The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling
Authors
Keywords
-
Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 12, Pages 4507
Publisher
MDPI AG
Online
2020-06-25
DOI
10.3390/ijms21124507
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- A phase I dose-escalation study of enzalutamide in combination with the AKT inhibitor AZD5363 (capivasertib) in patients with metastatic castration resistant prostate cancer.
- (2020) M.P. Kolinsky et al. ANNALS OF ONCOLOGY
- Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer
- (2020) Ivana Hermanova et al. JOURNAL OF EXPERIMENTAL MEDICINE
- mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges
- (2020) Zhilin Zou et al. Cell and Bioscience
- Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene
- (2019) Yamei Han et al. Nature Communications
- piRNA‐DQ722010 contributes to prostate hyperplasia of the male offspring mice after the maternal exposed to microcystin‐leucine arginine
- (2019) Ruitong Han et al. PROSTATE
- Targeting PI3K in cancer: mechanisms and advances in clinical trials
- (2019) Jing Yang et al. Molecular Cancer
- The PHLPP2 phosphatase is a druggable driver of prostate cancer progression
- (2019) Dawid G. Nowak et al. JOURNAL OF CELL BIOLOGY
- Sestrins at the Interface of ROS Control and Autophagy Regulation in Health and Disease
- (2019) Marco Cordani et al. Oxidative Medicine and Cellular Longevity
- Genomic correlates of clinical outcome in advanced prostate cancer
- (2019) Wassim Abida et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Loss of PTEN Accelerates NKX3.1 Degradation to Promote Prostate Cancer Progression
- (2019) Cai Bowen et al. CANCER RESEARCH
- Wnt-pathway Activating Mutations Are Associated with Resistance to First-line Abiraterone and Enzalutamide in Castration-resistant Prostate Cancer
- (2019) Pedro Isaacsson Velho et al. EUROPEAN UROLOGY
- The MAP3K7-mTOR Axis Promotes the Proliferation and Malignancy of Hepatocellular Carcinoma Cells
- (2019) Jin-Shiung Cheng et al. Frontiers in Oncology
- The PTEN–PI3K Axis in Cancer
- (2019) Papa et al. Biomolecules
- Phase Ib Study of Combination Therapy with MEK Inhibitor Binimetinib and Phosphatidylinositol 3‐Kinase Inhibitor Buparlisib in Patients with Advanced Solid Tumors with RAS/RAF Alterations
- (2019) Aditya Bardia et al. ONCOLOGIST
- Non-nuclear AR Signaling in Prostate Cancer
- (2019) Alice Zamagni et al. Frontiers in Chemistry
- Second-Generation Antiandrogens: From Discovery to Standard of Care in Castration Resistant Prostate Cancer
- (2019) Meghan A. Rice et al. Frontiers in Oncology
- Activation of β-catenin cooperates with loss of Pten to drive AR-independent castration-resistant prostate cancer
- (2019) Rachana Patel et al. CANCER RESEARCH
- Direct physical interaction of active Ras with mSIN1 regulates mTORC2 signaling
- (2019) Mehraj-U-Din Lone et al. BMC CANCER
- Therapies Targeted to Androgen Receptor Signaling Axis in Prostate Cancer: Progress, Challenges, and Hope
- (2019) Sirin Saranyutanon et al. Cancers
- Crosstalks of GSK3 signaling with the mTOR network and effects on targeted therapy of cancer
- (2019) Camilla Evangelisti et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Deptor is a novel target of Wnt/β-catenin/c-Myc and contributes to colorectal cancer cell growth
- (2018) Qingding Wang et al. CANCER RESEARCH
- Inhibition of the Wnt/β-catenin pathway overcomes resistance to enzalutamide in castration-resistant prostate cancer
- (2018) Zhuangzhuang Zhang et al. CANCER RESEARCH
- Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer
- (2018) Katherine A. Hoadley et al. CELL
- PIK3R3 Promotes Metastasis of Pancreatic Cancer via ZEB1 Induced Epithelial-Mesenchymal Transition
- (2018) Yun-Peng Peng et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Co‐targeting driver pathways in prostate cancer: two birds with one stone
- (2018) Amina Zoubeidi et al. EMBO Molecular Medicine
- Role of Wnt signalling in advanced prostate cancer
- (2018) Imran Ahmad et al. JOURNAL OF PATHOLOGY
- Revisiting the role of Wnt/β-catenin signaling in prostate cancer
- (2018) Jeffrey A. Schneider et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- The long tail of oncogenic drivers in prostate cancer
- (2018) Joshua Armenia et al. NATURE GENETICS
- Targeting the PI3K pathway in cancer: are we making headway?
- (2018) Filip Janku et al. Nature Reviews Clinical Oncology
- Clinical implications of PTEN loss in prostate cancer
- (2018) Tamara Jamaspishvili et al. Nature Reviews Urology
- Parallel PI3K, AKT and mTOR inhibition is required to control feedback loops that limit tumor therapy
- (2018) Anuja Sathe et al. PLoS One
- PDK1: At the crossroad of cancer signaling pathways
- (2018) Paolo Armando Gagliardi et al. SEMINARS IN CANCER BIOLOGY
- Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth
- (2018) Helen B. Pearson et al. Cancer Discovery
- Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention
- (2018) Rajesh Basnet et al. Acta Pharmaceutica Sinica B
- mTOR Cross-Talk in Cancer and Potential for Combination Therapy
- (2018) Fabiana Conciatori et al. Cancers
- CAMKK2 promotes prostate cancer independently of AMPK via increased lipogenesis
- (2018) Lucy Penfold et al. CANCER RESEARCH
- Androgen-targeted therapy in men with prostate cancer: evolving practice and future considerations
- (2018) E. David Crawford et al. PROSTATE CANCER AND PROSTATIC DISEASES
- The Dominant Role of Forkhead Box Proteins in Cancer
- (2018) Duc-Hiep Bach et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance
- (2018) Fei Han et al. Nature Communications
- Randomized Phase II Study Evaluating Akt Blockade with Ipatasertib, in Combination with Abiraterone, in Patients with Metastatic Prostate Cancer with and without PTEN Loss
- (2018) Johann S. de Bono et al. CLINICAL CANCER RESEARCH
- Phase Ib dose-finding study of abiraterone acetate plus buparlisib (BKM120) or dactolisib (BEZ235) in patients with castration-resistant prostate cancer
- (2017) Christophe Massard et al. EUROPEAN JOURNAL OF CANCER
- Phase II trial of the PI3 kinase inhibitor buparlisib (BKM-120) with or without enzalutamide in men with metastatic castration resistant prostate cancer
- (2017) Andrew J. Armstrong et al. EUROPEAN JOURNAL OF CANCER
- Nuclear mTOR acts as a transcriptional integrator of the androgen signaling pathway in prostate cancer
- (2017) Étienne Audet-Walsh et al. GENES & DEVELOPMENT
- ProCAID: a phase I clinical trial to combine the AKT inhibitor AZD5363 with docetaxel and prednisolone chemotherapy for metastatic castration resistant prostate cancer
- (2017) Simon J. Crabb et al. INVESTIGATIONAL NEW DRUGS
- Akt activation by Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) in ovarian cancer cells
- (2017) Angela M. Gocher et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PTEN loss and activation of K-RAS and β-catenin cooperate to accelerate prostate tumourigenesis
- (2017) Matthew T Jefferies et al. JOURNAL OF PATHOLOGY
- Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients
- (2017) Ahmet Zehir et al. NATURE MEDICINE
- WNT signalling in prostate cancer
- (2017) Virginia Murillo-Garzón et al. Nature Reviews Urology
- The androgen receptor is a negative regulator of eIF4E phosphorylation at S209: implications for the use of mTOR inhibitors in advanced prostate cancer
- (2017) L S D'Abronzo et al. ONCOGENE
- A Phase I Study of Abiraterone Acetate Combined with BEZ235, a Dual PI3K/mTOR Inhibitor, in Metastatic Castration Resistant Prostate Cancer
- (2017) Xiao X. Wei et al. ONCOLOGIST
- Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases
- (2017) Mazhar Pasha et al. Oxidative Medicine and Cellular Longevity
- PI3K-p110α mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85α
- (2017) Lauren M. Thorpe et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Twenty-five years of mTOR: Uncovering the link from nutrients to growth
- (2017) David M. Sabatini PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer
- (2017) Bi-Dar Wang et al. Nature Communications
- Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism
- (2017) Benoit Bilanges et al. Nature Communications
- Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling
- (2017) Inma M. Berenjeno et al. Nature Communications
- Inhibition of the PI3K/AKT/mTOR pathway activates autophagy and compensatory Ras/Raf/MEK/ERK signalling in prostate cancer
- (2017) Dominika E. Butler et al. Oncotarget
- PTEN loss is associated with prostate cancer recurrence and alterations in tumor DNA methylation profiles
- (2017) Milan S. Geybels et al. Oncotarget
- Therapeutic Approaches Targeting MYC-Driven Prostate Cancer
- (2017) Richard Rebello et al. Genes
- c-Myc Antagonises the Transcriptional Activity of the Androgen Receptor in Prostate Cancer Affecting Key Gene Networks
- (2017) Stefan J. Barfeld et al. EBioMedicine
- AR Signaling and the PI3K Pathway in Prostate Cancer
- (2017) Megan Crumbaker et al. Cancers
- The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34
- (2016) J. M. Backer BIOCHEMICAL JOURNAL
- Cancer treatment and survivorship statistics, 2016
- (2016) Kimberly D. Miller et al. CA-A CANCER JOURNAL FOR CLINICIANS
- PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition
- (2016) Pau Castel et al. CANCER CELL
- The hVps34‐SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth
- (2016) Ruzica Bago et al. EMBO JOURNAL
- Androgen receptor signaling in castration-resistant prostate cancer: a lesson in persistence
- (2016) Isabel Coutinho et al. ENDOCRINE-RELATED CANCER
- Repurposing Metformin as Therapy for Prostate Cancer within the STAMPEDE Trial Platform
- (2016) Silke Gillessen et al. EUROPEAN UROLOGY
- TSC1/2 mutations define a molecular subset of HCC with aggressive behaviour and treatment implication
- (2016) Daniel W H Ho et al. GUT
- SOX9 drives WNT pathway activation in prostate cancer
- (2016) Fen Ma et al. JOURNAL OF CLINICAL INVESTIGATION
- mTORC1 and mTORC2 in cancer and the tumor microenvironment
- (2016) L C Kim et al. ONCOGENE
- Energy sensing and cancer: LKB1 function and lessons learnt from Peutz–Jeghers syndrome
- (2016) Boris Y. Shorning et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Control of YAP/TAZ Activity by Metabolic and Nutrient-Sensing Pathways
- (2016) Giulia Santinon et al. TRENDS IN CELL BIOLOGY
- The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes
- (2016) Bernard Pereira et al. Nature Communications
- Lysosomal recruitment of TSC2 is a universal response to cellular stress
- (2016) Constantinos Demetriades et al. Nature Communications
- Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation
- (2016) Elmer Hoekstra et al. Oncotarget
- Targeted depletion of PIK3R2 induces regression of lung squamous cell carcinoma
- (2016) Jesús Vallejo-Díaz et al. Oncotarget
- Deptor transcriptionally regulates endoplasmic reticulum homeostasis in multiple myeloma cells
- (2016) Valeria Catena et al. Oncotarget
- Novel roles for class II Phosphoinositide 3-Kinase C2β in signalling pathways involved in prostate cancer cell invasion
- (2016) Ioanna Mavrommati et al. Scientific Reports
- Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling
- (2016) Mee-Sup Yoon et al. Cell Reports
- Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
- (2016) Linda S. Steelman et al. Aging-US
- Combined AKT and MEK Pathway Blockade in Pre-Clinical Models of Enzalutamide-Resistant Prostate Cancer
- (2016) Paul Toren et al. PLoS One
- The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis
- (2015) Lisa M. Ooms et al. CANCER CELL
- Feedback Suppression of PI3Kα Signaling in PTEN-Mutated Tumors Is Relieved by Selective Inhibition of PI3Kβ
- (2015) Sarit Schwartz et al. CANCER CELL
- SOX4 Is Essential for Prostate Tumorigenesis Initiated by PTEN Ablation
- (2015) B. Bilir et al. CANCER RESEARCH
- Alternative Wnt Signaling Activates YAP/TAZ
- (2015) Hyun Woo Park et al. CELL
- Integrative Clinical Genomics of Advanced Prostate Cancer
- (2015) Dan Robinson et al. CELL
- The Molecular Taxonomy of Primary Prostate Cancer
- (2015) Adam Abeshouse et al. CELL
- Genomic Classification of Cutaneous Melanoma
- (2015) Rehan Akbani et al. CELL
- FOXO3a modulates WNT/β-catenin signaling and suppresses epithelial-to-mesenchymal transition in prostate cancer cells
- (2015) Hao Liu et al. CELLULAR SIGNALLING
- Molecular Pathways: Is AMPK a Friend or a Foe in Cancer?
- (2015) D. G. Hardie CLINICAL CANCER RESEARCH
- TSC1 Activates TGF-β-Smad2/3 Signaling in Growth Arrest and Epithelial-to-Mesenchymal Transition
- (2015) Antje Thien et al. DEVELOPMENTAL CELL
- Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart
- (2015) Alex Morrison et al. FASEB JOURNAL
- PI3K and AKT: Unfaithful Partners in Cancer
- (2015) Seraina Faes et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Prostate Cancer Incidence and PSA Testing Patterns in Relation to USPSTF Screening Recommendations
- (2015) Ahmedin Jemal et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Phosphatidylinositolphosphate phosphatase activities and cancer
- (2015) Simon A. Rudge et al. JOURNAL OF LIPID RESEARCH
- MicroRNA-126 inhibits proliferation and metastasis by targeting pik3r2 in prostate cancer
- (2015) LEI SONG et al. Molecular Medicine Reports
- NFATc1 promotes prostate tumorigenesis and overcomes PTEN loss-induced senescence
- (2015) K R Manda et al. ONCOGENE
- Differential regulation of mTORC1 by leucine and glutamine
- (2015) J. L. Jewell et al. SCIENCE
- A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity
- (2015) Alejandro Conde-Perez et al. Nature Communications
- INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor
- (2015) S. Kofuji et al. Cancer Discovery
- In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes
- (2015) C. Li Chew et al. Cancer Discovery
- Reciprocal feedback inhibition of the androgen receptor and PI3K as a novel therapy for castrate-sensitive and -resistant prostate cancer
- (2015) Wenqing Qi et al. Oncotarget
- Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling
- (2015) Nicolas Aznar et al. eLife
- MEK and PI3K inhibition in solid tumors: rationale and evidence to date
- (2015) E. Jokinen et al. Therapeutic Advances in Medical Oncology
- Androgen receptor: structure, role in prostate cancer and drug discovery
- (2014) MH Eileen Tan et al. ACTA PHARMACOLOGICA SINICA
- PI3K-AKT-mTOR signaling in prostate cancer progression and androgen deprivation therapy resistance
- (2014) AndrewC Hsieh et al. ASIAN JOURNAL OF ANDROLOGY
- The TAK1-NF- B axis as therapeutic target for AML
- (2014) M. C. J. Bosman et al. BLOOD
- YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response
- (2014) Luca Azzolin et al. CELL
- Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2
- (2014) Constantinos Demetriades et al. CELL
- A Noncanonical Frizzled2 Pathway Regulates Epithelial-Mesenchymal Transition and Metastasis
- (2014) Taranjit S. Gujral et al. CELL
- TAK1 control of cell death
- (2014) S R Mihaly et al. CELL DEATH AND DIFFERENTIATION
- The emerging role of speckle-type POZ protein (SPOP) in cancer development
- (2014) Ram-Shankar Mani DRUG DISCOVERY TODAY
- A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis
- (2014) G. Zadra et al. EMBO Molecular Medicine
- Conversion of Androgen Receptor Signaling From a Growth Suppressor in Normal Prostate Epithelial Cells to an Oncogene in Prostate Cancer Cells Involves a Gain of Function in c-Myc Regulation
- (2014) Donald J. Vander Griend et al. International Journal of Biological Sciences
- Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
- (2014) Jacques Ferlay et al. INTERNATIONAL JOURNAL OF CANCER
- Targeting the PI3K/Akt pathway in prostate cancer: Challenges and opportunities (Review)
- (2014) PAUL TOREN et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Androgens and androgen receptor signaling in prostate tumorigenesis
- (2014) Ye Zhou et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- Suppression of Feedback Loops Mediated by PI3K/mTOR Induces Multiple Overactivation of Compensatory Pathways: An Unintended Consequence Leading to Drug Resistance
- (2014) E. Rozengurt et al. MOLECULAR CANCER THERAPEUTICS
- SGK3 Mediates INPP4B-Dependent PI3K Signaling in Breast Cancer
- (2014) Jessica A. Gasser et al. MOLECULAR CELL
- Comprehensive molecular characterization of gastric adenocarcinoma
- (2014) Adam J. Bass et al. NATURE
- A Genome-Wide RNAi Screen Identifies FOXO4 as a Metastasis-Suppressor through Counteracting PI3K/AKT Signal Pathway in Prostate Cancer
- (2014) Bing Su et al. PLoS One
- Expression of phosphorylated-mTOR during the development of prostate cancer
- (2014) Sarah I.M. Sutherland et al. PROSTATE
- INPP4B is highly expressed in prostate intermediate cells and its loss of expression in prostate carcinoma predicts for recurrence and poor long term survival
- (2014) Natalie K. Rynkiewicz et al. PROSTATE
- Androgen receptor (AR) suppresses normal human prostate epithelial cell proliferation via AR/β-catenin/TCF-4 complex inhibition ofc-MYCtranscription
- (2014) Lizamma Antony et al. PROSTATE
- An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control
- (2014) H. Clevers et al. SCIENCE
- The receptor tyrosine kinase ROR1 – An oncofetal antigen for targeted cancer therapy
- (2014) Mohammad Hojjat-Farsangi et al. SEMINARS IN CANCER BIOLOGY
- Destruction of Full-Length Androgen Receptor by Wild-Type SPOP, but Not Prostate-Cancer-Associated Mutants
- (2014) Jian An et al. Cell Reports
- Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex
- (2014) Anita Parmigiani et al. Cell Reports
- FOXO Transcription Factors: Their Clinical Significance and Regulation
- (2014) Yu Wang et al. Biomed Research International
- Glucocorticoid Receptor Activity Contributes to Resistance to Androgen-Targeted Therapy in Prostate Cancer
- (2014) Masis Isikbay et al. Hormones & Cancer
- Abiraterone in the treatment of metastatic castration-resistant prostate cancer
- (2014) Elahe Mostaghel Cancer Management and Research
- Targeting PI3K/Akt/mTOR Signaling in Cancer
- (2014) Camillo Porta et al. Frontiers in Oncology
- Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors
- (2013) Eeva M. Sommer et al. BIOCHEMICAL JOURNAL
- How does SHIP1/2 balance PtdIns(3,4)P2and does it signal independently of its phosphatase activity?
- (2013) Jingwei Xie et al. BIOESSAYS
- Impaired expression of protein phosphatase 2A subunits enhances metastatic potential of human prostate cancer cells through activation of AKT pathway
- (2013) P Pandey et al. BRITISH JOURNAL OF CANCER
- The p90 RSK Family Members: Common Functions and Isoform Specificity
- (2013) R. Lara et al. CANCER RESEARCH
- Targeting the PI3K/Akt/mTOR pathway in castration-resistant prostate cancer
- (2013) Rhonda L Bitting et al. ENDOCRINE-RELATED CANCER
- The multiple layers of non-genetic regulation of PTEN tumour suppressor activity
- (2013) Nádia C. Correia et al. EUROPEAN JOURNAL OF CANCER
- Next-generation Sequencing of Advanced Prostate Cancer Treated with Androgen-deprivation Therapy
- (2013) Prabhakar Rajan et al. EUROPEAN UROLOGY
- Class III phosphatidylinositol 3-kinase and its catalytic product PtdIns3P in regulation of endocytic membrane traffic
- (2013) Camilla Raiborg et al. FEBS Journal
- Genomic deletion of MAP3K7 at 6q12-22 is associated with early PSA recurrence in prostate cancer and absence of TMPRSS2:ERG fusions
- (2013) Martina Kluth et al. MODERN PATHOLOGY
- Synergistic Targeting of PI3K/AKT Pathway and Androgen Receptor Axis Significantly Delays Castration-Resistant Prostate Cancer ProgressionIn Vivo
- (2013) Christian Thomas et al. MOLECULAR CANCER THERAPEUTICS
- Integrated genomic characterization of endometrial carcinoma
- (2013) Gad Getz et al. NATURE
- Amino acid signalling upstream of mTOR
- (2013) Jenna L. Jewell et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch
- (2013) J B Tennakoon et al. ONCOGENE
- Different Patterns of Akt and ERK Feedback Activation in Response to Rapamycin, Active-Site mTOR Inhibitors and Metformin in Pancreatic Cancer Cells
- (2013) Heloisa P. Soares et al. PLoS One
- Conditional Deletion of the Pten Gene in the Mouse Prostate Induces Prostatic Intraepithelial Neoplasms at Early Ages but a Slow Progression to Prostate Tumors
- (2013) Mi Kyung Kwak et al. PLoS One
- Deregulation of FoxO3a accelerates prostate cancer progression in TRAMP mice
- (2013) Sanjeev Shukla et al. PROSTATE
- Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
- (2013) J. Gao et al. Science Signaling
- p110δ PI3 kinase pathway: emerging roles in cancer
- (2013) Niki Tzenaki et al. Frontiers in Oncology
- Regulation and cellular functions of class II phosphoinositide 3-kinases
- (2012) Marco Falasca et al. BIOCHEMICAL JOURNAL
- Suppression of Tak1 Promotes Prostate Tumorigenesis
- (2012) M. Wu et al. CANCER RESEARCH
- B-Raf Activation Cooperates with PTEN Loss to Drive c-Myc Expression in Advanced Prostate Cancer
- (2012) J. Wang et al. CANCER RESEARCH
- MEK Inhibition Leads to PI3K/AKT Activation by Relieving a Negative Feedback on ERBB Receptors
- (2012) A. B. Turke et al. CANCER RESEARCH
- Pten Loss and RAS/MAPK Activation Cooperate to Promote EMT and Metastasis Initiated from Prostate Cancer Stem/Progenitor Cells
- (2012) D. J. Mulholland et al. CANCER RESEARCH
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2
- (2012) K. D. Copps et al. DIABETOLOGIA
- Targeting the MAPK–RAS–RAF signaling pathway in cancer therapy
- (2012) Libero Santarpia et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- High levels of p110δ PI3K expression in solid tumor cells suppress PTEN activity, generating cellular sensitivity to p110δ inhibitors through PTEN activation
- (2012) Niki Tzenaki et al. FASEB JOURNAL
- PI3K-independent AKT activation in cancers: A treasure trove for novel therapeutics
- (2012) Kiran Mahajan et al. JOURNAL OF CELLULAR PHYSIOLOGY
- The AMPK 2 Subunit Is Required for Energy Homeostasis during Metabolic Stress
- (2012) B. Dasgupta et al. MOLECULAR AND CELLULAR BIOLOGY
- TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1
- (2012) Christian C. Dibble et al. MOLECULAR CELL
- Comprehensive molecular portraits of human breast tumours
- (2012) Daniel C. Koboldt et al. NATURE
- The mutational landscape of lethal castration-resistant prostate cancer
- (2012) Catherine S. Grasso et al. NATURE
- Hippo–YAP and mTOR pathways collaborate to regulate organ size
- (2012) Alfred Csibi et al. NATURE CELL BIOLOGY
- β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer
- (2012) Stephan P Tenbaum et al. NATURE MEDICINE
- The -Catenin Destruction Complex
- (2012) J. L. Stamos et al. Cold Spring Harbor Perspectives in Biology
- Opposing Effects of Androgen Deprivation and Targeted Therapy on Prostate Cancer Prevention
- (2012) Shidong Jia et al. Cancer Discovery
- The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.
- (2012) Ethan Cerami et al. Cancer Discovery
- FoxO family members in cancer
- (2011) Yuqing Zhang et al. CANCER BIOLOGY & THERAPY
- AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity
- (2011) Sarat Chandarlapaty et al. CANCER CELL
- Identification of PHLPP1 as a Tumor Suppressor Reveals the Role of Feedback Activation in PTEN-Mutant Prostate Cancer Progression
- (2011) Muhan Chen et al. CANCER CELL
- Cell Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer Growth
- (2011) David J. Mulholland et al. CANCER CELL
- Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer
- (2011) Brett S. Carver et al. CANCER CELL
- PDK1 Attenuation Fails to Prevent Tumor Formation in PTEN-Deficient Transgenic Mouse Models
- (2011) K. Ellwood-Yen et al. CANCER RESEARCH
- Decreased Expression and Androgen Regulation of the Tumor Suppressor Gene INPP4B in Prostate Cancer
- (2011) Myles C. Hodgson et al. CANCER RESEARCH
- Androgen Receptor and Nutrient Signaling Pathways Coordinate the Demand for Increased Amino Acid Transport during Prostate Cancer Progression
- (2011) Q. Wang et al. CANCER RESEARCH
- Cellular and molecular mechanisms of metformin: an overview
- (2011) Benoit Viollet et al. CLINICAL SCIENCE
- The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders
- (2011) Walter L. Miller et al. ENDOCRINE REVIEWS
- Intratumoral androgen biosynthesis in prostate cancer pathogenesis and response to therapy
- (2011) Changmeng Cai et al. ENDOCRINE-RELATED CANCER
- The role of LKB1 in lung cancer
