Clarithromycin inhibits autophagy in colorectal cancer by regulating the hERG1 potassium channel interaction with PI3K

Ion Channel Conformations Regulate Integrin-Dependent Signaling

(2019) Andrea Becchetti et al.   TRENDS IN CELL BIOLOGY

Phospho-ERK levels as predictors for chemotherapy of rectal carcinoma

(2019) Susanne Holck et al.   Oncotarget

Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers

(2019) Conan G. Kinsey et al.   NATURE MEDICINE

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

(2019) Kirsten L. Bryant et al.   NATURE MEDICINE

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Simultaneous induction and blockade of autophagy by a single agent

(2018) Karolina Kucharewicz et al.   Cell Death & Disease

Drug resistance and new therapies in colorectal cancer

(2018) Kevin Van der Jeught et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Chemopreventive effects of a low-side-effect antibiotic drug, erythromycin, on mouse intestinal tumors

(2017) Takahiro Hamoya et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

The conformational state of hERG1 channels determines integrin association, downstream signaling, and cancer progression

(2017) Andrea Becchetti et al.   Science Signaling

A novel microfluidic 3D platform for culturing pancreatic ductal adenocarcinoma cells: comparison with in vitro cultures and in vivo xenografts

(2017) Meike Beer et al.   Scientific Reports

The conformational state of hERG1 channels determines integrin association, downstream signaling, and cancer progression

(2017) Andrea Becchetti et al.   Science Signaling

Autophagy inhibition by chloroquine sensitizes HT-29 colorectal cancer cells to concurrent chemoradiation

(2017) Caitlin A Schonewolf et al.   World Journal of Gastrointestinal Oncology

Autophagy in cancer metastasis

(2016) E E Mowers et al.   ONCOGENE

Macrolide Antibiotics Exhibit Cytotoxic Effect under Amino Acid-Depleted Culture Condition by Blocking Autophagy Flux in Head and Neck Squamous Cell Carcinoma Cell Lines

(2016) Kazuhiro Hirasawa et al.   PLoS One

Prognostic relevance of autophagy-related markers LC3, p62/sequestosome 1, Beclin-1 and ULK1 in colorectal cancer patients with respect to KRAS mutational status

(2016) Klaus Juergen Schmitz et al.   World Journal of Surgical Oncology

Macrolide antibiotics exert antileukemic effects by modulating the autophagic flux through inhibition of hERG1 potassium channels

(2016) S Pillozzi et al.   Blood Cancer Journal

Ion channel expression as promising cancer biomarker

(2015) Elena Lastraioli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Heterozygous deletion of ATG5 inApcMin/+mice promotes intestinal adenoma growth and enhances the antitumor efficacy of interferon-gamma

(2015) Lu Wang et al.   CANCER BIOLOGY & THERAPY

Autophagy in malignant transformation and cancer progression

(2015) L. Galluzzi et al.   EMBO JOURNAL

Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines

(2015) SHUNTARO MUKAI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

hERG1 Potassium Channels: Novel Biomarkers in Human Solid Cancers

(2015) Elena Lastraioli et al.   Biomed Research International

Pharmacologic resistance in colorectal cancer: a review

(2015) William A. Hammond et al.   Therapeutic Advances in Medical Oncology

Autophagy in colorectal cancer: An important switch from physiology to pathology

(2015) Florin Burada   World Journal of Gastrointestinal Oncology

The cytoplasmic side of p53's oncosuppressive activities

(2014) Anna Comel et al.   FEBS LETTERS

hERG1 Channels and Glut-1 as Independent Prognostic Indicators of Worse Outcome in Stage I and II Colorectal Cancer: A Pilot Study

(2014) Elena Lastraioli et al.   Translational Oncology

Absence of Autophagy-Related Proteins Expression Is Associated with Poor Prognosis in Patients with Colorectal Adenocarcinoma

(2014) Ji Hye Choi et al.   Gastroenterology Research and Practice

Combined treatment with SAHA, bortezomib, and clarithromycin for concomitant targeting of aggresome formation and intracellular proteolytic pathways enhances ER stress-mediated cell death in breast cancer cells

(2013) Seiichiro Komatsu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prognostic impact of Beclin 1, p62/sequestosome 1 and LC3 protein expression in colon carcinomas from patients receiving 5-fluorouracil as adjuvant chemotherapy

(2013) Jae Myung Park et al.   CANCER BIOLOGY & THERAPY

Autophagy Inhibition Sensitizes Colon Cancer Cells to Antiangiogenic and Cytotoxic Therapy

(2013) M. Selvakumaran et al.   CLINICAL CANCER RESEARCH

Macrolide antibiotics block autophagy flux and sensitize to bortezomib via endoplasmic reticulum stress-mediated CHOP induction in myeloma cells

(2013) SHOTA MORIYA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

hERG1 channels modulate integrin signaling to trigger angiogenesis and tumor progression in colorectal cancer

(2013) Olivia Crociani et al.   Scientific Reports

Resistance of colon cancer to 5-fluorouracil may be overcome by combination with chloroquine, an in vivo study

(2012) Kazuhito Sasaki et al.   ANTI-CANCER DRUGS

Chloroquine enhances the chemotherapeutic activity of 5-fluorouracil in a colon cancer cell line via cell cycle alteration

(2012) Jung-Hye Choi et al.   APMIS

Clarithromycin enhances dasatinib-induced cell death in chronic myeloid leukemia cells, by inhibition of late stage autophagy

(2012) Lisa Schafranek et al.   LEUKEMIA & LYMPHOMA

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Fluorescently labeled macrolides as a tool for monitoring cellular and tissue distribution of azithromycin

(2012) Mario Matijašić et al.   PHARMACOLOGICAL RESEARCH

Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

(2012) R. C. Wang et al.   SCIENCE

Clarithromycin enhances bortezomib-induced cytotoxicity via endoplasmic reticulum stress-mediated CHOP (GADD153) induction and autophagy in breast cancer cells

(2011) SEIICHIRO KOMATSU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Autophagy-related proteins Beclin-1 and LC3 predict cetuximab efficacy in advanced colorectal cancer

(2011) Gui-Fang Guo   WORLD JOURNAL OF GASTROENTEROLOGY

Novel roles for hERG K+ channels in cell proliferation and apoptosis

(2011) J Jehle et al.   Cell Death & Disease

Regulation of Autophagy by Kinases

(2011) Savitha Sridharan et al.   Cancers

Chemotherapy resistance in acute lymphoblastic leukemia requires hERG1 channels and is overcome by hERG1 blockers

(2010) S. Pillozzi et al.   BLOOD

Autophagy regulation by p53

(2010) Maria Chiara Maiuri et al.   CURRENT OPINION IN CELL BIOLOGY

Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model

(2010) Jie Li et al.   EUROPEAN JOURNAL OF CANCER

Prognostic relevance of light chain 3 (LC3A) autophagy patterns in colorectal adenocarcinomas

(2010) A. Giatromanolaki et al.   JOURNAL OF CLINICAL PATHOLOGY

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

The expression ofbeclin 1is associated with favorable prognosis in stage IIIB colon cancers

(2009) Bao-Xiu Li et al.   Autophagy

Targeting Ion Channels in Cancer: A Novel Frontier in Antineoplastic Therapy

(2008) A. Arcangeli et al.   CURRENT MEDICINAL CHEMISTRY

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY