An anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell survival proteins

Emodin Suppresses Migration and Invasion through the Modulation of CXCR4 Expression in an Orthotopic Model of Human Hepatocellular Carcinoma

(2013) Kanjoormana Aryan Manu et al.   PLoS One

Dovitinib sensitizes hepatocellular carcinoma cells to TRAIL and tigatuzumab, a novel anti-DR5 antibody, through SHP-1-dependent inhibition of STAT3

(2012) Kuen-Feng Chen et al.   BIOCHEMICAL PHARMACOLOGY

Cancer statistics, 2012

(2012) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

TRAIL: A Sword for Killing Tumors

(2012) S. Wang   CURRENT MEDICINAL CHEMISTRY

Guggulsterone sensitizes hepatoma cells to TRAIL-induced apoptosis through the induction of CHOP-dependent DR5: Involvement of ROS-dependent ER-stress

(2011) Dong-Oh Moon et al.   BIOCHEMICAL PHARMACOLOGY

Aloe emodin inhibits colon cancer cell migration/angiogenesis by downregulating MMP-2/9, RhoB and VEGF via reduced DNA binding activity of NF-κB

(2011) Priya Suboj et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

TRADD is critical for resistance to TRAIL-induced cell death through NF-κB activation

(2011) Joo-Young Kim et al.   FEBS LETTERS

TRAIL-R4 Promotes Tumor Growth and Resistance to Apoptosis in Cervical Carcinoma HeLa Cells through AKT

(2011) Najoua Lalaoui et al.   PLoS One

Combining naturally occurring polyphenols with TNF-related apoptosis-inducing ligand: a promising approach to kill resistant cancer cells?

(2010) Guillaume Jacquemin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibition of casein kinase 2 enhances the death ligand- and natural kiler cell-induced hepatocellular carcinoma cell death

(2010) H.-R. Kim et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Suppression of Signal Transducer and Activator of Transcription 3 Activation by Butein Inhibits Growth of Human Hepatocellular Carcinoma In Vivo

(2010) Peramaiyan Rajendran et al.   CLINICAL CANCER RESEARCH

TRAIL receptor signaling and therapeutics

(2010) Junaid Abdulghani et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Butein Sensitizes Human Hepatoma Cells to TRAIL-Induced Apoptosis via Extracellular Signal-Regulated Kinase/Sp1-Dependent DR5 Upregulation and NF- B Inactivation

(2010) D.-O. Moon et al.   MOLECULAR CANCER THERAPEUTICS

The Synthetic Cannabinoid WIN 55,212-2 Sensitizes Hepatocellular Carcinoma Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-Induced Apoptosis by Activating p8/CCAAT/Enhancer Binding Protein Homologous Protein (CHOP)/Death Receptor 5 (DR5) Axis

(2010) O. Pellerito et al.   MOLECULAR PHARMACOLOGY

Hepatocellular carcinoma: a global view

(2010) Ju Dong Yang et al.   Nature Reviews Gastroenterology & Hepatology

Is There a Role for Nuclear Factor κB in Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Resistance?

(2009) Amandine Plantivaux et al.   Annals of the New York Academy of Sciences

Is TRAIL the holy grail of cancer therapy?

(2009) Thomas Newsom-Davis et al.   APOPTOSIS

Evaluation of Aloin and Aloe-Emodin as Anti-Inflammatory Agents in Aloe by Using Murine Macrophages

(2009) Mi-Young PARK et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Zerumbone Enhances TRAIL-Induced Apoptosis through the Induction of Death Receptors in Human Colon Cancer Cells: Evidence for an Essential Role of Reactive Oxygen Species

(2009) S. Yodkeeree et al.   CANCER RESEARCH

Bortezomib Overcomes Tumor Necrosis Factor-related Apoptosis-inducing Ligand Resistance in Hepatocellular Carcinoma Cells in Part through the Inhibition of the Phosphatidylinositol 3-Kinase/Akt Pathway

(2009) Kuen-Feng Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRAILing death in cancer

(2009) Gregory Mellier et al.   MOLECULAR ASPECTS OF MEDICINE

Involvement of Matrix Metalloproteinases on the Inhibition of Cells Invasion and Migration by Emodin in Human Neuroblastoma SH-SY5Y Cells

(2009) Hsu-Feng Lu et al.   NEUROCHEMICAL RESEARCH

Immunosuppressive Effects of Emodin: An In Vivo and In Vitro Study

(2009) Y.-X. Liu et al.   TRANSPLANTATION PROCEEDINGS

Potential pharmacological control of the NF-κB pathway

(2009) Gautam Sethi et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Differential responsiveness of human hepatoma cellsversusnormal hepatocytes to TRAIL in combination with either histone deacetylase inhibitors or conventional cytostatics

(2008) Johanna Dzieran et al.   CANCER SCIENCE

Aloe-emodin is an interferon-inducing agent with antiviral activity against Japanese encephalitis virus and enterovirus 71

(2008) Cheng-Wen Lin et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

The promise of cancer therapeutics targeting the TNF-related apoptosis-inducing ligand and TRAIL receptor pathway

(2008) S Wang   ONCOGENE

Rosiglitazone promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP

(2007) Yeoun Hee Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE