Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements

KLF9-dependent ROS regulate melanoma progression in stage-specific manner

(2019) Archis Bagati et al.   ONCOGENE

Activation of c-Met in cancer cells mediates growth-promoting signals against oxidative stress through Nrf2-HO-1

(2019) Samik Chakraborty et al.   Oncogenesis

MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1

(2019) Ying Yang et al.   Nature Communications

Subverted regulation of Nox1 NADPH oxidase-dependent oxidant generation by protein disulfide isomerase A1 in colon carcinoma cells with overactivated KRas

(2019) Tiphany Coralie De Bessa et al.   Cell Death & Disease

MDA-7/IL-24 regulates the miRNA processing enzyme DICER through downregulation of MITF

(2019) Anjan K. Pradhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Specific Inhibition of SOD1 Selectively Promotes Apoptosis of Cancer Cells via Regulation of the ROS Signaling Network

(2019) Xiang Li et al.   Oxidative Medicine and Cellular Longevity

MCUR1 facilitates epithelial-mesenchymal transition and metastasis via the mitochondrial calcium dependent ROS/Nrf2/Notch pathway in hepatocellular carcinoma

(2019) Mingpeng Jin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

RAS/MAPK signaling functions in oxidative stress, DNA damage response and cancer progression

(2019) Setareh Rezatabar et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeting autophagy using natural compounds for cancer prevention and therapy

(2019) Shuo Deng et al.   CANCER

High Glucose-reduced Apoptosis in Human Breast Cancer Cells Is Mediated by Activation of NF-κB

(2019) Atefeh Nasir Kansestani et al.   Iranian Journal of Allergy Asthma and Immunology

Reactive oxygen species: a volatile driver of field cancerization and metastasis

(2019) Zehuan Liao et al.   Molecular Cancer

Oxidative Stress-Driven Autophagy acROSs Onset and Therapeutic Outcome in Hepatocellular Carcinoma

(2019) Fabio Ciccarone et al.   Oxidative Medicine and Cellular Longevity

Arsenic Disulfide Combined with L-Buthionine-(S, R)-Sulfoximine Induces Synergistic Antitumor Effects in Two-Dimensional and Three-Dimensional Models of MCF-7 Breast Carcinoma Cells

(2019) Yuxue Zhao et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Overcoming Cancer Cell Drug Resistance by a Folic Acid Targeted Polymeric Conjugate of Buthionine Sulfoximine

(2019) Felisa Cilurzo et al.   Anti-Cancer Agents in Medicinal Chemistry

Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy

(2019) Yasmina K. Mahmoud et al.   BIOMEDICINE & PHARMACOTHERAPY

YAP promotes multi-drug resistance and inhibits autophagy-related cell death in hepatocellular carcinoma via the RAC1-ROS-mTOR pathway

(2019) Yuan Zhou et al.   Cancer Cell International

The thioredoxin system and cancer therapy: a review

(2019) Fariba Mohammadi et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Reactive oxygen species and cancer: A complex interaction

(2019) Sankaralingam Saikolappan et al.   CANCER LETTERS

Cross talk between SOD1 and the mitochondrial UPR in cancer and neurodegeneration

(2019) Maria Gomez et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Reactive oxygen species induce epithelial‑mesenchymal transition, glycolytic switch, and mitochondrial repression through the Dlx‑2/Snail signaling pathways in MCF‑7 cells

(2019) Su Lee et al.   Molecular Medicine Reports

PARP1 and Poly(ADP-ribosyl)ation Signaling during Autophagy in Response to Nutrient Deprivation

(2019) José Manuel Rodríguez-Vargas et al.   Oxidative Medicine and Cellular Longevity

Autophagy and mitophagy in cancer metabolic remodelling

(2019) Fabio Ferro et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Elevated level of mitochondrial reactive oxygen species via fatty acid β-oxidation in cancer stem cells promotes cancer metastasis by inducing epithelial–mesenchymal transition

(2019) Caihua Wang et al.   Stem Cell Research & Therapy

Human Aquaporin-5 Facilitates Hydrogen Peroxide Permeation Affecting Adaption to Oxidative Stress and Cancer Cell Migration

(2019) Claudia Rodrigues et al.   Cancers

The depletion of p38alpha kinase upregulates NADPH oxidase 2/NOX2/gp91 expression and the production of superoxide in mouse embryonic stem cells

(2019) Lucia Binó et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

MicroRNA Networks Modulate Oxidative Stress in Cancer

(2019) Yang-Hsiang Lin   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interplay Between Mitochondrial Peroxiredoxins and ROS in Cancer Development and Progression

(2019) Tayaba Ismail et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nitric oxide and interactions with reactive oxygen species in the development of melanoma, breast, and colon cancer: A redox signaling perspective

(2019) Hugo P. Monteiro et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Sestrins as a Therapeutic Bridge between ROS and Autophagy in Cancer

(2019) Sánchez-Álvarez et al.   Cancers

MRP1 modulators synergize with buthionine sulfoximine to exploit collateral sensitivity and selectively kill MRP1-expressing cancer cells

(2019) Christine C. Gana et al.   BIOCHEMICAL PHARMACOLOGY

Cancer and ER stress: Mutual crosstalk between autophagy, oxidative stress and inflammatory response

(2019) Yuning Lin et al.   BIOMEDICINE & PHARMACOTHERAPY

Effect of cigarette smoke extract on mitochondrial heme-metabolism: An in vitro model of oral cancer progression

(2019) Ripon Sarkar et al.   TOXICOLOGY IN VITRO

2,3′4,4′,5-Pentachlorobiphenyl induces hepatocellular carcinoma cell proliferation through pyruvate kinase M2-dependent glycolysis

(2019) Wenli Liang et al.   TOXICOLOGY LETTERS

Differential redox-regulation and mitochondrial dynamics in normal and leukemic hematopoietic stem cells: A potential window for leukemia therapy

(2019) Katharina Mattes et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Beyond symptomatic relief for chemotherapy-induced peripheral neuropathy: Targeting the source

(2018) Jiacheng Ma et al.   CANCER

Sorafenib improves alkylating therapy by blocking induced inflammation, invasion and angiogenesis in breast cancer cells

(2018) Alfeu Zanotto-Filho et al.   CANCER LETTERS

Formononetin-induced oxidative stress abrogates the activation of STAT3/5 signaling axis and suppresses the tumor growth in multiple myeloma preclinical model

(2018) Chulwon Kim et al.   CANCER LETTERS

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

(2018) Steven J. Forrester et al.   CIRCULATION RESEARCH

Blockade of JAK2/STAT3 intensifies the anti-tumor activity of arsenic trioxide in acute myeloid leukemia cells: Novel synergistic mechanism via the mediation of reactive oxygen species

(2018) Yashar Mesbahi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Activation of ER Stress-Dependent miR-216b Has a Critical Role in Salvia miltiorrhiza Ethanol-Extract-Induced Apoptosis in U266 and U937 Cells

(2018) Changmin Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glutathione metabolism in cancer progression and treatment resistance

(2018) Ankita Bansal et al.   JOURNAL OF CELL BIOLOGY

Synergistic effect of copper and arsenic upon oxidative stress, inflammation and autophagy alterations in brain tissues of Gallus gallus

(2018) Xiao Sun et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

MiR-148b functions as a tumor suppressor by targeting endoplasmic reticulum metallo protease 1 in human endometrial cancer cells

(2018) Jinfeng Qu et al.   ONCOLOGY RESEARCH

Resveratrol Inhibits ROS-Promoted Activation and Glycolysis of Pancreatic Stellate Cells via Suppression of miR-21

(2018) Bin Yan et al.   Oxidative Medicine and Cellular Longevity

Roles of ROS, Nrf2, and autophagy in cadmium-carcinogenesis and its prevention by sulforaphane

(2018) Yuting Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

MiR-422a regulates cellular metabolism and malignancy by targeting pyruvate dehydrogenase kinase 2 in gastric cancer

(2018) Zhongyuan He et al.   Cell Death & Disease

The role of ROS-induced autophagy in hepatocellular carcinoma

(2018) Xingxing Yuan et al.   Clinics and Research in Hepatology and Gastroenterology

Nicotinamide nucleotide transhydrogenase-mediated redox homeostasis promotes tumor growth and metastasis in gastric cancer

(2018) Shuai Li et al.   Redox Biology

Reactive Oxygen Species, Superoxide Dimutases, and PTEN-p53-AKT-MDM2 Signaling Loop Network in Mesenchymal Stem/Stromal Cells Regulation

(2018) Satoru Matsuda et al.   Cells

Oleuropein induces apoptosis via abrogating NF-κB activation cascade in estrogen receptor-negative breast cancer cells

(2018) Lian Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

GLOBOCAN 2018: counting the toll of cancer

(2018) The Lancet   LANCET

miR-9 regulates ferroptosis by targeting glutamic-oxaloacetic transaminase GOT1 in melanoma

(2018) Kexin Zhang et al.   MOLECULAR CARCINOGENESIS

GPx3-mediated redox signaling arrests the cell cycle and acts as a tumor suppressor in lung cancer cell lines

(2018) Byung Chull An et al.   PLoS One

Targeting glutathione S-transferase P and its interactome with selenium compounds in cancer therapy

(2018) D. Bartolini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Loss of TMEM126A promotes extracellular matrix remodeling, epithelial-to-mesenchymal transition, and breast cancer metastasis by regulating mitochondrial retrograde signaling

(2018) He-Fen Sun et al.   CANCER LETTERS

A mitochondrial ROS pathway controls matrix metalloproteinase 9 levels and invasive properties in RAS-activated cancer cells

(2018) Kazunori Mori et al.   FEBS Journal

The role of cellular reactive oxygen species in cancer chemotherapy

(2018) Haotian Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Oxidant stress induction and signalling in xenografted (human breast cancer-tissues) plus estradiol treated or N-ethyl-N-nitrosourea treated female rats via altered estrogen sulfotransferase (rSULT1E1) expressions and SOD1/catalase regulations

(2018) Aarifa Nazmeen et al.   MOLECULAR BIOLOGY REPORTS

Chemotherapy Treatment and Trials in Low-Grade Gliomas

(2018) Laura E. Donovan et al.   NEUROSURGERY CLINICS OF NORTH AMERICA

NOX2 inhibition reduces oxidative stress and prolongs survival in murine KRAS-induced myeloproliferative disease

(2018) Ebru Aydin et al.   ONCOGENE

Arsenic Trioxide for Treating Acute Promyelocytic Leukaemia: An Evidence Review Group Perspective of a NICE Single Technology Appraisal

(2018) Bram L. T. Ramaekers et al.   PHARMACOECONOMICS

Markers of Mitochondrial Metabolism in Tumor Hypoxia, Systemic Inflammation, and Adverse Outcome of Rectal Cancer

(2018) Paula A. Bousquet et al.   Translational Oncology

NOX2 oxidase expressed in endosomes promotes cell proliferation and prostate tumour development

(2018) Ian P. Harrison et al.   Oncotarget

Targeting STAT3 and oxidative phosphorylation in oncogene-addicted tumors

(2018) Matilda Lee et al.   Redox Biology

Chidamide-induced ROS accumulation and miR-129-3p-dependent cell cycle arrest in non-small lung cancer cells

(2018) Yueh-Feng Wu et al.   PHYTOMEDICINE

Breast cancer-associated mitochondrial DNA haplogroup promotes neoplastic growth via ROS-mediated AKT activation

(2017) Lin Ma et al.   INTERNATIONAL JOURNAL OF CANCER

ROS-modulated therapeutic approaches in cancer treatment

(2017) Muhammad Hassan Raza et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Improved Outcomes With Retinoic Acid and Arsenic Trioxide Compared With Retinoic Acid and Chemotherapy in Non–High-Risk Acute Promyelocytic Leukemia: Final Results of the Randomized Italian-German APL0406 Trial

(2017) Uwe Platzbecker et al.   JOURNAL OF CLINICAL ONCOLOGY

The pathophysiological role of mitochondrial oxidative stress in lung diseases

(2017) Xiaojing Liu et al.   Journal of Translational Medicine

The Roles of ROS in Cancer Heterogeneity and Therapy

(2017) Paulo Luiz de Sá Junior et al.   Oxidative Medicine and Cellular Longevity

Impact of NADPH oxidase functional polymorphisms in acute myeloid leukemia induction chemotherapy

(2017) J E Megías-Vericat et al.   PHARMACOGENOMICS JOURNAL

Targeting the Thioredoxin System for Cancer Therapy

(2017) Junmin Zhang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Induction of oxidative stress by anticancer drugs in the presence and absence of cells