- (2011) Montse Sanchez-Cespedes Familial Cancer
- AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function
- (2011) D. G. Hardie GENES & DEVELOPMENT
- mTOR-RAPTOR and 14-3-3 immunohistochemical expression in high grade prostatic intraepithelial neoplasia and prostatic adenocarcinomas: a tissue microarray study
- (2011) S. Evren et al. JOURNAL OF CLINICAL PATHOLOGY
- Integration of Regulatory Networks by NKX3-1 Promotes Androgen-Dependent Prostate Cancer Survival
- (2011) P. Y. Tan et al. MOLECULAR AND CELLULAR BIOLOGY
- Compensatory Pathways Induced by MEK Inhibition Are Effective Drug Targets for Combination Therapy against Castration-Resistant Prostate Cancer
- (2011) D. Gioeli et al. MOLECULAR CANCER THERAPEUTICS
- Minireview: Alternative Activation Pathways for the Androgen Receptor in Prostate Cancer
- (2011) Kristin R. Lamont et al. MOLECULAR ENDOCRINOLOGY
- The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
- (2011) Maria M. Mihaylova et al. NATURE CELL BIOLOGY
- Differential roles for the p101 and p84 regulatory subunits of PI3Kγ in tumor growth and metastasis
- (2011) J A Brazzatti et al. ONCOGENE
- PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer
- (2011) V Serra et al. ONCOGENE
- Cullin 3 mediates SRC-3 ubiquitination and degradation to control the retinoic acid response
- (2011) C. Ferry et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- HER2 overcomes PTEN (loss)-induced senescence to cause aggressive prostate cancer
- (2011) I. Ahmad et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors
- (2011) A. Chakrabarty et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling
- (2011) Y. Yu et al. SCIENCE
- The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation
- (2011) Michelle C. Mendoza et al. TRENDS IN BIOCHEMICAL SCIENCES
- mTOR Kinase Inhibition Causes Feedback-Dependent Biphasic Regulation of AKT Signaling
- (2011) V. S. Rodrik-Outmezguine et al. Cancer Discovery
- Integrative Genomic Profiling of Human Prostate Cancer
- (2010) Barry S. Taylor et al. CANCER CELL
- Tuberous Sclerosis Complex 1: An Epithelial Tumor Suppressor Essential to Prevent Spontaneous Prostate Cancer in Aged Mice
- (2010) R. D. Kladney et al. CANCER RESEARCH
- The Phosphoinositide 3-Kinase Regulatory Subunit p85 Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling
- (2010) C. M. Taniguchi et al. CANCER RESEARCH
- Fyn-Dependent Regulation of Energy Expenditure and Body Weight Is Mediated by Tyrosine Phosphorylation of LKB1
- (2010) Eijiro Yamada et al. Cell Metabolism
- FoxOs Inhibit mTORC1 and Activate Akt by Inducing the Expression of Sestrin3 and Rictor
- (2010) Chia-Chen Chen et al. DEVELOPMENTAL CELL
- Activation of an oncogenic TBC1D7 (TBC1 domain family, member 7) protein in pulmonary carcinogenesis
- (2010) Nagato Sato et al. GENES CHROMOSOMES & CANCER
- Second AKT: The rise of SGK in cancer signalling
- (2010) Maressa A. Bruhn et al. GROWTH FACTORS
- Functions and regulation of the 70kDa ribosomal S6 kinases
- (2010) Tim R. Fenton et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- ERK1/2 Phosphorylate Raptor to Promote Ras-dependent Activation of mTOR Complex 1 (mTORC1)
- (2010) Audrey Carriere et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The PI3K Pathway As Drug Target in Human Cancer
- (2010) Kevin D. Courtney et al. JOURNAL OF CLINICAL ONCOLOGY
- The emerging mechanisms of isoform-specific PI3K signalling
- (2010) Bart Vanhaesebroeck et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers
- (2010) C. G. Fedele et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A constitutively activated form of the p110 isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice
- (2010) S. H. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Divide and ProsPer: The emerging role of PtdIns3P in cytokinesis
- (2010) Ioannis P. Nezis et al. TRENDS IN CELL BIOLOGY
- A complex interplay between Akt, TSC2 and the two mTOR complexes: Figure 1
