOGY

SIRT5 desuccinylates and activates SOD1 to eliminate ROS

(2013) Zhi-Feng Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT5: A Safeguard Against Oxidative Stress-Induced Apoptosis in Cardiomyocytes

(2013) Ban Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

(2013) M. C. Jaramillo et al.   GENES & DEVELOPMENT

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival

(2013) Chiara Gorrini et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Arsenic Inhibits Autophagic Flux, Activating the Nrf2-Keap1 Pathway in a p62-Dependent Manner

(2013) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

Resveratrol Induces Premature Senescence in Lung Cancer Cells via ROS-Mediated DNA Damage

(2013) Hongmei Luo et al.   PLoS One

Cisplatin Induces a Mitochondrial-ROS Response That Contributes to Cytotoxicity Depending on Mitochondrial Redox Status and Bioenergetic Functions

(2013) Rossella Marullo et al.   PLoS One

Altered expression of SIRT gene family in head and neck squamous cell carcinoma

(2013) Chi-Chih Lai et al.   TUMOR BIOLOGY

Histone Deacetylase Inhibitors Demonstrate Significant Preclinical Activity as Single Agents, and in Combination with Bortezomib in Waldenström's Macroglobulinemia

(2012) Jenny Y. Sun et al.   Clinical Lymphoma Myeloma & Leukemia

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

Distinct regulation of mitochondrial localization and stability of two human Sirt5 isoforms

(2010) Nobuko Matsushita et al.   GENES TO CELLS

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle

(2009) Takashi Nakagawa et al.   CELL

Acquisition of doxorubicin resistance in ovarian carcinoma cells accompanies activation of the NRF2 pathway

(2009) Gi-seong Shim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Opposing Effects of Sirtuins on Neuronal Survival: SIRT1-Mediated Neuroprotection Is Independent of Its Deacetylase Activity

(2008) Jason A. Pfister et al.   PLoS One