(2017) Chikako Yokoyama et al.   Oncology Letters

Role of ginsenosides in reactive oxygen species-mediated anticancer therapy

(2017) Islam Sodrul et al.   Oncotarget

A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma

(2017) Xiaoyun Dai et al.   Oncotarget

Thymoquinone, as an anticancer molecule: from basic research to clinical investigation

(2017) Md. Asaduzzaman Khan et al.   Oncotarget

VEGF stimulated the angiogenesis by promoting the mitochondrial functions

(2017) Dongqing Guo et al.   Oncotarget

Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice

(2017) Vinodkumar B. Pillai et al.   Oncotarget

The molecular mechanisms of chemoresistance in cancers

(2017) Hua-Chuan Zheng   Oncotarget

Role of NOX2-Derived Reactive Oxygen Species in NK Cell–Mediated Control of Murine Melanoma Metastasis

(2017) Ebru Aydin et al.   Cancer Immunology Research

Emodin Enhances the Chemosensitivity of Endometrial Cancer by Inhibiting ROS-Mediated Cisplatin-resistance

(2017) Ning Ding et al.   Anti-Cancer Agents in Medicinal Chemistry

Nimbolide-Induced Oxidative Stress Abrogates STAT3 Signaling Cascade and Inhibits Tumor Growth in Transgenic Adenocarcinoma of Mouse Prostate Model

(2016) Jingwen Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Activation of apoptosis signalling pathways by reactive oxygen species

(2016) Maureen Redza-Dutordoir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Emodin enhances cisplatin-induced cytotoxicity in human bladder cancer cells through ROS elevation and MRP1 downregulation

(2016) Xinxing Li et al.   BMC CANCER

Influence of doxorubicin on apoptosis and oxidative stress in breast cancer cell lines

(2016) Nesstor Pilco-Ferreto et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

From inflammation to cancer

(2016) A. Korniluk et al.   IRISH JOURNAL OF MEDICAL SCIENCE

Mitochondria and Mitochondrial ROS in Cancer: Novel Targets for Anticancer Therapy

(2016) Yuhui Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Dual targeting of the thioredoxin and glutathione systems in cancer and HIV

(2016) Moran Benhar et al.   JOURNAL OF CLINICAL INVESTIGATION

Silver Nanoparticles Induce HePG-2 Cells Apoptosis Through ROS-Mediated Signaling Pathways

(2016) Bing Zhu et al.   Nanoscale Research Letters

Cross Talk Mechanism among EMT, ROS, and Histone Acetylation in Phorbol Ester-Treated Human Breast Cancer MCF-7 Cells

(2016) Tetsuro Kamiya et al.   Oxidative Medicine and Cellular Longevity

The ROS-mediated activation of STAT-3/VEGF signaling is involved in the 27-hydroxycholesterol-induced angiogenesis in human breast cancer cells

(2016) Dongmei Zhu et al.   TOXICOLOGY LETTERS

Copper as a target for prostate cancer therapeutics: copper-ionophore pharmacology and altering systemic copper distribution

(2016) Delphine Denoyer et al.   Oncotarget

Silver Nanoparticles Induce HePG-2 Cells Apoptosis Through ROS-Mediated Signaling Pathways

(2016) Bing Zhu et al.   Nanoscale Research Letters

Lung cancer patients withHER2mutations treated with chemotherapy andHER2-targeted drugs: results from the European EUHER2 cohort

(2015) J. Mazières et al.   ANNALS OF ONCOLOGY

Chemical Approaches to Discovery and Study of Sources and Targets of Hydrogen Peroxide Redox Signaling Through NADPH Oxidase Proteins

(2015) Thomas F. Brewer et al.   Annual Review of Biochemistry

Regulation of MMP-1 expression in response to hypoxia is dependent on the intracellular redox status of metastatic bladder cancer cells

(2015) Dong Hui Shin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

ROS and Autophagy: Interactions and Molecular Regulatory Mechanisms

(2015) Lulu Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Induction of MAPK- and ROS-dependent autophagy and apoptosis in gastric carcinoma by combination of romidepsin and bortezomib

(2015) Kwai Fung Hui et al.   Oncotarget

Role of miR-182 in response to oxidative stress in the cell fate of human fallopian tube epithelial cells

(2015) Yugang Liu et al.   Oncotarget

Copper activates HIF-1α/GPER/VEGF signalling in cancer cells

(2015) Damiano Cosimo Rigiracciolo et al.   Oncotarget

Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy

(2015) Laura Poillet-Perez et al.   Redox Biology

Metabolomic alterations in human cancer cells by vitamin C-induced oxidative stress

(2015) Megumi Uetaki et al.   Scientific Reports

Roles of Oxidative Stress in the Development and Progression of Breast Cancer

(2014) Ali Reza Nourazarian et al.   Asian Pacific Journal of Cancer Prevention

The role of GABARAPL1/GEC1 in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cells

(2014) Michaël Boyer-Guittaut et al.   Autophagy

MicroRNA-34a induces apoptosis in the human glioma cell line, A172, through enhanced ROS production and NOX2 expression

(2014) San-Zhong Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting antioxidants for cancer therapy

(2014) Andrea Glasauer et al.   BIOCHEMICAL PHARMACOLOGY

Increased expression of RRM2 by human papillomavirus E7 oncoprotein promotes angiogenesis in cervical cancer

(2014) N Wang et al.   BRITISH JOURNAL OF CANCER

Deferoxamine Promotes MDA-MB-231 Cell Migration and Invasion through Increased ROS-Dependent HIF-1a Accumulation

(2014) Yiping Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Nrf2 Amplifies Oxidative Stress via Induction of Klf9

(2014) Shoshanna N. Zucker et al.   MOLECULAR CELL

Insulin Regulates Glucose Consumption and Lactate Production through Reactive Oxygen Species and Pyruvate Kinase M2

(2014) Qi Li et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Celastrol Stimulates Hypoxia-Inducible Factor-1 Activity in Tumor Cells by Initiating the ROS/Akt/p70S6K Signaling Pathway and Enhancing Hypoxia-Inducible Factor-1α Protein Synthesis

(2014) Xiaoxi Han et al.   PLoS One

Chronic Inflammation and Cytokines in the Tumor Microenvironment

(2014) Glauben Landskron et al.   Journal of Immunology Research

The Role of Vimentin Intermediate Filaments in the Progression of Lung Cancer

(2013) Martha E Kidd et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

An anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell survival proteins

(2013) Aruljothi Subramaniam et al.   APOPTOSIS

Inhibiting cancer metastasis via targeting NAPDH oxidase 4

(2013) Biao Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Molecular mechanisms underlying chronic inflammation-associated cancers

(2013) Yongzhong Wu et al.   CANCER LETTERS

Garcinol, a Polyisoprenylated Benzophenone Modulates Multiple Proinflammatory Signaling Cascades Leading to the Suppression of Growth and Survival of Head and Neck Carcinoma

(2013) F. Li et al.   Cancer Prevention Research

Vitamin C suppresses cell death in MCF-7 human breast cancer cells induced by tamoxifen

(2013) Tamilselvan Subramani et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Targeting SOD1 reduces experimental non–small-cell lung cancer

(2013) Andrea Glasauer et al.   JOURNAL OF CLINICAL INVESTIGATION

The B55α Subunit of PP2A Drives a p53-Dependent Metabolic Adaptation to Glutamine Deprivation

(2013) Michael A. Reid et al.   MOLECULAR CELL

Plant polyphenol induced cell death in human cancer cells involves mobilization of intracellular copper ions and reactive oxygen species generation: A mechanism for cancer chemopreventive action

(2013) Husain Yar Khan et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Regulatory effects of resveratrol on antioxidant enzymes: A mechanism of growth inhibition and apoptosis induction in cancer cells

(2013) Md. Asaduzzaman Khan et al.   MOLECULES AND CELLS

Thymoquinone Inhibits Tumor Growth and Induces Apoptosis in a Breast Cancer Xenograft Mouse Model: The Role of p38 MAPK and ROS

(2013) Chern Chiuh Woo et al.   PLoS One

NADPH Oxidases as Regulators of Tumor Angiogenesis: Current and Emerging Concepts

(2012) Sanja Coso et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR-199a/125b and DNA methylation

(2012) Jun He et al.   EMBO REPORTS

Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression

(2012) Jong Hun Lee et al.   PHARMACOLOGY & THERAPEUTICS

β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation

(2011) Kyung-Ran Park et al.   CANCER LETTERS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Chronic inflammation, the tumor microenvironment and carcinogenesis

(2011) Tamas A. Gonda et al.   CELL CYCLE

miR-200c is upregulated by oxidative stress and induces endothelial cell apoptosis and senescence via ZEB1 inhibition

(2011) A Magenta et al.   CELL DEATH AND DIFFERENTIATION

Thymoquinone suppresses growth and induces apoptosis via generation of reactive oxygen species in primary effusion lymphoma

(2011) Azhar R. Hussain et al.   FREE RADICAL BIOLOGY AND MEDICINE

Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines

(2011) R. Somwar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cadmium Increases HIF-1 and VEGF Expression through ROS, ERK, and AKT Signaling Pathways and Induces Malignant Transformation of Human Bronchial Epithelial Cells

(2011) Yi Jing et al.   TOXICOLOGICAL SCIENCES

PI3K/AKT/mTOR Pathway in Angiogenesis

(2011) Jayashree Karar et al.   Frontiers in Molecular Neuroscience

Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-κB activation in breast and pancreatic tumor cells

(2010) Angeline Wei Ling Chua et al.   BIOCHEMICAL PHARMACOLOGY

Targeting transcription factor NF-κB to overcome chemoresistance and radioresistance in cancer therapy

(2010) Feng Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

Antioxidant enzymes and cancer

(2010) Md. Asaduzzaman Khan et al.   Chinese Journal of Cancer Research

Resveratrol attenuates the anticancer efficacy of paclitaxel in human breast cancer cells in vitro and in vivo

(2010) Masayuki Fukui et al.   EUROPEAN JOURNAL OF CANCER

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting microRNAs in cancer: rationale, strategies and challenges

(2010) Ramiro Garzon et al.   NATURE REVIEWS DRUG DISCOVERY

miR-23b* targets proline oxidase, a novel tumor suppressor protein in renal cancer

(2010) W Liu et al.   ONCOGENE

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

Molecular interactions in cancer cell metastasis

(2009) Susan A. Brooks et al.   ACTA HISTOCHEMICA

Mitochondrial Dysfunction and Reactive Oxygen Species Imbalance Promote Breast Cancer Cell Motility through a CXCL14-Mediated Mechanism

(2009) H. Pelicano et al.   CANCER RESEARCH

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Redox regulation of anoikis resistance of metastatic prostate cancer cells: key role for Src and EGFR-mediated pro-survival signals

(2009) E Giannoni et al.   ONCOGENE

Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment

(2008) Meghan B. Azad et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy

(2008) Masuko Ushio-Fukai et al.   CANCER LETTERS

Oxidative stress, DNA methylation and carcinogenesis

(2008) Rodrigo Franco et al.   CANCER LETTERS

p53 hot-spot mutants increase tumor vascularization via ROS-mediated activation of the HIF1/VEGF-A pathway

(2008) N.V. Khromova et al.   CANCER LETTERS

Elevated copper and oxidative stress in cancer cells as a target for cancer treatment

(2008) Anshul Gupte et al.   CANCER TREATMENT REVIEWS

Epigenetic Changes Induced by Reactive Oxygen Species in Hepatocellular Carcinoma: Methylation of the E-cadherin Promoter

(2008) Seung-Oe Lim et al.   GASTROENTEROLOGY

Simvastatin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, suppresses osteoclastogenesis induced by receptor activator of nuclear factor-κB ligand through modulation of NF-κB pathway

(2008) Kwang Seok Ahn et al.   INTERNATIONAL JOURNAL OF CANCER

Brevinin-2R1 semi-selectively kills cancer cells by a distinct mechanism, which involves the lysosomal-mitochondrial death pathway

(2008) Saeid Ghavami et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Inflammation and Lung Cancer: Roles of Reactive Oxygen/Nitrogen Species

(2008) Neelam Azad et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Keratin down-regulation in vimentin-positive cancer cells is reversible by vimentin RNA interference, which inhibits growth and motility

(2008) R. J. Paccione et al.   MOLECULAR CANCER THERAPEUTICS

NADPH oxidase 1 plays a critical mediating role in oncogenic Ras-induced vascular endothelial growth factor expression

(2008) D Komatsu et al.   ONCOGENE

Emodin-Induced Generation of Reactive Oxygen Species Inhibits RhoA Activation to Sensitize Gastric Carcinoma Cells to Anoikis

(2008) Jun Cai et al.   NEOPLASIA