- (2009) Jingxiang Huang et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Evidence that Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor that Inhibits PI3K Signaling
- (2009) Christina Gewinner et al. CANCER CELL
- mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice
- (2009) David A. Guertin et al. CANCER CELL
- 3-Phosphoinositide-Dependent Kinase 1 Potentiates Upstream Lesions on the Phosphatidylinositol 3-Kinase Pathway in Breast Carcinoma
- (2009) M. Maurer et al. CANCER RESEARCH
- DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival
- (2009) Timothy R. Peterson et al. CELL
- Suppression of HER2/HER3-Mediated Growth of Breast Cancer Cells with Combinations of GDC-0941 PI3K Inhibitor, Trastuzumab, and Pertuzumab
- (2009) E. Yao et al. CLINICAL CANCER RESEARCH
- Phosphatidylinositol 3-Kinase Signaling Does Not Activate the Wnt Cascade
- (2009) Ser Sue Ng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes
- (2009) Anne Simonsen et al. JOURNAL OF CELL BIOLOGY
- Characterization of Rictor Phosphorylation Sites Reveals Direct Regulation of mTOR Complex 2 by S6K1
- (2009) C. C. Dibble et al. MOLECULAR AND CELLULAR BIOLOGY
- mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling
- (2009) L.-A. Julien et al. MOLECULAR AND CELLULAR BIOLOGY
- Targeting the phosphoinositide 3-kinase pathway in cancer
- (2009) Pixu Liu et al. NATURE REVIEWS DRUG DISCOVERY
- Molecular mechanisms of mTOR-mediated translational control
- (2009) Xiaoju Max Ma et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity
- (2009) M-C Liang et al. ONCOGENE
- Coactivator selective regulation of androgen receptor activity
- (2009) Irina U. Agoulnik et al. STEROIDS
- GSK3: a multifaceted kinase in Wnt signaling
- (2009) Dianqing Wu et al. TRENDS IN BIOCHEMICAL SCIENCES
- A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression
- (2008) Carolyn L. Buller et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- The regulation and function of Class III PI3Ks: novel roles for Vps34
- (2008) Jonathan M. Backer BIOCHEMICAL JOURNAL
- mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
- (2008) Juan M. García-Martínez et al. BIOCHEMICAL JOURNAL
- Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation
- (2008) M. Wall et al. BLOOD
- Lkb1 Deficiency Causes Prostate Neoplasia in the Mouse
- (2008) H. B. Pearson et al. CANCER RESEARCH
- A Transcription-Independent Function of FOXO1 in Inhibition of Androgen-Independent Activation of the Androgen Receptor in Prostate Cancer Cells
- (2008) P. Liu et al. CANCER RESEARCH
- Crosstalk between the Androgen Receptor and -Catenin in Castrate-Resistant Prostate Cancer
- (2008) G. Wang et al. CANCER RESEARCH
- K-ras and Wnt Signaling Synergize to Accelerate Prostate Tumorigenesis in the Mouse
- (2008) H. B. Pearson et al. CANCER RESEARCH
- p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling
- (2008) Andrei V. Budanov et al. CELL
- Pilot Study of Rapamycin in Patients with Hormone-Refractory Prostate Cancer
- (2008) Robert J. Amato et al. Clinical Genitourinary Cancer
- Oncogenic MAPK Signaling Stimulates mTORC1 Activity by Promoting RSK-Mediated Raptor Phosphorylation
- (2008) Audrey Carrière et al. CURRENT BIOLOGY
- Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events
- (2008) C. Nardella et al. GENES & DEVELOPMENT
- Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model
- (2008) Carolyn Waugh Kinkade et al. JOURNAL OF CLINICAL INVESTIGATION
- Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
- (2008) Arkaitz Carracedo et al. JOURNAL OF CLINICAL INVESTIGATION
- AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
- (2008) Dana M. Gwinn et al. MOLECULAR CELL
- AKT1 E17K in human solid tumours
- (2008) F E Bleeker et al. ONCOGENE
- Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma
- (2008) C. K. Ratnacaram et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The p110 isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110
- (2008) J. Guillermet-Guibert et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started